AngelaReneeSmithMD

Pediatric Hematology & Oncology • Minneapolis, MN

Pediatric Blood and Marrow Trasplantation at the University of Minnesota

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Office
2450 Riverside Ave
Minneapolis, MN 55454
Phone+1 612-273-3000

Fax+1 612-273-4098
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Education & Training

University of MinnesotaFellowship, Pediatric Hematology/Oncology, 2005 - 2008
University of MinnesotaResidency, Pediatrics, 2002 - 2005
Medical College of WisconsinClass of 2002

Certifications & Licensure

MN State Medical License 2004 - 2024
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

T-Cell Depletion and Stem Cell Transplant for Immune Deficiencies and Histiocytic Disorders Start of enrollment: 2000 Sep 01
Terminated
Phase 2, Phase 3
Stem Cell Transplant for Hemoglobinopathy Start of enrollment: 2002 Jun 01
Completed
Phase 2, Phase 3
Stem Cell Transplant for Immunologic or Histiocytic Disorders Start of enrollment: 2002 Aug 01
Completed
Phase 2
Preservation of Ovarian Function After Hematopoietic Cell Transplant Start of enrollment: 2011 Jul 01
Terminated
Phase 2
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies Start of enrollment: 2012 Sep 04
Recruiting
Not Applicable
Study of Outcomes After Surgery/Treatment to Treat Bladder Cancer Start of enrollment: 2012 Jul 23
Completed
Safety of Romiplostim (Nplate®) Following UCBT Start of enrollment: 2015 Apr 10
Completed
Phase 1
Patients Treated for Wiskott-Aldrich Syndrome (WAS) Since 1990 Start of enrollment: 2014 Feb 02
Completed
Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation Start of enrollment: 2015 Feb 01
Completed
Phase 2
MT2013-37R: Voriconazole Monitoring in Pediatric Stem Cell Transplant Patients Start of enrollment: 2015 Jan 19
Completed
Phase 1
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Publications & Presentations

PubMed

12 citations
CYP2C19 phenotype and body weight-guided voriconazole initial dose in infants and children after hematopoietic cell transplantation
Takuto Takahashi, Maryam A. Mohamud, Angela R. Smith, Pamala A. Jacobson, Mutaz M. Jaber, Abeer F. Alharbi, James Fisher, Mark N. Kirstein> ;Antimicrobial Agents and Chemotherapy. 2021 Aug 17
1 citations
Delayed diagnosis of Griscelli syndrome type 2 with compound heterozygote RAB27A variants presenting with pulmonary failure
Yoav H. Messinger, Tamara C Pozos, Anne G Griffiths, William A. Mize, Damon R Olson, Angela R. Smith> ;Pediatric Hematology and Oncology. 2021 Apr 1
6 citations
Phase I Dose-Finding, Safety, and Tolerability Trial of Romiplostim to Improve Platelet Recovery After UCB Transplantation.
Georgios E. Christakopoulos, Todd E. DeFor, Stefanie M Hage, John E. Wagner, Michael A. Linden, Claudio G. Brunstein, Nelli Bejanyan, Michael R. Verneris, Angela R. Smith> ;Transplantation and Cellular Therapy. 2021 Mar 2
2 citations
CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant.
Takuto Takahashi, Angela R. Smith, Pamala A. Jacobson, Abeer F. Alharbi, James Fisher, Nathan Rubin, Mark N. Kirstein> ;International Journal of Clinical Pharmacology and Therapeutics. 2021 Jun 1
5 citations
Characterizing Immune-Mediated Cytopenias After Allogeneic Hematopoietic Cell Transplantation for Pediatric Nonmalignant Disorders
Robert Galvin, Qing Cao, Weston P. Miller, Jessica Knight-Perry, Angela R. Smith, Christen L. Ebens> ;Transplantation and Cellular Therapy. 2021 Apr 1
7 citations
Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders
Ashish Gupta, Jaap Jan Boelens, Christen L. Ebens, Joanne Kurtzberg, Troy C. Lund, Angela R. Smith, John E. Wagner, Robert Wynn, Bruce R. Blazar, Paul J. Orchard> ;Bone Marrow Transplantation. 2021 Jan 13
4 citations
Analysis of Time to Complete Response after Defibrotide Initiation in Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic ...
Paul G. Richardson, Angela R. Smith, Nancy A. Kernan, Leslie Lehmann, Robert J. Ryan, Stephan A. Grupp> ;Transplantation and Cellular Therapy. 2021 Jan 1
30 citations
Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Journal of Clinical Immunology. 2021 Jan 1
2 citations
Prognostic factors for clinical outcomes of patients with central nervous system leukemia
Jinai Bharucha, Qing Cao, Zohar Sachs, Angela R. Smith, Sarah Williams, Khalid Amin, Veronika Bachanova, Erica D. Warlick, Claudio G. Brunstein, Daniel J. Weisdorf, Ne...> ;Hematology/oncology and Stem Cell Therapy. 2021 Sep 1
4 citations
Impact of Obesity on Voriconazole Pharmacokinetics among Pediatric Hematopoietic Cell Transplant Recipients.
Takuto Takahashi, Angela R. Smith, Pamala A. Jacobson, James Fisher, Nathan Rubin, Mark N. Kirstein> ;Antimicrobial Agents and Chemotherapy. 2020 Nov 17
Successful Treatment of Skewed Lyonization Associated with X-Linked CGD in a Female Presenting with Recalcitrant Crohn's Disease
Erica L. Macke, Filippo Vairo, Deepti Vellaichamy Manian, Angela R. Smith, Jennifer L. Kemppainen, Eric W. Klee, Michael C. Stephens, Avni Y. Joshi> ;Journal of Clinical Immunology. 2020 Oct 1
64 citations
Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Blood. 2020 Jun 4
7 citations
A phase I dose finding study of intravenous voriconazole in pediatric patients undergoing hematopoietic cell transplantation
Jessica Knight-Perry, Cathryn Jennissen, Susie E. Long, Stefanie M Hage, Todd E. DeFor, Wing T. Chan, James Fisher, Mark N. Kirstein, Angela R. Smith> ;Bone Marrow Transplantation. 2020 May 1
3 citations
Using the SEER-Medicare Data to Assess Incident Chronic Myeloid Leukemia and Bladder Cancer Cases Missed by Cancer Registries.
Clara J K Lam, Joan L. Warren, Matthew E. Nielsen, Angela R. Smith, Eric Boyd, Michael J. Barrett, Angela B. Mariotto> ;Journal of the National Cancer Institute. Monographs. 2020 May 1
7 citations
Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dep...
Paul G. Richardson, Angela R. Smith, Nancy A. Kernan, Leslie Lehmann, Robert J. Soiffer, Robert J. Ryan, William Tappe, Stephan A. Grupp> ;British Journal of Haematology. 2020 Mar 10
10 citations
Reduced-Toxicity (BuFlu) Conditioning Is Better Tolerated but Has a Higher Second Transplantation Rate Compared to Myeloablative Conditioning (BuCy) in Children with I...
Ashish Gupta, Michael Downey, Ryan Shanley, Cathryn Jennissen, Weston P. Miller, Troy C. Lund, Paul J. Orchard, Angela R. Smith> ;Biology of Blood and Marrow Transplantation. 2020 Mar 1
11 citations
"Can you tell me why you made that choice?": A qualitative study of the influences on treatment decisions in advance care planning among adolescents and young adults u...
Jennifer Needle, Cynthia Peden-McAlpine, Joan Liaschenko, Kara S. Koschmann, Noah Sanders, Angela R. Smith, Sandra E Schellinger, Maureen E. Lyon> ;Palliative Medicine. 2020 Mar 1
41 citations
Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey
Alice Y. Chan, Jennifer W. Leiding, Xuerong Liu, Brent R. Logan, Lauri Burroughs, Eric J. Allenspach, Suzanne Skoda-Smith, Gulbu Uzel, Luigi D. Notarangelo, Mary Slatt...> ;Frontiers in Immunology. 2020 Feb 21
46 citations
The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018).
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;The Journal of Allergy and Clinical Immunology. 2019 Jan 1
37 citations
Related and unrelated donor transplantation for β-thalassemia major: results of an international survey.
Chunfu Li, Vikram Mathews, Soyoung Kim, Biju George, Kyle Hebert, Hua Jiang, Changgang Li, Yiping Zhu, Daniel A. Keesler, Jaap Jan Boelens, Christopher C. Dvorak, Rajn...> ;Blood Advances. 2018 Nov 29
105 citations
SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery
Elie Haddad, Brent R. Logan, Linda M. Griffith, Rebecca H. Buckley, Roberta E. Parrott, Susan E. Prockop, Trudy N. Small, Jessica Chaisson, Christopher C. Dvorak, Mega...> ;Blood. 2018 Oct 25
21 citations
Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome following nontransplant-associated chemotherapy: Final results from a p...
Nancy A. Kernan, Paul G. Richardson, Angela R. Smith, Brandon M. Triplett, Joseph H. Antin, Leslie Lehmann, Yoav H. Messinger, Wei Liang, Robin Hume, William Tappe, Ro...> ;Pediatric Blood & Cancer. 2018 Jun 6
24 citations
Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia.
Troy C. Lund, Kwang Woo Ahn, Heather R. Tecca, Megan V. Hilgers, Hisham Abdel-Azim, Allistair Abraham, Miguel Angel Diaz, Sherif M. Badawy, Larisa Broglie, Valerie I. ...> ;Biology of Blood and Marrow Transplantation. 2019 Feb 1
31 citations
Late Effects Screening Guidelines after Hematopoietic Cell Transplantation (HCT) for Hemoglobinopathy: Consensus Statement from the Second Pediatric Blood and Marrow T...
Shalini Shenoy, Javid Gaziev, Emanuele Angelucci, Allison A. King, Monica Bhatia, Angela R. Smith, Dorine Bresters, Anne E. Haight, Christine Duncan, Josu de la Fuente...> ;Biology of Blood and Marrow Transplantation. 2018 Jul 1
80 citations
Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome
Nancy A. Kernan, Stephan A. Grupp, Angela R. Smith, Sally Arai, Brandon M. Triplett, Joseph H. Antin, Leslie Lehmann, Tsiporah B. Shore, Vincent T. Ho, Nancy Bunin, Ma...> ;British Journal of Haematology. 2018 May 16
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Journal Articles

Successful Hematopoietic Cell Transplantation Following Cardiac Transplantation in Two Pediatric Patients
Paul J Orchard, Angela R Smith, Rachel Phelan, Rebecca K Ameduri, Pediatric Transplantation

Abstracts/Posters

Romiplostim Improves Platelet Recovery after UCB Transplant
Angela R. Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

Preliminary Results of a Phase 1/2 Clinical Study of Zinc Finger Nuclease-Mediated Editing of BCL11A in Autologous Hematopoietic Stem Cells for Transfusion-Dependent B...
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019

Press Mentions

Sangamo Annonce Des Présentations De Données Portant Sur La Thérapie Génique Et Sur La Thérapie Cellulaire Ex Vivo À Base De Gènes Modifiés, Qui Seront Données Au Congrès Annuel De L’American Society of HematologyNovember 7th, 2019