AngelGuillenPerezMD

PubMed

• 3 citations
  Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile.
  Ryota Nakajima, Hiroyuki Oono, Keiko Kumazawa, Tomohide Ida, Jun Hirata, Ryan White, Xiaoshan Min, Angel Guzman-Perez, Zhulun Wang, Antony Symons, Sanjay Singh, Sriniv...> ;Bioorganic & Medicinal Chemistry Letters. 2021 Mar 15
• 10 citations
  Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists.
  Ryota Nakajima, Hiroyuki Oono, Sakae Sugiyama, Yohei Matsueda, Tomohide Ida, Shinji Kakuda, Jun Hirata, Atsushi Baba, Akito Makino, Ryo Matsuyama, Ryan White, Ryan Ρ. ...> ;ACS Medicinal Chemistry Letters. 2020 Feb 27
• 15 citations
  Correction to Analyzing Learned Molecular Representations for Property Prediction.
  Kevin Yang, Kyle Swanson, Wengong Jin, Connor W. Coley, Philipp Eiden, Hua Gao, Angel Guzman-Perez, Timothy Hopper, Brian Kelley, Miriam Mathea, Andrew Palmer, Volker ...> ;Journal of Chemical Information and Modeling. 2019 Dec 9
• 466 citations
  Analyzing Learned Molecular Representations for Property Prediction.
  Kevin Yang, Kyle Swanson, Wengong Jin, Connor W. Coley, Philipp Eiden, Hua Gao, Angel Guzman-Perez, Timothy Hopper, Brian Kelley, Miriam Mathea, Andrew Palmer, Volker ...> ;Journal of Chemical Information and Modeling. 2019 Aug 13
• 4 citations
  Increased building block access through collaboration.
  Christopher John Helal, Alessandra Bartolozzi, Steven D. Goble, Neelakanda S. Mani, Angel Guzman-Perez, Ajay K. Ohri, Zhi-Cai Shi, Chakrapani Subramanyam> ;Drug Discovery Today. 2018 Mar 20
• 8 citations
  Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators.
  Nagasree Chakka, Kristin L. Andrews, Loren Berry, Howard Bregman, Hakan Gunaydin, Liyue Huang, Angel Guzman-Perez, Matthew H. Plant, Jeffrey R. Simard, Jacinthe Gingra...> ;European Journal of Medicinal Chemistry. 2017 Sep 8
• 3 citations
  Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors.
  Laurie B. Schenkel, Erin F. DiMauro, Hanh Nho Nguyen, Nagasree Chakka, Bingfan Du, Robert S. Foti, Angel Guzman-Perez, Michael Jarosh, Daniel S. La, Joseph Ligutti, Be...> ;Bioorganic & Medicinal Chemistry Letters. 2017 Aug 15
• 15 citations
  The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.
  Daniel S. La, Emily A. Peterson, Christiane Bode, Alessandro Boezio, Howard Bregman, Margaret Chu-Moyer, James R. Coats, Erin F. DiMauro, Thomas Dineen, Bingfan Du, Hu...> ;Bioorganic & Medicinal Chemistry Letters. 2017 Aug 1
• 32 citations
  Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
  Matthew Weiss, Thomas Dineen, Isaac E. Marx, Steven Altmann, Alessandro Boezio, Howard Bregman, Margaret Y. Chu-Moyer, Erin F. DiMauro, Elma Feric Bojic, Robert S. Fot...> ;Journal of Medicinal Chemistry. 2017 Apr 20
• 4 citations
  Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent NaV1.7 inhibitors
  Brian A. Sparling, Shuyan Yi, Jessica Able, Howie Bregman, Erin F. DiMauro, Robert S. Foti, Hua Gao, Angel Guzman-Perez, Hongbing Huang, Michael Jarosh, Thomas Korneco...> ;Medchemcomm. 2017 Apr 20
• 48 citations
  Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords ...
  Russell Graceffa, Alessandro Boezio, Jessica Able, Steven Altmann, Loren Berry, Christiane Boezio, John Butler, Margaret Y. Chu-Moyer, Melanie Cooke, Erin F. DiMauro, ...> ;Journal of Medicinal Chemistry. 2017 Apr 20
• 21 citations
  The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors
  Howard Bregman, Jeffrey R. Simard, Kristin L. Andrews, Shawn Ayube, Hao Chen, Hakan Gunaydin, Angel Guzman-Perez, Jiali Hu, Liyue Huang, Xin Huang, Paul Krolikowski, S...> ;Journal of Medicinal Chemistry. 2017 Feb 9
• 30 citations
  Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors
  Erin F. DiMauro, Stephen Altmann, Loren Berry, Howard Bregman, Nagasree Chakka, Margaret Y. Chu-Moyer, Elma Feric Bojic, Robert S. Foti, Robert T. Fremeau, Hua Gao, Ha...> ;Journal of Medicinal Chemistry. 2016 Aug 29
• 35 citations
  Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
  Laurie B. Schenkel, Philip R. Olivieri, Alessandro Boezio, Holly L. Deak, Renee Emkey, Russell Graceffa, Hakan Gunaydin, Angel Guzman-Perez, Josie H. Lee, Yohannes Tef...> ;Journal of Medicinal Chemistry. 2016 Mar 4
• 12 citations
  Identification of a novel conformationally constrained glucagon receptor antagonist.
  Esther C.Y. Lee, Meihua Tu, Benjamin D. Stevens, Jianwei Bian, Gary Erik Aspnes, Christian Perreault, Matthew F. Sammons, Stephen W. Wright, John Litchfield, Amit S. K...> ;Bioorganic & Medicinal Chemistry Letters. 2014 Feb 1
• 30 citations
  Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
  Zihao Hua, Howard Bregman, John L. Buchanan, Nagasree Chakka, Angel Guzman-Perez, Hakan Gunaydin, Xin Huang, Yan Gu, Virginia Berry, Jingzhou Liu, Yohannes Teffera, Li...> ;Journal of Medicinal Chemistry. 2013 Dec 11
• 20 citations
  Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors.
  Hongbing Huang, Angel Guzman-Perez, Lisa Acquaviva, Virginia Berry, Howard Bregman, Jennifer Dovey, Hakan Gunaydin, Xin Huang, Liyue Huang, Doug Saffran, Randy Serafin...> ;ACS Medicinal Chemistry Letters. 2013 Oct 23
• 12 citations
  Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor
  Robert L. Dow, Melissa P. Andrews, Jian-Cheng Li, E. Michael Gibbs, Angel Guzman-Perez, Jennifer L. LaPerle, Qifang Li, Dawn Mather, Michael John Munchhof, Mark Niosi,...> ;Bioorganic & Medicinal Chemistry. 2013 Sep 1
• 11 citations
  Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
  Kevin J. Filipski, Angel Guzman-Perez, Jianwei Bian, Christian Perreault, Gary Erik Aspnes, Mary Theresa Didiuk, Robert L. Dow, Richard F. Hank, Christopher S. Jones, ...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Aug 15
• 50 citations
  Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors
  Howard Bregman, Nagasree Chakka, Angel Guzman-Perez, Hakan Gunaydin, Yan Gu, Xin Huang, Virginia Berry, Jingzhou Liu, Yohannes Teffera, Liyue Huang, Bryan Egge, Erin L...> ;Journal of Medicinal Chemistry. 2013 May 23
• 27 citations
  The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of typ...
  Angel Guzman-Perez, Jeffrey A. Pfefferkorn, Esther C.Y. Lee, Benjamin D. Stevens, Gary Erik Aspnes, Jianwei Bian, Mary Theresa Didiuk, Kevin J. Filipski, Dianna E. Moo...> ;Bioorganic & Medicinal Chemistry Letters. 2013 May 15
• 10 citations
  Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
  Samit Kumar Bhattacharya, Gary Erik Aspnes, Scott W. Bagley, Markus Boehm, Brosius Arthur Douglas, Leonard Buckbinder, Jeanne S. Chang, Joseph DiBrino, Heather Eng, Ko...> ;Bioorganic & Medicinal Chemistry Letters. 2012 Dec 15
• 24 citations
  The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus
  Jeffrey A. Pfefferkorn, Meihua Tu, Kevin J. Filipski, Angel Guzman-Perez, Jianwei Bian, Gary Erik Aspnes, Matthew F. Sammons, Wei Song, Jian-Cheng Li, Christopher S. J...> ;Bioorganic & Medicinal Chemistry Letters. 2012 Dec 1
• Building structure-activity insights through patent mining
  Meihua Tu, Jeffrey A. Pfefferkorn, Angel Guzman-Perez, Kevin J. Filipski> ;Pharmaceutical Patent Analyst. 2012 Nov 23
• 12 citations
  Exploring Aromatic Chemical Space with NEAT: Novel and Electronically Equivalent Aromatic Template
  Meihua Tu, Brajesh K. Rai, Alan M. Mathiowetz, Mary Theresa Didiuk, Jeffrey A. Pfefferkorn, Angel Guzman-Perez, John William Benbow, Cristiano Ruch Werneck Guimarães, ...> ;Journal of Chemical Information and Modeling. 2012 Apr 22
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