CarlJPepineMD

Cardiology • Gainesville, FL

Preventive Cardiology

Professor of Medicine, University Fla College of Medicine

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Office
1329 SW Archer Road
Suite 5130, Room 5231
Gainesville, FL 32610
Phone+1 352-273-9082

Fax+1 352-392-3606
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Education & Training

Naval Regional Medical CenterResidency, Internal Medicine, 1968 - 1971
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Internal Medicine, 1967 - 1968
Allegheny Health Network Medical Education Consortium (AGH)Internship, Internal Medicine, 1966 - 1967
Rutgers New Jersey Medical SchoolClass of 1966

Certifications & Licensure

FL State Medical License 1974 - 2026
PA State Medical License 1967 - 1984
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Women's Health Castle Connolly, 2008
Men's Health Castle Connolly, 2007
Top Doctors: Florida Castle Connolly, 2000
Elected Member The American Society for Clinical Investigation, 1982
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study Start of enrollment: 1990 Nov 01
Completed
Phase 3
Women's Ischemia Syndrome Evaluation (WISE) Start of enrollment: 2001 May 01
Completed
Phase 3
INVEST: INternational VErapamil SR Trandolapril STudy Start of enrollment: 1997 Sep 01
Completed
Phase 4
QWISE - Study of Quinapril in Women With Chest Pain, Coronary Flow Reserve Limitations and Evidence of Myocardial Ischemia Start of enrollment: 2000 May 01
Completed
Phase 4
EWISE: Study of Eplerenone in Women With Chest Pain, Coronary Vascular Dysfunction and Evidence of Myocardial Ischemia Start of enrollment: 2004 Aug 01
Completed
Phase 4
WISE ARIC: Retinal Photography in Women With Chest Pain Start of enrollment: 2003 Jun 01
Completed
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction Start of enrollment: 2008 Sep 17
Active, not recruiting
IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction Start of enrollment: 2012 Apr 01
Completed
Not Applicable
Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia Start of enrollment: 2011 May 01
Completed
Not Applicable
Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration Start of enrollment: 2012 Nov 13
Terminated
Phase 1, Phase 2
Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia Start of enrollment: 2012 Jun 01
Completed
Phase 2
Patients With Intermittent Claudication Injected With ALDH Bright Cells Start of enrollment: 2013 Jun 01
Completed
Phase 2
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients Start of enrollment: 2014 Oct 01
Recruiting
Phase 4
The Role of Gut Microbiota in Hypertension Start of enrollment: 2014 Jul 01
Active, not recruiting
Combination of Mesenchymal and C-kit+ Cardiac Stem Cells as Regenerative Therapy for Heart Failure Start of enrollment: 2015 Oct 01
Completed
Phase 2
Stem Cell Injection in Cancer Survivors Start of enrollment: 2016 Aug 01
Completed
Phase 1
The Role of Gut Microbiota in Heart Failure and Pre-Heart Failure With Preserved Ejection Fraction Start of enrollment: 2016 Oct 01
Recruiting
Gut Organoid Study Start of enrollment: 2021 Mar 05
Active, not recruiting
Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM) Start of enrollment: 2021 Oct 06
Active, not recruiting
Early Phase 1
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Elevated high-density lipoprotein cholesterol and adverse outcomes in women with symptoms of ischemic heart disease.
Yujie Cui, Okezi Obrutu, Eileen Handberg, C Noel Bairey Merz, Sachini Ranasinghe, Amer Muhyieddeen, Janet Wei, Martha Gulati, Vera Bittner, Steven Reis, Carl J Pepine> ;American Heart Journal Plus. 2024 Apr 1
Physiology and functional significance of the coronary microcirculation: An overview of its implications in health and disease.
Samir Alam, Carl J Pepine> ;American Heart Journal Plus. 2024 Apr 1
Pericardial fat volume is related to endothelial-mediated coronary blood flow in women with suspected coronary microvascular dysfunction. A report from the Women's Isc...
Louise Thomson, Michael Pedram, Manish Motwani, Galen Cook-Weins, George Sopko, C Noel Bairey Merz, Damini Dey, Sofy Landes, Haider Aldiwani, Janet Wei, Ahmed Al-Badri...> ;American Heart Journal Plus. 2024 Apr 1
Comparison of risk profiles of participants in the Women's IschemiA TRial to reduce events in non-ObstRuctive CAD (WARRIOR) trial, using coronary computed tomography a...
Galen Cook-Wiens, Eileen M Handberg, Leslee J Shaw, C Noel Bairey Merz, Suvasini Lakshmanan, Janet Wei, Carl J Pepine, Matthew Budoff> ;Progress in Cardiovascular Diseases. 2024 Mar 26
Single Nucleotide Polymorphisms in Coronary Microvascular Dysfunction.
Andrew P Stein, Jonathan Harder, Henry R Holmes, C Noel Bairey Merz, Carl J Pepine, Ellen C Keeley> ;Journal of the American Heart Association. 2024 Feb 20
Initial Antihypertensive Prescribing in Relation to Blood Pressure Among Florida Medicaid and Medicare Recipients in the OneFlorida+ Research Consortium.
Smith, K., Keshwani, S., Walsh, M., Winterstein, A., Gurka, M., Libby, A., Hogan, W., Cooper-DeHoff, R., Smith, S., Pepine, C.> ;Hypertension. 2024 Feb 1
Dietary Composition, Angiographic Coronary Disease, and Cardiovascular Outcomes in the WISE Study (Women's Ischemia Syndrome Evaluation).
Schwartz, B., Choi, S., Mathews, A., Handberg, E., Reis, S., Cook-Wiens, G., Merz, C., Wei, J., Aggarwal, M., Pepine, C., Rogers, W.> ;Journal of Clinical Medicine. 2023 Dec 18
Association of abnormal electrocardiography response on dobutamine stress echocardiogram with longer-term major adverse cardiovascular events in women with symptoms of...
Wei, J., Lauzon, M., Luu, J., Shaw, L., Handberg, E., Merz, C., Ranasinghe, S., Tjoe, B., Shufelt, C., Asif, A., Lewis, J., Pepine, C.> ;Cardiovascular Diagnosis and Therapy. 2023 Dec 15
Reprograming of transcriptional profile of colonic organoids from patients with high blood pressure by minocycline.
Li, J., Richards, E., Handberg, E., Smith, S., Raizada, M., Pepine, C., Alakrad, E., Forsmark, C.> ;American Heart Journal Plus. 2023 Dec 1
2 citations
The CardiAMP Cell Therapy for Heart Failure trial.
Carl J Pepine, Amish N Raval> ;Texas Heart Institute Journal. 2023 Oct 23
3 citations
Long-term Adverse Outcomes in Black Women With Obstructive Coronary Artery Disease: A Study of the Women's Ischemia Syndrome Evaluation (WISE) Cohort.
Judy M Luu, Galen Cook-Wiens, Carl J Pepine, Eileen M Handberg, Steven E Reis, Vera Bittner, George Sopko, C Noel Bairey Merz, Janet Wei> ;The Canadian Journal of Cardiology. 2023 Nov 1
1 citations
Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial.
Amber Sleem, Mark B Effron, Amanda Stebbins, Lisa M Wruck, Guillaume Marquis-Gravel, Daniel Muñoz, Richard N Re, Kamal Gupta, Carl J Pepine, Sandeep K Jain, Saket Giro...> ;JAMA Cardiology. 2023 Nov 1
Modifiable statin characteristics associated with potential statin-related prescribing cascades.
Grace Hsin-Min Wang, Earl Morris, Scott M Vouri, Shailina Keshwani, Stephan Schmidt, Carl J Pepine, Steven M Smith> ;Pharmacotherapy. 2023 Dec 1
Symptom Presentation among Women with Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA).
Yasmeen K Taha, Jennifer R Dungan, Michael T Weaver, Ke Xu, Eileen M Handberg, Carl J Pepine, C Noel Bairey Merz> ;Journal of Clinical Medicine. 2023 Sep 8
Longitudinal cardiac remodeling in collegiate American football players as assessed by echocardiography during their collegiate career.
Robert F Hamburger, Yasmeen Taha, Mohammed Ruzieh, James R Clugston, Eileen M Handberg, Fred Reifsteck, Matthew W Martinez, Carl J Pepine, Katherine M Edenfield> ;Clinical Cardiology. 2023 Sep 1
Social Vulnerability Is Associated With Higher Rates of Hospitalizations and Amputations for Peripheral Arterial Disease.
Khanjan B Shah, Mohammed Elzeneini, Samir K Shah, Adrienne E Strong, Yujia Li, Juan Aranda, David Winchester, Yi Guo, Carl Pepine, Scott A Berceli> ;The American Journal of Cardiology. 2023 Sep 15
EXACT Trial: Results of the Phase 1 Dose-Escalation Study.
Thomas J Povsic, Timothy D Henry, Jay H Traverse, R David Anderson, Geoffrey A Answini, Benjamin C Sun, George J Arnaoutakis, Konstantinos D Boudoulas, Adam R Williams...> ;Circulation. Cardiovascular Interventions. 2023 Aug 1
1 citations
Sex-Specific Effects of Blood Pressure Lowering Pharmacotherapy for the Prevention of Cardiovascular Disease: An Individual Participant-Level Data Meta-Analysis.
Zeinab Bidel, Milad Nazarzadeh, Dexter Canoy, Emma Copland, Eva Gerdts, Mark Woodward, Ajay K Gupta, Christopher M Reid, William C Cushman, Kristian Wachtell, Barry R ...> ;Hypertension. 2023 Nov 1
2 citations
Left ventricular ejection fraction and long-term outcomes in women presenting with signs and symptoms of ischaemia.
Stephanie Wu, Janet Wei, Marie Lauzon, Nissi Suppogu, Sheryl F Kelsey, Steven E Reis, Leslee J Shaw, George Sopko, Eileen Handberg, Carl J Pepine, C Noel Bairey Merz> ;Heart. 2023 Oct 12
1 citations
Circulating Biomarkers in Coronary Microvascular Dysfunction.
Teja Chakrala, Roshni Prakash, Carlos Valdes, Carl J Pepine, Ellen C Keeley> ;Journal of the American Heart Association. 2023 Jun 20
Comparison of the effectiveness and safety of 2 aspirin doses in secondary prevention of cardiovascular outcomes in patients with chronic kidney disease: A subgroup an...
Kamal Gupta, Harsh Mehta, Hwasoon Kim, Amanda Stebbins, Lisa M Wruck, Daniel Muñoz, Mark B Effron, R David Anderson, Carl J Pepine, Sandeep K Jain, Saket Girotra, Darr...> ;American Heart Journal. 2023 Oct 1
Fitness attenuates long-term cardiovascular outcomes in women with ischemic heart disease and metabolic syndrome.
Odayme Quesada, Marie Lauzon, Rae Buttle, Janet Wei, Nissi Suppogu, Galen Cook-Wiens, Steven E Reis, Leslee J Shaw, George Sopko, Eileen Handberg, Carl J Pepine, C Noe...> ;American Journal of Preventive Cardiology. 2023 Jun 1
Clinically stable covid-19 patients presenting to acute unscheduled episodic care venues have increased risk of hospitalization: secondary analysis of a randomized con...
Joseph Bledsoe, Scott C Woller, Maria Brooks, Frank C Sciurba, Jerry A Krishnan, Deborah Martin, Peter Hou, Janet Y Lin, Andrei Kindzelski, Eileen Handberg, Bridget-An...> ;BMC Infectious Diseases. 2023 May 15
3 citations
Racial and Ethnic Differences in Cardiac Surveillance Evaluation of Patients Treated With Anthracycline-Based Chemotherapy.
David L DeRemer, Nam K Nguyen, Avirup Guha, Faraz S Ahmad, Rhonda M Cooper-DeHoff, Carl J Pepine, Michael G Fradley, Yan Gong> ;Journal of the American Heart Association. 2023 May 16
2 citations
High-throughput screening for prescribing cascades among real world statin initiators.
Scott M Vouri, Earl J Morris, Marta Walsh, Jessica Agalliu, Alyssa Dempsey, Leonie Hochleitner, Matthew R Muschett, Stephan Schmidt, Carl J Pepine, Steven M Smith> ;Pharmacoepidemiology and Drug Safety. 2023 Jul 1
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Journal Articles

Gut Microbiota and Serum Metabolite Differences in African Americans and White Americans with High Blood Pressure☆
Carl Pepine, MD, International Journal of Cardiology

Lectures

Refractory Angina: Options for Patients With 'No Options
2019 ACC Scientific Session & Expo, New Orleans - 3/18/2019

Authored Content

Invasive Functional Assessment in Patients with Angina and Coronary Microvascular Dysfunction A Plea for MoreMay 2020
Invasive Functional Assessment in Patients with Angina and Coronary Microvascular Dysfunction A Plea for MoreMay 2020
Hypertension Across a Woman’s Life CycleApril 2018

Press Mentions

Barriers to Acceptance, Management of Coronary Vasomotor Disorders PersistJanuary 15th, 2021
BioCardia Announces CardiAMP Heart Failure Pivotal Trial Continues with First Patient Randomized in COVID-19 EraJune 29th, 2020
Biocardia Reports 2019 Financial Results and Recent Business HighlightsApril 9th, 2020
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Grant Support

Ufrcc For Cardiovascular Cell Therapy Research NetworkNational Heart, Lung, And Blood Institute2012
Women'S Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionNational Heart, Lung, And Blood Institute2008–2011
Ancillary Functional Studies For The CctrnNational Heart, Lung, And Blood Institute2008–2011
Ufcc For Cardiovascular Cell Therapy Research NetworkNational Heart, Lung, And Blood Institute2007–2011
Renin Angiotensin For Coronary Microvascular DysfunctionNational Heart, Lung, And Blood Institute2001–2005
Scientific Review And Evaluation GrantNational Heart, Lung, And Blood Institute2001–2002
Ischemic Heart Disease In Women--Clinical CenterDivision Of Heart And Vascular Diseases1996–2001
Exercise Induced Ischemia In Patients With Stable Exertional AnginaNational Center For Research Resources1997–1999
DMP 754 In Patients With Chronic Stable Coronary Artery DiseaseNational Center For Research Resources1997