AdamAschMD

PubMed

• Safety and efficacy of zandelisib plus zanubrutinib in previously treated follicular and mantle cell lymphomas.
  Catherine S Diefenbach, Thomas A Jandl, William Novotny, Jane Huang, Lu Miao, Prabhu Rajagopalan, Richard G Ghalie, Jacob D Soumerai, Deepa Jagadeesh, Adam Asch, Abhij...> ;British Journal of Haematology. 2024 Mar 19
• Impact of primary organ site of involvement by peripheral T-cell lymphoma not otherwise specified on survival.
  Davis, O., Day, S., Truong, D., Pandey, M., Ibrahimi, S., Khawandanah, M., Holter-Chakrabarty, J., Asch, A., Al-Juhaishi, T.> ;Cancer Medicine. 2023 Dec 1
• 2 citations
  Tolerability and Efficacy of the Anticluster of Differentiation 47 Antibody Magrolimab Combined With Azacitidine in Patients With Previously Untreated AML: Phase Ib Re...
  Naval G Daver, Paresh Vyas, Suman Kambhampati, Monzr M Al Malki, Richard A Larson, Adam S Asch, Gabriel Mannis, Wanxing Chai-Ho, Tiffany N Tanaka, Terrence J Bradley, ...> ;Journal of Clinical Oncology. 2023 Nov 1
• 2 citations
  An unbiased seed-based RNAi selection screen identifies small RNAs that inhibit androgen signaling and prostate cancer cell growth.
  Joshua M Corbin, Constantin Georgescu, Lin Wang, Jonathan D Wren, Magdalena Bieniasz, Chao Xu, Adam S Asch, Maria J Ruiz Echevarría> ;Molecular Therapy. Nucleic Acids. 2023 Sep 12
• 2 citations
  Gilteritinib in Combination With Induction and Consolidation Chemotherapy and as Maintenance Therapy: A Phase IB Study in Patients With Newly Diagnosed AML.
  Keith W Pratz, Mohamad Cherry, Jessica K Altman, Brenda W Cooper, Nikolai A Podoltsev, Jose Carlos Cruz, Tara L Lin, Gary J Schiller, Joseph G Jurcic, Adam Asch, Ruish...> ;Journal of Clinical Oncology. 2023 Sep 10
• 1 citations
  Phase 1/2 Study of the Pan-PIM Kinase Inhibitor INCB053914 Alone or in Combination With Standard-of-Care Agents in Patients With Advanced Hematologic Malignancies.
  Manish R Patel, William Donnellan, Michael Byrne, Adam S Asch, Amer M Zeidan, Maria R Baer, Amir T Fathi, Andrew T Kuykendall, Fred Zheng, Chris Walker, Lulu Cheng, Ci...> ;Clinical Lymphoma, Myeloma & Leukemia. 2023 Sep 1
• 1 citations
  Impact of Race and Age and their Interaction on Survival Outcomes in Patients With Diffuse Large B-Cell Lymphoma.
  Kira MacDougall, Silas Day, Spencer Hall, Daniel Zhao, Manu Pandey, Sami Ibrahimi, Mohamad Khawandanah, Jennifer H Chakrabarty, Adam Asch, Ryan Nipp, Taha Al-Juhaishi> ;Clinical Lymphoma, Myeloma & Leukemia. 2023 May 1
• 4 citations
  Prevalence of neuropsychiatric symptoms and stroke in patients with hereditary thrombotic thrombocytopenic purpura.
  Azra Borogovac, Erika Tarasco, Johanna A Kremer Hovinga, Kenneth D Friedman, Adam S Asch, Sara K Vesely, Calin I Prodan, Deirdra R Terrell, James N George> ;Blood. 2022 Aug 18
• 14 citations
  Zandelisib with continuous or intermittent dosing as monotherapy or in combination with rituximab in patients with relapsed or refractory B-cell malignancy: a multicen...
  John M Pagel, Jacob D Soumerai, Nishitha Reddy, Deepa Jagadeesh, Anastasios Stathis, Adam Asch, Huda Salman, Vaishalee P Kenkre, Alexia Iasonos, Judith Llorin-Sangalan...> ;The Lancet. Oncology. 2022 Aug 1
• Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations.
  Chinthalapally V Rao, Chao Xu, Yuting Zhang, Adam S Asch, Hiroshi Y Yamada> ;Scientific Reports. 2022 Jul 11
• 24 citations
  Safety and feasibility of outpatient chimeric antigen receptor (CAR) T-cell therapy: experience from a tertiary care center.
  Azra Borogovac, Amany Keruakous, Michelle Bycko, Jennifer Holter Chakrabarty, Sami Ibrahimi, Mohamad Khawandanah, George B Selby, Carrie Yuen, Sarah Schmidt, Marcus T ...> ;Bone Marrow Transplantation. 2022 Jun 1
• 4 citations
  Prognostic impact of natural killer cell recovery on minimal residual disease after autologous stem cell transplantation in multiple myeloma.
  Amany R Keruakous, Adam Asch, Raid Aljumaily, Daniel Zhao, Carrie Yuen> ;Transplant Immunology. 2022 Apr 1
• 8 citations
  Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells.
  Joshua M. Corbin, Constantin Georgescu, Jonathan D. Wren, Chao Xu, Adam S. Asch, Maria J. Ruiz-Echevarria> ;Molecular Therapy. Nucleic Acids. 2021 Jun 4
• 5 citations
  Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma.
  Chinthalapally V. Rao, Chao Xu, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Yamada> ;Cancers. 2021 May 25
• 2 citations
  Research Staff Perspectives on Cancer Clinical Trials and Barriers to Recruitment: A Qualitative Research
  Amany R. Keruakous, Silas Day, Kenny D. Garcia-Ramiu, Melissa Yarbrough, Adam S. Asch> ;Cureus. 2021 Mar 18
• 1 citations
  Genomic profiling is a supplemental diagnostic and therapeutic modality for hairy cell leukemia variant.
  Amany R. Keruakous, Pragathi Balakrishna, Sarah A. Schmidt, Marcus Tad Autry, Adam S. Asch> ;Annals of Hematology. 2021 Jan 12
• 11 citations
  GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.
  Chinthalapally V. Rao, Mudassir Farooqui, Avanish Madhavaram, Yuting Zhang, Adam S. Asch, Hiroshi Yamada> ;Aging Cell. 2020 Aug 28
• 10 citations
  Development of thrombocytopenia is associated with improved survival in patients treated with immunotherapy.
  Hussein A. Assi, Adam S. Asch, Michael Machiorlatti, Sara K. Vesely, Sami Ibrahimi> ;Future Science OA. 2020 Jun 25
• 6 citations
  Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model.
  Venkateshwar Madka, Gaurav Kumar, Gopal Pathuri, Yuting Zhang, Stanley Lightfoot, Adam S. Asch, Altaf Mohammed, Vernon E. Steele, Chinthalapally V. Rao> ;Cancer Prevention Research. 2020 Feb 1
• 30 citations
  "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.
  Chinthalapally V. Rao, Adam S. Asch, Daniel J.J. Carr, Hiroshi Yamada> ;Aging Cell. 2020 Jan 25
• 9 citations
  A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer
  Constantin Georgescu, Joshua M. Corbin, Sandra Thibivilliers, Zachary D. Webb, Yan D. Zhao, Jan Koster, Kar Ming Fung, Adam S. Asch, Jonathan D. Wren, Maria J. Ruiz-Ec...> ;BMC Cancer. 2019 May 6
• 5 citations
  Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.
  Chinthalapally V. Rao, Mudassir Farooqui, Adam S. Asch, Hiroshi Yamada> ;Cell Cycle. 2018 Sep 20
• 15 citations
  Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model.
  Chinthalapally V. Rao, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Yamada> ;Aging Cell. 2018 Jun 25
• 41 citations
  Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo
  Chinthalapally V. Rao, Sanya Pal, Altaf Mohammed, Mudassir Farooqui, Mark P. Doescher, Adam S. Asch, Hiroshi Yamada> ;Oncotarget. 2017 May 10
• 41 citations
  Loss of natural killer T cells promotes pancreatic cancer in LSL‐KrasG12D/+ mice
  Naveena B. Janakiram, Altaf Mohammed, Taylor Bryant, Rebekah L. Ritchie, Nicole Stratton, Lydgia A. Jackson, Stan Lightfoot, Doris M. Benbrook, Adam S. Asch, Mark L. L...> ;Immunology. 2017 Sep 1
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Journal Articles

• A phase II trial of bendamustine in combination with rituximab in older patients with previously untreated diffuse large B-cell lymphoma  
  Park SI, Grover NS, Olajide O, Asch AS, Wall JG, Richards KL, Sobol AL, Deal AM, Ivanova A, Foster MC, Muss HB, Shea TC, Br J Haematol, 1/22/2016
• Emerging links among Chromosome Instability (CIN), cancer, and aging  
  Rao CV, Asch AS, Yamada HY, Mol Carcinog, 1/17/2016
• Caenorhabditis elegans: a model system for anti-cancer drug discovery and therapeutic target identification  
  Kobet RA, PanX, Zhang B, Pak SC, Asch AS, LeeMH, Biomol. Ther., 1/1/2014
• Role of PUF-8/PUF Protein in Stem Cell Control, Sperm-Oocyte Decision and Cell Fate Reprogramming  
  Datla US1, Scovill NC, Brokamp AJ, Kim E, Asch AS, Lee MH, J Cell Physiol, 1/1/2014
• The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells  
  Chen X, Corbin JM, Tipton GJ, Yang LV, Asch AS, Ruiz-Echevarria MJ, Biochim Biophys Acta, 1/1/2014
• Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the alpha subunit of the translation initiation factor 2  
  Ryan F. Overcash, Vesna A. Chappell, Thomas Green, Christopher B. Geyer, Asch AS and Ruiz-Echevarria MJ, PloS One, 1/1/2013
• Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway  
  Whelan JT, Hollis SE, Cha DS, Asch AS, Lee MH, J Cell Physiol, 1/1/2012
• Role of benzopyrenes in the generation of oxidatively-induced DNA damage in normal human breast tissue  
  Sigounas, G., Hairr, J. W. , Asch, A. S. , Cooke, C. D. , Rhinehart, J. E. , Douglas A. Weidner, John E. Wiley, Free Radic Biol Med, 1/1/2010
• Factor X deficiency and pregnancy  
  Hurria, A, Castellone, D., Peerschke, E.I.B., and Asch, A.S., Laboratory Medicine, 1/1/2003
• Link between diabetes and atherosclerosis: translational regulation of CD36 expression correlates with glucose  
  Griffin, E., Re, A., Fu, C., & Bush, H., McCaffrey, T. and Asch, A.S., Nat Med, 1/1/2002
• Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1  
  Simantov, R., Febbraio, M., Crombie, R., & Asch, A. S., Journal of Clinical Investigation, 1/1/2001
• Kaposi's sarcoma associated herpesvirus G protein-coupled receptor is a viral oncogene and angiogenesis activator  
  Bais, C., Santomasso, B., Coso, O., Arvanitakis, L., Geras Raak, E., J. S. Gutkind, Asch AS, E. Cesareman, M. Gershengorn and E.A.Mesri, Nature, 1/1/1998
• Establishment and characterization of a primary effusion (Body Cavity-Based) Lymphoma Cell Line (BC-3) Harboring Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV8) in...  
  Arvanitakis, L., Mesri, E. A. , Nador, R., Said, J., Asch, A. S. , D.M. Knowles, and E. Cesarman, Blood, 1/1/1996
• To tell the truth: Will the real CD36 please stand up? (editorial)  
  Asch, A. S., J Lab Clin Med, 1/1/1996
• Kaposi's sarcoma associated herpes virus isolation and transmission to B-lymphocytes  
  Mesri, E., Cesarman, E., Rafii, S., Moore, M. A. , Posnett, D. N. , D.M.Knowles, and Asch AS, J Exp Med, 1/1/1996
• HIV-1 replication in restricted Vbeta subsets due to human cytomegalovirus  
  Dobrescu, D., Ursea, B., Pope, M., Asch, A. S. , & Posnett, D. N., Cell, 1/1/1995
• HIV-1 reservoir in CD4+ T cells is restricted to certain V-beta subsets  
  Dobrescu, D., Kabak, S., Mehta, K., Suh, C. H. , Asch, A. S. , P.U. Cameron, A.S. Hodstev, D.N.Posnett., Proc Natl Acad Sci, 1/1/1995
• Human bone marrow microvascular cells support long term proliferation and differentiation of myeloid and megakaryocyte progenitors  
  Rafii, S. S., Shapiro, F., Ferris, B., Moore, M. A. , & Asch, A. S., Blood, 1/1/1995
• Characterization of hematopoietic cells arising on the textured surface of left ventricular assist devices  
  Rafii, S., Oz, M., Seldomridge, J. A. , Ferris, B., Asch, A. S*. , Nachman RL, Shapiro F, Rose EA, Levin HR, Ann Thorac Surg, 1/1/1995
• Analysis of CD36 binding domains: ligand specificity controlled by dephosphorylation of an ectodomain  
  Asch, A. S., Liu, I., Barnwell, J., Kwakye-Berko, F., Dokun, A., J. Goldberger, and M. Pernambuco, Science, 1/1/1993
• V-beta subsets are not preferentially deleted in AIDS  
  Posnett, D. N., Kabak, S., Hodtsev, A. S. , Goldberg, E. A. , & Asch, A. S., AIDS, 1/1/1993
• An amino acid sequence motif in thrombospondin is responsible for CD36 binding  
  Asch, A. S., Silbiger, S., Heimer, E., & Nachman, R. L., Biochem. Biophys. Res. Commun., 1/1/1992
• Cellular attachment to TSP: Cooperative interactions between receptor systems  
  Asch, A. S., Tepler, J., Silbiger, S., & Nachman, R. L., J Biological Chemistry, 1/1/1991
• Cytokine enhanced expression of GPIBalpha in human endothelium  
  Konkle, B., Shapiro, S., Asch, A. S. , & Nachman, R. L., Journal of Biological Chemistry, 1/1/1990
• A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes  
  Barnwell, J. W., Asch, A. S. , Nachman, R. L. , Yamaya, M., Aikawa, M., P. Ingravallo,, J Clin Invest, 1/1/1989
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Books/Book Chapters

• Blood Transfusion and Conservation in Cardiac Surgery 
  Chapter: Preoperative evaluation of bleeding risk 
  Asch, A. S.Editors: K.Kreiger, O.W. Isom.Springer-Verlag1996
• Superantigens: A pathogen's view of the immune system 
  Chapter: HIV-1 replication in T cells dependent on TCR V-beta expression 
  Page 163 - 177Posnett, D. N., Kabak, S., Asch, A. S. , & Hodtsev, A. S.Cold Spring Harbor Laboratory Press1993
• Thrombospondin 
  Chapter: The role of CD36 as a thrombospondin receptor 
  Asch, A. S.Editors: J. Lahav.CRC press1993
• Hemostasis and Thrombosis 
  Chapter: Thrombospondin: phenomenology to function 
  Asch, A. S. & Nachman, R. L.Editors: Grune and Stratton. B. Coller.1989
• Thrombosis and Haemostasis 
  Chapter: Thrombospondin: cell biology of an adhesive glycoprotein 
  Nachman, R. L., Silverstein, R. L. , & Asch, A. S.Leuven University Press1987
• Manual of Medical Therapy 
  Chapter: Drugs affecting blood 
  Asch, A. S.Raven press1986
• Cell Motility 
  Chapter: Regulation and polarity: results with myxomycete plasmodium and with human platelets 
  Nachmias, V. & Asch, A. S.Cold Spring Harbor Laboratory1976
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Abstracts/Posters

• The First-in-Class Anti-CD47 Antibody Magrolimab (5F9) in Combination with Azacitidine Is Effective in MDS and AML Patients: Ongoing Phase 1b Results
  Adam S. Asch, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Phase I/II Study of AZD2811 Nanoparticles (NP) As Monotherapy or in Combination in Treatment-Na¥ve or Relapsed/Refractory AML/MDS Patients Not Eligible for Intensive...
  Adam S. Asch, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
  Dong L, Li, Leffler N, Asch AS, Yang Y, 102nd Annual Meeting of the American Association for Cancer Research, 1/2/2011
• Translational regulation mediates hematopoietic progenitor cell generation in ES cell culture
  Asch AS, Ruiz-Echevarría MJ, Whelan J ,Green T, Andemariam B, Weidner D, and Hamel N, American Association for Cancer Research (AACR) 101th annual meeting, Washington, DC, 1/1/2010
• Role of erythropoietin on paracrine secretion of vascular endothelial growth factor
  CR Smith, KJ Salleng, VY Sigounas, L Katwa, AS Asch and G Sigounas, American Association for Cancer Research (AACR) 101th annual meeting, Washington, DC, 1/1/2010
• Translational control mediates hematopoietic lineage commitment
  Asch AS, Cold Spring Harbor Symposium on Translational control, 1/1/2002
• Role of endothelium as a component of stem cell niche
  Asch AS, Keystone conference, Hematopoiesis, 1/1/1996
• Translational control of CD36: uORF regulation of a transcript
  Asch AS, Cold Spring Harbor Symposium on Translational control, 1/1/1996
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Lectures

• Role of Somatic Mutations and Clonal Thrombopoiesis in Immune Thrombocytopenia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Thrombocytopenia Is a Biomarker for Response in Patients Treated with Anti PD-1/Pdl-1 Therapy 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Role of translational control in lineage commitment and plasticity 
  1/1/2005
• Role of endothelium as a component of stem cell niche 
  1/1/1998
• The role of CD36 as a thrombospondin receptor 
  1/1/1991
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