RobertB.DenMD

Radiation Oncology • Philadelphia, PA

Thomas Jefferson University Radiation Oncology

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Office
111 S 11th St
Bodine Center
Philadelphia, PA 19107
Phone+1 215-955-6702

Fax+1 215-955-5331
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Education & Training

Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Radiation Oncology, 2007 - 2011
Massachusetts General HospitalResidency, Internal Medicine, 2006 - 2007
Harvard Medical SchoolClass of 2007

Certifications & Licensure

PA State Medical License 2007 - 2024
NJ State Medical License 2017 - 2023
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2013

Clinical Trials

Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer Start of enrollment: 2011 Sep 22
Completed
Phase 1
Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer Start of enrollment: 2012 May 01
Active, not recruiting
Phase 3
High-Dose Rate Brachytherapy and Stereotactic Body Radiation Therapy in Treating Patients With Prostate Cancer Start of enrollment: 2012 Oct 04
Active, not recruiting
Not Applicable
Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy Start of enrollment: 2013 Mar 08
Completed
Not Applicable
Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer Start of enrollment: 2014 Apr 02
Active, not recruiting
Phase 1
Measuring Biomarker Response to AMP-514 in Blood Samples From Patients With Solid Tumors Undergoing Radiotherapy Start of enrollment: 2013 Nov 11
Completed
Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer Start of enrollment: 2014 Jul 22
Completed
Virtual Reality Education Module in Reducing Anxiety and Increasing Knowledge in Patients With Prostate Cancer Undergoing Radiation Therapy Start of enrollment: 2014 Aug 06
Terminated
Not Applicable
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Publications & Presentations

PubMed

Risk of Secondary Malignancies After Pelvic Radiation: A Population-based Analysis.
Joshua Banks, Hanan Goldberg, Benjamin Leiby, Connor McPartland, Andrew Salib, James R Mark, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Robert Den, Thenap...> ;European Urology Open Science. 2024 May 1
1 citations
Innate Immune System in the Context of Radiation Therapy for Cancer.
Ettickan Boopathi, Robert B Den, Chellappagounder Thangavel> ;Cancers. 2023 Aug 4
Enhancing bladder cancer care through the multidisciplinary clinic approach.
J Ryan Mark, Leonard G Gomella, Costas D Lallas, Katherine E Smentkowski, Anne Calvaresi, Nathan Handley, Robert B Den, Patrick Mille, William J Tester, Jean Hoffman-C...> ;The Canadian Journal of Urology. 2023 Jun 1
4 citations
A novel prostate cancer subtyping classifier based on luminal and basal phenotypes.
Adam B Weiner, Yang Liu, Alex Hakansson, Xin Zhao, James A Proudfoot, Julian Ho, Jj H Zhang, Eric V Li, R Jeffrey Karnes, Robert B Den, Amar U Kishan, Robert E Reiter,...> ;Cancer. 2023 Jul 15
2 citations
Diffusing Alpha-Emitters Radiation Therapy Promotes a Proimmunogenic Tumor Microenvironment and Synergizes With Programmed Cell Death Protein 1 Blockade.
Sara Del Mare, Yossi Nishri, Amit Shai, Margalit Efrati, Lisa Deutsch, Robert B Den, Itzhak Kelson, Yona Keisari, Vered Domankevich> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Mar 1
3 citations
Body composition and mortality in men receiving prostate radiotherapy: A pooled analysis of NRG/RTOG 9406 and NRG/RTOG 0126.
Andrew M McDonald, Lyudmila DeMora, Eddy S Yang, John M Hoyle, Andrew Lenzie, Grant R Williams, Jeff M Michalski, Don Yee, Jean-Paul Bahary, Robert B Den, Mack Roach 3...> ;Cancer. 2023 Mar 1
5 citations
Bone Health Management in the Continuum of Prostate Cancer Disease.
Ettickan Boopathi, Ruth Birbe, Sunday A Shoyele, Robert B Den, Chellappagounder Thangavel> ;Cancers. 2022 Sep 2
6 citations
Variation in Molecularly Defined Prostate Tumor Subtypes by Self-identified Race.
Kevin H Kensler, Shivanshu Awasthi, Mohamed Alshalalfa, Bruce J Trock, Stephen J Freedland, Michael R Freeman, Sungyong You, Brandon A Mahal, Robert B Den, Adam P Dick...> ;European Urology Open Science. 2022 Jun 1
1 citations
Subpathologies and genomic classifier for treatment individualization of post-prostatectomy radiotherapy.
Matthew Ramotar, Melvin L.K. Chua, Hong Truong, Ali Hosni, Melania Pintilie, Elai Davicioni, Neil Fleshner, Adam P. Dicker, Robert G. Bristow, Hansen H. He, Theo van d...> ;Urologic Oncology. 2021 Sep 17
17 citations
Adding Short-Term Androgen Deprivation Therapy to Radiation Therapy in Men With Localized Prostate Cancer: Long-Term Update of the NRG/RTOG 9408 Randomized Clinical Tr...
Christopher U. Jones, Stephanie L. Pugh, Howard M. Sandler, Michael Chetner, Mahul B. Amin, Deborah Watkins Bruner, Anthony L. Zietman, Robert B. Den, Mark H. Leibenha...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Sep 1
5 citations
Impact of Decipher on use of post-operative radiotherapy: Individual patient analysis of two prospective registries.
Mohammed Shahait, Vinnie Y T Liu, Neha Vapiwala, Priti Lal, Jessica Kim, Eduard J Trabulsi, Huei-Chung Huang, Elai Davicioni, Darby J S Thompson, Daniel Spratt, Robert...> ;BJUI Compass. 2021 Jul 1
33 citations
Transcriptional profiling of primary prostate tumor in metastatic hormone-sensitive prostate cancer and association with clinical outcomes: correlative analysis of the...
Anis A. Hamid, Huei-Chung Huang, Victoria Wang, Yu-Hui Chen, Felix Y. Feng, Robert B. Den, G. Attard, E.M. Van Allen, Phuoc T. Tran, Daniel E. Spratt, Ryan Dittamore, ...> ;Annals of Oncology. 2021 Jun 12
38 citations
Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences.
Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Sch...> ;Communications Biology. 2021 Jun 3
16 citations
Tumor subtype defines distinct pathways of molecular and clinical progression in primary prostate cancer
Deli Liu, Michael A. Augello, Ivana Grbeša, Davide Prandi, Yang Liu, Jonathan Shoag, R. Jeffrey Karnes, Bruce J. Trock, Eric A. Klein, Robert B. Den, Francesca Demiche...> ;The Journal of Clinical Investigation. 2021 May 17
34 citations
RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease.
Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Pascha...> ;Cancer Discovery. 2021 Apr 20
13 citations
A comparative study of PCS and PAM50 prostate cancer classification schemes.
Junhee Yoon, Minhyung Kim, Edwin M. Posadas, Stephen J. Freedland, Yang Liu, Elai Davicioni, Robert B. Den, Bruce J. Trock, R. Jeffrey Karnes, Eric A. Klein, Michael R...> ;Prostate Cancer and Prostatic Diseases. 2021 Feb 2
1 citations
Prostate cancer in young men represents a distinct clinical phenotype: gene expression signature to predict early metastases.
Yuan C. Ding, Huiqing Wu, Elai Davicioni, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Linda Steele, Susan L. Neuhausen> ;Journal of Translational Genetics and Genomics. 2021 Jan 1
38 citations
Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer.
Shivanshu Awasthi, Anders Berglund, Julieta Abraham-Miranda, Robert J. Rounbehler, Kevin H. Kensler, Amparo Serna, Adriana C. Vidal, Sungyong You, Michael R. Freeman, ...> ;Clinical Cancer Research. 2021 Jan 1
4 citations
Radiopharmaceuticals for Bone Metastases.
Andrew W. Smith, Benjamin A. Greenberger, Robert B. Den, Richard G. Stock> ;Seminars in Radiation Oncology. 2021 Jan 1
6 citations
Novel Transcriptomic Interactions Between Immune Content and Genomic Classifier Predict Lethal Outcomes in High-grade Prostate Cancer.
Kosj Yamoah, Shivanshu Awasthi, Brandon A. Mahal, Shuang G. Zhao, G. Daniel Grass, Anders Berglund, Julieta Abraham-Miranda, Travis Gerke, Robert J. Rounbehler, Elai D...> ;European Urology. 2020 Dec 7
78 citations
A Systematic Review of the Evidence for the Decipher Genomic Classifier in Prostate Cancer.
Neil K. Jairath, Alan Dal Pra, Randy Vince, Robert T. Dess, William C. Jackson, Jeffrey J. Tosoian, Sean McBride, Shuang G. Zhao, Alejandro Berlin, Brandon A. Mahal, A...> ;European Urology. 2021 Mar 1
1 citations
Interprofessional Image Verification Workshop for Physician and Physics Residents: A Multi-Institutional Experience.
Laura Padilla, Jay Burmeister, Omer L. Burnett, Elizabeth L. Covington, Robert B. Den, Michael M. Dominello, K.L. Du, P Galavis, Stephanie L. Junell, Jenna M. Kahn, Mo...> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Nov 1
1 citations
Development and Validation of a Genomic Tool to Predict Seminal Vesicle Invasion in Adenocarcinoma of the Prostate
William A. Hall, Nick Fishbane, Yang Liu, Melody J. Xu, Elai Davicioni, Brandon A. Mahal, Robert B. Den, Robert T. Dess, William C. Jackson, Anthony C. Wong, Edward M....> ;JCO Precision Oncology. 2020 Oct 16
15 citations
Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer
Amar U. Kishan, Tahmineh Romero, Mohammed Alshalalfa, Yang Liu, Phuoc T. Tran, Nicholas G. Nickols, Huihui Ye, Dipti Sajed, Matthew Rettig, Robert E. Reiter, Isla P. G...> ;European Urology. 2020 Sep 1
3 citations
Use of combined androgen deprivation therapy with postoperative radiation treatment for prostate cancer: Impact of randomized trials on clinical practice
Noelia Sanmamed, Rachel Glicksman, Jaime O. Herrera-Caceres, Eric J. Lehrer, Jaqueline Heaton, Aaron R. Hansen, Peter Chung, Neil Fleshner, Robert B. Den, Nicholas G. ...> ;Urologic Oncology. 2020 Jun 16
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Journal Articles

Tumor Cell Heterogeneity and Resistance; Report from the 2018 Coffey‐Holden Prostate Cancer Academy Meeting
Thomas A Hope, Kenneth J Pienta, Fatima Karzai, Simpa S Salami, Robert B Den, The Prostate
Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer with Adverse Pathological Features
Rahul D. Tendulkar, Kevin L. Stephans, Stanley L. Liauw, Robert B. Den, Shre Agrawal, Mitchel S. Anscher, Jason A. Efstathiou, Thomas M. Pisansky, Jason W. Hearn, Jef ..., JAMA

Press Mentions

Alpha Tau Announces Alpha DaRT™ Treatment of First Two Patients in Its Pivotal Multicenter Recurrent Skin Cancer (ReSTART) TrialMarch 8th, 2023
Decipher Biosciences Announces Publication of a Prospective Clinical Study Demonstrating That the Use of Decipher Prostate RP Guides Post-Operative Management Decisions and Improves Patient OutcomesDecember 16th, 2019
Alpha Tau Medical Appoints Jefferson University Radiation Oncologist Robert Den as Chief Medical OfficerSeptember 4th, 2019
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