AndrewJacobBrennerMDPhD

Oncology • San Antonio, TX

Breast Cancer

Institute for Drug Development, Cancer Therapy and Research Center at UTHSCSA

Join to view full profile

Dr. Brenner is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Brenner's full profile

Already have an account?

Office
7979 Wurzbach Road
San Antonio, TX 78229
Phone+1 210-450-1143

Fax+1 210-450-0407
Is this information wrong?

Education & Training

University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of MedicineFellowship, Hematology and Medical Oncology, 2006 - 2008
Texas A&M College of Medicine-Scott and White Medical Center (Temple)Residency, Internal Medicine, 2003 - 2006
Texas Tech University Health Sciences Center School of MedicineClass of 2003
University of Texas at Austin Dell Medical SchoolPh.D., Tumore Biology, 1997
Texas A&M UniversityB.S., Biochemistry, 1993

Certifications & Licensure

TX State Medical License 2005 - 2025
American Board of Internal Medicine Medical Oncology
Neuro-OncologyUnited Council for Neurologic Subspecialties

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Clinical Investigator Award Cancer Therapy and Research Center at UTHSCSA, 2012
Carmela Gigliardi Scholarship National Italian American Foundation, 2000
HEB Foundation Predoctoral Fellowship, Research Division UT MD Anderson Cancer Center, Science Park, 1993
Nestor R. Bottino Award for Aptitude and Excellence in Research Texas A&M University, 1992
Outstanding Undergraduate Biochemist Texas A&M University, 1992
Join now to see all

Clinical Trials

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Start of enrollment: 2006 Dec 01
Active, not recruiting
Phase 3
A Phase I Study to Assess the Safety and Distribution of VB-111 in Patients With Advanced Metastatic Cancer Start of enrollment: 2007 Nov 01
Unknown status
Phase 1
Single-Arm Open-Label Multicenter Study of VB-111 in Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2010 Dec 01
Completed
Phase 1, Phase 2
Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab Start of enrollment: 2011 Jun 01
Completed
Phase 2
Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma Start of enrollment: 2013 Jun 01
Completed
Phase 3
A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection Start of enrollment: 2013 Apr 01
Terminated
Phase 1
Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT) Start of enrollment: 2015 Jun 03
Recruiting
Phase 1, Phase 2
ANG1005 in Patients With Recurrent High-Grade Glioma Start of enrollment: 2013 Oct 01
Completed
Phase 2
ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases Start of enrollment: 2014 Apr 01
Completed
Phase 2
Impact of COX2 on Sera Biomarkers From Obese Subjects Start of enrollment: 2013 Oct 01
Completed
Early Phase 1
TH-302 in Combination With Bevacizumab for Glioblastoma Start of enrollment: 2015 May 01
Completed
Phase 2
A Phase 3, Pivotal Trial of VB-111 Plus Bevacizumab vs. Bevacizumab in Patients With Recurrent Glioblastoma (GLOBE) Start of enrollment: 2015 Aug 01
Completed
Phase 3
Impact of Omega 3 Fatty Acid Supplementation on Aromatase in Obese Subjects Start of enrollment: 2016 Apr 01
Completed
Early Phase 1
Sacituzumab Govitecan in Recurrent Glioblastoma Start of enrollment: 2022 Jan 06
Recruiting
Phase 2
Roles: Principal Investigator
Join now to see all

Publications & Presentations

PubMed

TIP24-199: Rhenium (Re-186) Obisbemeda {Re-186-Nanoliposome (186RNL)} in Leptomeningeal Metastases [LM] Phase 1/2A Dose Escalation Trial: Update of Initial Safety and ...
Norman LaFrance, Michael Youssef, Ande Bao, Melissa Moore, Joel Michalek, Marc Hedrick, William Phillips, Toral Patel, Jeffrey Weinberg, John Floyd, Andrew Brenner, Pr...> ;Journal of the National Comprehensive Cancer Network. 2024 Apr 5
Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.
Bryan McClellan, Crystal N Wilson, Andrew J Brenner, Christopher A Jolly, Linda deGraffenried> ;Oncogene. 2024 Mar 1
Predicting the spatio-temporal response of recurrent glioblastoma treated with rhenium-186 labelled nanoliposomes.
Christenson, C., Wu, C., Hormuth, D., Huang, S., Bao, A., Yankeelov, T., Brenner, A.> ;Brain Multiphysics. 2023 Dec 1
1 citations
Preclinical Development of Brain Permeable ERβ Agonist for the Treatment of Glioblastoma.
Uday P Pratap, Michael Tidwell, Henriette U Balinda, Nicholas A Clanton, Xue Yang, Suryavathi Viswanadhapalli, Gangadhara R Sareddy, Dong Liang, Huan Xie, Yidong Chen,...> ;Molecular Cancer Therapeutics. 2023 Nov 1
2 citations
AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages.
Chia-Nung Hung, Meizhen Chen, Daniel T DeArmond, Cheryl H-L Chiu, Catherine A Limboy, Xi Tan, Meena Kusi, Chih-Wei Chou, Li-Ling Lin, Zhao Zhang, Chiou-Miin Wang, Chun...> ;Cell Reports. 2023 Sep 26
5 citations
Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma.
William Kelly, Adolfo Enrique Diaz Duque, Joel Michalek, Brandon Konkel, Laura Caflisch, Yidong Chen, Sarath Chand Pathuri, Vinu Madhusudanannair-Kunnuparampil, John F...> ;Clinical Cancer Research. 2023 Jul 5
5 citations
Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.
Salvador Alejo, Bridgitte E Palacios, Prabhakar Pitta Venkata, Yi He, Wenjing Li, Jessica D Johnson, Yihong Chen, Sridharan Jayamohan, Uday P Pratap, Kyra Clarke, Yi Z...> ;Neuro-Oncology. 2023 Jul 6
10 citations
Targeting the IL4 receptor with MDNA55 in patients with recurrent glioblastoma: Results of a phase IIb trial.
John H Sampson, Achal Singh Achrol, Manish K Aghi, Krystof Bankiewicz, Martin Bexon, Steven Brem, Andrew Brenner, Chandtip Chandhasin, Sajeel Chowdhary, Melissa Coello...> ;Neuro-Oncology. 2023 Jun 2
117 citations
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A P...
Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E S...> ;JAMA Oncology. 2023 Jan 1
10 citations
The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events.
Santosh Timilsina, Subapriya Rajamanickam, Arhan Rao, Panneerdoss Subbarayalu, Saif Nirzhor, Nourhan Abdelfattah, Suryavathi Viswanadhapalli, Yidong Chen, Ismail Jatoi...> ;Cancer Letters. 2022 Aug 1
3 citations
ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
Adam Kosti, Jennifer Chiou, Gabriela D A Guardia, Xiufen Lei, Henriette Balinda, Tesha Landry, Xiyuan Lu, Mei Qiao, Andrea Gilbert, Andrew Brenner, Pedro A F Galante, ...> ;Neuro-Oncology. 2023 Mar 14
Targeting aberrant replication and DNA repair events for treating breast cancers.
Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S R Nirzhor, Vijay Eedunuri, Tabrez A Mohammad, K...> ;Communications Biology. 2022 May 24
6 citations
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas.
Yan Liu, Adwait Amod Sathe, Kalil G Abdullah, Samuel K McBrayer, Steven H Adams, Andrew J Brenner, Kimmo J Hatanpaa, Mariano S Viapiano, Chao Xing, Jamie M Walker, Tim...> ;Acta Neuropathologica Communications. 2022 Mar 9
1 citations
Supratentorial ependymoma, zinc finger translocation-associated fusion positive, with extensive synaptophysin immunoreactivity arising from malignant transformation of...
Jacob A Bethel, Kenneth M James, Samon G Tavakoli, Richard L Crownover, Andrew J Brenner, Alexander M Papanastassiou, Andrea R Gilbert> ;Surgical Neurology International. 2022 Jan 1
1 citations
Circulating metabolites associated with tumor hypoxia and early response to treatment in bevacizumab-refractory glioblastoma after combined bevacizumab and evofosfamide.
Alessia Lodi, Renu Pandey, Jennifer Chiou, Ayon Bhattacharya, Shiliang Huang, Xingxin Pan, Brandon Burgman, S Stephen Yi, Stefano Tiziani, Andrew J Brenner> ;Frontiers in Oncology. 2022 Jan 1
10 citations
LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer.
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrah...> ;Communications Biology. 2021 Oct 29
9 citations
Preservation of quality of life in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer treated with tucatinib or placebo when adde...
Volkmar Mueller, Andrew M Wardley, Elisavet Paplomata, Erika Hamilton, Amelia Zelnak, Louis Fehrenbacher, Erik Jakobsen, Elsa Curtit, Frances M. Boyle, Eva Harder Brix...> ;European Journal of Cancer. 2021 Jun 29
2 citations
Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.
Farah Andleeb, Nitesh Katta, Aleksandra Gruslova, Bharadwaj Muralidharan, Arnold D. Estrada, Austin McElroy, Hafeez Ullah, Andrew Brenner, Thomas E. Milner> ;Lasers in Surgery and Medicine. 2021 Jun 15
8 citations
Patient specific, imaging-informed modeling of rhenium-186 nanoliposome delivery via convection-enhanced delivery in glioblastoma multiforme.
Ryan T. Woodall, David A. Hormuth, Chengyue Wu, Michael Abdelmalik, William T. Phillips, Ande Bao, Thomas J. R. Hughes, Andrew Brenner, Thomas E. Yankeelov> ;Biomedical Physics & Engineering Express. 2021 May 28
14 citations
FASN inhibition as a potential treatment for endocrine-resistant breast cancer
Aleksandra Gruslova, Bryan Mcclellan, Henriette U. Balinda, Suryavathi Viswanadhapalli, Victoria Alers, Gangadhara R. Sareddy, Tim Huang, Michael E. Garcia, Linda A. d...> ;Breast Cancer Research and Treatment. 2021 Apr 24
17 citations
Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma.
Benjamin M. Ellingson, John H. Sampson, Achal S. Achrol, Manish K. Aghi, Krystof Krystof Bankiewicz, Chencai Wang, Martin Bexon, Steven Brem, Andrew Brenner, Sajeel Ch...> ;Clinical Cancer Research. 2021 Apr 16
14 citations
Assessment of tumor hypoxia and perfusion in recurrent glioblastoma following bevacizumab failure using MRI and 18F-FMISO PET.
Shiliang Huang, Joel E. Michalek, David A. Reardon, Patrick Y. Wen, John Floyd, Peter T. Fox, Geoffrey D. Clarke, Paul A Jerabek, Kathleen M. Schmainda, Mark Muzi, Hye...> ;Scientific Reports. 2021 Apr 7
91 citations
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced...
Gerald Steven Falchook, Jeffrey R. Infante, Hendrik-Tobias Arkenau, Manish R. Patel, Emma Dean, Erkut Borazanci, Andrew Brenner, Natalie Cook, Juanita Lopez, Shubham P...> ;Eclinicalmedicine. 2021 Mar 30
8 citations
Activation of estrogen receptor beta signaling reduces stemness of glioma stem cells
Gangadhara R. Sareddy, Uday P. Pratap, Prabhakar Pitta Venkata, Mei Zhou, Salvador Alejo, Suryavathi Viswanadhapalli, Rajeshwar R. Tekmal, Andrew Brenner, Ratna K. Vad...> ;Stem Cells. 2021 May 1
20 citations
Phase 2 trial of hypoxia activated evofosfamide (TH302) for treatment of recurrent bevacizumab-refractory glioblastoma
Andrew Brenner, John Floyd, Lisa Fichtel, Joel E. Michalek, Shiliang Huang, David A. Reardon, Patrick Y. Wen, Eudocia Q. Lee> ;Scientific Reports. 2021 Jan 27
Join now to see all

Lectures

Molecular profiling using the 92-gene assay for tumor classification of brain metastases.
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

Mays Cancer Center Conducts Only Clinical Trial in America of a Specific Drug Combination for Lethal Brain Cancer GlioblastomaMay 23rd, 2023
UT Health San Antonio-UTSA Team Studies Compounds Aimed at Brain CancerJanuary 24th, 2023
UTSA-UT Health San Antonio Team Studies Compounds Aimed at Treating Brain CancerJanuary 24th, 2023
Join now to see all