ChristinaMessineoAnnunziataMD

Oncology • Fairfax, VA

Physician

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Office
8081 Innovation Park Dr
Level 6 - Potomac Clinic
Fairfax, VA 22031
Phone+1 571-472-1660

Fax+1 571-472-1661
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Education & Training

National Institutes of Health Clinical CenterFellowship, Hematology and Medical Oncology, 2002 - 2006
MedStar Health/Georgetown University HospitalResidency, Internal Medicine, 2000 - 2002
Georgetown University School of MedicineClass of 2000

Certifications & Licensure

VA State Medical License 2000 - 2024
MD State Medical License 2016 - 2022
DC State Medical License 2001 - 2020
American Board of Internal Medicine Medical Oncology

Clinical Trials

Sorafenib and Bevacizumab to Treat Ovarian, Fallopian and Peritoneal Cancer Start of enrollment: 2006 Dec 12
Completed
Phase 2
Dasatinib in Combination With Bevacizumab to Treat Advanced Solid Tumors Start of enrollment: 2008 Dec 29
Completed
Phase 1
Blood Collection From People With Ovarian Cancer Start of enrollment: 2014 Mar 10
Completed
Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer Start of enrollment: 2017 Feb 08
Terminated
Phase 1
Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma Start of enrollment: 2018 Aug 27
Terminated
Phase 1
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Publications & Presentations

PubMed

Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer.
Kei Kudo, Yoshimi Endo Greer, Teruhiko Yoshida, Brittney S Harrington, Soumya Korrapati, Yusuke Shibuya, Leah Henegar, Jeffrey B Kopp, Takeo Fujii, Stanley Lipkowitz, ...> ;Cancer Gene Therapy. 2024 Feb 29
UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.
Brittney S Harrington, Rahul Kamdar, Franklin Ning, Soumya Korrapati, Michael W Caminear, Lidia F Hernandez, Donna Butcher, Elijah F Edmondson, Nadia Traficante, Joy H...> ;Journal of Experimental & Clinical Cancer Research. 2023 Oct 19
Patients' perspectives on prenatal screening results that suggest maternal cancer: A qualitative analysis.
Amy Turriff, Skye A Miner, Christina M Annunziata, Diana W Bianchi> ;Prenatal Diagnosis. 2023 Aug 1
1 citations
A Single-Arm, Open-Label Phase II Study of ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma.
Sarah L P Atkins, Yoshimi Endo Greer, Sarah Jenkins, Margaret E Gatti-Mays, Nicole Houston, Sunmin Lee, Min-Jung Lee, Shraddha Rastogi, Nahoko Sato, Christina Burks, C...> ;The Oncologist. 2023 Oct 3
2 citations
Correction: First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors.
Christopher B Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lip...> ;Journal of Experimental & Clinical Cancer Research. 2023 Apr 26
2 citations
NF-κB Signaling Modulates miR-452-5p and miR-335-5p Expression to Functionally Decrease Epithelial Ovarian Cancer Progression in Tumor-Initiating Cells.
Rahul D Kamdar, Brittney S Harrington, Emma Attar, Soumya Korrapati, Jyoti Shetty, Yongmei Zhao, Bao Tran, Nathan Wong, Carrie D House, Christina M Annunziata> ;International Journal of Molecular Sciences. 2023 Apr 25
3 citations
First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors.
Christopher B Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lip...> ;Journal of Experimental & Clinical Cancer Research. 2023 Mar 29
1 citations
SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling.
Yusuke Shibuya, Kei Kudo, Kristen P Zeligs, David Anderson, Lidia Hernandez, Franklin Ning, Christopher B Cole, Maria Fergusson, Noemi Kedei, John Lyons, Jason Taylor,...> ;Cancers. 2023 Feb 18
3 citations
Overcoming the challenges of drug development in platinum-resistant ovarian cancer.
Ramez N Eskander, Kathleen N Moore, Bradley J Monk, Thomas J Herzog, Christina M Annunziata, David M O'Malley, Robert L Coleman> ;Frontiers in Oncology. 2023 Jan 1
Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
David J Wisniewski, Mariya S Liyasova, Soumya Korrapati, Xu Zhang, Shashikala Ratnayake, Qingrong Chen, Samuel F Gilbert, Alexis Catalano, Donna Voeller, Daoud Meerzam...> ;The Journal of Biological Chemistry. 2023 Jan 1
1 citations
Identification of the O-Glycan Epitope Targeted by the Anti-Human Carcinoma Monoclonal Antibody (mAb) NEO-201.
Kwong Y Tsang, Massimo Fantini, Anjum Zaki, Sharon A Mavroukakis, Maria Pia Morelli, Christina M Annunziata, Philip M Arlen> ;Cancers. 2022 Oct 12
4 citations
Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial.
Daniel S Green, Franklin Ning, Anna Duemler, Timothy G Myers, Kathryn Trewhitt, Irene Ekwede, Ann McCoy, Nicole Houston, Jung-Min Lee, Stanley Lipkowitz, Alexandra Zim...> ;Clinical Cancer Research. 2023 Jan 17
4 citations
Development and Characterization of an Anti-Cancer Monoclonal Antibody for Treatment of Human Carcinomas.
Kwong Yok Tsang, Massimo Fantini, Sharon A Mavroukakis, Anjum Zaki, Christina M Annunziata, Philip M Arlen> ;Cancers. 2022 Jun 21
4 citations
Prenatal DNA Sequencing for Fetal Aneuploidy Also Detects Maternal Cancer: Importance of Timely Workup and Management in Pregnant Women.
Amy E Turriff, Christina M Annunziata, Diana W Bianchi> ;Journal of Clinical Oncology. 2022 Aug 1
2 citations
Another Wrinkle with Age: Aged Collagen and Intra-peritoneal Metastasis of Ovarian Cancer.
Elizabeth I Harper, Tyvette S Hilliard, Emma F Sheedy, Preston Carey, Paul Wilkinson, Michael D Siroky, Jing Yang, Elizabeth Agadi, Annemarie K Leonard, Ethan Low, Yue...> ;Aging and Cancer. 2022 Jun 1
8 citations
Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells.
Michael W Caminear, Brittney S Harrington, Rahul D Kamdar, Michael J Kruhlak, Christina M Annunziata> ;Frontiers in Oncology. 2022 Jan 1
2 citations
Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism.
Lidia Hernandez, Angie B. Dull, Soumya Korrapati, Christina M. Annunziata> ;Cell Death Discovery. 2021 Jun 4
22 citations
Driving Immune Responses in the Ovarian Tumor Microenvironment
Franklin Ning, Christopher Browning Cole, Christina M. Annunziata> ;Frontiers in Oncology. 2021 Jan 15
2 citations
Matrix drug screen identifies synergistic drug combinations to augment smac mimetic activity in ovarian cancer
Anne M. Noonan, Amanda Cousins, David E. Anderson, Kristen P. Zeligs, Kristen P. Bunch, Lidia Hernandez, Yusuke Shibuya, Ian S. Goldlust, Rajarshi Guha, Marc Ferrer, C...> ;Cancers. 2020 Dec 15
5 citations
Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome.
Farzana L. Walcott, Ping Yuan Wang, Christine M Bryla, Rebecca D. Huffstutler, Neha Singh, Michael Pollak, Payal P. Khincha, Sharon A. Savage, Phuong L. Mai, Kevin W D...> ;JNCI Cancer Spectrum. 2020 Jul 18
5 citations
Leveraging locus-specific epigenetic heterogeneity to improve the performance of blood-based DNA methylation biomarkers.
Brendan F. Miller, Thomas R. Pisanic, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tz...> ;Clinical Epigenetics. 2020 Oct 20
16 citations
The ASTRO clinical practice guidelines in cervical cancer: Optimizing radiation therapy for improved outcomes.
Junzo Chino, Christina M. Annunziata, Sushil Beriwal, Lisa Bradfield, Beth Erickson, Emma C. Fields, Jane Fitch, Matthew M. Harkenrider, Christine H. Holschneider, Mit...> ;Gynecologic Oncology. 2020 Sep 22
16 citations
Phase II trial of bevacizumab and sorafenib in recurrent ovarian cancer patients with or without prior-bevacizumab treatment
Jung-Min Lee, Christina M. Annunziata, John L. Hays, Liang Cao, Peter L. Choyke, Minshu Yu, Daniel An, Ismail B. Turkbey, Lori M. Minasian, Seth M. Steinberg, John Wri...> ;Gynecologic Oncology. 2020 Aug 1
61 citations
Rapid image deconvolution and multiview fusion for optical microscopy.
Min Guo, Yue Li, Yijun Su, Talley J. Lambert, Damian Dalle Nogare, Mark W. Moyle, Leighton H. Duncan, Richard Ikegami, Anthony Santella, Ivan Rey-Suarez, Daniel S. Gre...> ;Nature Biotechnology. 2020 Jun 29
23 citations
Drugs Targeting Tumor-Initiating Cells Prolong Survival in a Post-Surgery, Post-Chemotherapy Ovarian Cancer Relapse Model.
Brittney S. Harrington, Michelle K. Ozaki, Michael W Caminear, Lidia Hernandez, Elizabeth Jordan, Nicholas J Kalinowski, Ian S. Goldlust, Rajarshi Guha, Marc Ferrer, C...> ;Cancers. 2020 Jun 21
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Press Mentions

When Prenatal DNA Tests Point to CancerMay 17th, 2023
Trametinib Is a New Treatment Option for Rare Form of Ovarian CancerMarch 10th, 2022
Clinical Trial Tests CAR T-cell Therapy on Peritoneal MesotheliomaDecember 18th, 2018
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