DavidDenofrioMD

Cardiology • Boston, MA

Heart Failure & Transplantation

Associate Professor, Medicine, Tufts Medical Center

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Office
800 Washington Street
Tufts Medical Center
Boston, MA 02111
Phone+1 617-636-8068

Fax+1 617-636-6030
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Summary

Dr. David Denofrio is a cardiologist at Tufts Medical. He received his medical degree from Tufts University School of Medicine and has been in practice 29 years. He specializes in adult cardiovascular disease and heart failure & transplantation.

Education & Training

Duke University HospitalFellowship, Cardiovascular Disease, 1991 - 1994
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1988 - 1991
Tufts University School of MedicineClass of 1988

Certifications & Licensure

MA State Medical License 1999 - 2025
NH State Medical License 2009 - 2025
RI State Medical License 1999 - 2024
ME State Medical License 2020 - 2021
PA State Medical License 1994 - 2000
NC State Medical License 1992 - 1999
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2011-2014
Boston Magazine Castle Connolly, 2010-2013
CMS Meaningful Use Stage 1 Certification eClinicalWorks EHR, eClinicalWorks LLC, 2012-2013
Fellow (FACC) American College of Cardiology
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Clinical Trials

Hyponatremia Registry for Patients With Euvolemic and Hypervolemic Hyponatremia Start of enrollment: 2010 Sep 01
Completed

Publications & Presentations

PubMed

9 citations
Impella 5.5 Support Beyond 50 Days as Bridge to Heart Transplant in End-Stage Heart Failure Patients.
Mina Zaky, Taylor Nordan, Navin K Kapur, Amanda R Vest, David DeNofrio, Frederick Y Chen, Gregory S Couper, Masashi Kawabori> ;ASAIO Journal. 2023 Apr 1
4 citations
Association between postoperative hemodynamic metrics of pulmonary hypertension and right ventricular dysfunction and clinical outcomes after left ventricular assist d...
Gaurav Gulati, E Wilson Grandin, David DeNofrio, Jenica N Upshaw, Amanda R Vest, Michael S Kiernan> ;The Journal of Heart and Lung Transplantation. 2022 Oct 1
1 citations
Accuracy of echocardiographic estimations of right heart pressures in adult heart transplant recipients.
Aadhavi Sridharan, Monica M Dehn, Craig Cooper, Vidya S Madineedi, Linda J Ordway, David DeNofrio, Ayan R Patel> ;Clinical Cardiology. 2022 Jul 1
6 citations
Durable Left Ventricular Assist Device as a Bridge to Heart Transplantation Under the New Donor Heart Allocation System.
Taylor Nordan, Andre C. Critsinelis, Jamel Ortoleva, Michael S. Kiernan, Amanda R. Vest, David DeNofrio, Frederick Y. Chen, Gregory S. Couper, Masashi Kawabori> ;ASAIO Journal. 2021 Oct 26
3 citations
Immunosuppression and Heart Transplantation.
Nilay Sutaria, Lynne M Sylvia, David DeNofrio> ;Handbook of Experimental Pharmacology. 2021 Oct 21
9 citations
Microaxial Left Ventricular Assist Device versus Intraaortic Balloon Pump as a Bridge to Transplant.
Taylor Nordan, A. Critsinelis, Shant H. Mahrokhian, Navin K. Kapur, Amanda R. Vest, David DeNofrio, Frederick Y. Chen, Gregory S. Couper, Masashi Kawabori> ;The Annals of Thoracic Surgery. 2021 Aug 19
3 citations
Factors associated with neutropenia post heart transplantation.
Jennifer K. Chow, Robin Ruthazer, Helen W. Boucher, Amanda R. Vest, D. DeNofrio, David R. Snydman> ;Transplant Infectious Disease. 2021 May 13
1 citations
The Impact of COVID-19 on Heart Transplantations and Waitlist Additions in the United States.
Shant H. Mahrokhian, Caroline J Liang, Taylor Nordan, Amanda R. Vest, Michael S. Kiernan, David DeNofrio, Gregory S. Couper, Masashi Kawabori> ;ASAIO Journal. 2021 May 4
2 citations
Left thoracotomy vs full sternotomy for centrifugal durable LVAD implantation: 1-year outcome comparison post-LVAD and post-heart transplantation
Camille E Hironaka, Bowei Deng, Masashi Kawabori, Andre C. Critsinelis, Y. Zhan, Frederick Y. Chen, Amanda R. Vest, David DeNofrio, Michael S. Kiernan, Gregory S. Couper> ;Journal of Artificial Organs. 2021 Mar 19
20 citations
Understanding Longitudinal Changes in Pulmonary Vascular Resistance After Left Ventricular Assist Device Implantation.
Gaurav Gulati, Robin Ruthazer, David DeNofrio, Amanda R. Vest, David M. Kent, Michael S. Kiernan> ;Journal of Cardiac Failure. 2021 Jan 12
4 citations
Patterns of Use of Temporary Mechanical Circulatory Support as a Bridge to Transplant During the Coronavirus Disease 2019 Pandemic.
Taylor Nordan, Gregory S. Couper, Frederick Y. Chen, Amanda R. Vest, David DeNofrio, Masashi Kawabori> ;Journal of Cardiac Failure. 2020 Sep 11
6 citations
A case series: the outcomes, support duration, and graft function recovery after VA-ECMO use in primary graft dysfunction after heart transplantation.
Masashi Kawabori, Michael Mastroianni, Y. Zhan, Frederick Y. Chen, Hassan Rastegar, Kenneth G. Warner, John Adam Reich, Amanda R. Vest, David DeNofrio, Gregory S. Couper> ;Journal of Artificial Organs. 2020 Jun 1
9 citations
Two-year outcomes and cost for heart failure patients following discharge from the hospital after an acute heart failure admission.
Natalia Olchanski, Amanda R. Vest, Joshua T. Cohen, David DeNofrio> ;International Journal of Cardiology. 2020 May 15
2 citations
Transcatheter Aortic Valve Replacement of a Bicuspid Aortic Valve in a Heart Transplant Recipient
Robert Beale, Charles Beale, David DeNofrio, Paul C. Gordon, Daniel Levine, Neel R. Sodha, Rayan Yousefzai, Eirini Apostolidou> ;JACC. Case Reports. 2020 May 1
19 citations
Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside
Carrie Butler, Michelle J. Hickey, Ning Jiang, Ying Zheng, David W. Gjertson, Qiuheng Zhang, Ping Rao, Gregory A. Fishbein, Martin Cadeiras, Mario C. Deng, Hector L. B...> ;American Journal of Transplantation. 2020 Oct 1
12 citations
Comparing inpatient costs of heart failure admissions for patients with reduced and preserved ejection fraction with or without type 2 diabetes.
Natalia Olchanski, Amanda R. Vest, Joshua T. Cohen, David DeNofrio> ;Cardiovascular Endocrinology & Metabolism. 2020 Feb 21
3 citations
Timing and Trends of Right Atrial Pressure and Risk of Right Heart Failure After Left Ventricular Assist Device Implantation
Gaurav Gulati, Nilay Sutaria, Amanda R. Vest, David DeNofrio, Masashi Kawabori, Gregory S. Couper, Michael S. Kiernan> ;Journal of Cardiac Failure. 2020 May 1
Antibody-mediated rejection 16 years post-cardiac transplantation: a case report of an uncommon late presentation in a middle-aged woman.
Charles A. S. Miller, Knarik Arkun, David DeNofrio, Marwa A. Sabe> ;European Heart Journal. Case Reports. 2019 Sep 1
34 citations
Preimplant Phosphodiesterase-5 Inhibitor Use Is Associated With Higher Rates of Severe Early Right Heart Failure After Left Ventricular Assist Device Implantation
Gaurav Gulati, E. Wilson Grandin, Kevin Kennedy, F. Cabezas, David DeNofrio, Robb D. Kociol, J. Eduardo Rame, Francis D. Pagani, James K. Kirklin, Robert L. Kormos, Je...> ;Circulation. Heart Failure. 2019 Jun 11
13 citations
The Neutrophil-Lymphocyte Ratio and Survival During Left Ventricular Assist Device Support.
Sakthi Sundararajan, Michael S. Kiernan, Gregory S. Couper, Jenica N. Upshaw, David DeNofrio, Amanda R. Vest> ;Journal of Cardiac Failure. 2019 Jan 15
33 citations
Increased Plasma-Free Hemoglobin Levels Identify Hemolysis in Patients With Cardiogenic Shock and a Trans valvular Micro-Axial Flow Pump.
Michele Esposito, Kevin J. Morine, Shiva Annamalai, Ryan O'Kelly, Nima Aghili, Robert Pedicini, Catalina Breton, Andrew Mullin, Anas Hamadeh, Michael S. Kiernan, David...> ;Artificial Organs. 2019 Feb 1
16 citations
Cost comparison across heart failure patients with reduced and preserved ejection fractions: Analyses of inpatient decompensated heart failure admissions.
Natalia Olchanski, Amanda R. Vest, Joshua T. Cohen, Peter J. Neumann, David DeNofrio> ;International Journal of Cardiology. 2018 Jun 15
13 citations
Outcomes After Continuous-Flow Left Ventricular Assist Device Implantation as Destination Therapy at Transplant Versus Nontransplant Centers.
D. Marshall Brinkley, David DeNofrio, Robin Ruthazer, Amanda R. Vest, Navin K. Kapur, Gregory S. Couper, Michael S. Kiernan> ;Circulation. Heart Failure. 2018 Mar 1
31 citations
Impact of Advanced Therapies for Improving Survival to Heart Transplant in Patients with Hypertrophic Cardiomyopathy.
Ethan J. Rowin, Barry J. Maron, Patrick Abt, Michael S. Kiernan, Amanda R. Vest, Fred Costantino, Martin S. Maron, David DeNofrio> ;The American Journal of Cardiology. 2018 Jan 31
4 citations
Disseminated mucormycosis masquerading as rejection early after orthotopic heart transplantation.
Lindsay Margoles, David DeNofrio, Ayan R. Patel, Yoav Golan, Amanda R. Vest, Knarik Arkun, Helen W. Boucher, Michael S. Kiernan, Jenica N. Upshaw> ;Transplant Infectious Disease. 2018 Feb 1
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Lectures

Cardiorenal Syndrome in Heart Failure: Balancing the Needs of the Heart and Kidney
2019 ACC Scientific Session & Expo, New Orleans - 3/18/2019

Press Mentions

Skydiver Back in the Air Following Heart TransplantOctober 16th, 2017
Tufts Surgeons Perform 2 Double Transplants on Same DayMarch 9th, 2017
Tufts Medical Center Ranks Among Top-10 Heart Transplant Centers in Nation for 2016January 10th, 2017