ArchibaldJMixsonMD

PubMed

• 7 citations
  Location of a single histidine within peptide carriers increases mRNA delivery
  Jiaxi He, Songhui Xu, A. James Mixson> ;The Journal of Gene Medicine. 2021 Feb 1
• 23 citations
  The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges.
  Jiaxi He, A. James Mixson> ;Pharmaceutics. 2020 Aug 14
• 118 citations
  Advances in delivery systems for doxorubicin.
  Na Zhao, A. James Mixson> ;Journal of Nanomedicine & Nanotechnology. 2018 Jan 1
• 16 citations
  Targeted Delivery of siRNA Therapeutics to Malignant Tumors
  Qixin Leng, A. James Mixson> ;Journal of Drug Delivery. 2017 Nov 9
• 28 citations
  Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis
  , , , , , , , , , , , , , , , > ;Oncotarget. 2017 Sep 14
• Silver adducts of four-branched histidine rich peptides exhibit synergistic antifungal activity.
  Leng Q, Woodle MC, Liu Y, Mixson AJ> ;Biochem. Biophys. Res. Commun.. 2016-09-02
• 21 citations
  The neuropilin-1 receptor mediates enhanced tumor delivery of H2K polyplexes
  A. James Mixson> ;The Journal of Gene Medicine. 2016 Jul 1
• 7 citations
  siRNA nanoparticles: the future of RNAi therapeutics for oncology?
  A. James Mixson> ;Nanomedicine. 2014 Nov 21
• 30 citations
  Increased tumor distribution and expression of histidine‐rich plasmid polyplexes
  Qixin Leng, Szu-Ting Chou, Puthupparampil V. Scaria, A. James Mixson> ;The Journal of Gene Medicine. 2014 Sep 1
• 7 citations
  Direct Observation of Dynamic Mechanical Regulation of DNA Condensation by Environmental Stimuli
  Amy Lee, Adam Paul Karcz, Ryan Akman, Tai Zheng, Sara Kwon, Szu-Ting Chou, Sarah Sucayan, Lucas Tricoli, Jason M. Hustedt, Qixin Leng, A. James Mixson, Joonil Seog> ;Angewandte Chemie. 2014 Sep 26
• 2 citations
  Enhancement of antifungal activity by integrin-targeting of branched histidine rich peptides.
  Puthupparampil V. Scaria, Yijia Liu, Qixin Leng, A. James Mixson, Martin C. Woodle> ;Journal of Drug Targeting. 2014 Jun 11
• 48 citations
  Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds.
  Szu-Ting Chou, Kellie Hom, Daoning Zhang, Qixin Leng, Lucas Tricoli, Jason M. Hustedt, Amy Lee, Michael J. Shapiro, Joonil Seog, A. James Mixson> ;Biomaterials. 2014 Jan 1
• 26 citations
  Surface-Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition
  Szu-Ting Chou, Qixin Leng, Puthupparampil V. Scaria, Jason D. Kahn, Lucas Tricoli, A. James Mixson> ;Biomacromolecules. 2013 Feb 14
• 6 citations
  Buffering capacity and size of siRNA polyplexes influence cytokine levels.
  Qixin Leng, Szu-Ting Chou, Puthupparampil V. Scaria, A. James Mixson> ;Molecular Therapy. 2012 Dec 1
• 13 citations
  Zinc finger nucleases: Tailor-made for gene therapy
  Szu-Ting Chou, A. J. Mixson> ;Drugs of the Future. 2012 Mar 1
• 97 citations
  Peptide-based Antifungal Therapies against Emerging Infections.
  Agata Matejuk, Qixin Leng, M.D. Begum, Martin C. Woodle, Puthupparampil V. Scaria, A. J. Mixson> ;Drugs of the Future. 2010 Mar 1
• 8 citations
  Correspondence re: Q-R. Chen et al., Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res., 59: 3308-3312...
  Andrew L. Feldman, Steven K. Libutti, A. James Mixson> ;Cancer Research. 2000 Mar 1
• Antiangiogenic Gene Therapy in Cancer.
  Zhang, L.,Chen, Q. R.,Mixson, A. J.> ;Curr. Genomics. 2000 Jan 01
• 15 citations
  Oncogenes and tumor suppressor genes: therapeutic implications.
  Sanford A. Stass, A. James Mixson> ;Clinical Cancer Research. 1997 Dec 1
• 65 citations
  Thyrotropin-secreting pituitary carcinoma.
  A J Mixson, Theodore C. Friedman, David A. Katz, Irwin M. Feuerstein, J K Taubenberger, J M Colandrea, John L. Doppman, Edward H. Oldfield, Bruce D. Weintraub> ;The Journal of Clinical Endocrinology and Metabolism. 1993 Feb 1
• 59 citations
  Alteration in the IL-2 signal peptide affects secretion of proteins in vitro and in vivo.
  Lei Zhang, A. James Mixson> ;The Journal of Gene Medicine. 2005 Mar 1
• 57 citations
  Modified branched peptides with a histidine-rich tail enhance in vitro gene transfection
  A. James Mixson> ;Nucleic Acids Research. 2005 Jan 1
• 96 citations
  HIGHLY BRANCHED HK PEPTIDES AS EFFECTIVE CARRIERS OF siRNA
  A. J. Mixson> ;The Journal of Gene Medicine. 2005 Nov 17
• 26 citations
  Synthetic Histidine-Rich Peptides Inhibit Candida Species and Other Fungi In Vitro: Role of Endocytosis and Treatment Implications
  Jingsong Zhu, Paul W. Luther, A. James Mixson> ;Antimicrobial Agents and Chemotherapy. 2006 Aug 1
• 21 citations
  A branched histidine/lysine peptide, H2K4b, in complex with plasmids encoding antitumor proteins inhibits tumor xenografts
  Qixin Leng, Puthupparampil V. Scaria, Olga B. Ioffe, A. James Mixson> ;The Journal of Gene Medicine. 2006 Dec 1
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Journal Articles

• The uptake of pyrroline-5-carboxylate: group translocation mediating the transfer of reducing-oxidizing potential.  
  Mixson AJ and Phang JM, The Journal of Biological Chemistry
• The proto-oncogenes of c-fos and c-jun modulate thyroid hormone inhibition of human thyrotropin beta subunit gene expression in opposite directions.  
  Bodenner DL, McClaskey JH, Kim MK, Mixson AJ, and Weintraub BD, Biochemical and Biophysical Research Communications
• Thyrotropin-secreting pituitary carcinoma.  
  Mixson AJ. Friedman T, Katz DA, Feuerstein IM, Tauberger JK, Colandrea JM, Doppman JL, Oldfield EH, and Weintraub BD, Journal of Clinical Endocrinology and Metabolism
• Attention deficit hyperactivity disorder and altered metabolism in 18 kindreds with generalized resistance to thyroid hormone.  
  Hauser P, Zametkin AJ, Martinez P, Vitiello B., Matochik JA, Wiggs EA, Mixson, AJ, and Weintraub BD, New England Journal of Medicine
• Differential expression of mutant and normal hTRbeta receptor alleles in kindreds with generalized resistance to thyroid hormone.  
  Mixson AJ, Hauser P, Tennyson G, and Weintraub BD, The Journal of Clinical Investigation
• Systemic gene therapy with p53 interferes with progression of breast cancer in nude mice.  
  Lesoon-Wood L, Kim WH, Kleinman H, Weintraub B, and Mixson AJ, Human Gene Therapy
• Tumor suppressor genes.  
  Stass SA and Mixson J, Clinical Cancer Research
• Gene therapy with p53 inhibits human breast cancer in vivo.  
  Xu M, Kumar D, Stass S, and Mixson AJ, Molecular Genetics and Metabolism
• Recent advances in systemic gene therapy with p53.  
  Chen QR and Mixson AJ, Frontiers in Bioscience
• Liposomes complexed to angiostatin and endostatin inhibit breast cancer in nude mice.  
  Chen QR, Kumar D, Stass SA, and Mixson AJ, Cancer Research
• Anti-angiogenic Gene Therapy.  
  Zhang L, Chen QR, and Mixson AJ, Current Genomics
• Modified branch peptides with a histidine-rich tail enhance in vitro gene transfection.  
  Leng Q and Mixson AJ, Nucleic Acids Research
• Needle-like morphology of H2K4b polyplexes associated with increases in transfection in vitro.  
  Leng Q, Kahn J, Zhu J, Scaria P, and Mixson AJ, Cancer Therapy
• Advances in siRNA Delivery.  
  Leng Q, Woodle MC, Lu PY, Mixson AJ, Drugs of the Future
• Zinc Finger Nucleases: Tailor-made for Gene Therapy.  
  Chou ST, Leng Q, Mixson AJ, Drugs of the Future
• Buffering Capacity and Size of siRNA Polyplexes Influence Cytokine levels.  
  Leng Q, Chou ST, Scaria P, Woodle M, Mixson AJ, Molecular Therapy
• Surface modified HK:siRNA nanoplexes with enhanced pharmacokinetics and tumor growth inhibition.  
  Chou ST, Leng Q, Scaria P, Kahn JD, Tricoli LJ, Woodle M, Mixson AJ, Biomacromolecules
• Differential uptake of pyrroline-5-carboxylate in adriamycin sensitive and resistant tumor cells.  
  Mixson AJ, Yeh GC, Granger AN, and Phang JM, The FASEB Journal
• Inhibitors of pyrroline-5-carboxylate uptake: evidence for a specific carrier protein.  
  Mixson AJ and Phang JM, The FASEB Journal
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Books/Book Chapters

• Localizing mutations in human genes. 
  Chapter: Molecular Endocrinology: Basic Concept and Clinical Correlations 
  Weinstein, L.S. and Mixson, A.JEditors: Weintraub, B.D.Raven Press, New York
• Inhibiting tumor angiogenesis with molecular therapy. 
  Chapter: The Oncogenomics Handbook: Understanding and Treating Cancer in the 21st Century 
  Leng, Q. and Mixson, A.JEditors: Shimkets, R.A. and LaRochelle, W.J.

Abstracts/Posters

• The uptake of pyrroline-5-carboxylate: group translocation mediating redox transfers.
  Mixson AJ and Phang JM, Federal Proceedings
• Diverse phenotypes of 11 kindreds with generalized thyroid hormone resistance and novel mutations in the gene encoding the T3 beta receptor.
  Mixson AJ, Parrilla R, Usala SJ, Ransom SC, McClaskey JH, McPherson JA, and Weintraub B.D, Clinical Research
• Language fluency associated with Thyroid Hormone Resistance.
  Mixson AJ, International Symposium on Thyroid Hormone Resistance, Cambridge, England
• Systemic Therapy of Breast Cancer with Liposome: p53 Complexes.
  Mixson AJ, 2nd Annual New Cancer Strategies: p53, Atlanta, GA
• Treatment of Breast Cancer with Antiangiogenic Genes.
  Mixson AJ, Protenomics and Cancer Therapy, NCI, Bethesda, MD
• New Polymer Enhances Transfection.
  Mixson AJ, 3rd International Symposium on Molecular Medicine, Heraklion, Greece
• A Novel Non-Viral Carrier: Implications for Gene Therapy.
  Mixson AJ, Gene Delivery Systems: Improving pathways, efficiency, and stability. The Knowledge Foundation, Boston, MA
• Tumor angiogenesis inhibited by a VEGFR2 DNAzyme.
  Mixson AJ, 5th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece
• Development of HK Polymer as a Gene Delivery Agent.
  Mixson AJ, 2nd International Conference on Gene and Drug Therapy, Paris, France
• Novel Gene Therapy Approaches Toward Cancer.
  Mixson AJ, Nanomedicine Research Day, Baltimore, MD
• Advances in siRNA Delivery: Systemic non-viral delivery of siRNA Targeting Tumors.
  Mixson AJ, The Cloisters, National Institutes of Heath, Bethesda, MD
• Searching for the Elusive Carrier of Nucleic Acids: the HK Peptide Therapeutic Paradigm.
  Mixson AJ, NIH Metabolism and Cancer Susceptibility Section, Frederick, Maryland
• Size of HK polyplexes Affect Cytokine Induction.
  Mixson AJ, 3rd Annual World Congress of NanoMedicine, Senzhen, China
• Characterization of functional properties of eleven novel mutations of the T3beta receptor gene in kindreds with generalized thyroid hormone resistance.
  Parrilla R, Mixson AJ, McClaskey JH, Meier CA, Ransom SC, Usala SJ, and Weintraub BD, 73rd Annual Meeting of the Endocrine Society
• Association of attention-deficit hyperactivity disorder with generalized resistance to thyroid hormone in 18 kindreds.
  Hauser P, Zametkin AJ, Martinez O, Vitiello B, Matochik JA, Wiggs EA, Mixson AJ, and Weintraub BD, Clinical Research
• Neurological deficits of generalized resistance to thyroid hormone.
  Hauser P, Wiggs E, Leonard C, Mixson AJ, An S, and Weintraub BD, American Federation of Clinical Research Annual Meeting
• Direct Measurements of Mechanical Properties of Condensed DNA Using Optical Tweezers.
  Karcz A, Tie C, Sucayan S, Mixson AJ, Kahn, JD, and Seog, J, 6th Annual Cancer Nanobiology Think Tank
• A Modified HK Carrier of siRNA Enhances Silencing of Tumor Targets In Vivo.
  Chou ST, Leng Q, Scaria P, Mixson AJ, American Society of Cellular and Gene Therapy 14th Annual Meeting
• Direct Measurements of Mechanical Properties of Condensed DNA Using Optical Tweezers.
  Lee A, Karcz A, Tie C, Sucayan S, Mixson J, Kahn J and Seog J, Biomedical Engineering Society 11th Annual Meeting
• Direct Measurements of Mechanical Properties of Condensed DNA for Gene Delivery Using Optical Tweezers.
  Seog J, Lee A, Karcz A, Tie C, Sucayan S, Kahn J, Mixson A, International Conference of Young Researchers on Advanced Materials
• Modified HK siRNA Polyplexes with Improved Pharmacokinetics Enhance Tumor Inhibition.
  Chou ST, Leng Q, Scaria P, Mixson AJ, American Society of Cellular and Gene Therapy 15th Annual Meeting
• Hydrogen bonding between the imidazole-containing peptide and siRNA mediates greater stability and biological activity of the polyplex.
  Chou ST, Leng Q, Seog J, Kahn JD, Mixson AJ, 8th Annual Oligonucleotide Therapeutic Annual Meeting
• Genetic and clinical features of 100 patients with resistance to thyroid hormone (RTG-) from 39 families followed at the NIH.
  Brucker-Davis F, Skarulix M, Hauser P, Grace M.B, Wiggs E, Mixson AJ, Malley J, and Weintraub BD, 74th Annual Endocrine Meeting
• Allele specific associated polymorphism (ASAP) analysis of point mutations in the human thyroid receptor-beta (HTR-beta) gene associated with resistance to thyroid hor...
  Grace MB, Seto D, Mixson J, Buzard GS, and Weintraub B, 74th Annual Endocrine Meeting
• Systemic Gene Therapy with p53 Interferes with Progression of Breast Cancer in Nude Mice.
  Lesoon-Wood L, Kim WH, Kleinman H., Weintraub B, and Mixson AJ, 86th American Association for Cancer Research Meeting
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Lectures

• Liposomal Delivery Systems for Central and Peripheral Hyperalimentation solutions. 
  Cape Sunion Beach, Greece

Other

• Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy. 
  US patent
• Cationic vehicle: DNA complexes and their use in gene therapy. 
  #EPO819758B1
• Branched Histidine copolymers and methods for using the same. 
  US Patent
• Histidine copolymer and methods for using same. 
  US Patent
• Branched Cationic Copolymers and methods for using antimicrobial use. 
  USA Patent
• Highly branched HK peptides as effective carriers of siRNA. 
  US Patent
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