BabakRazaniMDPhD

PubMed

• Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis.
  Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F Semenkovich, Irfan J Lodhi> ;Molecular Metabolism. 2024 Apr 1
• Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk.
  Zhang, X., Kapoor, D., Jeong, S., Fappi, A., Stitham, J., Shabrish, V., Sergin, I., Yousif, E., Rodriguez-Velez, A., Yeh, Y., Park, A., Yurdagul, A., Rom, O., Epelman,...> ;Nature Metabolism. 2024 Feb 1
• 1 citations
  Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease.
  Sumit Kumar Anand, Theresea-Anne Governale, Xiangyu Zhang, Babak Razani, Arif Yurdagul Jr, Christopher B Pattillo, Oren Rom> ;The American Journal of Pathology. 2024 Apr 1
• Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets.
  Cristi L Galindo, Saifur Khan, Xiangyu Zhang, Yu-Sheng Yeh, Ziyang Liu, Babak Razani> ;Expert Opinion on Therapeutic Targets. 2023 Dec 30
• Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease.
  Mandy M Chan, Sabine Daemen, Joseph W Beals, Marina Terekhova, Bin Q Yang, Christina F Fu, Li He, Arick C Park, Gordon I Smith, Babak Razani, Kathleen Byrnes, Wandy L ...> ;JHEP Reports. 2023 Nov 1
• 2 citations
  TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
  Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V Kravitz, Kooresh I Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J...> ;Nature Communications. 2023 Sep 29
• metGWAS 1.0: an R workflow for network-driven over-representation analysis between independent metabolomic and meta-genome-wide association studies.
  Saifur R Khan, Andreea Obersterescu, Erica P Gunderson, Babak Razani, Michael B Wheeler, Brian J Cox> ;Bioinformatics. 2023 Sep 2
• 1 citations
  Enhancing autophagy in CD11cantigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome.
  Christine Quach, Doumet Georges Helou, Meng Li, Benjamin Pierre Hurrell, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Jing-Hsiung James Ou, Babak Razani, Viren...> ;Cell Reports. 2023 Aug 29
• 5 citations
  Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging.
  Erin H Seeley, Zhipeng Liu, Shuai Yuan, Chad Stroope, Elizabeth Cockerham, Nabil A Rashdan, Luisa F Delgadillo, Alexandra C Finney, Dhananjay Kumar, Sandeep Das, Babak...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Sep 1
• 2 citations
  Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling.
  Xiangyu Zhang, Trent D Evans, Sunny Chen, Ismail Sergin, Jeremiah Stitham, Se-Jin Jeong, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, In-Hyuk Jung, Abhinav Diwan,...> ;Circulation Research. 2023 Jul 21
• Heterogeneity in Early Postpartum Metabolic Profiles Among Women with GDM Who Progressed to Type 2 Diabetes During 10-Year Follow-Up: The SWIFT Study.
  Saifur R Khan, Hannes Rost, Brian Cox, Babak Razani, Stacey Alexeeff, Michael B Wheeler, Erica P Gunderson> ;Medrxiv. 2023 Jun 16
• 2 citations
  A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke.
  Vishwanath Jha, Bei Xiong, Tripti Kumari, Gavriel Brown, Jinzhi Wang, Kyungho Kim, Jingu Lee, Nathan Asquith, John Gallagher, Lillian Asherman, Taylor Lambert, Yanyan ...> ;Circulation Research. 2023 May 26
• 12 citations
  Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity.
  Mualla Ozcan, Zhen Guo, Carla Valenzuela Ripoll, Ahmed Diab, Antonino Picataggi, David Rawnsley, Aynaz Lotfinaghsh, Carmen Bergom, Jeff Szymanski, Daniel Hwang, Aarti ...> ;Cell Metabolism. 2023 Jun 6
• Correction to: Subcutaneous Transplantation of White Adipose Tissue.
  Yu-Sheng Yeh, Mari Iwase, Satoko Kawarasaki, Jungin Kwon, Astrid Rodriguez-Velez, Xiangyu Zhang, Se-Jin Jeong, Tsuyoshi Goto, Babak Razani> ;Methods in Molecular Biology. 2023 Jan 1
• Subcutaneous Transplantation of White Adipose Tissue.
  Yu-Sheng Yeh, Mari Iwase, Satoko Kawarasaki, Jungin Kwon, Astrid Rodriguez-Velez, Xiangyu Zhang, Se-Jin Jeong, Tsuyoshi Goto, Babak Razani> ;Methods in Molecular Biology. 2023 Jan 1
• PCSK9 Pleiotropism: In the Same Vein as Statins.
  Arick C Park, Xiangyu Zhang, Yu-Sheng Yeh, Babak Razani> ;Circulation Research. 2022 Nov 11
• Evaluation of mTORC1 signaling in mouse atherosclerotic macrophages by flow cytometry and immunofluorescence.
  Xiangyu Zhang, Jeremiah Stitham, Astrid Rodriguez-Velez, Se-Jin Jeong, Arick Park, Yu-Sheng Yeh, Divya Kapoor, Bettina Mittendorfer, Babak Razani> ;STAR Protocols. 2022 Dec 16
• 13 citations
  Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis.
  Xiangyu Zhang, Santosh Kumar Misra, Parikshit Moitra, Xiuli Zhang, Se-Jin Jeong, Jeremiah Stitham, Astrid Rodriguez-Velez, Arick Park, Yu-Sheng Yeh, William E Gillande...> ;Autophagy. 2023 Mar 1
• 5 citations
  Inequity and disparities mar existing global research evidence on Long COVID.
  Mohammad Hossein Taghrir, Hossein Akbarialiabad, Ashkan Abdollahi, Nasrollah Ghahramani, Bahar Bastani, Shahram Paydar, Babak Razani, John Mwangi, Ali A Asadi-Pooya, J...> ;Global Health Promotion. 2023 Mar 1
• 19 citations
  TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma.
  Efthymia Theofani, Maria Semitekolou, Konstantinos Samitas, Annie Mais, Ioanna E Galani, Vasiliki Triantafyllia, Joanna Lama, Ioannis Morianos, Athanasios Stavropoulos...> ;Allergy. 2022 Jul 1
• 2 citations
  Autophagy in Atherosclerosis: Not All Foam Cells Are Created Equal.
  Gordon A Francis, Babak Razani> ;Circulation Research. 2022 Mar 18
• 13 citations
  TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis.
  Xiucui Ma, David R Rawnsley, Attila Kovacs, Moydul Islam, John T Murphy, Chen Zhao, Minu Kumari, Layla Foroughi, Haiyan Liu, Kevin Qi, Aaradhya Diwan, Krzysztof Hyrc, ...> ;JACC. Basic to Translational Science. 2022 Mar 1
• 10 citations
  Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation.
  Jing Li, Tripti Kumari, Andrew Barazia, Vishwanath Jha, Si-Yeon Jeong, Amber Olson, Mijeong Kim, Bum Kyu Lee, Vijayprakash Manickam, Zhimin Song, Regina A. Clemens, Ba...> ;The Journal of Experimental Medicine. 2022 Jan 3
• 1 citations
  Autophagy Signaling and Oxidative Stress in Thoracic Aortic Aneurysms: Good, Bad, or Ugly?
  Arick C. Park, Yu-Sheng Yeh, Astrid Rodriguez-Velez, Xiangyu Zhang, Babak Razani> ;JACC. Basic to Translational Science. 2021 Sep 1
• 45 citations
  Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress.
  Rysa Zaman, Homaira Hamidzada, Crystal Kantores, Anthony Wong, Sarah A. Dick, Yiming Wang, Abdul Momen, Laura Aronoff, Julia Lin, Babak Razani, Seema Mital, Filio Bill...> ;Immunity. 2021 Sep 14
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Journal Articles

• PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN–Dependent Mechanism  
  Kassandra J Weber, Joel D Schilling, Babak Razani, The Journal of Immunology
• Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis  
  Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, and Razani B., Sci Signal., 1/1/2016
• Ursolic acid enhances macrophage autophagy and attenuates atherosclerosis  
  Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, Razani B, and Fan D., J Lipid Res, 1/1/2016
• Can the DNA Damage Response be Harnessed to Modulate Atherosclerotic Plaque Phenotype?  
  Razani B and Raines EW., Circ Res, 1/1/2015
• Degradation and Beyond: The Macrophage Lysosome as a Nexus for Nutrient Sensing and Processing in Atherosclerosis  
  Sergin I, Evans TD, and Razani B., Curr Opin Lipidol, 1/1/2015
• Embryonic and adultderived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation  
  Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsbe..., Immunity, 1/1/2014
• Induction of a Lysosomal Biogenesis Program in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae  
  Emanuel R, Sergin I, Bhattacharya S, Turner J, Epelman S, Settembre C, Diwan A, Ballabio A, and Razani B., Arterioscler Thromb Vasc Biol., 1/1/2014
• Self-eating in the Plaque: What Macrophage Autophagy Reveals About Atherosclerosis  
  Sergin I and Razani B., Trends Endocrinol Metab, 1/1/2014
• Hypoxia in Plaque Macrophages: A New Danger Signal for Interleukin-1Beta Activation?  
  Sergin I, Evans TD, Bhattacharya S, and Razani B, Circ Res, 1/1/2014
• Interleukins and Atherosclerosis: A Dysfunctional Family Grows  
  Spears LD, Razani B, and Semenkovich CF., Cell Metab, 1/1/2013
• Autophagy links inflammasomes to atherosclerotic progression  
  Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, and Semenkovich CF., Cell Metab, 1/1/2012
• The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy  
  Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguere PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, and..., Immunity, 1/1/2012
• Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity  
  Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, and Semenkovich CF, Cell Metab., 1/1/2012
• Fatty Acid Synthase modulates homeostatic responses to myocardial stress  
  Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW II, Nichols CG, and Semenkovic..., J Biol Chem., 1/1/2011
• Atheroprotective but not insulin sensitizing effects of chloroquine are p53-dependent  
  Razani B, Feng C, and Semenkovich CF., J Lipid Res, 1/1/2010
• Getting away from glucose: stop sugarcoating diabetes  
  Razani B and Semenkovich CF., Nat. Med., 1/1/2009
• Insulin resistance and atherosclerosis  
  Razani B, Chakravarthy MV, and Semenkovich CF, Endocrinol. Metab. Clin. North Am., 1/1/2008
• Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hy...  
  Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, and Lisanti MP, J. Biol. Chem, 1/1/2004
• Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice  
  Williams TM, Cheung MW, Park DS, Razani B, Cohen AW, Muller WJ, Di Vizio D, Chopra NG, Pestell RG, and Lisanti MP., Mol Biol Cell., 1/1/2003
• Caveolin-1 Deficient Mice show post-prandial hyper-insulinemia, insulin resistance, and defective Insulin Receptor (IR-{beta}) protein expression in adipose tissue  
  Cohen AW, Razani B, Wang XB, Combs TP, Williams TM, Scherer PE, and Lisanti MP., Am. J. Physiol. Cell Physiol, 1/1/2003
• Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities  
  Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks LA, Scherer PE, and Lisanti MP., J. Biol. Chem., 1/1/2002
• Caveolin-2 deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae  
  Razani B, Wang XB, Engelman JA, Battista M, Lagaud G, Zhang XL, Knietz B, Hou H Jr, Christ GJ, Edelmann W, and Lisanti MP., Mol. Cell Biol., 1/1/2002
• Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells  
  Sotgia F, Razani B, Bonuccelli G, Schubert W, Battista M, Lee H, Capozza F, Schubert AL, Minetti C, Buckley JT, and Lisanti MP, Mol. Cell Biol., 1/1/2002
• Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype  
  Park DS, Woodman SE, Schubert W, Cohen AW, Frank FG, Chandra M, Shirani J, Razani B, Tang B, Jelicks JA, Factor SM, Weiss LM, Tanowitz HB, and Lisanti MP, Am. J. Pathol., 1/1/2002
• Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice sh...  
  Lee H, Park DS, Razani B, Russell RG, Pestell RG, and Lisanti MP., Am. J. Path, 1/1/2002
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Lectures

• Building a Better Macrophage to Treat Atherosclerosis and Associated Metabolic Conditions 
  Graz, Austria - 1/9/2016
• Building a Better Macrophage to Treat Metabolic Disease 
  Cedars-Sinai Medical Center, Los Angeles, CA - 1/8/2016
• Harnessing the Autophagy-Lysosomal Biogenesis Response in Macrophages to Treat Atherosclerosis 
  Vail, CO, 2015; Seoul, South Korea, 2015 - 1/12/2015
• The Autophagy-Lysosome System in Macrophages: A Nexus for Lipid Metabolism and Inflammation in Atherosclerosis 
  UCLA, Los Angeles, CA - 1/4/2014
• p62-enriched Inclusion Bodies in Macrophages Play a Protective Role in Atherosclerosis 
  Toronto, ON - 1/2/2014
• p62, Protein Aggregation, and Atherosclerosis 
  Vail, CO - 1/29/2013
• p62- enriched Inclusion Bodies in Macrophages Play a Protective Role in Atherosclerosis 
  Stowe, VT - 1/20/2013
• The AutophagyLysosome System in Macrophages: A Nexus for Lipid Metabolism and Inflammation in Atherosclerosis 
  Cleveland Clinic, Cleveland, OH - 1/6/2013
• Novel Therapies in Atherosclerosis 
  John Cochran VA Medical Center, St. Louis, MO - 1/7/2012
• Genomic Stress and Autophagy: Emerging Themes in Cardiovascular Disease 
  University of Chicago School of Medicine, Chicago, IL - 1/30/2011
• When the Heart Can't Make its Own Fat: Fatty Acid Synthase in Myocardial Dysfunction 
  University of Maryland School of Medicine, Baltimore, MD, 2011; Division of Endocrinology, Universit - 1/28/2011
• Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress 
  Chicago, IL - 1/1/2011
• Autophagy Links Inflammasomes to Atherosclerotic Progression 
  Chicago, IL - 1/1/2011
• Cardiac Fatty Acid Synthase Mediates Survival with Acute Stress 
  Breckenridge, CO - 1/1/2008
• Caveolin-deficient mice: Insights into caveolar function and human disease 
  Lovelace Respiratory Research Institute, Albuquerque, NM - 1/1/2000
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Other

• Orgocards: Organic Chemistry Review. 
  Wang SQ, Razani B, Lee EJK, Wu J, and Berkowitz W.
  1/1/2002