DavidPSamuelMD

PubMed

• Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Con...
  Das, A., Fernandez, N., Levine, A., Bianchi, V., Stengs, L., Chung, J., Negm, L., Dimayacyac, J., Chang, Y., Nobre, L., Ercan, A., Sanchez-Ramirez, S., Sudhaman, S., E...> ;Cancer Discovery. 2024 Feb 8
• 2 citations
  Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature.
  Philipp Sievers, Martin Sill, Daniel Schrimpf, Zied Abdullaev, Andrew M Donson, Jessica A Lake, Dennis Friedel, David Scheie, Olli Tynninen, Tuomas Rauramaa, Kaisa L V...> ;NPJ Precision Oncology. 2023 Mar 24
• Correction to: Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
  Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K Wefers, Federico Ro...> ;Acta Neuropathologica. 2023 Apr 1
• 10 citations
  Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset.
  Jiil Chung, Logine Negm, Vanessa Bianchi, Lucie Stengs, Anirban Das, Zhihui Amy Liu, Sumedha Sudhaman, Melyssa Aronson, Ledia Brunga, Melissa Edwards, Victoria Forster...> ;Journal of Clinical Oncology. 2023 Feb 1
• 6 citations
  Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
  Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K Wefers, Federico Ro...> ;Acta Neuropathologica. 2023 Jan 1
• 6 citations
  Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions.
  Zhichao Wu, Sharika Rajan, Hye-Jung Chung, Mark Raffeld, Pavalan Panneer Selvam, Leonille Schweizer, Arie Perry, David Samuel, Caterina Giannini, Aditya Ragunathan, Ma...> ;Acta Neuropathologica. 2022 Dec 1
• 9 citations
  Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
  Calixto-Hope G Lucas, Emily A Sloan, Rohit Gupta, Jasper Wu, Drew Pratt, Harish N Vasudevan, Ajay Ravindranathan, Jairo Barreto, Erik A Williams, Anny Shai, Nicholas S...> ;Acta Neuropathologica. 2022 Oct 1
• 49 citations
  Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.
  Anirban Das, Sumedha Sudhaman, Daniel Morgenstern, Ailish Coblentz, Jiil Chung, Simone C Stone, Noor Alsafwani, Zhihui Amy Liu, Ola Abu Al Karsaneh, Shirin Soleimani, ...> ;Nature Medicine. 2022 Jan 1
• 1 citations
  An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors,...
  Cassie Kline, Schuyler Stoller, Lennox Byer, David Samuel, Janine M Lupo, Melanie A Morrison, Andreas M Rauschecker, Pierre Nedelec, Walter Faig, Dena B Dubal, Heather...> ;Frontiers in Oncology. 2022 Jan 1
• 15 citations
  Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma.
  Karisa C. Schreck, Andrew Morin, Guisheng Zhao, Amy Allen, Patrick C. Flannery, Michael Glantz, Adam L. Green, Chris Jones, Kenneth L. Jones, Lindsay Kilburn, Kellie J...> ;Clinical Cancer Research. 2021 Aug 25
• 25 citations
  Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance.
  Carol Durno, Ayse Bahar Ercan, Vanessa Bianchi, Melissa Edwards, Melyssa Aronson, Melissa Galati, Eshetu G. Atenafu, Gadi Abebe-Campino, Abeer Al-Battashi, Musa Alharb...> ;Journal of Clinical Oncology. 2021 May 4
• 16 citations
  Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition.
  Brittany Campbell, Melissa Galati, Simone C. Stone, Alexandra N. Riemenschneider, Melissa Edwards, Sumedha Sudhaman, Robert Siddaway, Martin Komosa, Nuno Miguel Nunes,...> ;Cancer Discovery. 2021 Feb 9
• 30 citations
  Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor
  Calixto-Hope G Lucas, Rohit Gupta, Pamela Doo, Julieann C. Lee, Cathryn R. Cadwell, Biswarathan Ramani, Jeffrey W. Hofmann, Emily A. Sloan, Bette K. Kleinschmidt-DeMas...> ;Acta Neuropathologica Communications. 2020 Aug 28
• 41 citations
  Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
  Gourish Mondal, Julieann C. Lee, Ajay Ravindranathan, Javier Villanueva-Meyer, Quynh T. Tran, Sariah Allen, Jairo Barreto, Rohit Gupta, Pamela Doo, Jessica Van Ziffle,...> ;Acta Neuropathologica. 2020 Apr 17
• 58 citations
  High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.
  Sean P. Ferris, José E. Velázquez Vega, Mariam Aboian, Julieann C. Lee, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Tara A. Saunders, Yunn-Yi Chen, Anu Ban...> ;Brain Pathology. 2020 Jan 1
• 16 citations
  Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas
  Emily A. Sloan, Tabitha Cooney, Nancy Ann Oberheim Bush, Robin A. Buerki, Jennie Taylor, Jennifer Clarke, Joseph Torkildson, Cassie Kline, Alyssa Reddy, Sabine Mueller...> ;Acta Neuropathologica. 2019 Sep 12
• 16 citations
  IGF1R Is a Potential New Therapeutic Target for HGNET-BCOR Brain Tumor Patients.
  Nadine Vewinger, Sabrina Huprich, Larissa Seidmann, Alexandra Russo, Francesca Alt, Hannah Bender, Clemens Sommer, David Samuel, Nadine Lehmann, Nora Backes, Lea Roth,...> ;International Journal of Molecular Sciences. 2019 Jun 21
• 40 citations
  Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PP...
  Julieann C. Lee, Tali Mazor, Richard Lao, Eunice Wan, Alpha B Diallo, Nicholas S Hill, Naina Thangaraj, Katherine Wendelsdorf, David Samuel, Cassie Kline, Anuradha Ban...> ;Acta Neuropathologica. 2019 Mar 14
• 21 citations
  Clinicopathologic features of anaplastic myxopapillary ependymomas.
  Julieann C. Lee, Nima Sharifai, Sonika Dahiya, Bette K. Kleinschmidt-DeMasters, Marc K. Rosenblum, Gerald F. Reis, David Samuel, Aleli Siongco, Mariarita Santi, Philli...> ;Brain Pathology. 2019 Jan 1
• 52 citations
  The genetic landscape of gliomas arising after therapeutic radiation
  Giselle Y. Lopez, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Iwei Yeh, Boris C. Bastian, Jennifer Clarke, Nancy Ann Oberheim Bush, Jennie Taylor, Susan M....> ;Acta Neuropathologica. 2019 Jan 1
• 207 citations
  Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
  Sebastian M. Waszak, Paul A. Northcott, Ivo Buchhalter, Giles W. Robinson, Christian Sutter, Susanne N. Groebner, Kerstin Grund, Laurence Brugières, David T.W. Jones, ...> ;The Lancet. Oncology. 2018 Jun 1
• 23 citations
  Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors.
  Matthew Nordstrom, Erin Felton, Katherine Sear, Benita Tamrazi, Joseph Torkildson, Karen Gauvain, Daphne A. Haas-Kogan, Josephine Chen, Benedict Del Buono, Anuradha Ba...> ;Journal of Child Neurology. 2018 Mar 26
• 18 citations
  Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.
  J. Bryan Iorgulescu, Jessica Van Ziffle, Meredith Stevers, James P. Grenert, Boris C. Bastian, Lukas Chavez, Damian Stichel, Ivo Buchhalter, David Samuel, Theodore Nic...> ;Acta Neuropathologica. 2018 Feb 12
• 23 citations
  Personalized therapy: CNS HGNET-BCOR responsiveness to arsenic trioxide combined with radiotherapy.
  Claudia Paret, Alexandra Russo, Henrike Otto, Arnulf Mayer, Sebastian Zahnreich, Wolfgang Wagner, David Samuel, David Scharnhorst, David A. Solomon, Girish Dhall, Kenn...> ;Oncotarget. 2017 Dec 11
• 503 citations
  Comprehensive Analysis of Hypermutation in Human Cancer
  Brittany Campbell, Nicholas Light, David Fabrizio, Matthew Zatzman, Fabio Fuligni, Richard de Borja, Scott Davidson, Melissa Edwards, Julia A. Elvin, Karl P. Hodel, Wa...> ;Cell. 2017 Nov 16
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Journal Articles

• The Genetic Landscape of Gliomas Arising After Therapeutic Radiation  
  Iwei Yeh, Corey Raffel, Mitchel Berger, Joanna J Phillips, James P Grenert, Boris C Bastian, David A Solomon, Nicholas Butowski, Sabine Mueller, Cassie Kline, Manish A..., Acta Neuropathologica