CharlesLLoprinziMD

Oncology • Rochester, MN

Professor of Medicine, Mayo Medical School

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Office
200 1st St Sw
Mayo Clinic, Dept Med Oncology
Rochester, MN 55905
Phone+1 507-284-2511
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Education & Training

University of Wisconsin Hospitals and ClinicsFellowship, Medical Oncology, 1982 - 1984
Creighton University School of Medicine/Maricopa Medical Center (Phoenix)Residency, Internal Medicine, 1979 - 1982
Oregon Health and Science University School of MedicineClass of 1979

Certifications & Licensure

MN State Medical License 1985 - 2025
AZ State Medical License 1988 - 2017
FL State Medical License 1987 - 2005
WI State Medical License 1982 - 1985
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2003-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Fellow (FASCO) American Society of Clinical Oncologists, 2008

Clinical Trials

Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed Start of enrollment: 1993 May 01
Completed
Phase 3
Shark Cartilage in Treating Patients With Advanced Colorectal or Breast Cancer Start of enrollment: 2001 Aug 01
Completed
Phase 3
Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy Start of enrollment: 2002 Feb 01
Completed
Phase 3
Gabapentin in Treating Hot Flashes in Patients With Prostate Cancer Start of enrollment: 2001 Dec 01
Completed
Phase 3
Medroxyprogesterone Compared With Venlafaxine in Treating Hot Flashes in Women Start of enrollment: 2002 Apr 01
Completed
Phase 3
Calcium With or Without Estrogen and/or Risedronate in Preventing Osteoporosis in Patients With Prostate Cancer Start of enrollment: 2002 Nov 01
Completed
Phase 3
Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery Start of enrollment: 2004 May 01
Completed
Phase 3
Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Start of enrollment: 2004 Feb 01
Completed
Phase 3
Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System Start of enrollment: 2004 Jan 01
Terminated
Phase 2
(Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy Start of enrollment: 2003 Aug 01
Completed
Phase 3
Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors Start of enrollment: 2004 Apr 01
Completed
Phase 3
Creatine in Treating Patients With Cancer-Associated Weight Loss Start of enrollment: 2004 Dec 01
Completed
Phase 3
Gabapentin With or Without Antidepressants in Treating Hot Flashes in Women Who Have Had Breast Cancer or Have Concerns About Taking Hormone Therapy Start of enrollment: 2004 Nov 01
Completed
Phase 3
Tetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for Cancer Start of enrollment: 2004 Dec 01
Completed
Not Applicable
Everolimus in Treating Patients With Stage IV Melanoma Start of enrollment: 2005 Apr 01
Completed
Phase 2
American Ginseng in Treating Patients With Cancer-Related Fatigue Start of enrollment: 2005 Oct 01
Completed
Not Applicable
Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer Start of enrollment: 2006 Jun 01
Completed
Phase 3
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery Start of enrollment: 2006 Jan 01
Completed
Phase 3
Pilocarpine in Treating Vaginal Dryness in Patients With Breast Cancer Start of enrollment: 2006 Dec 01
Completed
Phase 3
Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer Start of enrollment: 2006 Dec 01
Completed
Phase 3
Citalopram in Treating Postmenopausal Women With Hot Flashes Start of enrollment: 2006 Nov 01
Completed
Phase 3
Methylphenidate in Treating Patients With Fatigue Caused by Cancer Start of enrollment: 2008 Feb 01
Completed
Phase 3
Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Start of enrollment: 2007 May 01
Completed
Phase 2
Skin Conduction Device for Measuring Hot Flashes in Postmenopausal Women With Hot Flashes Start of enrollment: 2006 May 01
Completed
Not Applicable
Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Start of enrollment: 2006 Jan 01
Completed
Phase 3
Pregabalin in Treating Women With Hot Flashes Start of enrollment: 2008 Jun 01
Completed
Phase 3
American Ginseng in Treating Patients With Fatigue Caused by Cancer Start of enrollment: 2008 Oct 01
Completed
Phase 3
Acute Pain Caused by Paclitaxel in Patients With Cancer Start of enrollment: 2009 Feb 01
Completed
Stellate Ganglion Nerve Block in Treating Women With Hot Flashes Start of enrollment: 2009 Apr 01
Completed
Early Phase 1
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Start of enrollment: 2010 Jun 01
Completed
Phase 3
Short-Term Fasting Before Chemotherapy in Treating Patients With Cancer Start of enrollment: 2010 Aug 13
Completed
Not Applicable
Sulfasalazine in Preventing Acute Diarrhea in Patients With Cancer Who Are Undergoing Pelvic Radiation Therapy Start of enrollment: 2011 Apr 01
Completed
Phase 3
Scrambler Therapy in Treating Pain and Peripheral Neuropathy in Patients Previously Treated With Chemotherapy Start of enrollment: 2011 Mar 01
Completed
Scrambler Therapy in Treating Chronic Pain in Patients With Rash From Varicella Zoster Virus Infection Start of enrollment: 2011 Mar 01
Completed
Not Applicable
Magnesium Oxide in Treating Postmenopausal Women With Hot Flashes and a History of Breast Cancer Start of enrollment: 2011 Sep 01
Completed
Phase 2
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment Start of enrollment: 2013 Aug 01
Completed
Phase 3
Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel Start of enrollment: 2012 Jan 01
Topical Cryotherapy in Reducing Pain in Patients With Chemotherapy Induced Peripheral Neuropathy or Paclitaxel Induced Acute Pain Syndrome Start of enrollment: 2015 Dec 23
Completed
Not Applicable
Study of Cisplatin-Induced Peripheral Neuropathy in Patients With Germ Cell Tumor Start of enrollment: 2015 Jul 01
Completed
MC5-A Scrambler Therapy or TENS Therapy in Treating Patients With Chemotherapy-Induced Peripheral Neuropathy Start of enrollment: 2016 Apr 13
Completed
Not Applicable
Oxybutynin Chloride in Managing Hot Flashes Start of enrollment: 2016 Dec 09
Completed
Phase 3
Fingolimod in Preventing Paclitaxel-Associated Neuropathy in Patients With Breast Cancer Start of enrollment: 2019 Dec 12
Completed
Phase 1
Fingolimod in Treating Patients With Chemotherapy-Induced Neuropathy Start of enrollment: 2019 May 24
Completed
Early Phase 1
Rose Geranium in Sesame Oil Nasal Spray for the Improvement of Nasal Vestibulitis Symptoms in Cancer Patients Receiving Chemotherapy Start of enrollment: 2020 Nov 13
Completed
Phase 3
PEA for the Relief of Chemotherapy-Induced Peripheral Neuropathy Start of enrollment: 2022 May 16
Active, not recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Extending Venous Thromboembolism Secondary Prevention with Apixaban in Cancer Patients. The EVE Trial.
Robert D McBane 2nd, Charles L Loprinzi, Tyler Zemla, Alfonso Tafur, Kristen Sanfilippo, Jane Jijun Liu, David A Garcia, James Heun, Krishna Gundabolu, Adedayo A Oniti...> ;Journal of Thrombosis and Haemostasis. 2024 Mar 25
Prevalence and impact of fertility concerns in young women with breast cancer.
Larson, N., Khan, Z., Nichols, H., Su, H., Couch, F., Olson, J., Mannion, S., Higgins, A., Stewart, E., Shenoy, C., Partridge, A., Loprinzi, C., Ruddy, K.> ;Scientific Reports. 2024 Feb 22
Patient-targeted education (ePRO-E) to increase ePRO intent within an Alliance clinical trial (A221805-SI1).
Ellen M Lavoie Smith, Youmin Cho, Shauna Hillman, Mary R Scott, Elizabeth Harlos, Rachel Wills, Charles Loprinzi, Christina M Wilson, David Zahrieh> ;JNCI Cancer Spectrum. 2024 Jan 4
1 citations
Changes in vascular function and correlation with cardiotoxicity in women with newly diagnosed breast cancer undergoing HER2-directed therapy with and without anthracy...
Nhola, L., Kailash, V., Zhang, S., Lewis, B., Hazim, A., Sandhu, N., Lerman, A., Loprinzi, C., Ruddy, K., Villarraga, H., Herrmann, J.> ;European Heart Journal Open. 2024 Jan 1
Retrospective cohort study of CDK4/6-inhibitor-induced alopecia in breast cancer patients.
Abena Minta, Lucy Rose, Candice Park, Bhuvaneswari Ramaswamy, Daniel Stover, Margaret Gatti-Mays, Mathew Cherian, Nicole Williams, Preeti Sudheendra, Robert Wesolowski...> ;Supportive Care in Cancer. 2023 Nov 22
Sexual Dysfunction in Patients With Metastatic Breast Cancer.
Nusrat Jahan, Elizabeth Cathcart-Rake, Robert A Vierkant, Nicole Larson, Charles Loprinzi, Ciara C O'Sullivan, Stephanie Faubion, Carol Kuhle, Jennifer A Vencill, Ferg...> ;Clinical Breast Cancer. 2024 Jan 1
Changes in amount and intensity of physical activity over time in breast cancer survivors.
Paulina S Marell, Robert A Vierkant, Janet E Olson, Joerg Herrmann, Nicole L Larson, Nathan K Lebrasseur, Stacy D D'Andre, Diane K Ehlers, Daniela L Stan, Andrea L Che...> ;JNCI Cancer Spectrum. 2023 Aug 31
Measuring symptoms and toxicities: a 35-year experience.
Charles L Loprinzi, Paul Novotny, Kathryn J Ruddy, Aminah Jatoi, Jennifer Le-Rademacher, Shawna L Ehlers, Elizabeth Cathcart-Rake, Minji Lee> ;Supportive Care in Cancer. 2023 Jul 27
1 citations
Cutaneous Electroanalgesia for Relief of Chronic and Neuropathic Pain.
Thomas J Smith, Charles L Loprinzi, Wang, E. J., Eric J Wang> ;The New England Journal of Medicine. 2023 Jul 13
Olanzapine With or Without Fosaprepitant for Preventing Chemotherapy Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy: A Phase III Rand...
Rudolph M Navari, Jennifer Le-Rademacher, Fabrice Smieliauskas, Kathryn J Ruddy, Thomas James Saphner, Heshan Liu, Elizabeth Harlos, Adedayo A Onitilo, Karthik Giridha...> ;The Oncologist. 2023 Aug 3
A five arm natural history study of nasal vestibulitis.
Elizabeth J Cathcart-Rake, David Zahrieh, Deanne Smith, Susan Young, Shaylene McCue, Amanda O'Connor, Stephan Thomé, Mario Lacouture, Terra Register, Jill Piens, Bret ...> ;Cancer Medicine. 2023 Apr 1
1 citations
Dexamethasone to prevent everolimus-induced stomatitis (Alliance MIST Trial: A221701).
Kathryn J Ruddy, David Zahrieh, Jun He, Blake Waechter, Julianne L Holleran, Lionel D Lewis, Selina Chow, Jan Beumer, Matthias Weiss, Nikolaos Trikalinos, Bryan Faller...> ;Seminars in Oncology. 2023 Jan 17
1 citations
Financial hardship in breast cancer survivors: a prospective analysis of change in financial concerns over time.
Michael H Storandt, Urshila Durani, Daniela Stan, Nicole Larson, Charles Loprinzi, Fergus Couch, Janet E Olson, Nandita Khera, Kathryn J Ruddy> ;Supportive Care in Cancer. 2022 Dec 19
Dietary supplement use and recommendations for discontinuation in an integrative oncology clinic.
Stacy D D'Andre, Brent A Bauer, Margaret B Hofmann, Jenna L Burckhard, Heather N Montane, Charles L Loprinzi> ;Supportive Care in Cancer. 2022 Dec 16
2 citations
Slow Uptake of an Effective Therapy: Patterns of Olanzapine Prescribing for Those Receiving Highly Emetogenic Chemotherapy.
Daniel S Childs, David A Helfinstine Jr, Lindsey Sangaralingham, Jacob J Orme, Ciara C O'Sullivan, Charles L Loprinzi, Kathryn J Ruddy> ;JCO Oncology Practice. 2022 Dec 1
3 citations
A global survey on the utilization of cryotherapy and compression therapy for the prevention of chemotherapy-induced peripheral neuropathy.
Alexandre Chan, Amna Elsayed, Ding Quan Ng, Kathryn Ruddy, Charles Loprinzi, Maryam Lustberg> ;Supportive Care in Cancer. 2022 Dec 1
49 citations
Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline.
Jun J Mao, Nofisat Ismaila, Ting Bao, Debra Barton, Eran Ben-Arye, Eric L Garland, Heather Greenlee, Thomas Leblanc, Richard T Lee, Ana Maria Lopez, Charles Loprinzi, ...> ;Journal of Clinical Oncology. 2022 Dec 1
Pregabalin for chemotherapy-induced neuropathy: background and rationale for further study.
Mellar Davis, Charles Loprinzi> ;Supportive Care in Cancer. 2022 Nov 1
1 citations
Factors Associated With Physical Activity Levels in Patients With Breast Cancer.
Paulina S Marell, Robert A Vierkant, Janet E Olson, Joerg Herrmann, Nicole Larson, Nathan K LeBrasseur, Stacy D D'Andre, Andrea L Cheville, Toure Barksdale, Charles L ...> ;The Oncologist. 2022 Oct 1
31 citations
ESMO Expert Consensus Statements on Cancer Survivorship: promoting high-quality survivorship care and research in Europe.
I Vaz-Luis, M Masiero, G Cavaletti, A Cervantes, R T Chlebowski, G Curigliano, E Felip, A R Ferreira, P A Ganz, J Hegarty, J Jeon, C Johansen, F Joly, K Jordan, B Kocz...> ;Annals of Oncology. 2022 Nov 1
Surveillance mammography in older breast cancer survivors: Current practice patterns and patient perceptions.
Dhauna Karam, Robert A Vierkant, Shawna Ehlers, Rachel A Freedman, Jessica Austin, Sadia Khanani, Nicole L Larson, Charles L Loprinzi, Fergus Couch, Janet E Olson, Kat...> ;Journal of Geriatric Oncology. 2022 Sep 1
2 citations
Hot flash clinical trial baseline measurements: how long is needed?
Daniel S Childs, Paul J Novotny, Paulina S Marell, Kathryn J Ruddy, Charles L Loprinzi> ;BMJ Supportive & Palliative Care. 2024 Jan 8
1 citations
Temporal, Location- and Symptom-Specific Likelihood of Patient-Reported Sensory Symptoms Related to Oxaliplatin-Induced Peripheral Neuropathy (OIPN) in Patients Receiv...
David Zahrieh, Daniel Satele, Ellen M Lavoie Smith, Charles L Loprinzi, Jennifer Le-Rademacher> ;Cancers. 2022 Feb 25
11 citations
Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial.
Alyx B Porter, Heshan Liu, Sadhna Kohli, Jane L Cerhan, Jeff Sloan, Ryan P McMurray, Jennifer Le-Rademacher, Charles L Loprinzi, John L Villano, Sani H Kizilbash, Mine...> ;JAMA Oncology. 2022 Feb 1
1 citations
A Pill for Sexual Desire in Female Cancer Survivors: Too Good to Be True?
Maryam B Lustberg, Charles L Loprinzi, Lauren Streicher> ;Journal of Clinical Oncology. 2022 Feb 1
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Journal Articles

The Importance of a Cause-Based Protocol to Approach Cancer-Related Nausea and Vomiting—Reply
Charles L Loprinzi, Rudolph M Navari, JAMA Oncology
Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or Vomiting
Rudolph M Navari, Costantine Albany, Charles L Loprinzi, JAMA Oncology

Lectures

Scrambler therapy for established chemotherapy-induced neuropathy: A randomized phase II trial.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
Mayo Clinic Oncology Review
Mayo School of Continuous Professional Development, Minneapolis, Minnesota - 7/20/2013
MSCO Fellows Dinner Meeting
Minnesota Society of Clinical Oncology (MSCO), Minneapolis, Minnesota - 7/20/2013
18th Annual Network of Oncology Clinicians & Researchers (NOCR) Meeting
Imedex, Las Vegas, Nevada - 2/9/2012
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Other

Clinical features and pathogenesis of cancer cachexia
Loprinzi CL, Jatoi A
http://www.uptodate.com/contents/clinical-features-and-pathogenesis-of-cancer-cachexia
UpToDate, Wolters Kluwer Health - 2012-06-08
The role of parenteral and enteral/oral nutritional support in patients with cancer
Loprinzi CL, Jatoi A
http://www.uptodate.com/contents/the-role-of-parenteral-and-enteral-oral-nutritional-support-in-pati
UpToDate, Wolters Kluwer Health - 2013-03-14
Role of erythropoiesis-stimulating agents in the treatment of anemia in patients with cancer
Loprinzi CL, Steensma DP, Schrier SL
http://www.uptodate.com/contents/role-of-erythropoiesis-stimulating-agents-in-the-treatment-of-anemi
UpToDate, Wolters Kluwer Health - 2013-03-04

Authored Content

Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or VomitingMay 2020
Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or VomitingMay 2020

Press Mentions

ASCO Voices 2020August 9th, 2020
What Is Peripheral Neuropathy and How Can It Be Prevented or Treated?July 14th, 2020
Disarm Therapeutics Announces First Subject Enrolled in EPIPHANY Natural History Study of Chemotherapy-Induced Peripheral Neuropathy (CIPN)September 4th, 2019
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Grant Support

Survivorship Research Established Investigator AwardNational Cancer Institute2008–2011
Statistical Support UnitNational Cancer Institute2007–2011
Nursing And PharmacyNational Cancer Institute2007–2011
Community Clinical Oncology ProgramNational Cancer Institute2004–2011
SupplementNational Cancer Institute2007–2008
Operations UnitNational Cancer Institute2007
CapitationNational Cancer Institute2007
AuditNational Cancer Institute2007
AdministrationNational Cancer Institute2007
Ncctg CCOP Research Base - Foreign AccrualNational Cancer Institute2006
Community Clinical Oncology Program - Foreign AccrualNational Cancer Institute2005
Ncctg Foreign AccrualsNational Cancer Institute2004
Foreign Accural - NcctgNational Cancer Institute2003
Cancer Chemoprevention--Role Of Infection/ImmunityNational Cancer Institute1999–2003
Community Clinical Oncology ProgramNational Cancer Institute1994–2003
Inhibition Of Ornithine Decarboxylase By Oral CompoundsNational Cancer Institute1985