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Amit Khera, MD, Cardiology, Boston, MA, Massachusetts General Hospital

AmitVikramKheraMD

Cardiology • Boston, MA

Preventive Cardiology

Cardiologist and preventive genomics, Massachusetts General Hospital Group leader, MGH Center for Genomic Medicine Associate Director, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard Assistant Professor, Harvard Medical School

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Summary

  • Amit V. Khera, MD MSc, is a cardiologist, human geneticist, and population biologist at Massachusetts General Hospital (MGH), group leader within the MGH Center for Genomic Medicine, Associate Director of the Program in Medical and Population Genetics and Merkin Institute Fellow at the Broad Institute of MIT and Harvard, and Assistant Professor at Harvard Medical School.

    He received his MD with Alpha Omega Alpha distinction from the Perelman School of Medicine at the University of Pennsylvania and went on to complete clinical training in Internal Medicine and cardiology at Brigham and Women's Hospital and MGH. He completed a Masters of Science at the Harvard School of Public Health and a postdoctoral research fellowship with Dr. Sekar Kathiresan in human genetics at the Broad Institute of MIT and Harvard prior to accepting a faculty position.

    His research program (kheralab.org) uses genetic variation as a tool to uncover new biology and enable enhanced clinical care informed by inherited susceptibility.

    He has developed expertise in epidemiology, clinical medicine, and human genetics. Among his scientific contributions, he pioneered use of a new approach to quantify genetic risk (‘genome-wide polygenic scores’) for common diseases, developed biomarkers that provide new biologic insights, and analyzed large-scale gene sequencing data to highlight key pathways driving risk and identify molecular subtypes of cardiometabolic diseases.

    Dr. Khera has authored more than 80 scientific publications, including lead-authored publications in the New England Journal of Medicine, Journal of the American Medical Association, Cell, Nature Reviews Genetics, Nature Genetics, Journal of the American College of Cardiology, and Circulation. His work has been recognized as among the top ten research advances by the American Heart Association (in both 2016 and 2018), and he is the 2019 recipient of the Douglas P. Zipes Distinguished Young Scientist Award from the American College of

    • Khera Lab

    We use genetic variation to better understand the causes of cardiovascular and other important diseases and to enable a new era of personalized genomic medicine

Education & Training

  • Harvard School of Public Health
    Harvard School of Public HealthMSc, Epidemiology, 2015 - 2017
  • Massachusetts General Hospital
    Massachusetts General HospitalFellowship, Cardiovascular Disease, 2013 - 2016
  • Brigham and Women's Hospital
    Brigham and Women's HospitalResidency, Internal Medicine, 2010 - 2013
  • Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of PennsylvaniaClass of 2010

Certifications & Licensure

  • MA State Medical License
    MA State Medical License 2013 - 2026
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Cardiovascular Disease

Publications & Presentations

PubMed

Journal Articles

  • Genome-Wide Polygenic Scores for Common Diseases Identify Individuals with Risk Equivalent to Monogenic Mutations  
    Amit V Khera, Steven A Lubitz, Sekar Kathiresan, Patrick T Ellinor, Krishna G Aragam, Pradeep Natarajan, Nature

Press Mentions

  • Alzheimer’s: A New Method Can Spot the Disease Before Any Symptoms Appear
    Alzheimer’s: A New Method Can Spot the Disease Before Any Symptoms AppearSeptember 1st, 2022
  • OurHealth Explores Why South Asian Ancestry Is Now Considered a Risk-Enhancing Factor for Cardiovascular Disease
    OurHealth Explores Why South Asian Ancestry Is Now Considered a Risk-Enhancing Factor for Cardiovascular DiseaseJuly 13th, 2022
  • Heart Risk 'Calculators' Overlook Increased Risk for People of South Asian Ancestry
    Heart Risk 'Calculators' Overlook Increased Risk for People of South Asian AncestryJuly 12th, 2021
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Professional Memberships

Hospital Affiliations

Dr. Amit Khera, Dr. Amit Khera, MD, Dr. A Khera, Dr. Amit Vikram Khera