CanerSayginMD

Internal Medicine • Chicago, IL

Hematology/Oncology

Assistant Professor of Medicine at the University of Chicago

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Office
5841 S Maryland Ave
Chicago, IL 60637
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Education & Training

University of ChicagoFellowship, Hematology and Medical Oncology, 2020 - 2023
Ohio State University HospitalResidency, Internal Medicine, 2017 - 2020
Cleveland ClinicPost-Doctoral Fellowship, Cancer biology, hematologic malignancies, 2015 - 2017
Istanbul University, Cerrahpasa Faculty of MedicineClass of 2014

Certifications & Licensure

IL State Medical License 2020 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

LLS Special Fellow Award Leukemia Lymphoma Society, 2022
AACR/ASCO Methods in Clinical Cancer Research Workshop (Vail) AACR/ASCO, 2022
ASCO-Conquer Cancer Foundation Young Investigator Award ASCO-Conquer Cancer Foundation, 2022
Society of Translational Oncology Fellows Forum Society of Translational Oncology, 2022
AACR Molecular Biology in Clinical Oncology Workshop American Association for Cancer Research, 2021
FDA-AACR Oncology Fellowship Food and Drug Administration (FDA), American Association of Cancer Research (AACR), 2021
ECOG-ACRIN Young Investigator Symposium ECOG-ACRIN, 2021
ASH Research Training Award for Fellows (RTAF) American Society of Hematology, 2021
ASH Abstract Achievement Award American Society of Hematology, 2021
Chair`s Award for Scholary Achievement by a Senior Internal Medicine Resident The Ohio State University, 2020
Clara D Bloomfield Excellence in Hematology & Oncology Research Award The Ohio State University, 2019
AACR Early Career Hill Day American Association for Cancer Research, 2018
Pelotonia Postdoctoral Fellowship Award Ohio State University, 2018
ASH Resident HONORS Award American Society of Hematology, 2018
Elsa Albrecht Fellow Award Cleveland Clinic, 2018
Resident Excellence in Research Award Ohio State University, 2018
Annual Meeting Abstract Award American Society of Hematology, 2017
Research Program Committee Award Cleveland Clinic, 2016
Caregiver Appreciation Award Cleveland Clinic, 2016
Abstract Award Cancer Stem Cell Meeting, Cleveland, OH, 2016
Valedictorian, Magna cum laude Istanbul University Cerrahpasa School of Medicine, 2014
Research exchange scholarship IFMSA (International Federation of Medical Students’ Associations), 2011
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Publications & Presentations

PubMed

Treatment outcomes of venetoclax-combination regimens for relapsed/refractory myeloid malignancies after anti-CD47-directed therapy.
Rafael Madero-Marroquin, Emily Dworkin, Howard Weiner, Caner Saygin, Mariam T Nawas, Michael W Drazer, Adam S DuVall, Satyajit Kosuri, Michael J Thirman, Olatoyosi Ode...> ;Leukemia & Lymphoma. 2024 Mar 5
Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults.
Johnston, H., Youshanlouei, H., Osei, C., Patel, A., DuVall, A., Wang, P., Wanjari, P., Segal, J., Venkataraman, G., Cheng, J., Gurbuxani, S., Lager, A., Fitzpatrick, ...> ;Blood Advances. 2024 Jan 9
Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.
Geoffrey Parriott, Emma Hegermiller, Rosemary E Morman, Cameron Frank, Caner Saygin, Wendy Stock, Elizabeth T Bartom, Barbara L Kee> ;Leukemia. 2024 Mar 1
Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
Patel, A. A., Caner Saygin, Pu Zhang, Jacob Stauber, Ibrahim Aldoss, Adam S Sperling, Lachelle D Weeks, Marlise R Luskin, Todd C Knepper, Pankhuri Wanjari, Peng Wang, ...> ;Blood Cancer Discovery. 2023 Dec 27
Durable responses in acute lymphoblastic leukaemia with the use of FLT3 and IDH inhibitors.
Rafael Madero-Marroquin, Adam S DuVall, Caner Saygin, Peng Wang, Sandeep Gurbuxani, Richard A Larson, Wendy Stock, Anand Ashwin Patel> ;British Journal of Haematology. 2024 Apr 1
Sequential tumor molecular profiling identifies likely germline variants.
Basdag, H., Koppayi, A., Rodgers, C., Haribabu, Y., Wanjari, P., Niu, N., Das, S., de Jong, J., Saygin, C., Kraft, I., Segal, J., Godley, L.> ;Genetics in Medicine. 2024 Mar 1
1 citations
Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.
Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Dani...> ;Leukemia. 2023 Sep 1
2 citations
Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Caner Saygin, Giorgia Giordano, Kathryn Shimamoto, Bart Eisfelder, Anika Thomas-Toth, Girish Venkataraman, Vijayalakshmi Ananthanarayanan, Tiffaney L Vincent, Adam DuV...> ;Clinical Cancer Research. 2023 Aug 15
17 citations
Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies.
Saygin, C., Roloff, G., Hahn, C., Chhetri, R., Gill, S., Elmariah, H., Talati, C., Nunley, E., Gao, G., Kim, A., Bishop, M., Kosuri, S., Das, S., Singhal, D., Venugopa...> ;Blood Advances. 2023 Feb 28
From cell surface to nucleus: CCRL2 regulates response to hypomethylating agents in myelodysplastic syndromes.
Caner Saygin> ;Haematologica. 2023 Jul 1
2 citations
Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones.
Afaf E G Osman, Nuria Mencia-Trinchant, Caner Saygin, Luke Moma, Aelin Kim, Genevieve Housman, Matthew Pozsgai, Eti Sinha, Pooja Chandra, Duane C Hassane, Andrea Sbone...> ;Blood Advances. 2023 May 9
11 citations
Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients.
Caner Saygin, Joseph Cannova, Wendy Stock, Lori Muffly> ;Haematologica. 2022 Dec 1
2 citations
B-cell lymphoma-2 downregulation is a useful feature supporting a neoplastic phenotype in mature T-cell lymphomas.
Faiza Siddiqui, Vanessa Perez Silos, Kennosuke Karube, Srinath Nandakumar, Caner Saygin, Oluwakemi Onajin, Swetha S Prabu, Sandeep Gurbuxani, Daniel A Arber, Melissa T...> ;Human Pathology. 2022 Jul 1
873 citations
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.
Alaggio, R., Amador, C., Anagnostopoulos, I., Attygalle, A., Araujo, I., Berti, E., Bhagat, G., Borges, A., Boyer, D., Calaminici, M., Chadburn, A., Chan, J., Cheuk, W...> ;Leukemia. 2022 Jul 1
12 citations
Cytopenias After CD19 Chimeric Antigen Receptor T-Cells (CAR-T) Therapy for Diffuse Large B-Cell Lymphomas or Transformed Follicular Lymphoma: A Single Institution Exp...
Andrew Schaefer, Ying Huang, Adam Kittai, Joseph E. Maakaron, Caner Saygin, Jonathan E. Brammer, Sam Penza, Ayman Saad, Samantha Jaglowski, Basem M. William> ;Cancer Management and Research. 2021 Nov 30
Correction: Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq
Caner Saygin, Eileen Hu, Pu Zhang, Steven Sher, Arletta Lozanski, Tzyy-Jye Doong, Deedra Nicolet, Shelley Orwick, Jadwiga Labanowska, Jordan N. Skinner, Casey Cempre, ...> ;Leukemia. 2021 Sep 3
7 citations
Genetics of Myelodysplastic Syndromes.
Caner Saygin, Lucy A. Godley> ;Cancers. 2021 Jul 6
3 citations
Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.
Caner Saygin, Eileen Hu, Pu Zhang, Steven Sher, Arletta Lozanski, Tzyy-Jye Doong, Deedra Nicolet, Shelley Orwick, Jadwiga Labanowska, Jordan N. Skinner, Casey Cempre, ...> ;Leukemia. 2021 May 21
16 citations
Cedazuridine/decitabine: from preclinical to clinical development in myeloid malignancies.
Anand Patel, Kirk E. Cahill, Caner Saygin, Olatoyosi Odenike> ;Blood Advances. 2021 Apr 27
6 citations
Pretreatment with LCK inhibitors chemosensitizes cisplatin‐resistant endometrioid ovarian tumors
Katie K. Crean-Tate, Chad Braley, Goutam Dey, Emily Esakov, Caner Saygin, Alexandria Trestan, Daniel J. Silver, Soumya M. Turaga, Elizabeth V. Connor, Robert Debernard...> ;Journal of Ovarian Research. 2021 Apr 22
2 citations
Type of prior genotoxic insult determines the genomic characteristics of therapy‐related myeloid neoplasms
Michael Ozga, James S. Blachly, Ann-Kathrin Eisfeld, Nicole Grieselhuber, Karilyn Larkin, Alison Walker, Bhavana Bhatnagar, Gregory K. Behbehani, Meixiao Long, Tamanna...> ;American Journal of Hematology. 2021 Mar 24
5 citations
OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia
Bartholomew J. Eisfelder, Caner Saygin, Joseph Wynne, Margaret W Colton, Mariafausta Fischietti, Elspeth M. Beauchamp, Jason X. Cheng, Olatoyosi Odenike, Gail J. Roboz...> ;Blood Cancer Journal. 2021 Mar 3
31 citations
Current and emerging strategies for management of myelodysplastic syndromes.
Caner Saygin, Hetty E. Carraway> ;Blood Reviews. 2021 Jul 1
28 citations
Therapy for lower-risk MDS.
Hetty E. Carraway, Caner Saygin> ;Hematology. American Society of Hematology. Education Program. 2020 Dec 4
1 citations
A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysp...
Caner Saygin, Karilyn Larkin, James S. Blachly, Shelley Orwick, Apollinaire Ngankeu, Charles Thomas Gregory, Mitch A. Phelps, Shylaja Mani, Alison Walker, Ramiro Garzo...> ;American Journal of Hematology. 2020 Sep 19
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Abstracts/Posters

Rapid Molecular Diagnostics for Acute Myeloid Leukemia Using Single-Molecule Sequencing
Caner Saygin, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019