DavidGHarrisonMD

PubMed

• Legumain Regulates Regulatory T Cells in Hypertension.
  Alexander, M., Harrison, D.> ;Circulation Research. 2024 Jan 5
• 12 citations
  Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension.
  Justin P Van Beusecum, Natalia R. Barbaro, Charles D Smart, David M Patrick, Roxana Loperena, Shilin Zhao, Néstor de la Visitación, Mingfang Ao, Liang Xiao, Cyndya A. ...> ;Circulation Research. 2021 Nov 12
• 27 citations
  Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective.
  Eleanor Murray, Ryszard Nosalski, Neil MacRitchie, Maciej Tomaszewski, Pasquale Maffia, David G. Harrison, Tomasz J. Guzik> ;Cardiovascular Research. 2021 Oct 26
• 15 citations
  Innate immunity and clinical hypertension
  Justin P. Van Beusecum, Hietor Moreno, David G. Harrison> ;Journal of Human Hypertension. 2021 Oct 23
• 22 citations
  Tissue sodium stores in peritoneal dialysis and hemodialysis patients determined by 23-sodium magnetic resonance imaging.
  Melis Sahinoz, Supisara Tintara, Serpil Muge Deger, Aseel Alsouqi, Rachelle Crescenzi, Cindy Mambungu, Andrew Vincz, Olivia J Mason, Heather L. Prigmore, Andrew Guide,...> ;Nephrology, Dialysis, Transplantation. 2021 Jun 28
• 14 citations
  A Call to Action for New Global Approaches to Cardiovascular Disease Drug Solutions.
  Gemma A. Figtree, Keith Broadfoot, Barbara Casadei, Robert M. Califf, Filippo Crea, Grant R Drummond, Jane E. Freedman, Tomasz J. Guzik, David G. Harrison, Derek J. Ha...> ;Circulation. 2021 Jul 13
• 30 citations
  A call to action for new global approaches to cardiovascular disease drug solutions.
  Gemma A. Figtree, Keith Broadfoot, Barbara Casadei, Robert M. Califf, Filippo Crea, Grant R Drummond, Jane E. Freedman, Tomasz J. Guzik, David G. Harrison, Derek J. Ha...> ;European Heart Journal. 2021 Apr 14
• 70 citations
  Pathophysiology of Hypertension: The Mosaic Theory and Beyond.
  David G. Harrison, Thomas M. Coffman, Christopher S. Wilcox> ;Circulation Research. 2021 Apr 2
• 27 citations
  Isolevuglandin-Modified Cardiac Proteins Drive CD4+ T-Cell Activation in the Heart and Promote Cardiac Dysfunction
  Njabulo Ngwenyama, Annet Kirabo, Mark Aronovitz, Francisco Velazquez, Francisco J. Carrillo-Salinas, Ane M. Salvador, Tania Nevers, Venkataraman Amarnath, Albert K. Ta...> ;Circulation. 2021 Mar 23
• 6 citations
  Differences in perceptions of transition readiness between parents and teens with congenital heart disease: do parents and teens agree?
  David G. Harrison, Michelle Gurvitz, Sunkyung Yu, Ray Lowery, Katherine Afton, Angela T Yetman, Jonathan W. Cramer, Nancy Rudd, Scott Cohen, Russell Gongwer, Karen Uzark> ;Cardiology in the Young. 2021 Jan 11
• 114 citations
  Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta ...
  Yvonne Alexander, Elena Osto, Arno Schmidt-Trucksäss, Michael Shechter, Danijela Trifunovic, Dirk J. Duncker, Victor Aboyans, Magnus Bäck, Lina Badimon, Francesco Cose...> ;Cardiovascular Research. 2021 Jan 1
• 13 citations
  Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.
  David G. Harrison, Nicolas Boutard, Krzysztof Brzózka, Marta Bugaj, Stefan Chmielewski, Anna Cierpich, John R. Doedens, Charles-Henry Fabritius, Christopher A. Gabel, ...> ;Bioorganic & Medicinal Chemistry Letters. 2020 Dec 1
• 15 citations
  Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hype...
  Anna Dikalova, Vladimir Mayorov, Liang Xiao, Alexander Panov, Venkataraman Amarnath, Irene Zagol-Ikapitte, Aurelia Vergeade, Mingfang Ao, Valery Yermalitsky, Rafal R. ...> ;Hypertension. 2020 Oct 5
• 3 citations
  Immunity, inflammation and the vasculature in the COVID-19 era.
  Aletta E. Schutte, David G. Harrison> ;Journal of Hypertension. 2020 Sep 1
• 33 citations
  Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation.
  Natalia R. Barbaro, Justin P Van Beusecum, Liang Xiao, Luciana Simao do Carmo, Ashley Pitzer, Roxana Loperena, Jason D. Foss, Fernando Elijovich, Cheryl L. Laffer, Kim...> ;Cardiovascular Research. 2020 Jul 16
• 3558 citations
  Factors associated with COVID-19-related death using OpenSAFELY.
  Elizabeth A. Williamson, Alex J Walker, Krishnan Bhaskaran, Seb Bacon, Chris Bates, Caroline E Morton, Helen J Curtis, Amir Mehrkar, David M. Evans, Peter Inglesby, Jo...> ;Nature. 2020 Jul 8
• 4 citations
  E-vaporating benefits of e-vaping.
  Mateusz Siedlinski, David G. Harrison, Tomasz J. Guzik> ;European Heart Journal. 2020 Jul 7
• 14 citations
  Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension
  Joseph K. Prinsen, Prince J. Kannankeril, Tatiana N. Sidorova, Liudmila V. Yermalitskaya, Olivier Boutaud, Irene Zagol-Ikapitte, Joey V. Barnett, Matthew B Murphy, Tue...> ;JACC. Basic to Translational Science. 2020 Jun 1
• 41 citations
  Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
  Kevin Litchfield, Stacey Stanislaw, Lavinia Spain, Lisa L. Gallegos, Andrew Rowan, Desiree Schnidrig, Heidi Rosenbaum, Alexandre Harlé, Lewis Au, Samantha M. Hill, Zay...> ;Cell Reports. 2020 May 5
• 3 citations
  A New Look At the Mosaic Theory of Hypertension
  Rhian M. Touyz, Ross D. Feldman, David G. Harrison, Ernesto L. Schiffrin> ;The Canadian Journal of Cardiology. 2020 May 1
• 92 citations
  Inflammation in Hypertension
  Liang Xiao, David G. Harrison> ;The Canadian Journal of Cardiology. 2020 May 1
• 2 citations
  A T-Cell Small RNA With miRacle Effects on Aortic Stiffening
  David M Patrick, David G. Harrison> ;Circulation Research. 2020 Apr 10
• 17 citations
  Sympathetic Enhancement of Memory T-Cell Homing and Hypertension Sensitization.
  Liang Xiao, Luciana Simao do Carmo, Jason D. Foss, Wei Chen, David G. Harrison> ;Circulation Research. 2020 Mar 13
• 158 citations
  Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Ox...
  Anna Dikalova, Arvind K. Pandey, Liang Xiao, Liaisan Arslanbaeva, Tatiana N. Sidorova, Marcos G. Lopez, Frederic T. Billings, Eric Verdin, Johan Auwerx, David G. Harri...> ;Circulation Research. 2020 Feb 14
• 8 citations
  From Rags to Riches
  Meena S. Madhur, Annet Kirabo, Tomasz J. Guzik, David G. Harrison> ;Hypertension. 2020 Feb 10
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Journal Articles

• Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension  
  Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassegue B, Griendling KK, Harrison DG, Dikalova AE, Antioxid Redox Signal, 1/1/2014
• Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase  
  Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, and Harrison DG, Circ Res, 1/1/2014
• DC isoketal-modified proteins activate T cells and promote hypertension  
  Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K,..., J Clin Invest, 1/1/2014
• Oligoclonal CD8+ T Cells Play a Critical Role in the Development of Hypertension  
  Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani H, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, and Harrison DG, Hypertension, 1/1/2014
• Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension  
  Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin DC, and Farrow KN, Am J Physiol Lung Cell Mol Physiol, 1/1/2014
• GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus  
  Wolkow PP, Kosiniak-Kamysz W, Osmenda G, Wilk G, Bujak-Gizycka B, Ignacak A, Kanitkar M, Walus-Miarka M, Harrison DG, Korbut R, Malecki MT, and Guzik TJ, PLoS One, 1/1/2014
• From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production  
  Harrison DG, J Clin Invest, 1/1/2014
• Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations  
  Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, Miller AH, Brain Behav Immun, 1/1/2013
• Role of the NADPH Oxidases in the Subfornical Organ in Angiotensin II-Induced Hypertension  
  Lob HE, Schultz D, Marvar, PM, Davisson RL, Harrison DG, Hypertension, 1/1/2013
• Nitric Oxide reduces Cl-absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism  
  Pech V, Thumova M, Dikalov SI, Hummler E, Rossier BC, Harrison DG, Wall SM, Am J Physiol Renal Physiol, 1/1/2013
• Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling  
  Chow K, Fessel JP, Kaoriihida S, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Jr., Nozik-Grayck E, West JD, Klemm DJ, Majka SM, Pulm Circ, 1/1/2013
• Immune cells control skin lymphatic electrolyte homeostasis and blood pressure  
  Wiig H, Schroder A, Neuhofer W, Jantsch J, Kopp C, Karlsen TV, Boschmann M, Goss J, Bry M, Rakova N, Dahlmann A, Brenner S, Tenstad O, Nurmi H, Mervaala E, Wagner H, B..., J Clin Invest, 1/1/2013
• A common functional promoter variant links CNR1 gene expression to HDL cholesterol level  
  Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA, Nat Commun, 1/1/2013
• The Mosaic Theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension  
  Harrison DG, Journal of the American Society of Hypertension, 1/1/2013
• Knock, knock: Who's there? Nox1: Circulation  
  Itani HA, Dikalov S, Harrison DG, Circulation, 1/1/2013
• Senescent T Cells and Hypertension: New Ideas About Old Cells  
  Madhur MS, Harrison DG, Hypertension, 1/1/2013
• T Lymphocytes and Vascular Inflammation Contribute to Stress-Dependent Hypertension  
  Marvar PJ, Vinh A, Thabet S, Lob HE, Geem D, Ressler KJ, Harrison DG, Biological Psychiatry, 1/1/2012
• Endothelium-specific Sepiapterin Reductase Deficiency in DOCA-salt Hypertension  
  Youn JY, Wang T, Blair J, Laude KM, Oak JH, McCann LA, Harrison DG, Cai HL, Am J Physiol Heart Circ Physiol, 1/1/2012
• Report of the National Heart, Lung, and Blood Institute Working Group on Epigenetics and Hypertension  
  Cowley AW Jr, Nadeau JH, Baccarelli A, Berecek K, Fornage M, Gibbons GH, Harrison DG, Liang M, Nathanielsz PW, O'Connor DT, Ordovas J, Peng W, Soares MB, Szyf M, Tolun..., Hypertension, 1/1/2012
• Role of the Renin-Angiotensin System in the Pathogenesis of Intimal Hyperplasia: Therapeutic Potential for Prevention of Vein Graft Failure?  
  Osgood MJ, Harrison DG, Sexton KW, Hocking KM, Voskresensky IV, Komalavilas P, Cheung-Flynn J, Guzman RJ, Brophy CM, Ann Vasc Surg, 1/1/2012
• Vascular Inflammation in Hypertension  
  Harrison DG, Marvar PJ, Titze JM, Front Physiol, 1/1/2012
• Studies of the T-cell Angiotensin receptor using cre-lox technology: an unan-T-cellpated result  
  Harrison DG, Guzik TJ, Circ Res, 1/1/2012
• Stress-dependent hypertension and the role of T lymphocytes  
  Marvar PJ, Harrison DG, Exp Physiol, 1/1/2012
• Endoplasmic reticulum stress and hypertension-a new paradigm?  
  Hasty AH, Harrison DG, J Clin Invest, 1/1/2012
• Synapses, Signals, CDs, and Cytokines: Interactions of the Autonomic Nervous System and Immunity in Hypertension  
  Madhur MS, Harrison DG, Circ Res, 1/1/2012
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Books/Book Chapters

• Inflammatory Diseases of Blood Vessels 
  Chapter: Inflammatory Diseases of Blood Vessels. 
  Harrison DGEditors: Hoffman GS, Weyand CM, Langford CA, and Goronzy JJ.Blackwell Publishing Ltd.2012
• Medical Clinics of North America: Hypertensive Disease: Current Challenges, New Concepts and Management 
  Chapter: Oxidative stress and hypertension. 
  Page 621 - 635Harrison DG and Gongora MCEditors: Frohlich ED.Saunders, Philadelphia2009
• Surgery of the Chest 
  Chapter: Physiology of the Coronary Circulation. 
  Page 753 - 765Harrison DG, Doughan AR, Sellke FWEditors: Sellke Frank, del Nido Pedro J, Swanson Scott J.Elsevier Saunders, New York2005
• The Coronary Microcirculation and Angiogenesis 
  Page 65 - 106Voisine P, Wykrzykowska JJ, Boodhwani M, Harrison DG, Laham RJ, Sellke FWEditors: Laham R, Baim D.Humana Press, Totowa, NJ2005
• Antioxidants & Cardiovascular Disease 
  Chapter: Pharmacological Compounds with Antioxidant Activity. 
  Page 167 - 194Dikalov S, Harrison DGEditors: Bourassa, Martial G.; Tardif, Jean-Claude.Springer Publisher, New York, NY2005
• Molecular Mechanisms in Hypertension 
  Chapter: Oxidative events in cell and vascular biology. 
  Page 297 - 320Harrison DG, Dikalov SEditors: Re RN, DiPette DJ, Schiffrin E, Sowers JR.Taylor & Francis Medical Books, Quebec, Canada2005
• Vascular Biology Protocols, Methods in Molecular Medicine 
  Chapter: Detection of reactive oxygen species and nitric oxide in vascular cells: Comparison of sensitivity and specificity. 
  Cai H, Dikalov S, Griendling KK, Harrison DGEditors: Sreejayan N. and Ren J..Humana Press, Inc., New York2005
• Hurst's The Heart 
  Chapter: Biology of the vessel wall. 
  Page 135 - 154Griendling KK, Harrison DG, Alexander RWEditors: Fuster V, Alexander RW, and O'Rourke RA.McGraw-Hill, New York2004
• Hurst's The Heart 
  Chapter: Molecular and cellular biology of blood vessels. 
  Griendling KK, Harrison DG, Alexander RWEditors: Fuster V, Alexander RW, and O'Rourke RA.McGraw-Hill, New York2001
• Hypertension Primer 
  Chapter: Oxidative Stress and Hypertension. 
  Page 163 - 166Harrison DG, Galis Z, Parthasarathy S, Griendling KKLippincott, Williams & Wilkins, Baltimore1999
• Endothelium, Nitric Oxide, and Atherosclerosis 
  Chapter: Vascular Oxidant Stress and NO Bioactivity. 
  Page 133 - 144Zafari AM, Harrison DG, Griendling KKEditors: Richard O. Cannon and Julio A. Panza.Futura Publishing Company1999
• Oxidative Stress and Vascular Disease 
  Chapter: The role of oxidative stress in hypertension. 
  Somers MJ, Griendling KK, Harrison DGEditors: Keaney, JF, Jr..Kluwer Academic Publishers, Norwell1999
• Endocrinology of Cardiovascular Function 
  Chapter: Angiotensin II, oxidative stress and nitric oxide. 
  Page 79 - 98Griendling KK, Harrison DGEditors: Levin, E.R. and Nadler, J..Kluwer Academic Publishers, Norwell1998
• Coronary Microcirculation During Ischemia and Reperfusion 
  Chapter: Interactions of nitric oxide, superoxide and superoxide dismutase in the vessel wall: contributions to regulation of vasomotion. 
  Page 173 - 194Harrison DGEditors: Haunso S, Aldershvile J, Svendsen J.Munksgaard, Copenhagen1997
• Arteriosclerosis 
  Chapter: Endothelial Dysfunction in Atherosclerosis. 
  Page 87 - 102Harrison DGEditors: Just H, Hort W, Zeiher AM.Steinkipff Verlag Darmstadt1994
• Collateral Circulation 
  Chapter: Neurohumoral and Pharmacologic Regulation of Collateral Perfusion. 
  Page 329 - 343Harrison DGEditors: Schaper W and Schaper J.Kluwer Academic Publishers1993
• Preventive Aspects of Coronary Heart Disease 
  Chapter: Reversibility of Atherosclerosis. 
  Page 113 - 126Armstrong ML, Heistad DD, Megan MB, Lopez JAG, Harrison DGEditors: Frohlich, Ed., and Brest, AN.F.A. Davis Company1990
• Cardiovascular Significance of Endothelium-Derived Vasoactive Factors 
  Chapter: Endothelial Dysfunction in Atherosclerosis. 
  Page 263 - 280Harrison DG, Minor RL, Guerra R, Quillen JE, Sellke FWEditors: Rubanyi R.Futura Publishing Co.1990
• Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall 
  Chapter: Endothelial Regulation of Vasomotor Tone in Atherosclerosis. 
  Page 153 - 160Harrison DGEditors: Gotlieb AI, Langille BL, Fedoroff S.Plenum Press1990
• Resistance Arteries 
  Chapter: Harrison DG, Guerra R, Freiman PC, Armstrong ML 
  Page 54 - 67Harrison DG, Guerra R, Freiman PC, Armstrong MLEditors: Halpern W, Pegram BL, Brayden JE, Mackey K, McLaoughlin MK, and Osol G.Perinatology Press, Ithaca, NY1988
• Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium 
  Chapter: Responsiveness to Serotonin in Atherosclerotic Blood Vessels. 
  Page 245 - 259Heistad DD, Armstrong ML, Brown B, Harrison DGEditors: Vanhoutte P.Raven Press, New York1988
• Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium 
  Chapter: Atherosclerosis Alters Endothelium-Dependent Responses to a Variety of Neurohumoral Agents: Potential Mechanisms and Pathophysiologic Consequences. 
  Page 517 - 521Harrison DGEditors: Vanhoutte P.Raven Press, New York1988
• Proceeding of the Symposium on Resistance Vessels 
  Chapter: Impaired Endothelium-Dependent Mechanisms in Atherosclerosis. 
  Page 54 - 58Harrison DG, Guerra R Jr., Freiman PC, Armstrong MLPerinatology Press, Ithaca, NY1988
• International Journal of Cardiology 
  Chapter: erotonin and Experimental Vascular Disease. 
  Page 205 - 212Heistad DD, Harrison DG, Armstrong MLEditors: Frye, RL.Elsevier Science Publisher, Amsterdam1987
• Acute Coronary Care 
  Chapter: Post Thrombolytic Care. 
  Harrison DGEditors: Wagner, GS.Martinus Nijhoff Publishing, Boston1986
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Lectures

• High Blood Pressure Research 2012 Scientific Sessions 
  American Heart Association, Washington, Dist Of Col - 9/19/2012

Other

• Interactions of nitric oxide, superoxide and superoxide dismutase in the vessel wall: contributions to regulation of vasomotion. 
  Harrison DG, Coronary Microcirculation during Ischemia and Reperfusion, Alfred Benzon Symposium
  1/1/1997