DannySchustMD

PubMed

• Luteal Phase Defects and Progesterone Supplementation.
  Lucas C Collins, Luke A Gatta, Sarah K Dotters-Katz, Jeffrey A Kuller, Danny J Schust> ;Obstetrical & Gynecological Survey. 2024 Feb 1
• Phase I and II randomized clinical trial of an oral therapeutic vaccine targeting human papillomavirus for treatment of cervical intraepithelial neoplasia 2 and 3.
  Kei Kawana, Osamu Kobayashi, Yuji Ikeda, Hideaki Yahata, Takashi Iwata, Toyomi Satoh, Azusa Akiyama, Daichi Maeda, Yumiko Hori-Hirose, Yukari Uemura, Kaori Nakayama-Ho...> ;JNCI Cancer Spectrum. 2023 Oct 31
• Controlling Trophoblast Cell Fusion in the Human Placenta-Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1.
  Jun Sugimoto, Danny J Schust, Makiko Sugimoto, Yoshihiro Jinno, Yoshiki Kudo> ;Biomolecules. 2023 Nov 7
• In Reply.
  Kassie J Bollig, Danny J Schust> ;Obstetrics and Gynecology. 2023 Nov 1
• 3 citations
  Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes.
  Lyndsey E Shorey-Kendrick, Victoria H J Roberts, Rahul J D'Mello, Elinor L Sullivan, Susan K Murphy, Owen J T Mccarty, Danny J Schust, Jason C Hedges, A J Mitchell, Jo...> ;Clinical Epigenetics. 2023 Jul 6
• 1 citations
  Cannabis and Pregnancy: A Review.
  Sarena Hayer, Ava D Mandelbaum, Lester Watch, Kimberly S Ryan, Madeline A Hedges, Jennifer A Manuzak, Charles A Easley 4th, Danny J Schust, Jamie O Lo> ;Obstetrical & Gynecological Survey. 2023 Jul 1
• 2 citations
  An epigenetic synopsis of parental substance use.
  Jamie O Lo, Rahul J D'Mello, Lester Watch, Danny J Schust, Susan K Murphy> ;Epigenomics. 2023 Apr 1
• 1 citations
  Ectopic Pregnancy and Lifesaving Care.
  Kassie J Bollig, Hilary Friedlander, Danny J Schust> ;JAMA. 2023 Jun 20
• Reproductive Scientist Development Program: Bridging the Gap to the Physician Scientist Career.
  Jamie O Lo, Emily R Boniface, Amanda Heflin, Aleksandar K Stanic-Kostic, Katherine C Fuh, Danny J Schust> ;Reproductive Sciences. 2023 Sep 1
• 4 citations
  Basolateral secretions of human endometrial epithelial organoids impact stromal cell decidualization.
  Harriet C Fitzgerald, Andrew M Kelleher, Chaman Ranjit, Danny J Schust, Thomas E Spencer> ;Molecular Human Reproduction. 2023 Apr 3
• The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-deriv...
  Jie Zhou, Yuchen Tian, Ying Qu, Madyson Williams, Ye Yuan, Rowan M Karvas, Megan A Sheridan, Laura C Schulz, Toshihiko Ezashi, Michael R Roberts, Danny J Schust> ;Frontiers in Endocrinology. 2023 Jan 1
• 5 citations
  Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta.
  Jun Sugimoto, Danny J Schust, Tomomi Yamazaki, Yoshiki Kudo> ;Scientific Reports. 2022 Jun 22
• 1 citations
  Leveraging Optimized Transcriptomic and Personalized Stem Cell Technologies to Better Understand Syncytialization Defects in Preeclampsia.
  Sehee Choi, Teka Khan, R Michael Roberts, Danny J Schust> ;Frontiers in Genetics. 2022 Jan 1
• 60 citations
  Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses.
  Evan A. Bordt, Lydia L. Shook, Caroline Atyeo, Krista M. Pullen, Rose M. De Guzman, Marie-Charlotte Meinsohn, Maeva Chauvin, Stephanie Fischinger, Laura J. Yockey, Kai...> ;Science Translational Medicine. 2021 Oct 19
• 7 citations
  Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?
  Jun Sugimoto, Sehee Choi, Megan A. Sheridan, Iemasa Koh, Yoshiki Kudo, Danny J. Schust> ;International Journal of Molecular Sciences. 2021 Sep 23
• 6 citations
  Is SARS-CoV-2 infection a risk factor for early pregnancy loss? ACE2 and TMPRSS2 co-expression and persistent replicative infection in primitive trophoblast.
  Jie Zhou, Sehee Choi, H Liu, J Zhang, Yuchen Tian, Andrea G. Edlow, Toshihiko Ezashi, R. M. Roberts, Wenjun Ma, Danny J. Schust> ;The Journal of Infectious Diseases. 2021 Jul 22
• 7 citations
  Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?
  Lydia L. Shook, Evan A. Bordt, Marie-Charlotte Meinsohn, David Pépin, Rose M. De Guzman, Sara Brigida, Laura J. Yockey, Kaitlyn E. James, Mackenzie W. Sullivan, Lisa M...> ;The Journal of Infectious Diseases. 2021 Jul 22
• 18 citations
  Placental structural abnormalities in gestational diabetes and when they develop: A scoping review.
  Erin Ehlers, Omonseigho O. Talton, Danny J. Schust, Laura C. Schulz> ;Placenta. 2021 Apr 26
• 12 citations
  Modeling human peri-implantation placental development and function†.
  Jie Zhou, Rachel West, Erin Ehlers, Toshihiko Ezashi, Laura C. Schulz, R. M. Roberts, Ye Yuan, Danny J. Schust> ;Biology of Reproduction. 2021 Jul 2
• 12 citations
  Sexually dimorphic placental responses to maternal SARS-CoV-2 infection
  Evan A. Bordt, Lydia L. Shook, Caroline Atyeo, Krista M. Pullen, Rose M. De Guzman, Marie-Charlotte Meinsohn, Maeva Chauvin, Stephanie Fischinger, Laura J. Yockey, Kai...> ;Biorxiv. 2021 Mar 29
• 8 citations
  The Immunology of Syncytialized Trophoblast
  Danny J. Schust, Elizabeth A. Bonney, Jun Sugimoto, Toshi Ezashi, R. Michael Roberts, Sehee Choi, Jie Zhou> ;International Journal of Molecular Sciences. 2021 Feb 10
• 33 citations
  Syncytins expressed in human placental trophoblast.
  R. Michael Roberts, Toshihiko Ezashi, Laura C. Schulz, Jun Sugimoto, Danny J. Schust, Teka Khan, Jie Zhou> ;Placenta. 2021 Jan 15
• 10 citations
  Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice.
  Hiroko Oda, Takeshi Nagamatsu, Danny J. Schust, Horacio Cabral, Takuya Miyazaki, Takayuki Iriyama, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii> ;Endocrinology. 2021 Apr 1
• 4 citations
  A rational diagnostic approach to the "phantom hCG" and other clinical scenarios in which a patient is thought to be pregnant but is not.
  Oluwafunmilayo Oyatogun, Mandeep Sandhu, Stephanie Barata-Kirby, Erin Tuller, Danny J. Schust> ;Therapeutic Advances in Reproductive Health. 2021 Jan 1
• 11 citations
  Single Nucleus RNA Sequence (snRNAseq) Analysis of the Spectrum of Trophoblast Lineages Generated From Human Pluripotent Stem Cells in vitro.
  Teka Khan, Arun S. Seetharam, Jie Zhou, Nathan J. Bivens, Danny J. Schust, Toshihiko Ezashi, Geetu Tuteja, R. Michael Roberts> ;Frontiers in Cell and Developmental Biology. 2021 Jan 1
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Journal Articles

• Early Onset Preeclampsia in a Model for Human Placental Trophoblast  
  Danny J Schust, R Michael Roberts, Proceedings of the National Academy of Sciences
• Differentiation of Trophoblast Cells from Human Embryonic Stem Cells: To be or not to be  
  Roberts RM, Loh K, Amita M, Bernardo AS, Adachi K, Alexenko AP, Schust DJ, Schulz LC, Telugu B, Ezashi T, Pedersen RA, Reproduction, 1/1/2014
• Emerging roles of lysophospholipid mediators in pregnancy  
  Nagamatsu T, Iwasawa-Kawai Y, Ichikawa M, Kawana K, Yamashita T, Fujii T, Schust DJ, Am J Reprod Immunol, 1/1/2014
• Modeling preeclampsia: an emerging role for stem cells  
  Stephens AJ, Karvas RM, Adachi K, Schulz LC, Schust DJ, 1/1/2014
• Genetic aspects of recurrent pregnancy loss  
  Hyde KJ, Schust DJ, 1/1/2014
• Maternal hypothyroidism and pregnancy loss: Awaiting firm recommendations on testing and treatment  
  Lovegreen J, Schust DJ, Gynecol Obstet Curr Research, 1/1/2013
• Adapting cervical dysplasia screening, treatment and prevention approaches to low resource settings  
  Vonder Haar E, Kawana K, Schust DJ, Int J STD Res Rev, 1/1/2013
• Re-examining sonographic cut-off values for diagnosing early pregnancy loss  
  Bickhaus J, Perry E, Schust DJ, Gynecol Obstet Curr Research, 1/1/2013
• The Prevalence Of Cervical Regulatory T Cells in HPV-Related Cervical Intraepithelial Neoplasia (CIN) Correlates Inversely with Spontaneous Regression of CIN  
  Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Miura S, Adachi K, Nagamatsu T, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Wada-Hiraike O, Yano T, Taketani Y, Fuj..., Am J Reprod Immunol, 1/1/2013
• Complete and unidirectional conversion of human embryonic stem Cells to trophoblast by BMP4: Validation of the Model  
  Amita M, Adachi K, Alexenko AP, Sinha S, Schust DJ, Schulz LC, Roberts RM, Ezashi T, PNAS, 1/1/2013
• Suppressyn is a human endogenous retroviral protein that inhibits cell fusion  
  Sugimoto J, Sugimoto M, Jinno Y, Bernstein H, Schust DJ, Sci Rep, 1/1/2013
• Comparison of extravillous trophoblast cells derived from human embryonic stem cells from first trimester human placentas  
  Telugu B, Adachi K, Schust DJ, Schlitt JM, Ezashi T, Roberts RM, Schulz LC, Placenta, 1/1/2013
• Dendritic cells in the female reproductive tract: isolation and characterization  
  Schust DJ, Am J Reprod Immunol, 1/1/2013
• Modulation of innate immunity by Chlamydia trachomatis in endocervical epithelial cells  
  Buckner LR, Lewis ME, Schust DJ, Foster TP, Quayle AJ, Am J Reprod Immunol, 1/1/2013
• Pre-eclampsia: Novel trophoblast models  
  Schlitt J, Jackson D, Schulz L, Schust DJ, Disease Models and Mechanisms, 1/1/2012
• Advances in antichlamydial antibody screening for tubal factor infertility  
  Beffa LB, Stephens AJ, Zhong G, Aubuchon M, Schust DJ, Sexuality, Reprod and Menop, 1/1/2012
• Mucosal co-infections and HIV-1 transmission and pathogenesis  
  Schust DJ, Quayle AJ, Amedee AM, Current HIV Research, 1/1/2012
• Chlamydia: a much underestimated STI  
  Schust DJ (Attributed Quotes): Senior, K, Lancet ID, 1/1/2012
• A possible coagulation-independent mechanism for pregnancy loss involving Beta(2) glycoprotein 1-dependent antiphospholipid antibodies and CD1d  
  Iwasawa Y, Kawana K, Fujii T, Nagamatsu T, Schust DJ, Miura S, Matsumoto J, Hyodo H, Yamashita T,Kozuma S, Taketani Y, Am J Reprod Immunol, 1/1/2012
• Modulation of inhibitory NK cell ligands on the surface of endocervical epithelial cells in the presence of C trachomatis infection promotes NK-mediated killing of inf...  
  Ibana JA, Quayle AJ, Schust DJ, Immunol Med Microbiol, 1/1/2012
• Hyperosmolar glucose injection for treatment of heterotopic ovarian pregnancy: A case report  
  Allison JL, Aubuchon M, Leasure JD, Schust DJ, Obstet Gynecol, 1/1/2012
• Potential mechanisms for increased HIV-1 transmission across the endocervical epithelium during C trachomatis infection  
  Schust DJ, Ibana JA, Buckner LR, Ficarra M, Sugimoto J, Amedee AM, Quayle AJ, Current HIV Research, 1/1/2012
• Manuscripts are the sum of their parts (In reply)  
  Schust D, Aubuchon M, Allison J, Obstet Gynecol, 1/1/2012
• Preeclampsia: Animal models for a human cure  
  Aubuchon M, Schulz LC, Schust DJ, Proc Natl Acad Sci, USA, 1/1/2011
• Management of first trimester pregnancy loss can be safely moved into the office  
  Alison JL, Sherwood RS, Schust DJ, Rev Obstet Gynecol, 1/1/2011
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Books/Book Chapters

• Maternal Sepsis in Low Resource Settings. A World Health Organization and Global Library of Women's Medicine initiative. 
  Asay K, Vonder Haar E, Schust DJLippincott, Williams & Wilkins, Baltimore, MD2014
• Principles of Metabolism in Health and Disease. 
  Chapter: The Reproductive System. 
  Page 369 - 377Gullicks D, Schust DJEditors: Lammert E and Zeeb M.Springer Publishing Co., Inc., New York, NY2014
• Contraception and Pregnancy in Rheumatic Disease Patients. 
  Chapter: Immunology of Pregnancy. 
  Page 1 - 30Stephens AJ, Schust DJEditors: Sammaritano L and Bermas B.Springer2014
• Global Library of Women's Medicine. 
  Chapter: Immunology of Isolated and Recurrent Pregnancy Loss. 
  Hyde KJ, Andelin CO, Schust DJ2014
• A Global Library of Women's Medicine initiative with advice from the World Health Organization and Unicef. 
  Schust DJ, Vonder Haar E, Lematta K2014
• Human Reproduction at a glance. 
  Heffner LJ, Schust DJBlackwell Science Ltd., Oxford, Great Britain2014
• Yen and Jaffe's Reproductive Endocrinology. 
  Chapter: Immunology and Reproduction. 
  Page 287 - 307Kutteh W, Stovall D, Schust DJEditors: Strauss J and Barbieri R.WB Saunders Co., Harcourt Health Sciences, Philadelphia, PAEdition 7th,2013
• Infection, Immune Homeostasis and Immune Privilege. 
  Chapter: The mechanisms underlying maternal-fetal tolerance and their relevance to the etiology of perinatal infectious diseases. 
  Page 53 - 92Nagamatsu T, Jackson DL, Schust DJEditors: Stein-Streilein J.2013
• Reproductive Endocrinology and Infertility: Handbook for Clinicians. 
  Chapter: Recurrent Pregnancy Loss. 
  Page 335 - 355Schust DJEditors: Lebovic DI, Gordon JD, Taylor RN.Scrub Hill Press, Glen Cove, NYEdition 2nd,2013
• Good News-Bad News: Two faces of Immune Privilege. 
  Chapter: Manifestations of immune tolerance in the human female reproductive tract. 
  Page 26 - 39Clark GF, Schust DJEditors: Caspi RR and Stein-Streilein J.Front Immunol Tol2013
• Chlamydia. 
  Chapter: Host-pathogen co-evolution: Chlamydial trachomatis modulates surface ligand expression in genital epithelial cells to evade immune recognition. 
  Caesar G, Ibana J, Kawana K, Quayle AJ, Schust DJInTech publishers2012
• Maternal-Fetal Medicine. 
  Chapter: Preimplantation Genetic Testing. 
  Miller C, Schust DJ, Aubuchon MInforma Healthcare, London, UKEdition 2nd,2012
• Sub-Saharan Africa: A primer. A World Health Organization and Global Library of Women's Medicine initiative. 
  Chapter: Prevention of HIV transmission in at risk populations. 
  Vonder Haar E, Schust DJLippincott, Williams & Wilkins, Baltimore, MD2012
• Gynecology and Obstetrics. 
  Chapter: Hypothalamic hypogonadism. 
  Jackson DL, Schust DJLippincott, Williams & Wilkins, Baltimore, MD2012
• The Placenta: from Development to Disease. 
  Chapter: The role of the placenta autoimmune disease and early pregnancy loss. 
  Page 215 - 221Jackson DL, Schust DJEditors: Kay H, Nelson DM and Wang Y.Wiley-Blackwell Publishing, Inc., Hoboken, NJ2011
• Maternal-Fetal Medicine. 
  Chapter: Recurrent Pregnancy Loss. 
  Ryan CE, Schust DJEditors: Winn HN, Chervenak FA and Romero R.Informa Healthcare, London, UKEdition 2nd,2011
• Maternal-Fetal Medicine. 
  Chapter: Chlamydial infections. 
  Ibana J, Schust DJEditors: Winn HN, Chervenak FA and Romero R.Informa Healthcare, London, UKEdition 2nd,2011
• Human Reproduction at a glance. 
  Heffner LJ, Schust DJBlackwell Science Ltd., Oxford, Great Britain2010
• Yen and Jaffe's Reproductive Endocrinology 
  Chapter: Reproductive Immunology and its Disorders. 
  Barrier B, Gargiulo A, Schust DJEditors: Strauss J and Barbieri R.WB Saunders Co., Philadelphia, PAEdition 6th,2008
• Gynecology and Obstetrics 
  Chapter: Immunology of Spontaneous and Recurrent Pregnancy Loss. 
  Andelin CO, Schust DJEditors: Sciarra, JJ.Lippincott, Williams & Wilkins, Baltimore, MD2008
• Human Reproduction at a glance. 
  Heffner LJ, Schust DJBlackwell Science Ltd., Oxford, Great Britain2006
• Novak's Gynecology 
  Chapter: Infertility. 
  Burney RO, Schust DJ, Yao MEditors: Berek JS, Adashi E, Hilliard P.William & Wilkins, Baltimore, MDEdition 14th,2006
• Novak's Gynecology 
  Chapter: Recurrent Spontaneous Early Pregnancy Loss. 
  Fox-Lee L, Schust DJEditors: Berek JS, Adashi E, Hilliard P.William & Wilkins, Baltimore, MDEdition 14th,2006
• Reproductive Endocrinology and Infertility: Handbook for Clinicians 
  Chapter: Recurrent Pregnancy Loss. 
  Page 278 - 297Schust DJEditors: Lebovic DI, Gordon JD, Taylor RN.Scrub Hill Press, Glen Cove, NYEdition 1st,2005
• Reproductive Endocrinology and Infertility: Handbook for Clinicians 
  Chapter: Luteal Phase Deficiency. 
  Page 260 - 264Schust DJEditors: Lebovic DI, Gordon JD, Taylor RN.Scrub Hill Press, Glen Cove, NYEdition 1st,2005
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Abstracts/Posters

• Identification of a potential receptor for suppressyn, a novel protein that inhibits trophoblast syncytialization.
  Hall DG, 2011 European Society for Human Reproduction and Endocrinology, Stockholm, Sweden, 1/1/2011
• Feto-maternal immunologic interactions mediated by inducible costimulator (ICOS) signaling.
  Hall DG, American Society for Reproductive Medicine's 66th Annual Meeting, Denver, CO, 1/1/2010
• Suppressyn is a human endogenous retroviral protein that inhibits cell fusion.
  Hall DG, 56th Annual Meeting of The Japan Society of Human Genetics, Tokyo, Japan, 1/1/2010
• The promoter activity of placental HERV type-Fb and its epigenetic regulation.
  Hall DG, The Society for the Study of Reproduction Annual Meeting Annual Meeting, Kona, HI, 1/1/2008
• Expression of surface CD1d in the extravillous trophoblast cells of early gestation placenta is downregulated in a manner dependent on trophoblast differentiation.
  Hall DG, The International Society for Reproductive Immunology Annual Meeting, Opatija, Croatia, 1/1/2007
• Expression of GATA-3, a key transcription factor for T helper cell type 2 (Th2) development, is regulated in trophoblast cells by reproductive hormone exposure.
  Hall DG, Annual meeting, The Society for Gynecologic Investigation, Toronto, Canada, 1/1/2006
• Murine female reproductive tract intraepithelial lymphocytes display both peripheral and mucosal selection characteristics.
  Gould DS, Ploegh H, Schust DJ, Annual meeting, The Second International Conference on Experimental and Clinical Reproductive Immunobiology, Amsterdam, The Netherlands, 1/1/2000
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Lectures

• Evidence-based immune testing and treatment in infertility. 
  1/1/2014
• Disorders of steroid hormone biosynthesis. 
  1/1/2014
• Derivation of trophoblast stem cells from human embryonic stem cells. 
  Florence, Italy - 1/1/2014
• Higher sensitivity to oxidative stress in umbilical cord fibroblasts derived from preeclampsia patients. 
  1/1/2014
• Trophoblast cells generated from human induced pluripotent stem cells (iPSCs) derived from umbilical cord by using BMP4 can be disease models for early placental disor... 
  Honolulu, HI - 1/1/2014
• Should One Biopsy for the Diagnosis of Chronic Endometritis in Recurrent Pregnancy Loss? A Debate. 
  Honolulu, HI - 1/1/2014
• Recurrent Implantation Failure: Defining, Evaluating and Treating. 
  Honolulu, HI - 1/1/2014
• Cells with features of totipotency derived from human ESC and iPSC. 
  Grand Rapids, MI - 1/1/2014
• Modeling the earliest events in preeclampsia using stem cells. 
  Tokyo, Japan - 1/1/2014
• Trophoblast stem cell derived from human embryonic stem cell. 
  Florence, Italy - 1/1/2014
• Sexually Transmitted Infections. 
  1/1/2013
• Fertility: Diagnosis, work-up and treatment. 
  1/1/2013
• Congenital anomalies of the female genital tract. 
  1/1/2013
• Recurrent Pregnancy Loss. 
  Multiple Locations, 2009, 2010, 2011, 2012, 2013 - 1/1/2013
• Can We Model Human EVT Differentiation Using Stem Cells? 
  Columbia, MO - 1/1/2013
• Higher sensitivity to oxidative stress in umbilical cord fibroblast derived from preeclampsia patients. 
  Montreal, Canada - 1/1/2013
• Modulation of innate immunity by Chlamydia trachomatis in endocervical epithelial cells. 
  Boston, MA - 1/1/2013
• Short term exposure to BMP4 and inhibitors of activin and FGF signaling generates a valuable trophoblast model from human stem cells. 
  Boston, MA - 1/1/2013
• Retroviruses and Placentation. 
  Boulder, CO - 1/1/2013
• Diagnosis and Management of Congenital anomalies of the female genital tract. 
  Madison, WI - 1/1/2013
• Retroviral involvement in human placentation. 
  Orlando, FL - 1/1/2013
• Dendritic cells in the female reproductive tract: isolation and characterization. 
  Boston, MA - 1/1/2013
• Could a novel, retrovirally-derived inhibitor of trophoblast syncytialization play a role in limiting cell fusion between extravillous trophoblast and maternal decidua? 
  London, UK - 1/1/2013
• Microscopic Diagnosis of Common Parasites. 
  San Juan La Laguna, Guatemala, 2013; San Pablo La Laguna, Guatemala, 2013 - 1/1/2013
• Generation of extravillous trophoblast and syncytiotrophoblast from human pluripotent stem cells: a model for differentiation of the placenta. 
  Montreal, Canada - 1/1/2013
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