DanielCLinkMD

PubMed

• 1 citations
  Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation.
  Laneshia K Tague, Karolyn A Oetjen, Anirudh Mahadev, Matthew J Walter, Hephzibah Anthony, Daniel Kreisel, Daniel C Link, Andrew E Gelman> ;JCI Insight. 2023 Apr 10
• 25 citations
  Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.
  Michael H Kramer, Qiang Zhang, Robert Sprung, Ryan B Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M Helton, Daniel R George, Yiling Mi, Peter Westervelt, Ja...> ;Blood. 2022 Sep 29
• 6 citations
  Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
  Andrew J Menssen, Ajay Khanna, Christopher A Miller, Sridhar Nonavinkere Srivatsan, Gue Su Chang, Jin Shao, Joshua Robinson, Michele O'Laughlin, Catrina C Fronick, Rob...> ;Blood Cancer Discovery. 2022 Jul 6
• 5 citations
  Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
  Pawan Upadhyay, Jeremy Beales, Nakul M Shah, Agata Gruszczynska, Christopher A Miller, Allegra A Petti, Sai Mukund Ramakrishnan, Daniel C Link, Timothy J Ley, John S W...> ;Experimental Hematology. 2022 Jul 1
• 3 citations
  IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.
  Sidan Li, Juo-Chin Yao, Karolyn A Oetjen, Joseph R Krambs, Jun Xia, Jingzhu Zhang, Amy P Schmidt, Nichole M Helton, Robert S Fulton, Sharon E Heath, Isaiah R Turnbull,...> ;Blood. 2022 Oct 6
• 14 citations
  Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
  Elisabeth R Wilson, Nichole M Helton, Sharon E Heath, Robert S Fulton, Jacqueline E Payton, John S Welch, Matthew J Walter, Peter Westervelt, John F DiPersio, Daniel C...> ;Leukemia. 2022 Apr 1
• 3 citations
  Decitabine salvage for-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy.
  Francesca Ferraro, Agata Gruszczynska, Marianna B Ruzinova, Christopher A Miller, Mary Elizabeth Percival, Geoffrey L Uy, Iskra Pusic, Meagan A Jacoby, Mathew J Christ...> ;Haematologica. 2022 Jul 1
• 2 citations
  Impaired myelopoiesis in congenital neutropenia: insights into clonal and malignant hematopoiesis.
  Julia T Warren, Daniel C Link> ;Hematology. American Society of Hematology. Education Program. 2021 Dec 10
• 18 citations
  Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
  Francesca Ferraro, Christopher A. Miller, Keegan A. Christensen, Nichole M. Helton, Margaret O’Laughlin, Catrina Fronick, Robert S. Fulton, Jessica Kohlschmidt, Ann-Ka...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Dec 7
• 30 citations
  Organ-on-a-chip model of vascularized human bone marrow niches.
  Drew Elizabeth Glaser, Matthew B. Curtis, Peter A. Sariano, Zachary A. Rollins, Bhupinder S. Shergill, Aravind Anand, Alyssa M. Deely, Venktesh S. Shirure, Leif S. And...> ;Biomaterials. 2021 Nov 12
• 3 citations
  Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice.
  Joseph R. Krambs, Darlene Monlish, Feng Gao, Laura G. Schuettpelz, Daniel C. Link> ;Frontiers in Immunology. 2021 Oct 19
• 6 citations
  Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
  Allegra A. Petti, Saad M. Khan, Ziheng Xu, Nichole M. Helton, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Sridhar Nonavinkere Srivatsan, Sharon Heath, ...> ;Blood Cancer Discovery. 2021 Aug 24
• 18 citations
  Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia.
  Julia T. Warren, Ryan R. Cupo, Peeradol Wattanasirakul, David H. Spencer, Adam E. Locke, Vahagn Makaryan, Audrey Anna Bolyard, Meredith L Kelley, Natalie L Kingston, J...> ;Blood. 2021 Jun 11
• 117 citations
  Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
  Eric J. Duncavage, Molly C Schroeder, Michele O'Laughlin, R. Wilson, Sandra MacMillan, Andrew Bohannon, Scott Kruchowski, John Garza, Feiyu Du, Andrew E. O. Hughes, Jo...> ;The New England Journal of Medicine. 2021 Mar 10
• 7 citations
  TLR7/8 agonist treatment induces an increase in bone marrow resident dendritic cells and hematopoietic progenitor expansion and mobilization.
  Sidan Li, Juo-Chin Yao, Justin T. Li, Amy P. Schmidt, Daniel C. Link> ;Experimental Hematology. 2021 Feb 5
• 21 citations
  Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations.
  Abigael Cheruiyot, Shan Li, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Yuhao Chen, Delphine Lemaçon, Ying Li, Zheng Yang, Brian A. Wadugu, Wayne A. Warner, Shondra M...> ;Cancer Research. 2021 Jul 2
• 11 citations
  TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
  Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Katherine Sullivan-Reed, Margaret Nieborowska-Skorska, Konstantin Golovine, Juo-Chin Yao, Reza Nejati, Kat...> ;Cell Reports. 2020 Oct 6
• 43 citations
  Clonal hematopoiesis and risk for hematologic malignancy.
  Julia T. Warren, Daniel C. Link> ;Blood. 2020 Oct 1
• 28 citations
  Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
  Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L. Kostecki, Joseph B. Monahan, Deborah J. Veis, Yousef Abu-Amer, Daniel...> ;Plos Biology. 2020 Aug 6
• 6 citations
  Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs
  Malte U Ritter, Maksim Klimiankou, Olga Klimenkova, Axel Schambach, Dirk Hoffmann, Amy P. Schmidt, Lothar Kanz, Daniel C. Link, Karl Welte, Julia Skokowa> ;Annals of Hematology. 2020 Aug 3
• Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
  Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Dani...> ;Nature Communications. 2020 Jul 28
• 1 citations
  Soil and Seed: Coconspirators in Therapy-Induced Myeloid Neoplasms.
  Kevin Shannon, Daniel C. Link> ;Blood Cancer Discovery. 2020 Jun 22
• 4 citations
  Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions
  Joseph R. Krambs, Grazia Abou Ezzi, Juo-Chin Yao, Daniel C. Link> ;Plos One. 2020 May 29
• Shaping clonal hematopoiesis
  Daniel C. Link> ;Blood. 2020 May 28
• 6 citations
  Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow.
  Vaishali Kapoor, Andrea Collins, Kaylan Griffith, Subhajit Ghosh, Nathan Wong, Xiaowei Wang, Grant A. Challen, Joseph R. Krambs, Daniel C. Link, Dennis E. Hallahan, Di...> ;Oncotarget. 2020 May 12
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Journal Articles

• Age-realted mtuations associated with clonal hematopoietic expansion and malignancies  
  Xie M. Lu C, Wang J. McLellan MD, Johnson KF, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MK, Mardis ER, Di..., Nat Med, 10/1/2014
• Inherited bone marrow failure syndromes in adolescents and young adults  
  Wilson DB, Link DC, Mason PJ, Bessler M, Annals of Internal Medicine, 1/1/2014
• Caspase 9 is required for normal hematpoietic development and protection from alkylator-induced DNA damage in mice  
  Lu EP, McLellan M, Ding L, Fulton R. Mardis ER, Wilson RK, Miller C, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, and Graubert TA, Blood, 1/1/2014
• Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer  
  Panni RA, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gilliam A, Link DC, Deardo DG, Goedegebuure SP, Linehan DC, Cancer Immunol Immunother, 1/1/2014
• Megakaryocytes in the hematopoietic stem cell niche  
  Day RB and Link DC, Nat Med, 1/1/2014
• Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing  
  Hughes AEO, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliot K, Hath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, ..., Plos Genetics, 1/1/2014
• Regulation of hematopoietic stem cells by bone marrow stromal cells  
  Anthony BA, and Link DC, Trends in immunology, 1/1/2014
• Regulation of hematopoietic stem cell activity by inflammation  
  Schuettpelz L and Link DC, Frontiers in Immunology, 7/1/2013
• SNAREing a new cause of neutropenia  
  Link DC, Blood Commentary, 1/1/2013
• CXCL12 production by early mesenchymal progenitors is required for hematopoietic stem cell maintenance  
  Greenbaum A, Hsu MS, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC, Nature, 1/1/2013
• Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia  
  Link DC, NEJM, 1/1/2013
• Molecular Genetics of AML  
  Link DC, Best Practice & Research Clinical Haematology, 1/1/2012
• N-cadherin in osteolineage cell is not required for maintenance of hematopoietic stem cells  
  Greenbaum AM, Revollo LD, Woloszynek JR, Civitelli R, and Link DC, Blood, 1/1/2012
• Kruppel like factor 7 suppresses hematopoietic stem and progenitor cell function  
  Schuettpelz L, Gopalan PK, Romine M, Fiuste F, and Link DC, Blood, 1/1/2012
• The origin and evolution of mutations in acute myeloid leukemia  
  Welch, J.S., Ley, T.J., Link, D.C. (co-first author), Miller, C.A., Larson, D.E., Koboldt, D.C., Wartman, L.D., Lamprecht, T.L., Liu, F., Xia, J., et al, Cell, 1/1/2012
• Regulation of neutrophil trafficking from the bone marrow  
  Day RB and Link DC, Cellular and Molecular Life Sciences, 1/1/2012
• Enhancing growth factor performance (Invited Commentary)  
  Yen-Michael S. Hsu and Link DC, Nat Med, 1/1/2012
• Clonal evolution in relapsed acute myeloid leukaemia revealed by whole genome sequencing  
  Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling D..., Nature, 1/1/2012
• Clonal architecture of secondary acute myeloid leukemia  
  Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidet H, Kalicki-Veizer J, O’Laughlin M, Fa..., NEJM, 1/1/2012
• Genomics of AML: Clinical Applications of Next Generation Sequencing  
  Blood, American Society of Hematology Education Program, 1/1/2011
• CXCR2 is the TPO of the iceberg (Inside Blood Commentary)  
  Greenbaum AM and Link DC, Blood, 1/1/2011
• Dual functions of cell-autonomous ADAM10 activity in granulopoiesis  
  Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, Takito J, Morioka H, Matsumoto M, Link DC, Chiba K, Okada Y, Toyama Y, Horiuch K, Blood, 1/1/2011
• Alterations in the bone marrow microenvironment contribute to oxidate stess and DNA damage in hematopoietic stem/progenitors carrying a Csf3r truncation mutation  
  Kunter G, Woloszynek JR, and Link DC, Experimental Hematology, 1/1/2011
• The identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML  
  Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Ivanovich J, LeBeau M, Koboldt DC, Dooling DJ, Fulton RS, Schmidt H, Maupin R, O’Laughin M, Chen K, McL..., JAMA, 1/1/2011
• Niche competition and cancer metastasis to bone (Invited Commentary)  
  Schuettpelz LG and Link DC, JCI, 1/1/2011
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Books/Book Chapters

• Cellular complexity of the bone marrow hematopoietic stem cell niche. 
  Calvi LM, and Link DC2014
• American Society of Hematology Self-Assessment Program (SAP) 
  Chapter: Myeloid disorders. 
  Link DC and Wun TEditors: Kahn MJ and Gregory S.American Society of Hematology PublishersEdition 3rd,2007
• Current topics in developmental biology. 
  Chapter: Mechanisms of disordered granulopoiesis in congenital neutropenia. 
  Grenda DS and Link DCEditors: Gerald P. Schatten.Elsevier Inc. Publishers2006
• Clinical applications of cytokines and growth factors. 
  Chapter: Mechanisms of growth factor mobilization of hematopoietic progenitors. 
  Link DCEditors: Wingard J.R., Demetri, G..Kluwer Academic Publishers, Norwell, MA2000
• Nathan and Oski’s Hematology of Infancy and Childhood 
  Chapter: Inherited bone marrow failure syndromes 
  Bessler M, Mason PJ, Link DC, and Wilson DBEditors: Orkin SH, Nathan DG, Ginsburg D, Look AT, and Fisher DE.Edition 7th,
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Abstracts/Posters

• Severe Chronic Neutropenia in the Large Granular Lymphocyte Syndrome: Outcomes in Response to Granulocyte Colony Stimulating Factor (G-CSF) and Immunosuppressive Thera...
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• CXCR4 Inhibition with BL-8040 in Combination with Nelarabine in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Canonical Signaling By TGF Family Members in Mesenchymal Stromal Cells Is Dispensable for Hematopoietic Niche Maintenance Under Basal and Stress Conditions
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• TGF-_ Signaling Contributes to Myelofibrosis and Clonal Dominance of Myeloproliferative Neoplasms
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

• New concepts in stem cell activity regulation. Invited Speaker 
  Denver, CO - 1/1/2013
• Chemokine Regulation of Neutrophil Trafficking. Invited Speaker 
  New Orleans, LA - 1/1/2013
• Genomics of AML (Invited Speaker) 
  San Francisco, CA - 1/1/2012
• AML in the Genomics Age, Education Session (Chair and Speaker) 
  San Diego, CA - 1/1/2011
• Hematology-Oncology Grand Rounds. Invited Speaker 
  Northwestern University - 1/1/2009
• Apoptosis Seminar Series. Invited Speaker 
  Houston, TX - 1/1/2008
• Neutrophils and Monocytes. Moderator 
  San Francisco, CA - 1/1/2008
• Plenary Scientific Session. Introducer 
  San Francisco, CA - 1/1/2008
• Regulation of Normal and Malignant Hematopoietic Stem cells. 
  1/1/2008
• Monocytes and Granulocytes. Moderator 
  Atlanta, GA - 1/1/2007
• Effect of SBDS mutations on Hematopoiesis. Invited Speaker 
  Boston, MA - 1/1/2007
• Herman B Wells Seminar Series. Invited Speaker 
  Indianapolis, IN - 1/1/2007
• Cancer Center Seminar Series. Invited Speaker 
  St. Louis University - 1/1/2007
• Frontiers in Medicine Seminar Series. Invited Speaker 
  Washington University - 1/1/2007
• Molecular Pathogenesis of Severe Congenital Neutropenia 
  Orlando, FL - 1/1/2006
• Regulation of Myelopoiesis Session. Invited Speaker 
  New London, CT - 6/1/2005
• Hematopoiesis: Microenvironment, cell adhesion, and mesenchymal stem cells. Moderator 
  San Francisco, CA - 1/1/2005
• Symposium on Regulation of Hematopoiesis. Invited Speaker 
  Seattle, WA - 1/1/2003
• Signaling and In Vivo Hematopoiesis. Moderator 
  Philadelphia, PA - 1/1/2002
• Workshop on Myeloid Development IInvited speaker) 
  Philadelphia, PA - 1/1/2002
• Molecular Structure of hematopoietic growth receptors. Moderator 
  Miami, FL - 1/1/1998
• Preclinical models of hematopoietic progenitor mobilization. 
  1/1/1997
• Cytokine regulation of granulopoiesis: Lessons from G-CSF receptor deficient mice. 
  1/1/1996
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