BrentAlanOrrMDPhd

PubMed

• Atypical teratoid/rhabdoid tumour-TYR subtype arising in the setting of germline ring chromosome 22: An uncommon form of tumour predisposition.
  Julieann C Lee, Quynh T Tran, Rose B McGee, Melissa R Perrino, Santhosh A Upadhyaya, Emily M Hanzlik, Nicholas Pytel, Andrew J Carroll, Wilda Orisme, Mohammad Eldomery...> ;Neuropathology and Applied Neurobiology. 2024 Apr 1
• NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.
  Kathryn L Eschbacher, Quynh T Tran, Evgeny A Moskalev, Sarah Jenkins, Karen Fritchie, Robert Stoehr, Alissa Caron, Michael J Link, Paul D Brown, Andrew Guajardo, Danie...> ;Brain Pathology. 2024 Mar 24
• Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.
  Galbraith, K., Garcia, M., Wei, S., Chen, A., Schroff, C., Serrano, J., Pacione, D., Placantonakis, D., William, C., Faustin, A., Zagzag, D., Barbaro, M., Eibl, M., Sh...> ;Neuro-Oncology. 2024 Jan 19
• A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity.
  Patel, A., Ashenberg, O., Collins, N., Segerstolpe, Å., Jiang, S., Slyper, M., Huang, X., Caraccio, C., Jin, H., Sheppard, H., Xu, K., Chang, T., Orr, B., Shirinifard,...> ;Biorxiv. 2024 Jan 16
• Concurrent peripheral T-cell lymphoma and T-cell lymphoblastic leukemia/lymphoma with identical::fusion events.
  Mahsa Khanlari, Wei Wang, Yen-Chun Liu, Lu Wang, Jeffrey E Rubnitz, Stephanie Dixon, Brent A Orr, Zhongshan Cheng, Vidya Balagopal, Jeffery M Klco, Anelo, O.> ;Haematologica. 2024 Mar 1
• 5 citations
  Mapping pediatric brain tumors to their origins in the developing cerebellum.
  Konstantin Okonechnikov, Piyush Joshi, Mari Sepp, Kevin Leiss, Ioannis Sarropoulos, Florent Murat, Martin Sill, Pengbo Beck, Kenneth Chun-Ho Chan, Andrey Korshunov, Fe...> ;Neuro-Oncology. 2023 Oct 3
• DNA-methylation subgroups carry no prognostic significance in ATRT-SHH patients in clinical trial cohorts.
  Quynh T Tran, Santhosh A Upadhyaya, Catherine A Billups, Arzu Onar-Thomas, Md Zahangir Alom, Steven S Carey, Giles W Robinson, David W Ellison, Amar Gajjar, Brent A Orr> ;Acta Neuropathologica. 2023 Sep 1
• 3 citations
  High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience.
  Chiang, J., Bagchi, A., Li, X., Dhanda, S., Huang, J., Pinto, S., Sioson, E., Dalton, J., Tatevossian, R., Jia, S., Partap, S., Fisher, P., Bowers, D., Hassall, T., Lu...> ;Neuro-Oncology. 2024 Jan 5
• Predicting methylation class from diffusely infiltrating adult gliomas using multimodality MRI data.
  Zahangir Alom, Quynh T Tran, Asim K Bag, John T Lucas, Brent A Orr> ;Neuro-Oncology Advances. 2023 Apr 19
• Diffuse leptomeningeal glioneuronal tumor in a child masquerading as an intramedullary spinal pilocytic astrocytoma.
  Peter J Madsen, Madison L Hollawell, Mariarita Santi, Lea F Surrey, Arastoo Vossough, Brent A Orr, Christine Hill-Kayser, Alexander M Tucker, Phillip B Storm, Jessica ...> ;Neuro-Oncology Advances. 2023 Apr 19
• 6 citations
  Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 a...
  Anthony P Y Liu, Sandeep K Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C Bowers, Tim Hassal...> ;Acta Neuropathologica. 2022 Oct 1
• 33 citations
  Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
  Kyle S Smith, Laure Bihannic, Brian L Gudenas, Parthiv Haldipur, Ran Tao, Qingsong Gao, Yiran Li, Kimberly A Aldinger, Igor Y Iskusnykh, Victor V Chizhikov, Matthew Sc...> ;Nature. 2022 Sep 1
• 1 citations
  Revised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemot...
  John T Lucas, Christopher L Tinkle, Jie Huang, Arzu Onar-Thomas, Sudharsan Srinivasan, Parker Tumlin, Jared B Becksfort, Paul Klimo, Frederick A Boop, Giles W Robinson...> ;Neuro-Oncology. 2022 Jul 1
• 3 citations
  Comprehensive study of semi-supervised learning for DNA methylation-based supervised classification of central nervous system tumors.
  Quynh T Tran, Md Zahangir Alom, Brent A Orr> ;BMC Bioinformatics. 2022 Jun 8
• 2 citations
  Sustained and durable response with Alisertib monotherapy in the treatment of relapsed Atypical Teratoid Rhabdoid Tumor (ATRT).
  Kaitlyn Howden, Patrick J McDonald, Colin Kazina, Annie Ong, Ben Ho, Annie Huang, Brent A Orr, Magimairajan Issai Vanan> ;Neuro-Oncology Advances. 2022 Jun 7
• 6 citations
  Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor.
  Santhosh A Upadhyaya, Olivia Campagne, Catherine A Billups, Brent A Orr, Arzu Onar-Thomas, Ruth G Tatevossian, Roya Mostafavi, Jason R Myers, Anna Vinitsky, Daniel C M...> ;Neuro-Oncology. 2023 Feb 14
• 12 citations
  Primary cilia control translation and the cell cycle in medulloblastoma.
  Yong Ha Youn, Shirui Hou, Chang-Chih Wu, Daisuke Kawauchi, Brent A Orr, Giles W Robinson, David Finkelstein, Makoto M Taketo, Richard J Gilbertson, Martine F Roussel, ...> ;Genes & Development. 2022 Jun 1
• 3 citations
  Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor.
  Sasi Arunachalam, Karol Szlachta, Samuel W Brady, Xiaotu Ma, Bensheng Ju, Bridget Shaner, Heather L Mulder, John Easton, Benjamin J Raphael, Matthew Myers, Christopher...> ;Acta Neuropathologica Communications. 2022 May 31
• 14 citations
  The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma.
  Anand G Patel, Xiang Chen, Xin Huang, Michael R Clay, Natalia Komorova, Matthew J Krasin, Alberto Pappo, Heather Tillman, Brent A Orr, Justina McEvoy, Brittney Gordon,...> ;Developmental Cell. 2022 May 23
• 10 citations
  Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG.
  Christopher L Tinkle, Alberto Broniscer, Jason Chiang, Olivia Campagne, Jie Huang, Brent A Orr, Xiaoyu Li, Zoltan Patay, Jinghui Zhang, Suzanne J Baker, Thomas E Merch...> ;Neuro-Oncology Advances. 2021 Dec 1
• 7 citations
  Methylation profiling reveals novel molecular classes of rhabdomyosarcoma.
  Michael R Clay, Anand G. Patel, Quynh T. Tran, Dale Hedges, Ti-Cheng Chang, Elizabeth Stewart, Greg W. Charville, Cynthia Cline, Michael A. Dyer, Brent A. Orr> ;Scientific Reports. 2021 Nov 15
• 54 citations
  Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
  Anthony P. Y. Liu, Kyle S. Smith, Rahul Kumar, Leena Paul, Laure Bihannic, Tong Lin, Kendra K. Maass, Kristian W. Pajtler, Murali Chintagumpala, Jack Su, Eric Bouffet,...> ;Cancer Cell. 2021 Nov 8
• 27 citations
  Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature Communications. 2021 Sep 20
• 17 citations
  Lorlatinib in a Child with ALK -Fusion-Positive High-Grade Glioma.
  Aditi Bagchi, Brent A. Orr, Olivia Campagne, Sandeep Kumar Dhanda, Sreenath Nair, Quynh T. Tran, Anthony M Christensen, Amar Gajjar, Larissa V. Furtado, Aksana Vasilye...> ;The New England Journal of Medicine. 2021 Aug 18
• 40 citations
  Retinoblastoma from human stem cell-derived retinal organoids
  Jackie L. Norrie, Anjana Nityanandam, Karen Lai, Xiang Chen, Matthew W. Wilson, Elizabeth Stewart, Lyra Griffiths, Hongjian Jin, Gang Wu, Brent A. Orr, Quynh T. Tran, ...> ;Nature Communications. 2021 Jul 27
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Journal Articles

• Advances in the Classification of Pediatric Brain Tumors Through Dna Methylation Profiling: From Research Tool to Frontline Diagnostic  
  Brent A Orr, Giles W Robinson, Cancer