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Michael Lesem, MD

Michael Lesem, MD

Psychiatry Houston, TX

Executive Medical Director CLRC, Ltd.

Office Address

Office Map
  • 1010 Waverly
    Houston, TX 77008
    Phone: (713) 965-7900

Summary

  • I graduated from UT Medical School in 1981. I was recognized as Outstanding Student in Psychiatry in my class. I then did one year of Internal Medicine (Internship) at UT Southwestern affliated program. I returned to UT Houston Medical School to complete my 3 years training in psychiatry. Very neuroscience oriented program under Chairman Louis Faillace, MD. My last year I was Chief Resident and acted as junior faculty assisting Ken Reed MD, PhD in re-organizing the Consultation service to our main teaching hospital-Memorial Hermann. I received perhaps the best training possible in psychiatry through the UTMSH residency program under Dr. Faillace. I then was accepted for a 2 year Research Fellowship at NIMH in Bethesda under Dennis Murphy, MD and others such as Bill Potter, MD, PhD in the Laboratory of Clinical Sciences. 1 year on research ward implementing protocols in eating disorder patients, completed a protocol in age/sex/nml weight matched normals who underwent pre and post LP's following 5% weight loss over 6 weeks. Year 2 I help develop assay to measure CSF Dynorphin A1-8 under guidance of Wade Berretini MD, PHD. I returned to UT Houston as Asst. Prof. and ran acute research units at HCPC for 3 yrs. I entered private practice in late 1989 and began mainly as hospitalist. Jim Claghorn, MD asked me to work at his private research clinic, CRA, and I transitioned to full ownership in 1994. Renamed CRA-to CLRC, Ltd. Focus became inpatient early drug developement. We developed our own 24 bed free-standing research unit and 8000 sq. ft. outpt. research center owned by the clinic. We have been one of just 2 sites in first Qtc studies in 2nd generation antipsychotics. We also have a strong reputation in developing medications for psychotic agitation. Recently we have developed infusion capabilities with dedicated space and equipment. We have experience with P-50/MMN. Our staff prides itself on implementing cutting edge protocols. Current website being updated.

Dr. Lesem's Clinical Specialties & Interests

  • Psychiatry: Geriatric, Neuropsychiatry, Psychopharmacology, Forensic, Sleep Medicine

Dr. Lesem's Faculty Appointments & Work History

  • Clinical Assistant ProfessorUniversity of Texas Medical School
    Houston, TX
  • PhysicianPrivate Practice
    Houston, TX
  • Medical DirectorClaghorn-Lesem Research Clinic, Ltd
    Houston, TX
  • Executive Medical Director CLRC, Ltd.Claghorn-Lesem Research Clinic, Ltd.
    Houston, TX
    Medical Director/Owner Private CNS Clinical Trials Research Center with ownership of 24 bed research facilty and separate 8000 sq. ft. outpt center. One of oldest private research centers in Houston-now celebrating our 31st year.
  • ConsultantNovartis, Pfizer and Janssen
  • ConsultantGlaxoSmithKline
  • Chief ConsultantSumitomo Pharmaceutical for NDA Lurasidone Registration Program
  • Courtesy StaffKingwood Health Center
    Houston, TX
  • Active StaffIntraCare Hospital
    Houston, TX
  • Courtesy StaffMemorial Southwest Hospital
    Houston, TX
  • Unit Medical DirectorColumbia Parkview Center
    Houston, TX
  • Research DirectorA Counseling Place
    Houston, TX
  • Unit Medical DirectorWest Oaks Hospital
    Houston, TX
  • Provisional ConsultingTIRR
    Houston, TX
  • Active StaffWest Oaks Hospital
    Houston, TX
  • ConsultingTexas Orthopedic Hospital
    Houston, TX
  • Medical DirectorGeropsychiatric Unit, HCA Medical Center
    Houston, TX
  • Medical DirectorGeropsychiatric Unit, Heights Hospital
    Houston, TX
  • Courtesy StaffSt. Luke's Hospital
    Kansas City, MO
  • Intensive Care Unit DirectorHouston International Hospital
    Houston, TX
  • Intensive Study Unit DirectorHarris County Psychiatric Center
    Houston, TX
    ECT Service Director (1987-1989); Geriatric Unit Director (1987-1989); Chief Adult Service (1988-1989)
  • Assistant ProfessorUniversity of Texas Medical School
    Houston, TX
  • Assistant ProfessorUniversity Texas Medical School
    Houston, TX
  • Co-directorNeuropsychiatric Consultation Service, Hermann Hospital
    Houston, TX

Dr. Lesem's Education & Medical Training

  • National Institute of Mental HealthNational Institute of Mental HealthFellowship, Research
  • University of Texas at HoustonUniversity of Texas at HoustonChief Residency, Psychiatry
  • University of Texas at HoustonUniversity of Texas at HoustonResidency, Psychiatry
  • St. Paul's HospitalSt. Paul's HospitalInternship, Medicine
  • U of TX Med Sch, HoustonUniversity of Texas Medical School at HoustonMedical School
  • University of TexasUniversity of TexasOther Training, B.A, History, Cum Laude

Dr. Lesem's Certifications & Licensure

  • TX State Medical LicenseTX State Medical License1981 - 2014
  • American Board of Psychiatry and NeurologyAmerican Board of Psychiatry and NeurologyPsychiatry, 1986
  • American Board of Psychiatry and NeurologyAmerican Board of Psychiatry and NeurologyGeriatric Psychiatry, 1992, Current

Dr. Lesem's Awards, Honors, & Recognition

  • University of Texas Medical School, Houston, TX, 1987, 1988, 1989Dean's Teaching Excellence ListUniversity of Texas Medical School, Houston, TX, 1987, 1988, 1989, 1990
  • Psychiatry Residents, University of Texas Medical School, Houston, TX, 1989-1990Inpatient Teaching AwardPsychiatry Residents, University of Texas Medical School, Houston, TX, 1989-1990, 1990
  • University of Texas Medical School, Houston, TX, 1988Resident's Service AwardUniversity of Texas Medical School, Houston, TX, 1988, 1989
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Dr. Lesem's Clinical Trials

Dr. Lesem's Publications & Presentations

PubMed | Citations by Web of Science®

Journal Articles

  • Repercussions of Redefining a Consultation-Liaison Service in a General Teaching Hospital.Reed, K., Lesem, M. D., and O'Malley, M, Letter of Hospital and Community Psychiatry, 38:673-674
  • Enhanced Thermic Effect of Food after Exercising During Refeeding of Anorexic Patients.Obarzanek, E. O., Lesem, M. D., and Jimerson, D. C, Proceedings of the Annual Meeting of FASEB: 2:A1224
  • Gender Differences and the Interpretation of Genetic Instability in Alzheimer's Disease.Cherry, L. M., Funk, J., Lesser, J. M., Lesem, M. D, Mutation Research. 275, 57-67

Books/Book Chapters

  • Serotonin in Human Eating Disorders - a chapter in the Neuropharmacology of Serotonin.
    Jimerson, D. C., Lesem, M. D., Hegg, A. P., and Brewerton, T. D
    Editors: Whitaker-Azmitia, P. M. and Peroutka, S.J.
  • Serotonin in Eating Disorders - a chapter in Serotonin in Major psychiatric Disorders.
    Brewerton, T. D., Brandt, H. A., Lesem, M. D., Murphy, D. L., and Jimerson, D. C
    Editors: Cocarro, E. F. and Murphy, D. L.

Abstracts/Posters

  • Neuroendocrine studies with 5 HT agents in bulimia.Brewerton TD, Mueller EA, Brandt HA, Lesem MD, Jimerson DC, Murphy DL, Am Psychiatric Association Annual Meeting Proceedings; 140:85-86 #38E
  • Serotonin function in anorexia nervosa; longitudinal perspectives.Jimerson, D.C., Brewerton, T. D., Hegg, A. P., Lesem, M. D., Murphy, D. L, Proceeds AM Coll. Neuropsychopharmacology: 26.74
  • Evidence for serotonin dysregulation in anorexia.Brewerton, T. D., Mueller, E. A., Brandt, H. A., Lesem, M. D., Murphy, D. L., Jimerson, D. C, Proceeds Am. Psychiatric Assoc: 140:NR195
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Lectures

  • A Case of Schizoaffective Disorder in an Elderly Patient.Department of Psychiatry, Grand Rounds, University of Texas Medical School-Houston
  • Alcoholism and Affective Disorders - Two Case Presentations.Department of Psychiatry, Grand Rounds, University of Texas Medical School-Houston
  • State-Related Changes in Plasma NE in Anorexia Nervosa.LCS Section, NIMH Seminar
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Hospital Affiliations


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