AndrewNorrisMDPhD

Pediatric Diabetes Endocrinology

Director of the Division of Pediatric Endocrinology & Diabetes; Co-Director (Interim) of the Fraternal Order of Eagles Diabetes Research Center; Professor of Pediatrics; Professor of Biochemistry

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Office
200 Hawkins Dr
Department of Pediatrics
Iowa City, IA 52242
Phone+1 319-356-4443

Fax+1 319-356-8170
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Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Endocrinology, 2000 - 2003
Joslin Diabetes CenterFellowship, Pediatric Diabetes, 2000 - 2003
University of Iowa Hospitals and ClinicsResidency, Pediatrics, 1997 - 2000
Washington University in St. Louis School of MedicineClass of 1997

Certifications & Licensure

IA State Medical License 1997 - 2024
MA State Medical License 2003 - 2007
American Board of Pediatrics Pediatric Endocrinology

Awards, Honors, & Recognition

Elected member American Pediatric Society, 2019
“America's Top Doctors” Castle Connolly
Diabetes Research Scholar Award Fraternal Order of Eagles Diabetes Research Center, 2014
Bernard Proctor Award for Undergraduate Research in Applied Biology Massachusetts Institute of Technology
Olin Fellow Washington University School of Medicine
Resident Teacher of the Year University of Iowa Department of Pediatrics
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Publications & Presentations

PubMed

Monovalent SARS-CoV-2 mRNA vaccine does not boost Omicron-specific immune response in diabetic and control pediatric patients.
Alan Sariol, Molly A Vickers, Shannon M Christensen, Daniela Weiskopf, Alessandro Sette, Andrew W Norris, Michael J Tansey, Catherina T Pinnaro, Stanley Perlman> ;The Journal of Infectious Diseases. 2023 Aug 25
13 citations
Glycemia and β-cell function before and after elexacaftor/tezacaftor/ivacaftor in youth and adults with cystic fibrosis.
Christine L Chan, Andrea Granados, Amir Moheet, Sachinkumar Singh, Timothy Vigers, Ana Maria Arbeláez, Yaling Yi, Shanming Hu, Andrew W Norris, Katie Larson Ode> ;Journal of Clinical & Translational Endocrinology. 2022 Dec 1
11 citations
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Susheel K Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R Chheda, Chen Kang, David M Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E Gerber, Wojciech J ...> ;Nature Communications. 2022 Feb 10
Diabetes Device Downloading: Benefits and Barriers Among Youth With Type 1 Diabetes.
Benjamin A. Palmer, Karissa Soltys, M. Bridget Zimmerman, Andrew W. Norris, Eva Tsalikian, Michael Tansey, Catherina T. Pinnaro> ;Journal of Diabetes Science and Technology. 2021 Nov 22
Hypoglycemia secondary to insulinoma masking the onset of type 1 diabetes in an adolescent.
Sriya Subramani, Andrew M. Bellizzi, Simon C. Kao, Joseph S. Dillon, James R. Howe, Andrew W. Norris, Michael Tansey, Catherina T. Pinnaro, Nicholas Borcherding> ;Clinical Case Reports. 2021 Sep 24
6 citations
Lack of CFTR alters the ferret pancreatic ductal epithelial secretome and cellular proteome: Implications for exocrine/endocrine signaling
Pavana G. Rotti, Idil A Evans, Yulong Zhang, Bo Liang, Nathan Cunicelli, Yunxia O'Malley, Andrew W. Norris, Aliye Uc, John F. Engelhardt> ;Journal of Cystic Fibrosis. 2021 May 17
Acute pancreatitis-induced islet dysfunction in ferrets.
Yaling Yi, Xingshen Sun, Bo Liang, Nan He, Katherine N. Gibson-Corley, Andrew W. Norris, John F. Engelhardt, Aliye Uc> ;Pancreatology. 2021 May 11
27 citations
A tale of two pancreases: exocrine pathology and endocrine dysfunction
Michael R. Rickels, Andrew W. Norris, Rebecca L. Hull> ;Diabetologia. 2020 Sep 7
47 citations
Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.
Arpit Sharma, Lalita Oonthonpan, Ryan D. Sheldon, Adam J. Rauckhorst, Zhiyong Zhu, Sean C. Tompkins, Kevin Cho, Wojciech J. Grzesik, Lawrence R. Gray, Diego A Scerbo, ...> ;Elife. 2019 Jul 18
2 citations
Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin.
Xingshen Sun, Yaling Yi, Bo Liang, Yu Yang, Nan He, Katie Larson Ode, Aliye Uc, Kai Wang, Katherine N. Gibson-Corley, John F. Engelhardt, Andrew W. Norris> ;Journal of Cystic Fibrosis. 2019 Jul 1
7 citations
Is Cystic Fibrosis-related Diabetes Reversible? New Data on CFTR Potentiation and Insulin Secretion.
Andrew W. Norris> ;American Journal of Respiratory and Critical Care Medicine. 2019 Feb 1
42 citations
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.
Scott R. Tyler, Pavana G. Rotti, Xingshen Sun, Yaling Yi, Weiliang Xie, Michael C. Winter, Miles J. Flamme-Wiese, Budd A. Tucker, Robert F. Mullins, Andrew W. Norris, ...> ;Cell Reports. 2019 Feb 12
29 citations
Survival in a bad neighborhood: pancreatic islets in cystic fibrosis
Andrew W. Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F. Engelhardt, Rebecca L. Hull> ;The Journal of Endocrinology. 2019 Feb 1
8 citations
Fetal hyperglycemia acutely induces persistent insulin resistance in skeletal muscle.
Kok Lim Kua, Shanming Hu, Chunlin Wang, Jianrong Yao, Diana Dang, Alexander B. Sawatzke, Jeffrey L. Segar, Kai Wang, Andrew W. Norris> ;The Journal of Endocrinology. 2019 Jul 1
2 citations
A Novel Stomach-Pancreas Connection: More than Physical
Andrew W. Norris, Aliye Uc> ;Ebiomedicine. 2018 Nov 1
10 citations
Development of a polarized pancreatic ductular cell epithelium for physiological studies
Yunxia O'Malley, Pavana G. Rotti, Ian M. Thornell, Oriana G. Vanegas Calderón, Christopher A. Febres-Aldana, Katelin Durham, Jianrong Yao, Xiaopeng Li, Zheng Zhu, Andr...> ;Journal of Applied Physiology. 2018 Jul 1
19 citations
Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets.
Pavana G. Rotti, Weiliang Xie, Ananta Poudel, Yaling Yi, Xingshen Sun, Scott R. Tyler, Aliye Uc, Andrew W. Norris, Manami Hara, John F. Engelhardt, Katherine N. Gibson...> ;The American Journal of Pathology. 2018 Apr 1
59 citations
SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
Chen Kang, Litao Xie, Susheel K. Gunasekar, Anil Mishra, Yanhui Zhang, Saachi Pai, Yiwen Gao, Ashutosh Kumar, Andrew W. Norris, Samuel B. Stephens, Rajan Sah> ;Nature Communications. 2018 Jan 25
55 citations
CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors.
Xingshen Sun, Yaling Yi, Weiliang Xie, Bo Liang, Michael C. Winter, Nan He, Xiaoming Liu, Meihui Luo, Yu Yang, Katie Larson Ode, Aliye Uc, Andrew W. Norris, John F. En...> ;Endocrinology. 2017 Oct 1
4 citations
Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence.
William Coryell, Douglas R. Langbehn, Andrew W. Norris, Jianrong Yao, Lilian Dindo, Chadi A. Calarge> ;Psychiatry Research. 2017 Oct 1
61 citations
Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.
Yaling Yi, Andrew W. Norris, Kai Wang, Xingshen Sun, Aliye Uc, Antoinette Moran, John F. Engelhardt, Katie Larson Ode> ;American Journal of Respiratory and Critical Care Medicine. 2016 Oct 14
11 citations
Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development.
Madeliene Stump, Deng-Fu Guo, Ko-Ting Lu, Masashi Mukohda, Martin D. Cassell, Andrew W. Norris, Kamal Rahmouni, Curt D. Sigmund> ;Endocrinology. 2016 Aug 30
32 citations
A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling.
Yaling Yi, Xingshen Sun, Katherine N. Gibson-Corley, Weiliang Xie, Bo Liang, Nan He, Scott R. Tyler, Aliye Uc, Louis H. Philipson, Kai Wang, Manami Hara, Katie Larson ...> ;Endocrinology. 2016 Feb 10
165 citations
Hepatic Mitochondrial Pyruvate Carrier 1 is Required for Efficient Regulation of Gluconeogenesis and Whole-body Glucose Homeostasis
Lawrence R. Gray, Mst Rasheda Sultana, Adam J. Rauckhorst, Lalita Oonthonpan, Sean C. Tompkins, Arpit Sharma, Xiaorong Fu, Ren Miao, Alvin D. Pewa, Kathryn S. Brown, E...> ;Cell Metabolism. 2015 Oct 6
54 citations
Regulation of Glucose Tolerance and Sympathetic Activity by MC4R Signaling in the Lateral Hypothalamus
Donald A. Morgan, Latisha McDaniel, Terry Yin, Michael Z. Khan, Jingwei Jiang, Michael R. Acevedo, Susan A. Walsh, Laura L. Boles Ponto, Andrew W. Norris, Michael Lutt...> ;Diabetes. 2015 Jun 1
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Books/Book Chapters

Clinical Pediatric Endocrinology
Chapter: Diabetes Mellitus
Page 458 - 504Norris AW & Wolfsdorf JIEditors: Brook, P Clayton, & R Brown.Wiley-BlackwellEdition 6,2009

Grant Support

“Early Pathogenesis of Cystic Fibrosis Related Diabetes”NIH2014–Present
“Fatty Acid Defects & Oxidative Stress Modulate Islet Function in Cystic Fibrosis”NIH2012–Present
Diabetes Research Training ProgramNIH2017–2022
Splanchno-Hormonal Mechanisms of Cystic Fibrosis Related DiabetesNIH2018–2021