DavidPearceMD

PubMed

• 6 citations
  Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.
  Bidisha Saha, Waheed Shabbir, Enzo Takagi, Xin-Peng Duan, Deise Carla Almeida Leite Dellova, John Demko, Anna Manis, Dominique Loffing-Cueni, Johannes Loffing, Mads Va...> ;Journal of the American Society of Nephrology. 2023 Jun 1
• 6 citations
  WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.
  Bidisha Saha, Deise C A Leite-Dellova, Mads Vaarby Sørensen, Enzo Takagi, Catherine E Gleason, Waheed Shabbir, David Pearce, Demko, J.> ;Journal of Cell Science. 2022 Dec 1
• 1 citations
  Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
  Nisha I Parikh, Folagbayi Arowolo, Matthew S Durstenfeld, Gregory Nah, Joyce Njoroge, Eric Vittinghoff, Carlin S Long, Peter Ganz, David Pearce, Priscilla Hsue, Alan H...> ;Journal of the Endocrine Society. 2022 Oct 26
• 10 citations
  Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
  Zanlin Yu, Junliang Chen, Enzo Takagi, Feng Wang, Bidisha Saha, Xi Liu, Lydia-Marie Joubert, Catherine E Gleason, Mingliang Jin, Chengmin Li, Carlos Nowotny, David Aga...> ;The Journal of Biological Chemistry. 2022 Sep 1
• 12 citations
  Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.
  David Pearce, Anna D Manis, Viatcheslav Nesterov, Christoph Korbmacher> ;Pflugers Archiv. 2022 Aug 1
• 7 citations
  Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold
  Prasanna K.R. Allu, Esther Paulo, Ambre M. Bertholet, Gavin Situ, Seunghwan Lee, Yixuan Wu, Catherine E. Gleason, Bidisha Saha, Ajay Chawla, Biao Wang, David A. Pearce> ;The Journal of Biological Chemistry. 2021 Jan 1
• 2 citations
  Building a hemodiafiltration system from readily available components for continuous renal replacement therapy under disasters and pandemics: preparing for an acute ki...
  Ramy M Hanna, Antoney Ferrey, Connie M. Rhee, Ramin Sam, David A. Pearce, Kamyar Kalantar-Zadeh, Burl R. Don> ;Current Opinion in Nephrology and Hypertension. 2021 Jan 1
• 37 citations
  Potassium acts through mTOR to regulate its own secretion
  Mads V. Sorensen, Bidisha Saha, Iben Skov Jensen, Peng Wu, Niklas Ayasse, Catherine E. Gleason, Samuel L Svendsen, Wen-Hui Wang, David A. Pearce> ;JCI Insight. 2019 Jun 25
• 38 citations
  Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt.
  Catherine E. Gleason, Juan A. Oses-Prieto, Kathy H. Li, Bidisha Saha, Gavin Situ, Alma L. Burlingame, David A. Pearce> ;Journal of Cell Science. 2019 Apr 1
• 11 citations
  Association of Urinary Plasminogen-Plasmin with Edema and Epithelial Sodium Channel Activation in Patients with Nephrotic Syndrome.
  Junliang Chen, Li Wang, Xing-Mei Yao, Yingjun Zang, Yi Wang, Zhi-Jun Li, David A. Pearce, Hao Wang> ;American Journal of Nephrology. 2019 Jan 1
• 16 citations
  Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo
  Cornelius von Morze, Prasanna K.R. Allu, Gene Y. Chang, Irene Marco-Rius, Eugene Milshteyn, Zhen J. Wang, Michael A. Ohliger, Catherine E. Gleason, John Kurhanewicz, D...> ;Scientific Reports. 2018 Feb 1
• 19 citations
  Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.
  Cornelius von Morze, Michael A. Ohliger, Irene Marco-Rius, David M. Wilson, Robert R. Flavell, David A. Pearce, Daniel B. Vigneron, John Kurhanewicz, Zhen J. Wang> ;Magnetic Resonance in Medicine. 2018 Jan 3
• 25 citations
  Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
  Irene Marco-Rius, Cornelius von Morze, Renuka Sriram, Peng Cao, Gene Yuan Chang, Eugene Milshteyn, Robert Bok, Michael A. Ohliger, David A. Pearce, John Kurhanewicz, P...> ;Magnetic Resonance in Medicine. 2017 Jan 1
• 11 citations
  Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron
  Priyanka Rashmi, GianLuca Colussi, Michael Ng, Xinhao Wu, Atif Kidwai, David A. Pearce> ;Kidney International. 2017 May 1
• 31 citations
  Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.
  Cornelius von Morze, Gene-Yuan Chang, Peder E. Z. Larson, Hong Shang, Prasanna K.R. Allu, Robert Bok, Jason C. Crane, Marram P. Olson, Chou T. Tan, Irene Marco-Rius, S...> ;Magnetic Resonance in Medicine. 2017 Apr 1
• 11 citations
  Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
  Irene Marco-Rius, Peng Cao, Cornelius von Morze, Matthew E. Merritt, Karlos X. Moreno, Gene Yuan Chang, Michael A. Ohliger, David A. Pearce, John Kurhanewicz, Peder E....> ;Magnetic Resonance in Medicine. 2017 Apr 1
• 48 citations
  Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway
  Florian Lang, David A. Pearce> ;Nephrology, Dialysis, Transplantation. 2015 Jul 9
• A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.
  Beraldi, R.,Chan, C. H.,Rogers, C. S.,Kovács, A. D.,Meyerholz, D. K.,Trantzas, C.,Lambertz, A. M.,Darbro, B. W.,Weber, K. L.,White, K. A.,Rheeden, R. V.,Kruer, M. C.,D...> ;Hum. Mol. Genet.. 2015 Sep 17
• Abnormally increased surface expression of AMPA receptors in the cerebellum, cortex and striatum of Cln3(-/-) mice.
  Kovács, A. D.,Hof, C.,Pearce, D. A.> ;Neurosci. Lett.. 2015 Sep 17
• 185 citations
  Collecting Duct Principal Cell Transport Processes and Their Regulation
  David A. Pearce, Rama Soundararajan, Christiane Trimpert, Ossama B. Kashlan, Peter M.T. Deen, Donald E. Kohan> ;Clinical Journal of the American Society of Nephrology. 2015 Jan 7
• The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.
  Miller JN, Kovács AD, Pearce DA> ;Hum. Mol. Genet.. 2015-01-01
• The human synaptic vesicle protein, SV2A, functions as a galactose transporter in Saccharomyces cerevisiae.
  Madeo M, Kovács AD, Pearce DA> ;J. Biol. Chem.. 2014-11-28
• The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis.
  Miller JN, Chan C, Pearce DA> ;Hum. Mol. Genet.. 2013-07-01
• Scaffold protein Connector-Enhancer-of-Kinase-Suppressor-of-Ras isoform-3 (CNK3) coordinates assembly of a multiprotein Epithelial Sodium Channel (ENaC)-regulatory com...
  Soundararajan, R., Ziera, T., Koo, E., Ling, K., Wang, J., Borden, S., Pearce, D.> ;J Biol Chem. 2012 Sep 21
• Organization of the ENaC-regulatory machinery.
  Soundararajan, R., Lu, M., Pearce, D.> ;Crit Rev Biochem Mol Biol. 2012 Apr 18
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