BlairArdmanMD

Oncology • Lowell, MA

Director of Clinical Research at Lowell General Hospital

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Office
295 Varnum Ave
Lowell, MA 01854
Phone+1 978-937-6258

Fax+1 978-788-7968
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Education & Training

Tufts Medical CenterFellowship, Hematology and Medical Oncology, 1980 - 1984
UPMC Medical EducationResidency, Internal Medicine, 1977 - 1980
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1977

Certifications & Licensure

MA State Medical License 1980 - 2025
PA State Medical License 1979 - 1990
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Super Doctor SuperDoctors.com
Top MD Consumers Checkbook

Clinical Trials

Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy Start of enrollment: 2008 Nov 10
Active, not recruiting
Phase 3
A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer Start of enrollment: 2010 Aug 13
Completed
Phase 3
S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery Start of enrollment: 2011 Apr 01
Active, not recruiting
Phase 3
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Start of enrollment: 2010 Jun 01
Active, not recruiting
Phase 3
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Start of enrollment: 2011 Jan 06
Active, not recruiting
Phase 3
The Young Women's Breast Cancer Study Start of enrollment: 2006 Nov 01
Active, not recruiting
Study of Vitamin D in Untreated Metastatic Colorectal Cancer Start of enrollment: 2012 Apr 13
Completed
Phase 2
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer Start of enrollment: 2013 Sep 12
Active, not recruiting
Phase 3
Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer Start of enrollment: 2014 Mar 17
Active, not recruiting
Phase 2, Phase 3
Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer Start of enrollment: 2015 Jul 26
Recruiting
Phase 3
Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches Start of enrollment: 2014 Nov 01
Completed
Phase 2
Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Sep 01
Completed
Phase 2, Phase 3
Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Start of enrollment: 2015 Dec 29
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

8 citations
Cardiac outcomes of subjects on adjuvant trastuzumab emtansine vs paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT) study (TB...
Romualdo Barroso-Sousa, Paolo Tarantino, Nabihah Tayob, Chau Dang, Denise A Yardley, Steven J Isakoff, Vicente Valero, Meredith Faggen, Therese Mulvey, Ron Bose, Jiani...> ;NPJ Breast Cancer. 2022 Feb 16
14 citations
Chemotherapy-related amenorrhea (CRA) after adjuvant ado-trastuzumab emtansine (T-DM1) compared to paclitaxel in combination with trastuzumab (TH) (TBCRC033: ATEMPT Tr...
Kathryn J. Ruddy, Yue Zheng, Nabihah Tayob, Jiani Hu, Chau T. Dang, Denise A. Yardley, Steven J. Isakoff, Vicente Valero, Meredith Faggen, Therese M. Mulvey, Ron Bose,...> ;Breast Cancer Research and Treatment. 2021 Jun 12
63 citations
Adjuvant Trastuzumab Emtansine Versus Paclitaxel in Combination With Trastuzumab for Stage I HER2-Positive Breast Cancer (ATEMPT): A Randomized Clinical Trial
Sara M. Tolaney, Nabihah Tayob, Chau T. Dang, Denise A. Yardley, Steven J. Isakoff, Vicente Valero, Meredith Faggen, Therese M. Mulvey, Ron Bose, Jiani Hu, Douglas Wec...> ;Journal of Clinical Oncology. 2021 Jun 2
25 citations
A phase II study of oxaliplatin, pemetrexed, and bevacizumab in previously treated advanced non-small cell lung cancer.
Rebecca S. Heist, Panos Fidias, Mark S. Huberman, Blair Ardman, Lecia V. Sequist, Jennifer S. Temel, Thomas J. Lynch> ;Journal of Thoracic Oncology. 2008 Oct 1
100 citations
Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death
Joseph D. Hernandez, Julie T. Nguyen, Jiale He, Wei Wang, Blair Ardman, Jonathan M. Green, Minoru Fukuda, Linda G. Baum> ;Journal of Immunology. 2006 Oct 15
39 citations
A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43.
Candida Fratazzi, N. Manjunath, Robert D. Arbeit, Claudio Carini, Thomas A. Gerken, Blair Ardman, Eileen Remold-O'Donnell, Heinz G. Remold> ;The Journal of Experimental Medicine. 2000 Jul 17
31 citations
A novel CD8 T cell-restricted CD45RB epitope shared by CD43 is differentially affected by glycosylation.
Douglas A. Carlow, Blair Ardman, Hermann J. Ziltener> ;Journal of Immunology. 1999 Aug 1
111 citations
Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site
Anne I. Sperling, John R. Sedy, N. Manjunath, Abraham Kupfer, Blair Ardman, Janis K. Burkhardt> ;Journal of Immunology. 1998 Dec 15
30 citations
Regulation of in vitro and in vivo T cell activation by CD43.
Elizabeth C. Thurman, Joy Walker, Sundararajan Jayaraman, N. Manjunath, Blair Ardman, Jonathan M. Green> ;International Immunology. 1998 May 1
95 citations
Negative Regulation of T Cell Homing by CD43
Britt M. Stockton, Guiying Cheng, N. Manjunath, Blair Ardman, Ulrich H. von Andrian> ;Immunity. 1998 Mar 1
14 citations
CD43 regulates tyrosine phosphorylation of a 93-kD protein in T lymphocytes.
N. Manjunath, Blair Ardman> ;Blood. 1995 Dec 1
191 citations
Negative regulation of T-cell adhesion and activation by CD43
N. Manjunath, Mariangela Correa, Margarett R. Ardman, Blair Ardman> ;Nature. 1995 Oct 12
4 citations
Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43.
R V Srinivas, Tao Su, Linda A. Trimble, Judy Lieberman, Blair Ardman> ;AIDS Research and Human Retroviruses. 1995 Sep 1
111 citations
Targeted disruption of CD43 gene enhances T lymphocyte adhesion.
N. Manjunath, Randall S. Johnson, Donald E. Staunton, Renata Pasqualini, Blair Ardman> ;Journal of Immunology. 1993 Aug 1
139 citations
CD43 interferes with T-lymphocyte adhesion
Blair Ardman, Maria A. Sikorski, Donald E. Staunton> ;Proceedings of the National Academy of Sciences of the United States of America. 1992 Jun 1
112 citations
Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion.
Eirik Helseth, Udy Olshevsky, Dana Gabuzda, B Ardman, William A. Haseltine, Joseph Sodroski> ;Journal of Virology. 1990 Dec 1
57 citations
Human immunodeficiency virus type 1-infected individuals make autoantibodies that bind to CD43 on normal thymic lymphocytes.
Blair Ardman, M A Sikorski, M Settles, D E Staunton> ;The Journal of Experimental Medicine. 1990 Oct 1
9 citations
Surface immunoglobulin-positive T lymphocytes in HIV-1 infection: relationship to CD4+ lymphocyte depletion.
Blair Ardman, Kenneth H. Mayer, John Bristol, Mark Ryan, Michael Settles, Elinor M. Levy> ;Clinical Immunology and Immunopathology. 1990 Aug 1
19 citations
Effects on CD4 binding of anti-peptide sera to the fourth and fifth conserved domains of HIV-1 gp120.
Blair Ardman, Mark Kowalski, Bristol J, William A. Haseltine, Joseph Sodroski> ;Journal of Acquired Immune Deficiency Syndromes. 1990 Jan 1
50 citations
Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1.
Mark Kowalski, Blair Ardman, Ladan Basiripour, Yichen Lu, Dietmar Blohm, William A. Haseltine, Joseph Sodroski> ;Proceedings of the National Academy of Sciences of the United States of America. 1989 May 1
1 citations
Idiotype mimicry by a differentiation antigen on Friend erythroleukemia cells.
Blair Ardman, E DiMambro, Stuart B. Levy, Robert S. Schwartz> ;Journal of Immunology. 1987 Sep 15
42 citations
Parallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network.
Paola Migliorini, Blair Ardman, J Kaburaki, Rs Schwartz> ;The Journal of Experimental Medicine. 1987 Feb 1
12 citations
Recognition of a leukemia-related antigen by an antiidiotypic antiserum to an anti-gp70 monoclonal antibody
Blair Ardman, Raman H. Khiroya, Robert S. Schwartz> ;The Journal of Experimental Medicine. 1985 Apr 1
4 citations
Characterization of thymic lymphoid-stromal cell complex-forming cells in preleukemic AKR mice
Hiroshi Hiai, Blair Ardman> ;Gan. 1984 Oct 1
1 citations
Benign Pulmonary Nodule and Small-Cell Cancer
Blair Ardman, Richard A. Rudders> ;Annals of Internal Medicine. 1982 Jul 1
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Grant Support

CD43 And T Lymphocyte TraffickingNational Institute Of Allergy And Infectious Diseases1997–2000
CD43 In Humoral And Cellular ImmunityNational Institute Of Allergy And Infectious Diseases1996
Anti-Cd4 Autoantibodies In HIV InfectionNational Institute Of Allergy And Infectious Diseases1989–1991
NCI Clinical Investigator Award ProgramNational Cancer Institute1985