AlbertoBroniscerMD

Pediatric Hematology & Oncology • Pittsburgh, PA

Full Visiting Professor, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh

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Office
Childrens Hospital Of Pittsburgh
4401 Penn Avenue
Pittsburgh, PA 15224
Phone+1 412-692-5056

Fax+1 412-692-3412
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Education & Training

Zucker School of Medicine at Hofstra/Northwell at Cohen Children's Medical CenterResidency, Pediatrics, 1999 - 2000
University of TennesseeFellowship, Pediatric Hematology/Oncology, 1993 - 1996
Universidade de Sao Paulo Faculty of MedicineClass of 1989

Certifications & Licensure

PA State Medical License 2017 - 2024
TN State Medical License 2002 - 2019
NY State Medical License 2000 - 2002
MD State Medical License 2001 - 2002
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma Start of enrollment: 2005 Mar 01
Completed
Phase 1, Phase 2
Vandetanib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Diffuse Brainstem Glioma Start of enrollment: 2007 Apr 01
Completed
Phase 1
Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System Start of enrollment: 2009 Feb 25
Completed
Phase 1
DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma Start of enrollment: 2006 Jun 01
Completed
Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) Start of enrollment: 2009 Oct 01
Completed
Phase 1
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Start of enrollment: 2010 Apr 19
Active, not recruiting
Phase 1, Phase 2
PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma Start of enrollment: 2011 Jul 01
Completed
Phase 1
Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG) Start of enrollment: 2012 Nov 27
Completed
Phase 1
Peginterferon Alfa-2b in Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery Start of enrollment: 2014 Apr 01
Terminated
Phase 2
p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors Start of enrollment: 2013 Aug 01
Completed
Phase 1
Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors Start of enrollment: 2014 May 14
Active, not recruiting
Phase 2
Panobinostat in Treating Younger Patients With Progressive Diffuse Intrinsic Pontine Glioma Start of enrollment: 2016 Apr 01
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration Start of enrollment: 2020 Jan 17
Recruiting
Phase 1, Phase 2
Roles: Contact, Principal Investigator
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery Start of enrollment: 2019 Jul 25
Suspended
Phase 1, Phase 2
Roles: Contact
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Publications & Presentations

PubMed

3 citations
High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience.
Chiang, J., Bagchi, A., Li, X., Dhanda, S., Huang, J., Pinto, S., Sioson, E., Dalton, J., Tatevossian, R., Jia, S., Partap, S., Fisher, P., Bowers, D., Hassall, T., Lu...> ;Neuro-Oncology. 2024 Jan 5
5 citations
A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis.
Han Zou, Bradley Poore, Emily E Brown, Jieqi Qian, Bin Xie, Evridiki Asimakidou, Vladislav Razskazovskiy, Deanna Ayrapetian, Vaibhav Sharma, Shunjin Xia, Fei Liu, Apen...> ;Nature Cell Biology. 2023 Mar 1
6 citations
Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 a...
Anthony P Y Liu, Sandeep K Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C Bowers, Tim Hassal...> ;Acta Neuropathologica. 2022 Oct 1
1 citations
Author Correction: Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
Rich, J., Brian J Golbourn, Matthew E Halbert, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E Mbah, Nisha Kabir, Ann-Catherine J Stanton, Abigail L Loc...> ;Nature Cancer. 2022 Jul 1
7 citations
Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor.
Santhosh A Upadhyaya, Olivia Campagne, Catherine A Billups, Brent A Orr, Arzu Onar-Thomas, Ruth G Tatevossian, Roya Mostafavi, Jason R Myers, Anna Vinitsky, Daniel C M...> ;Neuro-Oncology. 2023 Feb 14
10 citations
The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery.
Maria I Kontaridis, Amy E Roberts, Lisa Schill, Lisa Schoyer, Beth Stronach, Gregor Andelfinger, Yoko Aoki, Marni E Axelrad, Annette Bakker, Anton M Bennett, Alberto B...> ;American Journal of Medical Genetics. Part A. 2022 Jun 1
14 citations
Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
Felker, J. T., Brian J Golbourn, Matthew E Halbert, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E Mbah, Nisha Kabir, Ann-Catherine J Stanton, Abigail ...> ;Nature Cancer. 2022 May 1
10 citations
Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG.
Christopher L Tinkle, Alberto Broniscer, Jason Chiang, Olivia Campagne, Jie Huang, Brent A Orr, Xiaoyu Li, Zoltan Patay, Jinghui Zhang, Suzanne J Baker, Thomas E Merch...> ;Neuro-Oncology Advances. 2021 Dec 1
9 citations
[11C]-Methionine PET for Identification of Pediatric High-Grade Glioma Recurrence.
Asim K. Bag, Melissa N. Wing, Noah D. Sabin, Scott N. Hwang, Gregory T. Armstrong, Yuanyuan Han, Yimei Li, Scott E. Snyder, Giles W. Robinson, Ibrahim Qaddoumi, Albert...> ;Journal of Nuclear Medicine. 2021 Aug 26
19 citations
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel R. Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu ...> ;Nature Communications. 2021 Jul 2
28 citations
TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma.
Itay Raphael, Rajeev Kumar, Lauren McCarl, Karsen Shoger, Lin Wang, Poorva Sandlesh, Chaim T Sneiderman, Jordan Allen, Shuyan Zhai, Marissa Lynn Campagna, Alexandra Fo...> ;Frontiers in Immunology. 2021 May 7
28 citations
Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials
Santhosh A. Upadhyaya, Giles W. Robinson, Arzu Onar-Thomas, Brent A. Orr, Pascal Johann, Gang Wu, Catherine A. Billups, Ruth G. Tatevossian, Sandeep Kumar Dhanda, Asho...> ;Clinical Cancer Research. 2021 Mar 18
80 citations
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03)
Amar Gajjar, Giles W. Robinson, Kyle S. Smith, Tong Lin, Thomas E. Merchant, Murali Chintagumpala, Anita Mahajan, Jack Su, Eric Bouffet, Ute Bartels, Tal Schechter, Ti...> ;Journal of Clinical Oncology. 2021 Jan 6
24 citations
The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: experience from three pediatric institutions with review of the literature.
Oscar Lopez-Nunez, Barbara Cafferata, Mariarita Santi, Sarangarajan Ranganathan, Thomas M. Pearce, Scott M. Kulich, Kelly M. Bailey, Alberto Broniscer, Sabrina Rossi, ...> ;Brain Pathology. 2021 Jan 1
12 citations
Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.
Stewart Goldman, Ian F. Pollack, Regina I. Jakacki, Catherine A. Billups, Tina Young Poussaint, Adekunle M. Adesina, Ashok Panigrahy, Donald W Parsons, Alberto Bronisc...> ;Neuro-Oncology. 2020 Nov 26
4 citations
Improving long-term survival in diffuse intrinsic pontine glioma.
James Felker, Alberto Broniscer> ;Expert Review of Neurotherapeutics. 2020 Jun 16
47 citations
A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study
Patricia Baxter, Jack Su, Arzu Onar-Thomas, Catherine A. Billups, Xiao-Nan Li, Tina Young Poussaint, Edward R. Smith, Patrick A. Thompson, Adekunle M. Adesina, P. Anse...> ;Neuro-Oncology. 2020 Jun 9
29 citations
Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG
Jason Chiang, Alexander K. Diaz, Lydia Makepeace, Xiaoyu Li, Yuanyuan Han, Yimei Li, Paul Klimo, Frederick A. Boop, Suzanne J. Baker, Amar Gajjar, Thomas E. Merchant, ...> ;Acta Neuropathologica Communications. 2020 Apr 23
41 citations
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
Gourish Mondal, Julieann C. Lee, Ajay Ravindranathan, Javier Villanueva-Meyer, Quynh T. Tran, Sariah Allen, Jairo Barreto, Rohit Gupta, Pamela Doo, Jessica Van Ziffle,...> ;Acta Neuropathologica. 2020 Apr 17
6 citations
Defining Optimal Target Volumes of Conformal Radiation Therapy for Diffuse Intrinsic Pontine Glioma.
Christopher L. Tinkle, Brittany Simone, Jason Chiang, Xiaoyu Li, Kristen Campbell, Yuanyuan Han, Yimei Li, Laura D. Hover, Jason K. Molitoris, Jared Becksfort, John T....> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Mar 15
13 citations
Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma.
Han Zou, Brad Poore, Alberto Broniscer, Ian F. Pollack, Baoli Hu> ;Cancers. 2020 Mar 10
4 citations
Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma.
Christopher L. Tinkle, Kristen Campbell, Yuanyuan Han, Yimei Li, Brandon Bianski, Alberto Broniscer, Raja B. Khan, Thomas E. Merchant> ;Journal of Neuro-Oncology. 2020 Feb 3
Correction to: Pharmacokinetics and safety of erlotinib and its metabolite OSI-420 in infants and children with primary brain tumors.
Samuel J. Reddick, Olivia Campagne, Jie Huang, Arzu Onar-Thomas, Alberto Broniscer, Amar Gajjar, Clinton F. Stewart> ;Cancer Chemotherapy and Pharmacology. 2020 Feb 1
95 citations
Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
Darren Hargrave, Eric Bouffet, Uri Tabori, Alberto Broniscer, Kenneth J. Cohen, Jordan R. Hansford, Birgit Geoerger, Pooja Hingorani, Ira J. Dunkel, Mark W. Russo, Lil...> ;Clinical Cancer Research. 2019 Dec 15
53 citations
A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors
Mark W. Kieran, Birgit Geoerger, Ira J. Dunkel, Alberto Broniscer, Darren Hargrave, Pooja Hingorani, Isabelle Aerts, Anne Isabelle Bertozzi, Kenneth J. Cohen, Trent R....> ;Clinical Cancer Research. 2019 Dec 15
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Hospital Affiliations

UPMC Children's Hospital of PittsburghPittsburgh, Pennsylvania
UPMC Presbyterian ShadysidePittsburgh, Pennsylvania