AlexanderGerhardMiethkeMD

Pediatric Gastroenterology • Cincinnati, OH

Pediatric Hepatology and Liver Transplantation

Assistant Professor, Pediatrics, University of Cincinnati College of Medicine

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Office
3333 Burnet Avenue
Gastroenterology & Nutrition Ml 2010
Cincinnati, OH 45229
Phone+1 513-636-4415

Fax+1 513-636-7805
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Education & Training

Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Transplant Hepatology, 2008 - 2009
Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Gastroenterology, 2005 - 2008
Cincinnati Children's Hospital Medical CenterResidency, Pediatrics, 2002 - 2005
Humboldt University of Berlin - Charite Faculty of MedicineClass of 2000

Certifications & Licensure

OH State Medical License 2002 - 2024
MI State Medical License 2016 - 2020
American Board of Pediatrics Pediatric Gastroenterology
American Board of Pediatrics Pediatric Transplant Hepatology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

A Prospective Database of Infants With Cholestasis Start of enrollment: 2004 Apr 21
Recruiting
Biliary Atresia Study in Infants and Children Start of enrollment: 2006 May 16
Recruiting
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) Start of enrollment: 2007 Nov 30
Recruiting
Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Start of enrollment: 2010 Oct 01
Completed
Phase 1
Longitudinal Study of Mitochondrial Hepatopathies Start of enrollment: 2010 Aug 18
Recruiting
Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome Start of enrollment: 2014 Nov 24
Completed
Phase 2
Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis Start of enrollment: 2014 Mar 01
Completed
Phase 2
A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC) Start of enrollment: 2019 Jul 09
Completed
Phase 3
MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease Start of enrollment: 2017 Feb 20
Recruiting
Roles: Principal Investigator, Contact
MRI Based Biomarkers in Pediatric Autoimmune Liver Disease Start of enrollment: 2017 Jan 17
Recruiting
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases.
Van Hove, J., Friederich, M., Strode, D., Van Hove, R., Miller, K., Sharma, R., Shah, H., Estrella, J., Gabel, L., Horslen, S., Kohli, R., Lovell, M., Miethke, A., Mol...> ;Hepatology Communications. 2024 Jan 1
Red cell abnormalities characterized by ektacytometry in children with cholestasis.
Theodore S Kocoshis, Theodosia A Kalfa, Alexander G Miethke, William F Balistreri, Katie G Seu, Crystal G Slaughter, Ruchi Singh, Mary Mullen, Samuel A Kocoshis> ;Pediatric Research. 2024 Mar 1
Sarcopenia is associated with osteopenia and impaired quality of life in children with genetic intrahepatic cholestatic liver disease.
Julia M Boster, Nathan P Goodrich, Cathie Spino, Kathleen M Loomes, Estella M Alonso, Binita M Kamath, Ronald J Sokol, Saul Karpen, Alexander Miethke, Benjamin L Shnei...> ;Hepatology Communications. 2023 Nov 1
1 citations
Deleterious variants in TNFAIP3 are associated with type II and seronegative pediatric autoimmune hepatitis.
Sindhu Pandurangi, Astha Malik, Joshua Owens, C Alexander Valencia, Alexander G Miethke> ;Journal of Hepatology. 2024 Jan 1
2 citations
Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children.
James E Squires, Alexander G Miethke, C Alexander Valencia, Kieran Hawthorne, Lisa Henn, Johan L K Van Hove, Robert H Squires, Kevin Bove, Simon Horslen, Rohit Kohli, ...> ;Hepatology Communications. 2023 Jun 1
Presence of Alpha 1 Antitrypsin Risk Variants is Not Associated With Histologic Severity of Pediatric NAFLD.
Maya Khan, Corie Klepper, Sarah Orkin, Ana Catalina Arce-Clachar, Kristen Bramlage, Lin Fei, Alexander Miethke, Rohit Kohli, Stavra Xanthakos, Marialena Mouzaki> ;Journal of Pediatric Gastroenterology and Nutrition. 2023 Aug 1
3 citations
Recent Increase in Incidence of Severe Acute Hepatitis of Unknown Etiology in Children is Associated with Infection with Adenovirus and Other Nonhepatotropic Viruses.
Anna L Peters, Seung Kim, Reena Mourya, Akihiro Asai, Amy Taylor, Michael Rogers, Kathleen Campbell, Lin Fei, Alexander Miethke, William F Balistreri, Jorge A Bezerra> ;The Journal of Pediatrics. 2023 Aug 1
Longitudinal changes in quantitative magnetic resonance imaging metrics in children and young adults with autoimmune liver disease.
Neeraja Mahalingam, Andrew T Trout, Bin Zhang, Cyd Castro-Rojas, Alexander G Miethke, Jonathan R Dillman> ;Abdominal Radiology. 2023 Jun 1
1 citations
Corrected T1 Mapping in Children and Young Adults With Autoimmune Liver Disease: Correlation With Histology.
Andrew T Trout, Amy E Taylor, Jennifer L Kasten, Cyd Castro-Rojas, Neeraja Mahalingam, Alexander G Miethke, Jonathan R Dillman> ;AJR. American Journal of Roentgenology. 2023 Jun 1
5 citations
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis.
Tiffany Shi, Astha Malik, Annika Yang Vom Hofe, Louis Matuschek, Mary Mullen, Celine S Lages, Ramesh Kudira, Ruchi Singh, Wujuan Zhang, Kenneth D R Setchell, David Hil...> ;Science Translational Medicine. 2022 Dec 14
2 citations
Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report.
Sindhu Pandurangi, Seung Kim, Akihiro Asai, Alexander Bondoc, William Balistreri, Kathleen Campbell, Alexander Miethke, Anna Peters, Michael Rogers, Amy Taylor, Suzann...> ;Journal of Pediatric Surgery. 2023 Aug 1
3 citations
Differential recruitment of monocyte-derived macrophages in control and stellate cell-depleted mice during recurrent carbon tetrachloride-induced acute liver injury.
Akanksha Sharma, Ramesh Kudira, Jiang Wang, Alexander Miethke, Chandrashekhar R Gandhi> ;Journal of Cellular Physiology. 2022 Nov 1
8 citations
Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia.
Lee M Bass, Wen Ye, Kieran Hawthorne, Daniel H Leung, Karen F Murray, Jean P Molleston, Rene Romero, Saul Karpen, Philip Rosenthal, Kathleen M Loomes, Kasper S Wang, R...> ;Hepatology. 2022 Sep 1
23 citations
Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study.
Loomes, K., Squires, R., Kelly, D., Rajwal, S., Soufi, N., Lachaux, A., Jankowska, I., Mack, C., Setchell, K., Karthikeyan, P., Kennedy, C., Dorenbaum, A., Desai, N., ...> ;Hepatology Communications. 2022 Sep 1
9 citations
Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome.
Shneider, B., Spino, C., Kamath, B., Magee, J., Ignacio, R., Huang, S., Horslen, S., Molleston, J., Miethke, A., Kohli, R., Leung, D., Jensen, M., Loomes, K., Karpen, ...> ;Hepatology Communications. 2022 Aug 1
3 citations
Associations Between Quantitative MRI Metrics and Clinical Risk Scores in Children and Young Adults With Autoimmune Liver Disease.
Joseph McCrary, Andrew T Trout, Neeraja Mahalingam, Ruchi Singh, Cyd Castro Rojas, Alexander G Miethke, Jonathan R Dillman> ;AJR. American Journal of Roentgenology. 2022 Jul 1
Children undergoing early liver re-transplantation for primary non-function have improved survival.
Michael E Rogers, Aaron Delman, Kathleen Campbell, Alexander Miethke, Greg Tiao, Bhargava Mullapudi, Alex Bondoc> ;Pediatric Transplantation. 2022 Nov 1
1 citations
Pediatric Living Donor Liver Transplantation Outcomes-Is it Time for Outcome Optimization of Technical Aspects of Transplantation Using Learning Networks?
Alexander Bondoc, Mitzi Barker, Bhargava Mullapudi, Alexander Miethke, Gregory Tiao> ;Liver Transplantation. 2022 Jun 1
Correction to: Associations between MRI T1 mapping, liver stiffness, quantitative MRCP, and laboratory biomarkers in children and young adults with autoimmune liver di...
Neeraja Mahalingam, Andrew T Trout, Deep B Gandhi, Rashmi D Sahay, Ruchi Singh, Alexander G Miethke, Jonathan R Dillman> ;Abdominal Radiology. 2022 Apr 1
7 citations
Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency.
Chao Zheng Li, Hiromi Ogawa, Soon Seng Ng, Xindi Chen, Eriko Kishimoto, Kokoro Sakabe, Aiko Fukami, Yueh-Chiang Hu, Christopher N Mayhew, Jennifer Hellmann, Alexander ...> ;JHEP Reports. 2022 Apr 1
1 citations
Associations between MRI T1 mapping, liver stiffness, quantitative MRCP, and laboratory biomarkers in children and young adults with autoimmune liver disease.
Neeraja Mahalingam, Andrew T Trout, Deep B Gandhi, Rashmi D Sahay, Ruchi Singh, Alexander G Miethke, Jonathan R Dillman> ;Abdominal Radiology. 2022 Feb 1
1 citations
Clinically available testing options resulting in diagnosis in post-exome clinic at one medical center.
Elizabeth K Baker, Elizabeth A Ulm, Alyce Belonis, Diana S Brightman, Barbara E Hallinan, Nancy D Leslie, Alexander G Miethke, Marissa Vawter-Lee, Yaning Wu, Loren D M...> ;Frontiers in Genetics. 2022 Jan 1
8 citations
Sarcopenia is highly prevalent in children with Autoimmune Liver Diseases and is linked to visceral fat and parent-perceived general health.
Antoinette A. Amevor, Toshifumi Yodoshi, Andrew T. Trout, Jonathan R. Dillman, Ruchi Singh, Ryan Jarvis, Lin Fei, Chunyan Liu, Amy Taylor, Alexander Miethke, Marialena...> ;Liver International. 2021 Nov 24
2 citations
Isolation and Culturing Primary Cholangiocytes from Mouse Liver
Ramesh Kudira, Bal Krishan Sharma, Mary P. Mullen, Sujit K. Mohanty, Bryan Donnelly, Gregory M. Tiao, Alexander Miethke> ;Bio-Protocol. 2021 Oct 20
7 citations
Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms.
Duc-Hung Pham, Ramesh Kudira, Lingfen Xu, C. Alexander Valencia, Jillian L. Ellis, Tiffany Shi, Kimberley J. Evason, Immaculeta Osuji, Nelson Matuschek, Liva Pfuhler, ...> ;Gastroenterology. 2021 Jul 1
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Journal Articles

Putting It All Together: Established and Emerging MRI Techniques for Detecting and Measuring Liver Fibrosis
Stavra A Xanthakos, Eric Diaz, Jonathan R Dillman, Alexander Miethke, Pediatric Radiology

Press Mentions

Deleterious Variants in ABCC12 Are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model OrganismsMarch 23rd, 2021