Christopher BruceLockMDPhD

PubMed

• Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis.
  Anne H Cross, Jeffrey M Gelfand, Simon Thebault, Jeffrey L Bennett, H Christian von Büdingen, Briana Cameron, Robert Carruthers, Keith Edwards, Robert Fallis, Rachel G...> ;JAMA Neurology. 2024 Mar 11
• Prevalence, Demographic, and Clinical Factors Associated With Cognitive Dysfunction in Patients With Neuromyelitis Optica Spectrum Disorder.
  Hinman, J., Tomczak, A., Palmer, C., Cook, L., Yeaman, M., Burnett, M., Deutsch, G., Nelson, L., , Vlahovic, L., McDonald, J., Lock, C., Han, M.> ;Neurology. 2024 Jan 9
• Progression of Mycosis Fungoides After Fingolimod Treatment for Multiple Sclerosis and Targeted Next-Generation Sequencing Demonstrating Potential Links Between the Tw...
  Saisindhu Narala, Yonglu Che, Atif Saleem, Christopher B Lock, Youn H Kim, Kerri E Rieger> ;JCO Precision Oncology. 2023 Feb 1
• 14 citations
  Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity.
  Koji Shinoda, Rui Li, Ayman Rezk, Ina Mexhitaj, Kristina R Patterson, Mihir Kakara, Leah Zuroff, Jeffrey L Bennett, H-Christian von Büdingen, Robert Carruthers, Keith ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 17
• 6 citations
  Evaluation of neurotrophic factor secreting mesenchymal stem cells in progressive multiple sclerosis.
  Jeffrey A Cohen, Fred D Lublin, Christoper Lock, Daniel Pelletier, Tanuja Chitnis, Munish Mehra, Yael Gothelf, Revital Aricha, Stacy Lindborg, Chaim Lebovits, Yossef L...> ;Multiple Sclerosis. 2023 Jan 1
• 292 citations
  Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.
  Tobias V Lanz, R Camille Brewer, Peggy P Ho, Jae-Seung Moon, Kevin M Jude, Daniel Fernandez, Ricardo A Fernandes, Alejandro M Gomez, Gabriel-Stefan Nadj, Christopher M...> ;Nature. 2022 Mar 1
• 1 citations
  A variant of uncertain significance in SDHAF1, the succinate dehydrogenase chaperone protein, in an adult patient with spastic paraparesis and leukoencephalopathy.
  L. Vlahovic, C.B. Lock, May H. Han, K. Van Haren, Jacinda B. Sampson> ;Multiple Sclerosis and Related Disorders. 2021 Jul 3
• 2 citations
  MR susceptibility contrast imaging using a 2D simultaneous multi-slice gradient-echo sequence at 7T.
  Wei Bian, Adam B. Kerr, Eric Tranvinh, Sherveen N. Parivash, Benjamin Zahneisen, May H. Han, Christopher Lock, Maged Goubran, Kongrong Zhu, Brian K. Rutt, Michael Zeineh> ;Plos One. 2019 Jul 17
• 113 citations
  Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice
  May H. Han, Deborah H. Lundgren, Siddhartha Jaiswal, Mark P. Chao, Kareem L. Graham, Christopher Garris, Robert C. Axtell, Peggy P. Ho, Christopher Lock, Joslyn I. Woo...> ;The Journal of Experimental Medicine. 2012 Jul 2
• 347 citations
  Inhibitory role for GABA in autoimmune inflammation.
  Roopa Bhat, Robert L. Axtell, Ananya Mitra, Melissa Miranda, Christopher Lock, Richard W. Tsien, Lawrence Steinman> ;Proceedings of the National Academy of Sciences of the United States of America. 2010 Feb 9
• 5 citations
  Are “statins” beneficial or harmful in multiple sclerosis?
  Christopher Lock> ;Neurology. 2008 Oct 28
• 19 citations
  Gene microarray analysis of multiple sclerosis lesions
  Christopher Lock, Renu A. Heller> ;Trends in Molecular Medicine. 2003 Dec 1
• 1310 citations
  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
  Christopher Lock, Guy Hermans, Rosetta Pedotti, Andrea Brendolan, Eric E. Schadt, Hideki Garren, Annette Langer-Gould, Samuel Strober, Barbara Cannella, John Allard, K...> ;Nature Medicine. 2002 May 1
• 734 citations
  The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
  Dorothee Chabas, Sergio E. Baranzini, Dennis J. Mitchell, Claude C.A. Bernard, Susan R. Rittling, David T. Denhardt, Raymond A. Sobel, Christopher Lock, Marcela Karpuj...> ;Science. 2001 Nov 23
• 220 citations
  Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis
  David Voehringer, David L. Hirschberg, J. Xiao, Q. Lu, Mario Roederer, Christopher Lock, Leonore A. Herzenberg, Lawrence Steinman> ;Proceedings of the National Academy of Sciences of the United States of America. 2000 Mar 14
• 35 citations
  The role of TNFalpha and lymphotoxin in demyelinating disease
  Christopher Lock, Jorge R. Oksenberg, Lawrence Steinman> ;Annals of the Rheumatic Diseases. 1999 Nov 1
• 20 citations
  The specificity of the antibody response in multiple sclerosis.
  Hideki Garren, Lawrence Steinman, Christopher Lock> ;Annals of Neurology. 1998 Jan 1
• 26 citations
  Prevention of insulin-dependent diabetes mellitus in nonobese diabetic mice by immunogenic but not by tolerated peptides.
  M Vaysburd, Christopher Lock, Hugh O. McDevitt> ;The Journal of Experimental Medicine. 1995 Sep 1
• 73 citations
  Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response
  Lars Fugger, Sara A. Michie, Ingrid C. Rulifson, Christopher Lock, Grete Sonderstrup McDevitt> ;Proceedings of the National Academy of Sciences of the United States of America. 1994 Jun 21
• 52 citations
  Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules : implications in induction of autoimmunity
  Anand M. Gautam, Christopher Lock, Dawn E. Smilek, C.I. Pearson, Lawrence Steinman, Hugh O. McDevitt> ;Proceedings of the National Academy of Sciences of the United States of America. 1994 Jan 18
• 7 citations
  Competitive inhibition of antigen presentation in animal models of autoimmune disease.
  Christopher Lock, Dawn E. Smilek, Anand M. Gautam, M Vaysburd, Dwivedy S, Hugh O. McDevitt> ;Seminars in Immunology. 1991 Jul 1
• 22 citations
  Antigen recognition and peptide-mediated immunotherapy in autoimmune disease.
  Dawn E. Smilek, Christopher Lock, Hugh O. McDevitt> ;Immunological Reviews. 1990 Dec 1
• 10 citations
  Genetic factors in sleep disorders.
  J D Parkes, Christopher Lock> ;Journal of Neurology, Neurosurgery, and Psychiatry. 1989 Jun 1
• 55 citations
  Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients.
  David Wilkinson, R. R. P. De Vries, J. A. Madrigal, Christopher Lock, J. P. Morgenstern, John Trowsdale, Daniel M. Altmann> ;The Journal of Experimental Medicine. 1988 Apr 1
• 42 citations
  MHC class II sequences of an HLA-DR2 narcoleptic.
  Christopher Lock, A. K. L. So, Kenneth I. Welsh, J D Parkes, John Trowsdale> ;Immunogenetics. 1988 Jan 1
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