BishoySobhy MorrisFaltasMD

PubMed

• Elucidating the Role of PIK3CA in Early-Stage Bladder Tumorigenesis: New Insights from a Novel Transgenic Mouse Model.
  Faltas, B. S., Bishoy M Faltas> ;The American Journal of Pathology. 2023 Dec 1
• A Pilot Study on Hyperthermic Intraperitoneal Chemotherapy after Radical or Partial Cystectomy with Pelvic Lymph Node Dissection for High-risk Muscle-invasive Bladder ...
  Leonardo D Borregales, Siv Venkat, Lina Posada Calderon, Patrick Lewicki, Thomas Flynn, Ana M Molina, David M Golombos, Padraic O'Malley, Douglas S Scherr, Faltas, B. ...> ;European Urology. 2023 Dec 1
• A new era in the treatment of urothelial carcinoma.
  Bishoy Faltas> ;Urologic Oncology. 2023 Oct 1
• 2 citations
  Immunotherapy in the Treatment of Localized Genitourinary Cancers.
  Andrea Necchi, Susan F Slovin, Joshua J Meeks, Sumanta K Pal, Lawrence H Schwartz, Richard S P Huang, Roger Li, Brandon Manley, Jad Chahoud, Jeffrey S Ross, Philippe E...> ;JAMA Oncology. 2023 Oct 1
• 5 citations
  Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
  Kyle M Rose, Heather L Huelster, Joshua J Meeks, Guru P Sonpavde, Seth P Lerner, Jeffrey S Ross, Philippe E Spiess, G Daniel Grass, Rohit K Jain, Ashish M Kamat, Aram ...> ;Nature Reviews. Urology. 2023 Jul 1
• 1 citations
  Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations.
  Shan Li, Alicia Wong, Huiyun Sun, Vipul Bhatia, Gerardo Javier, Sujata Jana, Robert B Montgomery, Jonathan L Wright, Hung-Ming Lam, Andrew C Hsieh, Michael C Haffner, ...> ;Biorxiv. 2023 Apr 14
• 6 citations
  Immune Checkpoint Inhibitors and Long-term Survival of Patients With Metastatic Urothelial Cancer.
  Alec Zhu, Jorge Alberto Garcia, Bishoy Faltas, Petros Grivas, Pedro Barata, Jonathan E Shoag> ;JAMA Network Open. 2023 Apr 3
• 11 citations
  The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.
  Weisi Liu, Kevin P Newhall, Francesca Khani, LaMont Barlow, Duy Nguyen, Lilly Gu, Ken Eng, Bhavneet Bhinder, Manik Uppal, Charlotte Récapet, Andrea Sboner, Susan R Ros...> ;Cancer Research. 2023 Feb 15
• Tumor-Infiltrating Myeloid Cells Confer De Novo Resistance to PD-L1 Blockade through EMT-Stromal and Tgfβ-Dependent Mechanisms.
  Haocheng Yu, John P Sfakianos, Li Wang, Yang Hu, Jorge Daza, Matthew D Galsky, Harkirat S Sandhu, Olivier Elemento, Bishoy M Faltas, Adam M Farkas, Nina Bhardwaj, Jun ...> ;Molecular Cancer Therapeutics. 2022 Nov 3
• 5 citations
  Tumor-immune microenvironment revealed by Imaging Mass Cytometry in a metastatic sarcomatoid urothelial carcinoma with a prolonged response to pembrolizumab.
  Hussein Alnajar, Hiranmayi Ravichandran, André Figueiredo Rendeiro, Kentaro Ohara, Wael Al Zoughbi, Jyothi Manohar, Noah Greco, Michael Sigouros, Jesse Fox, Emily Muth...> ;Cold Spring Harbor Molecular Case Studies. 2022 Apr 1
• 15 citations
  Impact of Use of Antibiotics on Response to Immune Checkpoint Inhibitors and Tumor Microenvironment.
  Uqba Khan, Kaylee Ho, Eun Kyeong Hwang, Cristian Peña, Julianna Brouwer, Katherine Hoffman, Doron Betel, Gregory F. Sonnenberg, Bishoy Faltas, Ashish Saxena, Kaitlin E...> ;American Journal of Clinical Oncology. 2021 Apr 6
• 4 citations
  The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy.
  Johannes C van der Mijn, Kenneth W Eng, Pooja Chandra, Evan Fernandez, Sinan Ramazanoglu, Alexandros Sigaras, Clara Oromendia, Lorraine J Gudas, Scott T Tagawa, David ...> ;Molecular Oncology. 2022 Jun 1
• 14 citations
  Serial ctDNA analysis predicts clinical progression in patients with advanced urothelial carcinoma.
  Kyrillus S Shohdy, Dario M Villamar, Yen Cao, Janson Trieu, Kristin S Price, Rebecca Nagy, Scott T Tagawa, Ana M Molina, Cora N Sternberg, David M Nanus, Juan Miguel M...> ;British Journal of Cancer. 2022 Feb 1
• Loss of function mutations inare permissive for APOBEC3-induced mutagenesis in urothelial carcinoma.
  Weisi Liu, Bishoy M Faltas> ;American Journal of Cancer Research. 2022 Jan 1
• 6 citations
  Functional comparison of exome capture-based methods for transcriptomic profiling of formalin-fixed paraffin-embedded tumors
  Kyrillus S. Shohdy, Rohan Bareja, Michael Sigouros, David Wilkes, Princesca Dorsaint, Jyothi Manohar, Daniel Bockelman, Jenny Xiang, Rob Kim, Kentaro Ohara, Kenneth En...> ;NPJ Genomic Medicine. 2021 Aug 12
• 8 citations
  Validation of a Circulating Tumor DNA-Based Next-Generation Sequencing Assay in a Cohort of Patients with Solid tumors: A Proposed Solution for Decentralized Plasma Te...
  Wael Al Zoughbi, Jesse Fox, Shaham Beg, Eniko Papp, Erika Hissong, Kentaro Ohara, Laurel Keefer, Michael Sigouros, Troy Kane, Daniel Bockelman, Donna Nichol, Emily Pat...> ;The Oncologist. 2021 Aug 4
• 9 citations
  Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology.
  Shaham Beg, Rohan Bareja, Kentaro Ohara, Kenneth Wha Eng, David Wilkes, David J. Pisapia, Wael Al Zoughbi, Sarah Kudman, Wei Zhang, Rema Rao, Jyothi Manohar, Troy Kane...> ;Translational Oncology. 2021 Jan 1
• 18 citations
  Common germline-somatic variant interactions in advanced urothelial cancer
  Aram Vosoughi, Tuo Zhang, Kyrillus S. Shohdy, Panagiotis J. Vlachostergios, David Wilkes, Bhavneet Bhinder, Scott T. Tagawa, David M. Nanus, Ana M. Molina, Himisha Bel...> ;Nature Communications. 2020 Dec 3
• 25 citations
  Circulating Tumor DNA Alterations in Advanced Urothelial Carcinoma and Association with Clinical Outcomes: A Pilot Study
  Petros Grivas, Aly-Khan A. Lalani, Gregory R. Pond, Rebecca J. Nagy, Bishoy Faltas, Neeraj Agarwal, Sumati Gupta, Alexandra Drakaki, Ulka N. Vaishampayan, Jue Wang, Pe...> ;European Urology Oncology. 2020 Oct 1
• Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
  Bailey MH, Meyerson WU, Dursi LJ, Wang LB, Dong G, Liang WW, Weerasinghe A, Li S, Li Y, Kelso S, MC3 Working Group, PCAWG novel somatic mutation calling methods workin...> ;Nature communications. 2020-09-21
• Sex differences in oncogenic mutational processes.
  Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N, PCAWG Tumour Subtypes and Clinical Translation, Boutros PC, PCAWG Consortium> ;Nature communications. 2020-08-28
• 55 citations
  Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature.
  Melanie R. Hassler, Freddie Bray, James W.F. Catto, Arthur P. Grollman, Arndt Hartmann, Vitaly Margulis, Surena F. Matin, Morgan Rouprêt, John P. Sfakianos, Shahrokh F...> ;European Urology. 2020 Jun 20
• 30 citations
  Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
  John P. Sfakianos, Jorge Daza, Yang Hu, Harry Anastos, Geoffrey Bryant, Rohan Bareja, Ketan K. Badani, Matthew D. Galsky, Olivier Elemento, Bishoy Faltas, David J. Mul...> ;Nature Communications. 2020 May 21
• 86 citations
  Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes.
  Joshua J. Meeks, Hikmat Al-Ahmadie, Bishoy Faltas, John A. Taylor, Thomas W. Flaig, David J. DeGraff, Emil Christensen, Benjamin L. Woolbright, David J. McConkey, Lars...> ;Nature Reviews. Urology. 2020 Mar 31
• A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
  Jiao W, Atwal G, Polak P, Karlic R, Cuppen E, PCAWG Tumor Subtypes and Clinical Translation Working Group, Danyi A, de Ridder J, van Herpen C, Lolkema MP, Steeghs N, G...> ;Nature communications. 2020-02-05
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Journal Articles

• Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response.  
  Beltran H, Eng K, Mosquera JM, Sigaras A, Romanel A, Rennert H, Kossai M, Pauli C, Faltas B, Fontugne J, Park K, Banfelder J, Prandi D, Madhukar N, Zhang T, Padilla J,..., JAMA Oncol
• Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation  
  Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JA, Dunn AS, Garcia DA, Jacobson A, Jaffer AK, Kong DF, Schulman S, Turpie AG, Hasselblad V, Ortel TL; BRIDGE ..., N Engl J Med, 1/1/2015
• A Precision Medicine Trial for Whole Exome Sequencing of Metastatic Cancer Reveals Biomarkers of Treatment Response  
  Beltran H, Eng K, Mosquera JM, Sigaras A, Romanel A, Rennert H, Kossai M, Pauli C, Faltas B, Fontugne J, Park K, Banfelder J, Prandi D, Madhukar N, Zhang T, Padilla J,..., JAMA Oncol, 1/1/2015
• Radical Cystectomy for Bladder Cancer in Patients With and Without a History of Pelvic Irradiation: Survival Outcomes and Diversion-related Complications  
  DP, Al Hussein Al Awamlh B, Faltas BM, O'Malley P, Ayangbesan A, Inoyatov IM, Scherr DS, Urology, 1/1/2015
• Recurrence Patterns After Open and Robot-assisted Radical Cystectomy for Bladder Cancer  
  Nguyen D, Al Awamlh BA, Wu X, O’Malley P , Inoyatov IM, Ayangbesan A, Faltas B, Christos PJ, Scherr DS, Eur Urol, 1/1/2015
• Sustained remission in a patient with myelodysplastic syndrome and a complex karyotype after erythropoiesis-stimulating therapy followed by colonic T-cell lymphoblasti...  
  Zeidan A, Faltas B, Fricke W, Gore S, Ketterling R, Sham R, Leuk Lymphoma, 1/1/2013
• Prolonged and increased postoperative risk of venous thromboembolism: rationale for even more 'extended' prophylaxis?  
  Faltas B, Expert Rev Hematol, 1/1/2010
• Sarcoidosis "unmasked"  
  Nigweker S,Faltas B, Hix J, American Journal of Kidney Diseases, 1/1/2008
• Electronic health records  
  Bishoy Morris (Faltas), Student British Medical Journal, 1/1/2005
• Neglected diseases: Why do some major diseases receive less attention than others?  
  Bishoy Morris (Faltas), McGill Journal of Medicine, 1/1/2005
• Bilharzia: war against the worm  
  Bishoy Morris (Faltas), Student British Medical Journal, 1/1/2003
• A CRISPR Way to Move Things Around  
  Faltas B. M., Sci Transl Med
• Checkpoint Therapy to the Rescue  
  Faltas B. M., Sci Transl Med
• Lumpers and Splitters: A New Molecular Taxonomy for Cancer  
  Faltas B. M., Sci Transl Med
• SNFing Out Vulnerability in Cancer  
  Faltas B. M., Sci Transl Med
• Studying the "Soil" for Metastatic "Seeds"  
  Faltas B. M., Sci Transl Med
• The GRM Face of Chondromyxoid Fibroma  
  Faltas B. M., Sci Transl Med
• Urothelial Carcinogenesis: a Tale of Two Cells  
  Faltas B. M., Sci Transl Med
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Abstracts/Posters

• Identification of druggable transcriptional outliers in urothelial carcinoma
  Bishoy Faltas, Rohan Bareja, Ethan Shelkey, Rebecca Mayer, Andrea Sboner, Mark A. Rubin, Olivier Elemento, American Association for Cancer research (AACR) annual meeting, 1/1/2016
• Treatment for metastatic platinum-resistant urothelial cancer (PRUC) with an anti-Trop-2-SN-38 antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132): phase I...
  Scott T. Tagawa, Bishoy Faltas, Elaine Lam, Wells A. Messersmith, Philip Saylor, Aditya Bardia, Julio J. Hajdenberg, Alicia K. Morgans, Jordan D. Berlin, Emerson Lim, ..., American Association for Cancer research (AACR) annual meeting, 1/1/2016
• Integrated whole exome and RNA sequencing reveals distinct genomic and transcriptomic landscape of upper tract urothelial carcinoma.
  Bishoy Faltas, Rohan Bareja, Himisha Beltran, Joanna Cyrta, Manoj P. Rai, Scott T. Tagawa, David Nanus, Juan Miguel Mosquera, Andrea Sboner, Douglas Scherr, Olivier El..., American Society of Clinical Oncology Genitourinary Symposium (ASCO-GU), 1/1/2016
• Whole exome sequencing reveals 19q13 amplification and actionable mutations in carcinosarcoma of the bladder.
  Peyman Tavassoli, Bishoy Faltas, Joanna Cyrta, Juan Miguel Mosquera, Brian D Robinson, Mark Rubin, United States & Canadian Academy of Pathology (USCAP) Meeting, 1/1/2016
• Next generation sequencing for discovery of somatic mutations and clonal relationships in platinum-resistant metastatic urothelial cancer.
  Bishoy Faltas, Himisha Beltran, Kenneth Eng, Chantal Pauli, Brian D. Robinson, Juan-Miguel Mosquera, David M. Nanus, Scott T. Tagawa, Olivier Elemento, Mark A. Rubin, American Association for Cancer Research (AACR) Annual Meeting, 1/1/2015
• Development of 2D - cell strain and 3D - tumor spheroid models for Precision Medicine.
  Chantal Pauli, Jonathan Pauwels, Juan Miguel Mosquera, Bishoy Faltas, Andrea Sboner, Olivier Elemento, David Rickman, Francesca Demichelis, Davide Prandi, Himisha Belt..., American Association for Cancer Research (AACR) Annual Meeting, 1/1/2015
• Precision cancer medicine program for whole-exome sequencing of metastatic tumors reveals biomarkers of response.
  Himisha Beltran, Kenneth Eng, Juan Miguel Mosquera, Alexandros Sigaras, Alessandro Romanel, Hanna Rennart, Myriam Kossai, Chantal Pauli, Bishoy Faltas, Jacqueline Font..., American Association for Cancer Research Annual Meeting (AACR), 1/1/2015
• Clonal heterogeneity in platinum-resistant metastatic urothelial cancer.
  Bishoy Faltas, Himisha Beltran, Kenneth Eng, Chantal Pauli, Brian D. Robinson, Juan-Miguel Mosquera, David M. Nanus, Scott T. Tagawa, Olivier Elemento, Mark A. Rubin, American Society of Clinical Oncology (ASCO) Annual Meeting, 1/1/2015
• Use and outcomes of metastasectomy in older patients with urothelial cancers.
  Bishoy Faltas, Renee L. Gennarelli, Daniel P. Nguyen, Scott T. Tagawa, Elena B. Elkin, American Society of Clinical Oncology (ASCO) Annual Meeting, 1/1/2015
• Outcomes of preoperative chemotherapy in bladder cancer patients including node-positive disease.
  Bishoy Faltas, Pravin R. Date, Douglas Scherr, Daniel P. Nguyen, Bashir A. Al Awamlh, Padraic O'Malley, Paul J. Christos, Himisha Beltran, David M. Nanus, Scott T. Tagawa, American Society of Clinical Oncology Genitourinary Symposium (ASCO-GU), 1/1/2015
• Precision medicine program for whole-exome sequencing (WES) provides new insight on platinum sensitivity in advanced prostate cancer (PCa).
  Himisha Beltran, Andrea Sboner, Juan Miguel Mosquera, David Rickman, Kenneth Eng, Davide Prandi, Myriam Kossai, Bishoy Faltas, Chantal Pauli, Jacqueline Fontugne, Coli..., American Society of Clinical Oncology Genitourinary symposium (ASCO-GU), 1/1/2015
• Differences in the distribution of recurrence locations between patients who undergo open and robot-assisted radical cystectomy for bladder cancer.
  Daniel Nguyen,Bashir Al Hussein Al Awamlh,Xian Wu,Igor Inoyatov,Abimbola Ayangbesan,Bishoy Faltas,Paul Christos,Padraic O'Malley, Douglas Scherr, American Urological Association (AUA) Meeting, 1/1/2015
• Outcomes of pre-operative chemotherapy in bladder cancer patients including node-positive disease.
  Bashir Al Hussein Al Awamlh. Daniel P.Nguyen, Bishoy Faltas, Padraic O'Malley, Pravin Date, Paul J Christos Himisha Beltran,David M Nanus, Scott Tagawa, Douglas Scherr, European Association of Urology (EAU) Meeting, 1/1/2015
• Radical cystectomy for bladder cancer in patients with and without a history of pelvic irradiation: a comparison of survival outcomes and diversion-related complications.
  Daniel P. Nguyen, Bashir Al Hussein Al Awamlh, Padraic O’Malley, Bishoy M. Faltas, Abimbola Ayangbesan, Igor M. Inoyatov, Douglas S. Scherr, European Association of Urology (EAU) Meeting, 1/1/2015
• Differences in the distribution of recurrence locations between patients who undergo open and robot-assisted radical cystectomy for bladder cancer.
  Daniel P. Nguyen, Bashir Al Hussein Al Awamlh, Xian Wu, Igor M. Inoyatov, Abimbola Ayangbesan, Bishoy M. Faltas, Paul J. Christos, Padraic O’Malley, Douglas S. Scherr, European Association of Urology (EAU) Meeting, 1/1/2015
• Next-Generation Sequencing Application in a Rapid Autopsy Program.
  Kyung Park, Myriam Kossai, Jacqueline Fontugne, Chantal Pauli, Kenneth Hennrick, Robert Kim, Jessica Padilla, Bishoy Faltas, David Pisapia, Steven Salvatore, Brian D R..., United States & Canadian Academy of Pathology (USCAP) Meeting, 1/1/2015
• Molecular correlates of activity and survival in a phase I/II trial of sorafenib plus gemcitabine and capecitabine for advanced renal cell carcinoma.
  Bishoy Faltas, Gurveen Kaur, Naveed H. Akhtar, Paul Christos, Brian Robinson, Himisha Beltran, David M. Nanus, Scott T. Tagawa, American Association for Cancer Research Annual Meeting, 1/1/2014
• Salvage Autologous Hematpoeitic Stem Cell Transplants (AHSCT2) for Myeloma: Single Center Experience.
  Bishoy Faltas, Jane L. Liesveld, Michael Becker, Jainulabdeen J. Ifthikharuddin and Gordon L. Phillips II, American Society of Hematology, Orlando, FL, 1/1/2010
• Cultural Humility: an Educational Exercise for International Medical Graduates.
  Kathleen McGrail, Bishoy Faltas, David Lee, Julia Smith, Scott Schabel, Chris Reynolds, International Conference on Communication in health care, Miami, FL, 1/1/2009
• Sarcoidosis "Unmasked", Severe Hypercalcemia Following Ergocalciferol Supplementation in a Patient with Chronic Kidney Disease.
  Sagar Nigweker, Bishoy Faltas, John Hix, National Kidney Foundation Spring Clinical Meeting, Dallas, TX, 1/1/2008
• A Case of Adult Onset Intractable Nonhepatic Hyperammonemia.
  Ihab Akladious, Bishoy Faltas, John Hix, Citywide Poster Competition, Rochester General Hospital, Rochester, NY, 1/1/2008
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Lectures

• Generating a neoantigen map of advanced urothelial carcinoma by whole exome sequencing. 
  1/1/2016
• Clonal heterogeneity in platinum-resistant metastatic urothelial cancer. 
  1/1/2015

Other

• Making new medicines- How next generation sequencing is transforming drug-development. 
  Faltas B, Bitesizebio
  1/18/2013
• Never a Dull Moment: A Day in the Life of an Oncology Fellow. 
  Faltas B, ASCO Post
  1/15/2013
• The Nuts and Bolts of Getting into an Oncology Fellowship 
  Faltas B, ASCO Post
  1/15/2012
• Robotic Surgery: Applications, Limitations, and Impact on Surgical Education. 
  Bishoy Morris
  http://www.medscape.com/viewarticle/511854
  1/27/2005
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