DavidMarkLoebMD

Pediatric Hematology & Oncology • Bronx, NY

Pediatric Sarcoma Oncology, Pediatric Solid Tumor Oncology

Associate Professor of Pediatrics; Chief, Pediatric Hematology, Oncology, and Marrow & Blood Cell Transplantation, Children's Hospital at Montefiore

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Office
3415 Bainbridge Ave
Bronx, NY 10467
Phone+1 718-741-2426
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Education & Training

Johns Hopkins UniversityFellowship, Pediatric Hematology/Oncology, 1997 - 2000
Johns Hopkins UniversityResidency, Pediatrics, 1994 - 1997
Columbia University Vagelos College of Physicians and SurgeonsClass of 1994

Certifications & Licensure

NY State Medical License 2017 - 2025
MD State Medical License 1997 - 2018
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2012-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013-2014
America's Top Doctors for Cancer Castle Connolly, 2011-2013
Top Doctors:Baltimore Area Castle Connolly, 2012
Top Doctors:Washington-Baltimore Castle Connolly, 2012
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Clinical Trials

Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Start of enrollment: 2004 Oct 01
Completed
Phase 2
Cyclophosphamide in Treating Young Patients With Severe Autoimmune Enteropathy Start of enrollment: 2005 Aug 15
Completed
Phase 2
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Start of enrollment: 2009 Sep 01
Completed
Phase 1, Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Stereotactic Radiation Therapy for Pediatric Sarcomas Start of enrollment: 2013 Nov 01
Completed
Not Applicable
Combination of External Beam Radiotherapy With 153Sm-EDTMP to Treat High Risk Osteosarcoma Start of enrollment: 2013 Aug 19
Terminated
Phase 2
Myeloablative Haploidentical BMT With Post-transplant Cyclophosphamide for Pediatric Patients With Hematologic Malignancies Start of enrollment: 2015 Jul 02
Completed
Phase 2
Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma Start of enrollment: 2016 Oct 25
Recruiting
Phase 2
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Publications & Presentations

PubMed

Delayed Solid Tumor Presentations in Adolescent and Young Adults Patients in the Bronx.
Rachel Offenbacher, Sarah Norris, David M Loeb, Adam Levy> ;Journal of Adolescent and Young Adult Oncology. 2024 Apr 1
Drivers of Differential Time to Diagnosis in Pediatric ALL Tied to Race and Ethnicity.
Meghan Davitt, Lisa Gennarini, David M Loeb, H Dean Hosgood> ;Journal of Pediatric Hematology/oncology. 2023 Oct 1
Respiratory Failure Due to Idiopathic Pneumonia Syndrome in a Pediatric Patient After Recipient-derived Allogeneic Chimeric Antigen Receptor T-Cell Therapy.
Rachelle Zipper, David M Loeb, Michelle A Lee, Jennifer Oliver-Krasinski, Mark C Liszewski, Ellen Fraint> ;Journal of Pediatric Hematology/oncology. 2023 Aug 1
Impact of race/ethnicity and language preferences on pediatric ALL survival outcomes.
Meghan Davitt, Lisa Gennarini, David Loeb, Melissa Fazzari, H Dean Hosgood> ;Cancer Medicine. 2023 Jun 1
1 citations
Acetophenone protection against cisplatin-induced end-organ damage.
Brian Geohagen, Elizabeth Zeldin, Kimberly Reidy, Tao Wang, Evripidis Gavathiotis, Yonatan I Fishman, Richard LoPachin, David M Loeb, Daniel A Weiser> ;Translational Oncology. 2023 Jan 1
3 citations
Social Genomics as a Framework for Understanding Health Disparities Among Adolescent and Young Adult Cancer Survivors: A Commentary.
Lauren V Ghazal, Steve Cole, John M Salsman, Lynne Wagner, Fenghai Duan, Ilana Gareen, Lauren Lux, Susan K Parsons, Christabel Cheung, David M Loeb, Pinki Prasad, Shir...> ;JCO Precision Oncology. 2022 Jun 1
28 citations
Impact of COVID-19 on case fatality rate of patients with cancer during the Omicron wave.
Lee, M., Quinn, R., Pradhan, K., Fedorov, K., Levitz, D., Fromowitz, A., Thakkar, A., Shapiro, L., Kabarriti, R., Ruiz, R., Andrews, E., Thota, R., Chu, E., Kalnicki, ...> ;Cancer Cell. 2022 Apr 11
11 citations
Avelumab in paediatric patients with refractory or relapsed solid tumours: dose-escalation results from an open-label, single-arm, phase 1/2 trial.
David M Loeb, Daniel A Morgenstern, Yvan Samson, Anne Uyttebroeck, Chuhl Joo Lyu, An Van Damme, Karsten Nysom, Margaret E Macy, Alexandra P Zorzi, Julia Xiong, Petra P...> ;Cancer Immunology, Immunotherapy. 2022 Oct 1
1 citations
SARS-CoV-2 as a mimicker of pulmonary metastasis in osteosarcoma.
Rachel Offenbacher, Lara Fabish, Alissa C. Baker, David M. Loeb> ;Pediatric Blood & Cancer. 2021 Nov 12
8 citations
The Utility of 18FDG PET/CT Versus Bone Scan for Identification of Bone Metastases in a Pediatric Sarcoma Population and a Review of the Literature.
Adit L. Tal, Hiten Doshi, Fauziya Parkar, Tony Abraham, Charito Love, Kenny Ye, Rui Yang, Bang H. Hoang, David M. Loeb, Alexander J. Chou, David S. Geller, Renee M. Mo...> ;Journal of Pediatric Hematology/oncology. 2021 Mar 1
2 citations
A multicenter report on the safety and efficacy of plerixafor based stem cell mobilization in children with malignant disorders.
Nabanita Bhunia, Rolla Abu-Arja, Joseph R. Stanek, Lubna S Mehyar, Peter J. Shaw, Hyoung Jin Kang, Jerry Stein, Tracey A. O'Brien, Catherine H. Roberts, Acw Lee, David...> ;Transfusion. 2021 Jan 21
14 citations
Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma.
Jichuan Wang, Kenji Sato, Ed O'Donnell, Amit Singla, Simon Yaguare, Osama Aldahamsheh, Brian Batko, Hasibagan Borjihan, Janet Tingling, Jinghang Zhang, Daniel A. Weise...> ;Translational Oncology. 2020 Oct 1
14 citations
A clinically and genomically annotated nerve sheath tumor biospecimen repository
Kai Pollard, Jineta Banerjee, Xengie Doan, Jiawan Wang, Xindi Guo, Robert J. Allaway, Shannon Langmead, Bronwyn Slobogean, Christian F. Meyer, David M. Loeb, Carol D. ...> ;Scientific Data. 2020 Jun 19
25 citations
An evolutionary framework for treating pediatric sarcomas
Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, Masanori Hayashi, Michael S. Isakoff, David M. Loeb, Rikesh J Makanji, Ryan D. Roberts, Matteo Truc...> ;Cancer. 2020 Jun 1
7 citations
Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition.
Eoin P. McNeill, Robert W. Reese, Abishek Tondon, Bret H. Clough, Simin Pan, Jeremiah J Froese, Daniel Palmer, Ulf Krause, David M. Loeb, Roland Kaunas, Carl A. Gregory> ;Cell Death & Disease. 2018 Nov 26
17 citations
A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas
Matteo Trucco, Christian F. Meyer, Katherine Thornton, Preeti Shah, Allen R. Chen, Breelyn A. Wilky, Maria A. Carrera-Haro, Lillian C. Boyer, Margaret F. Ferreira, Umb...> ;Clinical Sarcoma Research. 2018 Nov 5
5 citations
Knock-In of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice
Colleen Annesley, Cara A Rabik, Amy S. Duffield, Rachel E. Rau, Daniel Magoon, Li Li, Vicki Huff, Donald Small, David M. Loeb, Patrick Brown> ;Oncotarget. 2018 Oct 19
23 citations
Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal F...
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Biology of Blood and Marrow Transplantation. 2018 Oct 1
22 citations
Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib.
Scott M. Schuetze, Vanessa Bolejack, Dafydd G. Thomas, Margaret von Mehren, Shreyaskumar Patel, Brian L. Samuels, Edwin Choy, Gina Z. D'Amato, Arthur P. Staddon, Krist...> ;JAMA Oncology. 2018 Jun 1
56 citations
Consensus and controversies regarding the treatment of rhabdomyosarcoma.
Scott C. Borinstein, Diana Steppan, Masanori Hayashi, David M. Loeb, Michael S. Isakoff, Odion Binitie, Andrew S. Brohl, Julia A. Bridge, Mark J. Stavas, Eric T. Shino...> ;Pediatric Blood & Cancer. 2018 Feb 1
18 citations
Electrophysiological effects of anthracyclines in adult survivors of pediatric malignancy.
Timothy M. Markman, Kathryn Ruble, David M. Loeb, Allen R. Chen, Yiyi Zhang, Gary S. Beasley, W. Reid Thompson, Saman Nazarian> ;Pediatric Blood & Cancer. 2017 Nov 1
38 citations
A phase II trial evaluating the feasibility of adding bevacizumab to standard osteosarcoma therapy
Fariba Navid, Victor M. Santana, Michael D. Neel, M. Beth McCarville, Barry L. Shulkin, Jianrong Wu, Catherine A. Billups, Shenghua Mao, Vinay M. Daryani, Clinton F. S...> ;International Journal of Cancer. 2017 Oct 1
38 citations
Size-based detection of sarcoma circulating tumor cells and cell clusters.
Masanori Hayashi, Peixuan Zhu, Gregory McCarty, Christian F. Meyer, Christine A. Pratilas, Adam S. Levin, Carol D. Morris, Catherine M. Albert, Kyle W. Jackson, Cha Me...> ;Oncotarget. 2017 Sep 7
21 citations
Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties
Atreyi Dasgupta, Matteo Trucco, Nino Rainusso, Ronald J. Bernardi, Ryan Shuck, Lyazat Kurenbekova, David M. Loeb, Jason T. Yustein> ;Oncotarget. 2017 Aug 26
15 citations
Reduced-Intensity Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Solid Tumors in Pediatric and Young Adult Patients
Nicolas J. Llosa, Kenneth R. Cooke, Allen R. Chen, Christopher Gamper, Orly R. Klein, Elias T. Zambidis, Brandon Luber, Gary L. Rosner, Nicholas Siegel, Mary Jo Holuba...> ;Biology of Blood and Marrow Transplantation. 2017 Dec 1
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Abstracts/Posters

Long-Term Outcomes of Subjects with Epstein-Barr Virus-Driven Post-Transplant Lymphoproliferative Disorder (EBV+PTLD) Following Solid Organ (SOT) or Allogeneic Hematop...
David Loeb, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019