JohnWChristmanMD

PubMed

• 1 citations
  NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophage.
  Yunjuan Nie, Xiaorun Zhai, Jiao Li, Aijuan Sun, Huilian Che, John W Christman, Gaoshang Chai, Peng Zhao, Manjula Karpurapu> ;Aging and Disease. 2023 Dec 11
• Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma.
  Min-Ae Song, Ji Young Kim, Matthew W Gorr, Roy A Miller, Manjula Karpurapu, Jackie Nguyen, Devki Patel, Kellie J Archer, Navjot Pabla, Peter G Shields, Loren E Wold, J...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2023 Nov 1
• Complement C1q essential for aeroallergen sensitization via CSF1Rconventional dendritic cells type 2.
  Hyung-Geun Moon, Jacob D Eccles, Seung-Jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Pinal Kanabar, John W Christman, Steven J Ackerman, Christian Asco...> ;The Journal of Allergy and Clinical Immunology. 2023 Nov 1
• 2 citations
  NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophages.
  Yunjuan Nie, Xiaorun Zhai, Jiao Li, Aijuan Sun, Huilian Che, John W Christman, Gaoshang Chai, Peng Zhao, Manjula Karpurapu> ;Aging and Disease. 2023 Aug 1
• Long-Term Impact of Daily E-cigarette Exposure on the Lungs of Asthmatic Mice.
  Min-Ae Song, Loren E Wold, David M Aslaner, Kellie J Archer, Devki Patel, Hyeongseon Jeon, Dongjun Chung, Peter G Shields, John W Christman, Sangwoon Chung> ;Nicotine & Tobacco Research. 2023 Nov 22
• 5 citations
  Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury.
  Ji Young Kim, Josie A Silvaroli, Gabriela Vasquez Martinez, Bijay Bisunke, Alanys V Luna Ramirez, Laura A Jayne, Mei Ji He Ho Feng, Bhavya Girotra, Shirely M Acosta Ma...> ;Kidney International. 2023 Jun 1
• 2 citations
  CXCRMacrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26.
  Hyung-Geun Moon, Seung-Jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Yi-Chien Wu, Steve Seung-Young Lee, John W Christman, Steven J Ackerman, Minhyung ...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Jun 1
• 5 citations
  Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation.
  Katelyn Dunigan-Russell, Michael J Yaeger, Myles X Hodge, Brita Kilburg-Basnyat, Sky W Reece, Anastasiya Birukova, Marissa A Guttenberg, Caymen Novak, Sangwoon Chung, ...> ;Toxicology and Applied Pharmacology. 2023 Mar 1
• 1 citations
  Early Titration of Oxygen During Mechanical Ventilation Reduces Hyperoxemia in a Pilot, Feasibility, Randomized Control Trial for Automated Titration of Oxygen Levels.
  Sonal R Pannu, Matthew Exline, Brett Klamer, Guy Brock, Elliott D Crouser, John W Christman, Philip Diaz> ;Critical Care Explorations. 2022 Jun 1
• 4 citations
  Exosomal Transfer of DNA Methyl-Transferase mRNA Induces an Immunosuppressive Phenotype in Human Monocytes.
  Jon R Wisler, Kanhaiya Singh, Adara McCarty, Ryan Harkless, Manjula Karpurapu, Edward Hernandez, Debasmita Mukherjee, Ahmed S Abouhashem, John W Christman, Chandan K Sen> ;Shock. 2022 Jun 1
• Rationale and design of a randomized controlled clinical trial; Titration of Oxygen Levels (TOOL) during mechanical ventilation.
  Sonal R Pannu, Tyler Haddad, Matthew Exline, John W Christman, Jeffrey C Horowitz, Jonathan Peters, Guy Brock, Philip Diaz, Elliott D Crouser> ;Contemporary Clinical Trials. 2022 Aug 1
• 5 citations
  Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury.
  Teja Srinivas Nirujogi, Sainath R Kotha, Sangwoon Chung, Brenda F Reader, Anita Yenigalla, Liwen Zhang, John P Shapiro, Jon Wisler, John W Christman, Krishnarao Maddip...> ;Journal of Innate Immunity. 2022 Jan 1
• 6 citations
  Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation.
  Ji Young Kim, Patrick Stevens, Manjula Karpurapu, Hyunwook Lee, Joshua A Englert, Pearlly Yan, Tae Jin Lee, Navjot Pabla, Maciej Pietrzak, Gye Young Park, John W Chris...> ;Frontiers in Immunology. 2022 Jan 1
• 6 citations
  mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury
  Hyunwook Lee, Qinqin Fei, Adam Streicher, Wenjuan Zhang, Colleen Isabelle, Pragi Patel, Hilaire C. Lam, Antonio J. Arciniegas-Rubio, Miguel Pinilla-Vera, Diana Amador-...> ;JCI Insight. 2021 Jul 22
• 1 citations
  Can acute respiratory distress syndrome be treated
  John W. Christman, Manjula Karpurapu, Dehua Pei> ;Future Medicinal Chemistry. 2021 Mar 16
• 18 citations
  Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation.
  Christopher M Bobba, Qinqin Fei, Vasudha C. Shukla, Hyunwook Lee, Pragi Patel, Rachel K. Putman, Carleen R. Spitzer, MuChun Tsai, Mark D. Wewers, Robert J. Lee, John W...> ;Nature Communications. 2021 Jan 12
• 16 citations
  PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury.
  Yunjuan Nie, Teja Srinivas Nirujogi, Ravi Ranjan, Brenda F. Reader, Sangwoon Chung, Megan N. Ballinger, Joshua A. Englert, John W. Christman, Manjula Karpurapu> ;Journal of Innate Immunity. 2021 Mar 1
• 15 citations
  Workforce, Workload, and Burnout in Critical Care Organizations: Survey Results and Research Agenda.
  Craig M. Lilly, John Oropello, Stephen M. Pastores, Craig M. Coopersmith, Roozehra Khan, Curtis N. Sessler, John W. Christman> ;Critical Care Medicine. 2020 Nov 1
• 8 citations
  A Peptidyl Inhibitor that Blocks Calcineurin–NFAT Interaction and Prevents Acute Lung Injury
  Patrick G Dougherty, Manjula Karpurapu, Amritendu Koley, Jessica K Lukowski, Ziqing Qian, Teja Srinivas Nirujogi, Luiza Rusu, Sangwoon Chung, Amanda B. Hummon, Hao W L...> ;Journal of Medicinal Chemistry. 2020 Oct 19
• 42 citations
  Macrophages are the primary effector cells in IL-7-induced arthritis.
  Seung Jae Kim, Huan J Chang, Michael V. Volin, Sadiq Umar, Katrien Van Raemdonck, Aimee Chevalier, Karol Palasiewicz, John W. Christman, Suncica Volkov, Shiva Arami, M...> ;Cellular & Molecular Immunology. 2020 Jul 1
• 2 citations
  Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia.
  Rebecca M. Baron, John W. Christman, Kathleen D. Liu, Michael A. Matthay, Wesley H. Self, Bryan J. McVerry, R. Duncan Hite, Robert Paine, Mark M. Wurfel, Nathan I. Sha...> ;American Journal of Respiratory and Critical Care Medicine. 2020 May 1
• 27 citations
  A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.
  Jiyoung Kim, Yuntao Bai, Laura A. Jayne, Ralph D. Hector, Avinash K. Persaud, Su Sien Ong, Shreshtha Rojesh, Radhika Raj, Mei Ji He Ho Feng, Sangwoon Chung, Rachel E. ...> ;Nature Communications. 2020 Apr 21
• 7 citations
  IRAK-M Regulates Monocyte Trafficking to the Lungs in Response to Bleomycin Challenge.
  Brenda F. Reader, Shruthi Sethuraman, Bryan R. Hay, Rose Viguna Thomas Becket, Manjula Karpurapu, Sangwoon Chung, Yong Gyu Lee, John W. Christman, Megan N. Ballinger> ;Journal of Immunology. 2020 Apr 6
• 17 citations
  Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.
  Jiyoung Kim, Laura A. Jayne, Yuntao Bai, Mei Ji He Ho Feng, Matthew A. Clark, Sangwoon Chung, John W. Christman, Rachel E. Cianciolo, Navjotsingh Pabla> ;Biochemical Pharmacology. 2020 Mar 27
• 12 citations
  Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2
  Sangwoon Chung, Yong Gyu Lee, Manjula Karpurapu, Joshua A. Englert, Megan N. Ballinger, Ian C. Davis, Gye Young Park, John W. Christman> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2020 Mar 11
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Journal Articles

• FoxO1 Is a Critical Regulator of M2‐like Macrophages Activation in Allergic Asthma  
  Joshua A Englert, John W Christman, Allergy
• Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery Following Ischemic Damage  
  John Christman, MD, The Journal of Immunology
• Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2  
  Kim KH, Sadikot RT, Xiao L, Christman JW, Freeman ML, Chan JY, Oh YK, Blackwell TS, Joo M, Free Radic Biol Med., 9/1/2013
• The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis  
  Chen Z, Kim SJ, Chamberlain ND, Pickens SR, Volin MV, Volkov S, Arami S, Christman JW, Prabhakar BS, Swedler W, Mehta A, Sweiss N, Shahrara S, J Immunol, 5/1/2013
• Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples  
  Yu R, Zhao G, Christman JW, Xiao L, van Breemen RB, J AOAC Int., 1/1/2013
• Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury  
  Kim KH, Kwun MJ, Choi JY, Ahn KS, Oh SR, Lee YG, Christman JW, Sadikot RT, Han CW, Joo M, Evid Based Complement Alternat Med., 1/1/2013
• Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages  
  Xiao L, Ornatowska M, Zhao G, Cao H, Yu R, Deng J, Li Y, Zhao Q, Sadikot RT, Christman JW, PLoS One., 1/1/2012
• Lung inflammation and inflammatory gene expression in response to endotoxemia are attenuated in bone marrow chimera mice with functionally inactive PU1  
  Karpurapu M, Wang X, Deng J, Park H, Xiao L, Sadikot RT, Frey RS, Maus UA, Park GY, Scott E, Christman JW, Blood, 11/1/2011
• Local deliver of GM-CSF protects mice from lethal pneumonoccal pneumonia  
  Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Langer F, Christman JW, Ask K, Kolb M, Gauldie J, Welte T, Maus UA, J Immunol, 11/1/2011
• Dendritic Cell Depletion and Repopulation in the Lung after Irradiation and Bone Marrow Transplantation in Mice  
  Hahn I, Klaus A, Maus R, Christman JW, Welte T, Maus UA, Am J Respir Cell Mol Biol., 9/1/2011
• Anthrax Lethal Factor Activates K+ Channels To Induce IL-1{beta} Secretion in Macrophages  
  Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I, J Immunol., 1/1/2011
• MAP kinase phosphatase 5 protects against sepsis-induced acute lung injury  
  Qian F, Deng J, Garntner BN, Dong C, Christman JW, Wu D, Ye RD, AJP Lung Cell and Molecular Physiolog, 1/1/2011
• Expression of TREM-1 is inhibited by PGD(2) and PGJ(2) in macrophages  
  Syed MA, Joo M, Abbas Z, Rodger D, Christman JW, Mehta D, Sadikot RT, Exp Cell Res, 8/23/2010
• Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection  
  Herbold W, Maus R, Hahn I, Ding N, Srivastava M, Christman JW, Mack M, Reutershan J, Briles DE, Paton JC, Winter C, Welte T, Maus UA, Infect Immun., 4/5/2010
• Myeloid cells control termination of lung inflammation throught the NF-kB pathway  
  Han W, Joo M, Everhart MB, Christman JW, Yull FE, Blackwell TS, AJ Physiol Lung Cell Mol Phys., 12/19/2009
• NF-kB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-B site in the ICAM-1 gene  
  Xue J, Thippegowda PB, Hu G, Bachmaier K, Christman JW, Malik AB, Tiruppathi C. C., Physiol Genomics, 4/7/2009
• A PU1 and cJun interaction determines lipocalin-type prostaglandin D synthase protein production and enzyme activity in macrophages  
  Joo M, Kwon M, Cho UJ, Hu NN, Pedchenko T, Sadikot RT, Blackwell TS, Christman JW, Am J Physiol Lung Cell Mol Physiol., 1/30/2009
• The NF-kappaB pathway in airway epithelium regulates neutrophil recruitment and host defense following Pseudomonas aeruginosa  
  Chen SM, Cheng DS, Sherrill TP, Han W, Clont M, Saint-Jean L, Christman JW, Sadikot RT, Yull FE, Blackwell TS, Clinical and Experimental Immunology Clin and Exp Immun, 9/1/2008
• TNFalpha-mediated suppression of adipocytes apolipoprotein E gene transcription: Primary role for the NFkappaB pathway and NFkappaB p50  
  Yue L, Christman JW, Mazzone T, Endocrinology, 8/1/2008
• Genetic determination of the role of PU1 in macrophage gene expression  
  Joo M, Kwon M, Azim AC, Sadikot RT, Blackwell TS, Christman JW, Bichem Biophys Res Com, 7/1/2008
• The Shanghai Women’s Asthma and Allergy Study (SWAAS) Objectives, Design, and Recruitment Results  
  Gross M, Hartman T, Christman JW, Gao YT, Jin M, Bai C, Deng X, Wen W, Yang G, Gebretsadik T, Roberts LJ, Sheller J, Dupont W, Griffin MR, Zheng W, Shu HO, and Hartert TV, Amer J of Epidemiology, 6/1/2008
• Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae  
  Taut K, Winter C, BRiles DE, Paton JC, Christman JW, Maus R, Baumann R, Welte T, Maus UA, Amer J of Lung Cell and Molec Biology, 1/1/2008
• Quantitative LC-MS/MS analysis of prostaglandins E2 and D2 in cellular supernatants  
  Cao HM, Park GY, Azim AC, Mathew B, Wang X, Christman JW, van Breemen RB, Anal Biochem, 1/1/2008
• NF-kappa B inducing kinase (NIK) regulates COX-2 gene expression in macrophage by phosphorylation of PU1  
  Azim AC, Wang X, Park GY, Sadikot RT, Cai HM, Mthew B, Atchison ML, van Breemen RB, Joo M, Christman JW, J Immunol, 12/1/2007
• Conditional regulation of COX-2 in trachealbronchial epithelial cells modulates pulmonary immunity  
  Park GY, Hu NN, Wang X, Sadikot RT, Yull F, Peebles RS, Blackwell TS, Christman JW, Clinical and Experimental Immunology, 11/1/2007
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