DavidMBrizelMDFASTRO

Radiation Oncology • Durham, NC

Head & Neck, Skin Cancer

Professor of Radiation Oncology, Duke University

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Office
20 Duke Medicine Circle
Durham, NC 27710
Phone+1 919-660-2100
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Education & Training

Brigham and Women's Hospital/Joint Center for Radiation TherapyResidency, Radiation Oncology, 1984 - 1987
Beth Israel Deaconess Medical CenterInternship, Internal Medicine, 1983 - 1984
Northwestern University The Feinberg School of MedicineClass of 1983

Certifications & Licensure

NC State Medical License 1987 - 2025
FL State Medical License 2013 - 2017
VA State Medical License 1991 - 2006
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2003-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2005-2013

Clinical Trials

EF5 Compared With Other Methods of Detecting Oxygen Levels in Tumor Cells of Patients With Head and Neck Cancer Start of enrollment: 2002 Aug 01
Completed
Phase 2
Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer Start of enrollment: 2005 Aug 01
Completed
Early Phase 1
Caphosol for the Reduction of Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer Start of enrollment: 2009 May 01
Unknown status
Phase 1, Phase 2
Functional Imaging of Tumor and Normal Tissue Start of enrollment: 2009 Oct 01
Terminated
TRYHARD: Radiation Therapy Plus Cisplatin With or Without Lapatinib in Treating Patients With Head and Neck Cancer. Start of enrollment: 2013 Mar 15
Completed
Phase 2
Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx Start of enrollment: 2021 Apr 12
Recruiting
Not Applicable
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Publications & Presentations

PubMed

Prognostic value of different discretization parameters influorodeoxyglucose positron emission tomography radiomics of oropharyngeal squamous cell carcinoma.
Breylon A Riley, Jack B Stevens, Xiang Li, Zhenyu Yang, Chunhao Wang, Fang-Fang Yin, Kyle J Lafata, Yvonne M Mowery, David M Brizel> ;Journal of Medical Imaging. 2024 Mar 1
1 citations
Radiomics on spatial-temporal manifolds via Fokker-Planck dynamics.
Stevens, J., Riley, B., Je, J., Gao, Y., Wang, C., Yin, F., Liu, J., Lafata, K., Mowery, Y., Brizel, D.> ;Medical Physics. 2024 Jan 8
2 citations
Clinical outcomes of oropharyngeal squamous cell carcinoma stratified by human papillomavirus subtype: A systematic review and meta-analysis.
Rachel F Shenker, Niema B Razavian, Ralph B D'Agostino Jr, Yvonne M Mowery, David M Brizel, Ryan T Hughes> ;Oral Oncology. 2024 Jan 1
1 citations
Long-term risk of carotid stenosis and cerebrovascular disease after radiation therapy for head and neck cancer.
David J Carpenter, Pranalee Patel, Donna Niedzwiecki, Mairead Dillon, Alexander K Diaz, Abhishek Kumar, Yvonne M Mowery, Kerri-Anne Crowell, Rachel D'Anna, Qiuwen Wu, ...> ;Cancer. 2023 Oct 28
Low contralateral neck recurrence risk with ipsilateral neck radiotherapy in N2b tonsillar squamous cell carcinoma.
Divya Natesan, Christina K Cramer, Taofik Oyekunle, Donna Niedzwiecki, David M Brizel, Yvonne M Mowery> ;Oral Oncology. 2023 Apr 1
3 citations
The Affordable Care Act and suicide incidence among adults with cancer.
Justin M Barnes, Evan M Graboyes, Eric Adjei Boakye, Erin E Kent, Jeffrey F Scherrer, Eliza M Park, Donald L Rosenstein, Yvonne M Mowery, Junzo P Chino, David M Brizel...> ;Journal of Cancer Survivorship. 2023 Apr 1
229 citations
NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022.
Jimmy J Caudell, Maura L Gillison, Ellie Maghami, Sharon Spencer, David G Pfister, Douglas Adkins, Andrew C Birkeland, David M Brizel, Paul M Busse, Anthony J Cmelak, ...> ;Journal of the National Comprehensive Cancer Network. 2022 Mar 1
4 citations
Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.
Hangjie Ji, Kyle Lafata, Yvonne Mowery, David Brizel, Andrea L Bertozzi, Fang-Fang Yin, Chunhao Wang> ;Frontiers in Oncology. 2022 Jan 1
1 citations
A systematic review on sinonasal mixed adenoneuroendocrine carcinoma
Khalil Issa, Blaine D. Smith, Samantha J. Kaplan, John F. Madden, David W. Jang, Ali R. Zomorodi, David M. Brizel, Ralph Abi Hachem> ;International Forum of Allergy & Rhinology. 2021 May 19
16 citations
Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.
Kyle Lafata, Yushi Chang, Chunhao Wang, Yvonne M. Mowery, Irina Vergalasova, Donna Niedzwiecki, David S. Yoo, Jian-Guo Liu, David M. Brizel, Fang-Fang Yin> ;Medical Physics. 2021 Jul 1
34 citations
Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis
Claire Petit, Benjamin Lacas, Jean-Pierre Pignon, Quynh-Thu Le, Vincent Grégoire, Cai Grau, Allan Hackshaw, Björn Zackrisson, Mahesh K. B. Parmar, Ju-Whei Lee, Maria G...> ;The Lancet. Oncology. 2021 May 1
124 citations
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.
Benjamin Lacas, Alexandra Carmel, Cécile Landais, Stuart J. Wong, Lisa Licitra, Jeffrey S Tobias, Barbara Burtness, Maria Grazia Ghi, Ezra E.W. Cohen, Cai Grau, Gregor...> ;Radiotherapy and Oncology. 2021 Mar 1
Establishing ADC-Based Histogram and Texture Features for Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.
A Rodrigues, Kelly Loman, Jeff Nawrocki, Jenny K. Hoang, Zheng Chang, Yvonne M. Mowery, Taofik Oyekunle, Donna Niedzwiecki, David M. Brizel, Oana Craciunescu> ;Frontiers in Oncology. 2021 Jan 1
8 citations
Adjuvant Radiation Therapy for Clinical Stage III Melanoma in the Modern Therapeutic Era
Richard J. Straker, Yun Song, James Sun, Adrienne B. Shannon, Leah S. Cohen, Elnara Muradova, Hala Daou, Kate Krause, Siming Li, Dennie T. Frederick, Kristen E. Rhodin...> ;Annals of Surgical Oncology. 2021 Jul 1
2 citations
Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.
April K.S. Salama, Manisha Palta, Christel Rushing, M. Angelica Selim, Kristen N. Linney, Brian G. Czito, David S. Yoo, Brent A. Hanks, Georgia M. Beasley, Paul J. Mos...> ;Clinical Cancer Research. 2021 Mar 1
12 citations
Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.
David J Thomson, David Palma, Matthias Guckenberger, Panagiotis Balermpas, Jonathan J Beitler, Pierre Blanchard, David Brizel, Wilfred Budach, Jimmy Caudell, June Corr...> ;Radiotherapy and Oncology. 2020 Oct 1
17 citations
Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.
Chunhao Wang, Chenyang Liu, Yushi Chang, Kyle Lafata, Yunfeng Cui, Jiahan Zhang, Yang Sheng, Yvonne M. Mowery, David M. Brizel, Fang-Fang Yin> ;Frontiers in Oncology. 2020 Aug 18
17 citations
Early 18F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.
Yvonne M. Mowery, Irina Vergalasova, Christel Rushing, Kingshuk Roy Choudhury, Donna Niedzwiecki, Qiuwen Wu, David S. Yoo, Shiva K. Das, Terence Z. Wong, David M. Brizel> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Aug 13
573 citations
Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
David G. Pfister, Sharon A. Spencer, David J. Adelstein, Douglas Adkins, Yoshimi Anzai, David M. Brizel, Justine Yang Bruce, Paul M. Busse, Jimmy J. Caudell, Anthony J...> ;Journal of the National Comprehensive Cancer Network. 2020 Jul 1
3 citations
Development and Implementation of an Educational Simulation Workshop in Fiberoptic Laryngoscopy for Radiation Oncology Residents.
J.G. Price, Daphna Y. Spiegel, David S. Yoo, Michael J. Moravan, Yvonne M. Mowery, Donna Niedzwiecki, David M. Brizel, Joseph K. Salama> ;International Journal of Radiation Oncology, Biology, Physics. 2020 May 14
29 citations
Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement.
David J Thomson, David Palma, Matthias Guckenberger, Panagiotis Balermpas, Jonathan J Beitler, Pierre Blanchard, David Brizel, Wilfred Budach, Jimmy Caudell, June Corr...> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Jul 15
15 citations
Treatment Outcomes in Anaplastic Thyroid Cancer.
Kelsey L. Corrigan, Hannah Williamson, Danielle Elliott Range, Donna Niedzwiecki, David M. Brizel, Yvonne M. Mowery> ;Journal of Thyroid Research. 2019 May 23
391 citations
NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018
A. Dimitrios Colevas, Sue S. Yom, David G. Pfister, Sharon A. Spencer, David J. Adelstein, Douglas Adkins, David M. Brizel, Barbara Burtness, Paul M. Busse, Jimmy J. C...> ;Journal of the National Comprehensive Cancer Network. 2018 May 1
1 citations
Response to ASTRO consensus guideline for oropharyngeal cancer: In Regard to Walker et al
David J. Sher, David J. Adelstein, Gopal K. Bajaj, David M. Brizel, Ezra E.W. Cohen, Aditya Halthore, Louis B. Harrison, Charles Lu, Benjamin J. Moeller, Harry Quon, J...> ;Practical Radiation Oncology. 2017 Aug 5
52 citations
The risk of carotid stenosis in head and neck cancer patients after radiation therapy
David Carpenter, Yvonne M. Mowery, Gloria Broadwater, A Rodrigues, Amy J. Wisdom, Jennifer A. Dorth, Pretesh Patel, Cynthia K. Shortell, Robert W. Clough, David M. Brizel> ;Oral Oncology. 2018 May 1
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Lectures

Cancer Imaging and Radiation Therapy Symposium
American Society for Radiation Oncology, Lake Buena Vista, Florida - 2/8/2013

Press Mentions

Checkpoint Inhibitors with Surgery and Radiotherapy Offer Promise in Head and Neck CancersJune 6th, 2016
ASTRO Issues ‘Choosing Wisely’ ListOctober 25th, 2013