DavidSRussellMD, PhD

Movement Disorder, Neurodegenerative

Director. Clinical Research Institute for Neurodegenerative Disorders; Invicro, a Konica-Minolta Company Assistant Clinical Professor, Yale University School of Medicine

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Office
60 Temple St
Suite 8B
New Haven, CT 06510
Phone+1 203-401-4300

Fax+1 203-401-4301
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Education & Training

Yale-New Haven Medical CenterResidency, Neurology, 1992 - 1995
Yale-New Haven Medical CenterInternship, Internal Medicine, 1991 - 1992
Weill Cornell MedicineClass of 1991

Certifications & Licensure

CT State Medical License 1995 - 2024
PA State Medical License 1995 - 1996

Clinical Trials

A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions Start of enrollment: 2009 Mar 01
Completed
Phase 1
Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression Start of enrollment: 2010 Jun 01
Completed
Phase 2
Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo Start of enrollment: 2013 Jul 01
Terminated
Phase 3
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects Start of enrollment: 2014 Feb 01
Completed
Phase 1
Efficacy of Isradipine in Early Parkinson Disease Start of enrollment: 2014 Nov 01
Completed
Phase 3
Systemic Synuclein Sampling Study (S4) Start of enrollment: 2015 Oct 01
Completed
Early Longitudinal Imaging in Parkinson's Progression Markers Initiative Using [¹⁸F] AV-133 and DaTscan™ Start of enrollment: 2020 Sep 10
Active, not recruiting
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Publications & Presentations

PubMed

3 citations
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.
Shunsuke Koga, Michael A Metrick 2nd, Lawrence I Golbe, Alessia Santambrogio, Minji Kim, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Cristhoper Fernand...> ;Acta Neuropathologica Communications. 2023 Jun 1
5 citations
Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study.
James Robert Brašić, Jack Alexander Goodman, Ayon Nandi, David S Russell, Danna Jennings, Olivier Barret, Samuel D Martin, Keith Slifer, Thomas Sedlak, Anil Kumar Math...> ;Brain Sciences. 2022 Feb 26
15 citations
Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome: A Pilot Study.
James Robert Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith J. Slifer, Thomas W. Sedlak, John Seibyl, Dean F. Wong, Deja...> ;International Journal of Molecular Sciences. 2021 Mar 11
12 citations
Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome.
James Robert Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Anil Mathur, Keith J. Slifer, Thomas W. Sedlak, Samuel D. Martin, Zabecca Brinson, P...> ;Brain Sciences. 2020 Nov 24
110 citations
Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy.
Matthias Brendel, Henryk Barthel, Thilo van Eimeren, Ken Marek, Leonie Beyer, Mengmeng Song, Carla Palleis, Mona Gehmeyr, Urban M. Fietzek, Gesine Respondek, Julia Sau...> ;JAMA Neurology. 2020 Nov 1
12 citations
Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.
Mark E. Schmidt, Luc Janssens, Diederik Moechars, Frederik J. R. Rombouts, Maarten Timmers, Olivier Barret, Cristian Constantinescu, Jennifer Madonia, David S. Russell...> ;European Journal of Nuclear Medicine and Molecular Imaging. 2020 Jun 13
26 citations
Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
Leonie Beyer, Alexander Nitschmann, Henryk Barthel, Thilo van Eimeren, Marcus Unterrainer, Julia Sauerbeck, Ken Marek, Mengmeng Song, Carla Palleis, Gesine Respondek, ...> ;European Journal of Nuclear Medicine and Molecular Imaging. 2020 Apr 21
12 citations
Experiences of Parachute NYC: An Integration of Open Dialogue and Intentional Peer Support.
Christina Wusinich, David C. Lindy, David Russell, Neil Pessin, Phoebe Friesen> ;Community Mental Health Journal. 2020 Feb 8
31 citations
Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial
Michael A. Schwarzschild, Eric A. Macklin, Rachit Bakshi, Shamik Battacharyya, Robert Logan, Alberto J. Espay, Albert Y. Hung, Grace Bwala, Christopher G. Goetz, David...> ;Neurology. 2019 Oct 1
11 citations
The Qualification of an Enrichment Biomarker for Clinical Trials Targeting Early Stages of Parkinson's Disease.
Diane Stephenson, Derek Hill, Jesse M Cedarbaum, Maria Tome, Spiros Vamvakas, Klaus Romero, Daniela J Conrado, David T Dexter, John Seibyl, Danna Jennings, Timothy Nic...> ;Journal of Parkinson's Disease. 2019 Jan 1
116 citations
18F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study
Daniel R. Schonhaut, Corey T. McMillan, Salvatore Spina, Bradford C. Dickerson, Andrew Siderowf, Michael D. Devous, Richard M. Tsai, Joseph R. Winer, David S. Russell,...> ;Annals of Neurology. 2017 Oct 1
19 citations
A randomized trial of a low-dose Rasagiline and Pramipexole combination (P2B001) in early Parkinson's disease.
C. Warren Olanow, Karl Kieburtz, Mika Leinonen, Lawrence Elmer, Nir Giladi, Robert A. Hauser, Olga S. Klepiskaya, David L. Kreitzman, Mark F. Lew, David S. Russell, Sh...> ;Movement Disorders. 2017 May 1
22 citations
Clinical utility of DaTscan™ imaging in the evaluation of patients with parkinsonism: a US perspective.
Stuart Isaacson, Stanley Fisher, Fiona Gupta, Neal Hermanowicz, Daniel Kremens, Mark F. Lew, Kenneth Marek, Rajesh Pahwa, David S. Russell, John Seibyl> ;Expert Review of Neurotherapeutics. 2017 Mar 1
9 citations
Identifying Sociodemographic Characteristics Associated With Burden Among Caregivers of the Urban Homebound: The Importance of Racial and Relationship Differences
Ania Wajnberg, Tacara N. Soones, Kristofer L. Smith, David S. Russell, Joseph S. Ross, Alex D. Federman> ;Gerontology & Geriatric Medicine. 2016 Sep 8
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
Skarpengland T, Dahl TB, Skjelland M, Scheffler K, de Sousa MML, Gregersen I, Kuśnierczyk A, Sharma A, Slupphaug G, Eide L, Segers FM, Skagen KR, Dahl CP, Russell D, F...> ;Free Radic. Biol. Med.. 2016-08-01
Semiautomated Magnetic Resonance Imaging Assessment of Carotid Plaque Lipid Content.
Skagen K, Evensen K, Scott H, Krohg-Sørensen K, Vatnehol SA, Hol PK, Skjelland M, Russell D> ;J Stroke Cerebrovasc Dis. 2016-08-01
Cerebral Microemboli Detection and Differentiation During Transcatheter Closure of Patent Ductus Arteriosus.
Wallace S, Døhlen G, Holmstrøm H, Lund C, Russell D> ;Pediatr Cardiol. 2016-08-01
Carotid Atherosclerosis in Adult Patients with Persistently Active Juvenile Idiopathic Arthritis Compared with Healthy Controls.
Evensen K, Aulie HA, Rønning OM, Flatø B, Russell D> ;J. Rheumatol.. 2016-04-01
51 citations
Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging
David S. Russell, Danna Jennings, Olivier Barret, Gilles Tamagnan, Vincent M. Carroll, Fabien Caillé, David Alagille, Thomas J. Morley, Caroline Papin, John Seibyl, Ke...> ;Neurology. 2016 Feb 23
Rates and risks for late referral to hospice in patients with primary malignant brain tumors.
Diamond EL, Russell D, Kryza-Lacombe M, Bowles KH, Applebaum AJ, Dennis J, DeAngelis LM, Prigerson HG> ;Neuro-oncology. 2016-01-01
7 citations
Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease.
Danny Bega, Sheng Luo, Hubert H. Fernandez, Kelvin L. Chou, Michael J. Aminoff, Sotirios A. Parashos, Harrison C. Walker, David S. Russell, Chadwick W. Christine, Rohi...> ;Movement Disorders Clinical Practice. 2015 Jul 14
Large-Vessel Occlusion Stroke: Effect of Recanalization on Outcome Depends on the National Institutes of Health Stroke Scale Score.
Skagen K, Skjelland M, Russell D, Jacobsen EA> ;J Stroke Cerebrovasc Dis. 2015-07-01
Carotid plaque inflammation assessed with (18)F-FDG PET/CT is higher in symptomatic compared with asymptomatic patients.
Skagen K, Johnsrud K, Evensen K, Scott H, Krohg-Sørensen K, Reier-Nilsen F, Revheim M, Fjeld JG, Skjelland M, Russell D> ;Int J Stroke. 2015-07-01
38 citations
Characterization in Humans of 18F-MNI-444, a PET Radiotracer for Brain Adenosine 2A Receptors
Olivier Barret, Jonas Hannestad, Christine Vala, David Alagille, Adriana Tavares, Marc Laruelle, Danna Jennings, Ken Marek, David S. Russell, John Seibyl, Gilles Tamagnan> ;Journal of Nuclear Medicine. 2015 Apr 1
Interleukin 23 levels are increased in carotid atherosclerosis: possible role for the interleukin 23/interleukin 17 axis.
Abbas A, Gregersen I, Holm S, Daissormont I, Bjerkeli V, Krohg-Sørensen K, Skagen KR, Dahl TB, Russell D, Almås T, Bundgaard D, Alteheld LH, Rashidi A, Dahl CP, Michel...> ;Stroke. 2015-03-01
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