BrianLeyland-JonesMD

PubMed

• 34 citations
  Molecular profiling of advanced malignancies guides first-line N-of-1 treatments in the I-PREDICT treatment-naïve study.
  Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Hitendra Patel, Mina Nikanjam, Paul T. Fanta, Michael E. Hahn, Pradip De, Casey Williams, Jessica Guido, Benjamin M. S...> ;Genome Medicine. 2021 Oct 4
• 37 citations
  Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clini...
  W. Fraser Symmans, Christina Yau, Yunn Yi Chen, Ronald Balassanian, Molly Klein, Lajos Pusztai, Rita Nanda, Barbara A. Parker, Brian Datnow, Gregor Krings, Shi Wei, Mi...> ;JAMA Oncology. 2021 Sep 16
• 3 citations
  Intra- and Interlaboratory Reproducibility of the Sensitivity to Endocrine Therapy Assay for Stage II/III Breast Cancer.
  Veerle Bossuyt, Rosanna Lau, Brandon Young, John G. Howe, Fengmin Zhao, Brian Leyland-Jones, Lili Du, Tiffany Foli, Christos Hatzis, W. Fraser Symmans> ;Clinical Chemistry. 2021 Sep 1
• 5 citations
  A tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy.
  Nandini Dey, Jennifer C. Aske, Xiaoqian Lin, Yuliang Sun, Brian Leyland-Jones, Lori Friedman, Pradip De> ;American Journal of Cancer Research. 2021 Jun 15
• 4 citations
  Attrition of Patients on a Precision Oncology Trial: Analysis of the I-PREDICT Experience.
  Sandy S Bohan, Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Vincent A. Miller, Brian Leyland-Jones, Scott M. Lippman, Razelle Kurzrock> ;The Oncologist. 2020 Nov 1
• 99 citations
  Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Can...
  Douglas Yee, Angela DeMichele, Christina Yau, Claudine Isaacs, W. Fraser Symmans, Kathy S. Albain, Yunn Yi Chen, Gregor Krings, Shi Wei, Shuko Harada, Brian Datnow, Ol...> ;JAMA Oncology. 2020 Sep 1
• 2 citations
  DNA derived from archival tumor specimens can be used for germline pharmacogenetic analyses.
  Daniel L. Hertz, Kelley M. Kidwell, Julie A. Douglas, Giuseppe Viale, Brian Leyland-Jones, Meredith M. Regan, James M. Rae> ;Pharmacogenomics. 2020 Jul 29
• 8 citations
  A Small Hypoxia Signature Predicted pCR Response to Bevacizumab in the Neoadjuvant GeparQuinto Breast Cancer Trial.
  Thomas Karn, Tobias Meissner, Karsten Weber, Christine Solbach, Carsten Denkert, Knut Engels, Peter A. Fasching, Bruno Valentin Sinn, Iris Schrader, Jan Budczies, Fred...> ;Clinical Cancer Research. 2020 Jan 13
• 1 citations
  Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therap...
  Steven Buechler, Kathryn P. Gray, Yesim Gökmen-Polar, Scooter Willis, Beat Thürlimann, Rosita Kammler, Giuseppe Viale, Brian Leyland-Jones, Sunil Badve, Meredith M. Regan> ;JNCI Cancer Spectrum. 2019 Dec 1
• 6 citations
  Dasatinib attenuates overexpression of Src signaling induced by the combination treatment of veliparib plus carboplatin in triple-negative breast cancer.
  Yuliang Sun, Xiaoqian Lin, Jennifer C. Aske, Ping Ye, Casey Williams, Mark Abramovitz, Brian Leyland-Jones> ;Cancer Chemotherapy and Pharmacology. 2019 Sep 20
• 373 citations
  Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study
  Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Maria Schwaederle, Michael E. Hahn, Casey Williams, Pradip De, Amy Krie, David Piccioni, Vincent A. Miller, Jeffrey S....> ;Nature Medicine. 2019 Apr 22
• Autoimmunity and Benefit from Trastuzumab Treatment in Breast Cancer: Results from the HERA Trial.
  Amir Sonnenblick, Andrew Bailey, Beatrice Uziely, Michael Untch, Ian E. Smith, Luca Gianni, José Baselga, Christian Jackisch, David Cameron, Richard Bell, Dimitrios Za...> ;Anticancer Research. 2019 Feb 1
• 73 citations
  RET rearrangements are actionable alterations in breast cancer
  Bhavna S. Paratala, Jon Chung, Casey Williams, Bahar Yilmazel, Whitney Petrosky, Kirstin Williams, Alexa B. Schrock, Ellen Lee, Sonia C. Dolfi, Kien Pham, Stephanie Li...> ;Nature Communications. 2018 Nov 16
• 2 citations
  Exploratory Analysis of Single-Gene Predictive Biomarkers in HERA DASL Cohort Reveals That C8A mRNA Expression Is Prognostic of Outcome and Predictive of Benefit of Tr...
  Scooter Willis, Varvara Polydoropoulou, Yuliang Sun, Brandon Young, Zoi Tsourti, Dimitris Karlis, Bradley C. Long, Xiaoqian Lin, Stephanie Theel, Jennifer H. Carlson, ...> ;JCO Precision Oncology. 2018 Nov 1
• 64 citations
  Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing
  Thomas P. Slavin, Kimberly C. Banks, Darya Chudova, Geoffrey R. Oxnard, Justin I. Odegaard, Rebecca J. Nagy, Kar Wing Kevin Tsang, Susan L. Neuhausen, Stacy W. Gray, M...> ;Journal of Clinical Oncology. 2018 Oct 19
• 46 citations
  Triple Fluorescence staining to Evaluate Mechanism-based Apoptosis following Chemotherapeutic and Targeted Anti-cancer Drugs in Live Tumor Cells.
  Pradip De, Jennifer H. Carlson, Brian Leyland-Jones, Casey Williams, Nandini Dey> ;Scientific Reports. 2018 Sep 4
• 1 citations
  RNA based individualized drug selection in breast cancer patients without patient-matched normal tissue.
  Michael Forster, Adam Mark, Friederike Egberts, Elisa Rosati, Elke Rodriguez, Martin Stanulla, Dirk Bauerschlag, Christian Schem, Nicolai Maass, Anu Amallraja, Karla K...> ;Oncotarget. 2018 Aug 17
• 14 citations
  Association of p27 and cyclin D1 expression and benefit from adjuvant trastuzumab treatment in HER2-positive early breast cancer: a TransHERA study
  Martin Filipits, Urania Dafni, Michael Gnant, Varvara Polydoropoulou, Margaret Hills, Astrid Kiermaier, Evandro de Azambuja, Denis Larsimont, Federico Rojo, Giuseppe V...> ;Clinical Cancer Research. 2018 Jul 1
• 66 citations
  Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer
  Ryan J. Hartmaier, Sally E. Trabucco, Nolan Priedigkeit, Jon Chung, Christine A. Parachoniak, P. Vanden Borre, Samantha Morley, Margaret Rosenzweig, Michael E. Goldber...> ;Annals of Oncology. 2018 Apr 1
• 1 citations
  Promise of Precision Medicine in Cancers: Lessons Learned.
  Nandini Dey, Casey Williams, Brian Leyland-Jones, Pradip De> ;South Dakota Medicine. 2017 Nov 1
• 55 citations
  Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer
  Jon Chung, Dean Pavlick, Ryan J. Hartmaier, Alexa B. Schrock, Lauren Young, Brady Forcier, Ping Ye, Maren K. Levin, Michael E. Goldberg, H. A. Burris, A. D. Hoffman, P...> ;Annals of Oncology. 2017 Nov 1
• 6 citations
  High Expression of FGD3, a Putative Regulator of Cell Morphology and Motility, Is Prognostic of Favorable Outcome in Multiple Cancers
  Scooter Willis, Yuliang Sun, Mark Abramovitz, Teng Fei, Brandon Young, Xiaoqian Lin, Min Ni, Justin Achua, Meredith M. Regan, Kathryn P. Gray, Robert Gray, Victoria Wa...> ;JCO Precision Oncology. 2017 Oct 13
• 82 citations
  Utility of Genomic Analysis In Circulating Tumor DNA from Patients with Carcinoma of Unknown Primary.
  Shumei Kato, Nithya Krishnamurthy, Kimberly C. Banks, Pradip De, Kirstin Williams, Casey Williams, Brian Leyland-Jones, Scott M. Lippman, Richard B. Lanman, Razelle Ku...> ;Cancer Research. 2017 Aug 15
• 64 citations
  Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer.
  Mariaelena Pierobon, Corinne Ramos, Shukmei Wong, K. Alex Hodge, Jessica Aldrich, Sara A. Byron, Stephen P. Anthony, Nicholas J. Robert, Donald W. Northfelt, Mohammad ...> ;Clinical Cancer Research. 2017 Aug 15
• 11 citations
  Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse eve...
  Tobias Meißner, Adam Mark, Casey Williams, Wolfgang E. Berdel, Stephanie Wiebe, Andrea Kerkhoff, Eva Wardelmann, Timo Gaiser, Carsten Müller-Tidow, Philip Rosenstiel, ...> ;Cold Spring Harbor Molecular Case Studies. 2017 Jul 5
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