DavidAlanKassMD

Cardiology • Baltimore, MD

Adult Congenital Heart Disease, Heart Failure & Transplantation

Professor of Medicine, Johns Hopkins University School of Medicine

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Office
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287
Phone(443) 997-0270
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Education & Training

Johns Hopkins UniversityFellowship, Cardiovascular Disease, 1983 - 1985
George Washington UniversityResidency, Internal Medicine, 1980 - 1983
Yale University School of MedicineClass of 1980

Certifications & Licensure

MD State Medical License 1983 - 2022
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1994

Clinical Trials

Randomized Evaluation of HFpEF Patients With Acute Heart Failure and Dopamine (ROPA-DOP) Trial Start of enrollment: 2013 Aug 01Kass, D.A.,Schulman, S.P.,Weiss, R.G.,Sharma, K.,Thiemann, D.R.,Russell, S.D.

Publications & Presentations

PubMed

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury.
Mark J. Ranek, Christian U. Oeing, Rebekah Sanchez-Hodge, Kristen M. Kokkonen-Simon, Danielle Dillard, M. Imran Aslam, Peter P. Rainer, Sumita Mishra, Brittany L. Dunk...> ;Nature Communications. 2020 Oct 20
Letter by Tedford et al Regarding Article, "Effective Arterial Elastance in the Pulmonary Arterial Circulation: Derivation, Assumptions, and Clinical Applications".
Tedford, R. J., Hsu, S., Kass, D. A.> ;Circulation. Heart failure. 2020 May 16
PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy.
Oeing, C. U., Nakamura, T., Pan, S., Mishra, S., Dunkerly-Eyring, B. L., Kokkonen-Simon, K. M., Lin, B. L., Chen, A., Zhu, G., Bedja, D., Lee, D. I., Kass, D. A., Rane...> ;Circulation research. 2020 May 13
Obesity could shift severe COVID-19 disease to younger ages.
Kass, D. A., Duggal, P., Cingolani, O.> ;Lancet (London, England). 2020 May 8
Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary.
Shah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., Granzier, H., Hum...> ;Circulation. 2020 Mar 24
Cyclic Guanosine Monophosphate and Risk of Incident Heart Failure and Other Cardiovascular Events: the ARIC Study.
Zhao, D., Guallar, E., Vaidya, D., Ndumele, C. E., Ouyang, P., Post, W. S., Lima, J. A., Ying, W., Kass, D. A., Hoogeveen, R. C., Shah, S. J., Subramanya, V., Michos, ...> ;Journal of the American Heart Association. 2020 Jan 14
Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA.
Ying, W., Zhao, D., Ouyang, P., Subramanya, V., Vaidya, D., Ndumele, C. E., Guallar, E., Sharma, K., Shah, S. J., Kass, D. A., Hoogeveen, R. C., Lima, J. A., Heckbert,...> ;Journal of the American Heart Association. 2019 Dec 17
Myocardial Phosphodiesterases and Their Role in cGMP Regulation.
Dunkerly-Eyring, B., Kass, D. A.> ;Journal of cardiovascular pharmacology. 2019 Oct 28
Large Particle Fluorescence-Activated Cell Sorting Enables High-Quality Single-Cell RNA Sequencing and Functional Analysis of Adult Cardiomyocytes.
Kannan, S., Miyamoto, M., Lin, B. L., Zhu, R., Murphy, S., Kass, D. A., Andersen, P., Kwon, C.> ;Circulation research. 2019 Aug 16
Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway.
Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D. I., Hahn, V. S., Kass, D. A., Ha...> ;Journal of the American College of Cardiology. 2019 May 31
Response by Kass et al to Letter Regarding Article, "Chronic Atrial and Ventricular Pacing in the Mouse: Application to Model Cardiac Dyssynchrony and Resynchronizatio...
David A. Kass, Ryo Nakagawa, Marcus Ståhlberg> ;Circulation-heart Failure. 2019 May 1
In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.
Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D.,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Apr 28
Nitrosative stress drives heart failure with preserved ejection fraction
Gabriele G. Schiattarella, Francisco Altamirano, Dan Tong, Kristin M. French, Elisa Villalobos, Soo Young Kim, Xiang Luo, Nan Jiang, Herman I. May, Zhao V. Wang, Theod...> ;Nature. 2019 Apr 18
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.
Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., ...> ;Journal of molecular and cellular cardiology. 2019 Mar 14
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Ranek, M. J., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinsk...> ;Nature. 2019 Feb 1
Chronic Atrial and Ventricular Pacing in the Mouse.
Marcus Ståhlberg, Ryo Nakagawa, Djahida Bedja, Guangshuo Zhu, Brian L. Lin, Amir Saberi, Dong I. Lee, David A. Kass> ;Circulation-heart Failure. 2019 Feb 1
Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis.
Zhang, Q. J.,Tran, TAT.,Wang, M.,Ranek, M. J.,Kokkonen-Simon, K. M.,Gao, J.,Luo, X.,Tan, W.,Kyrychenko, V.,Liao, L.,Xu, J.,Hill, J. A.,Olson, E. N.,Kass, D. A.,Martine...> ;Nat Commun. 2018 Dec 12
Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition
Toru Hashimoto, Grace E. Kim, Richard S. Tunin, Tolulope Adesiyun, Steven Hsu, Ryo Nakagawa, Guangshuo Zhu, Jennifer J. O'Brien, Joseph P. Hendrick, Robert E. Davis, W...> ;Circulation. 2018 Oct 30
Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial
Kavita Sharma, Joban Vaishnav, Rohan Kalathiya, Jiun-Ruey Hu, John B. Miller, Nishant P. Shah, Terence Hill, Michelle Sharp, Allison L. Tsao, Kevin M. Alexander, Richa...> ;Jacc-Heart Failure. 2018 Oct 1
Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.
Kokkonen-Simon, K. M.,Saberi, A.,Nakamura, T.,Ranek, M. J.,Zhu, G.,Bedja, D.,Kuhn, M.,Halushka, M. K.,Lee, D. I.,Kass, D. A.> ;JCI Insight. 2018 Aug 10
Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease.
Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R., Mathai, S. C., Kasper,...> ;Circulation. Heart failure. 2018 Apr 13
2 citations
Protein <i>S</i>-Nitrosylation Controls Glycogen Synthase Kinase 3Î² Function Independent of Its Phosphorylation State.
Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B., Van Eyk, J. E.> ;Circulation research. 2018 Mar 23
1 citation
Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice
Rosanne Rouf, Elena Gallo MacFarlane, Eiki Takimoto, Rahul Chaudhary, Varun Nagpal, Peter P. Rainer, Julia G. Bindman, Elizabeth E. Gerber, Djahida Bedja, Christopher ...> ;JCI insight. 2017 Aug 3
Why publish in the <i>American Journal of Physiology-Heart and Circulatory Physiology</i>?
Zucker, I. H., Lindsey, M. L., Delmar, M., De Windt, L. J., Rosiers, C. D., Diz, D. I., Hester, R. L., Jones, S. P., Kanagy, N. L., Kitakaze, M., Liao, R., Lopaschuk, ...> ;American journal of physiology. Heart and circulatory physiology. 2017 Jun 20
Inorganic Nitrates: Qi for Heart Failure With Preserved Ejection Fraction?
Kavita Sharma, David A. Kass> ;Circulation Research. 2017 Mar 31
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Press Mentions

Scientists Find Hints for How a Fatty Compound Functions in the Cell's PowerhouseJanuary 06, 2021 12:30
Research News Tip Sheet: Story Ideas from Johns Hopkins MedicineDecember 23, 2020 12:06
Poverty and Obesity: A Paradox Amid COVID-19August 18, 2020 10:51
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