DavidQuanShihMDPhD

PubMed

• 3 citations
  Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2.
  Ying Xie, Lindsey Fontenot, Andrea Chupina Estrada, Becca Nelson, Jiani Wang, David Q Shih, Wendy Ho, S Anjani Mattai, Florian Rieder, Dane D Jensen, Nigel W Bunnett, ...> ;Cellular and Molecular Gastroenterology and Hepatology. 2022 Jan 1
• 16 citations
  Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
  Jia Wenxiu, Yang Mingyue, Han Fei, Luo Yuxin, Wu Mengyao, Li Chenyang, Song Jia, Zhang Hong, David Q. Shih, Stephan R. Targan, Zhang Xiao-lan> ;Mediators of Inflammation. 2021 Jun 25
• 19 citations
  Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to IBD.
  Yu Chen Pai, Li Ting Weng, Shu-Chen Wei, Li Ling Wu, David Q. Shih, S. R. Targan, Jerrold R. Turner, Linda C.H. Yu> ;Journal of Crohn's & Colitis. 2021 Feb 1
• 4 citations
  TL1A primed dendritic cells activation exacerbated chronic murine colitis.
  Fei Han, Jia Song, Wenxiu Jia, Mingyue Yang, Dong Wang, Hong Zhang, David Q. Shih, Stephan R. Targan, Xiaolan Zhang> ;Life Sciences. 2020 Dec 1
• 15 citations
  Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
  Noam Jacob, Kotaro Kumagai, Jay P. Abraham, Yosuke Shimodaira, Yuefang Ye, Justin Luu, Anna Y. Blackwood, Sofi Castanon, Dalton T. Stamps, Lisa S. Thomas, Rivkah Gonsk...> ;Scientific Reports. 2020 Oct 23
• 5 citations
  Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.
  Jiani Wang, Christina Ortiz, Lindsey Fontenot, Riya Mukhopadhyay, Ying Xie, Ivy Ka Man Law, David Q. Shih, S. Anjani Mattai, Zhaoping Li, Hon Wai Koon> ;Scientific Reports. 2020 Jul 30
• 17 citations
  High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.
  Jiani Wang, Christina Ortiz, Lindsey Fontenot, Ying Xie, Wendy Ho, S. Anjani Mattai, David Q. Shih, Hon Wai Koon> ;Plos One. 2020 Apr 14
• 20 citations
  Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis
  Mingyue Yang, Wenxiu Jia, Dong Wang, Fei Han, Weiwei Niu, Hong Zhang, David Q. Shih, Xiaolan Zhang> ;Digestive Diseases and Sciences. 2019 Apr 4
• 45 citations
  Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
  Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Steph...> ;Science. 2019 Mar 1
• 102 citations
  Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis
  Jim G. Castellanos, Viola Woo, Monica Viladomiu, Gregory G. Putzel, Svetlana Lima, Gretchen E. Diehl, Andrew R. Marderstein, Jorge Gandara, Alexendar R. Perez, David R...> ;Immunity. 2018 Dec 18
• 3 citations
  A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study.
  Chang Kyun Lee, Gil Y. Melmed, Amy Mann, Itai Danovitch, Rebecca Hedrick, Dermot P.B. McGovern, Stephan R. Targan, David Q. Shih, Eric A. Vasiliauskas, Waguih William ...> ;Inflammatory Bowel Diseases. 2018 Nov 29
• 8 citations
  Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Primer for Internists
  Gaurav Syal, Amir H. Kashani, David Q. Shih> ;The American Journal of Medicine. 2018 Sep 1
• 15 citations
  Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice
  Guo chao Niu, Lei Liu, Libo Zheng, Hong Zhang, David Q. Shih, Xiaolan Zhang> ;BMC Gastroenterology. 2018 Aug 13
• 63 citations
  Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome.
  Noam Jacob, Jonathan P. Jacobs, Kotaro Kumagai, Connie W.Y. Ha, Yoshitake Kanazawa, Venu Lagishetty, Katherine Altmayer, Ariel M. Hamill, Aimee Von Arx, R. Balfour Sar...> ;Mucosal Immunology. 2018 Jul 9
• 5 citations
  Serological, genetic and clinical associations with increased health-care resource utilization in inflammatory bowel disease
  Phillip Gu, Anshika Kapur, Dalin Li, Talin Haritunians, Eric A. Vasiliauskas, David Q. Shih, Stephan R. Targan, Brennan Mr Spiegel, Dermot P.B. McGovern, Jeanne T. Bla...> ;Journal of Digestive Diseases. 2018 Jan 1
• 10 citations
  Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis.
  Jill M. Hoffman, Aristea Sideri, Jonathan J. Ruiz, Dimitris Stavrakis, David Q. Shih, Jerrold R. Turner, Charalabos Pothoulakis, Iordanes Karagiannides> ;Cellular and Molecular Gastroenterology and Hepatology. 2018 Jan 1
• 10 citations
  CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway.
  Chunlan Xu, Sally Ghali, Jiani Wang, David Q. Shih, Christina Ortiz, Elaine C. Lee, Diana H. Tran, Jonathan P. Jacobs, Venu Lagishetty, Phillip Fleshner, Lori Robbins,...> ;Scientific Reports. 2017 Nov 27
• 27 citations
  TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice
  Hui Li, Jia Song, Guochao Niu, Hong Zhang, Jinbo Guo, David Q. Shih, Stephan R. Targan, Xiaolan Zhang> ;Pathology, Research and Practice. 2017 Nov 26
• 8 citations
  Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis
  Shurui Xie, Junyan An, Libo Zheng, Xiaoxia Huo, Jian Guo, David Q. Shih, Xiaolan Zhang> ;World Journal of Gastroenterology. 2017 Aug 28
• 19 citations
  Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD.
  Soon Man Yoon, Talin Haritunians, Sultan Chhina, Zhenqiu Liu, Shaohong Yang, Carol J. Landers, Dalin Li, Byong Duk Ye, David Q. Shih, Eric A. Vasiliauskas, Andrew Ippo...> ;Inflammatory Bowel Diseases. 2017 Aug 1
• 22 citations
  The protection role of Atg16l1 in CD11c+dendritic cells in murine colitis.
  Hong Zhang, Libo Zheng, Jeremy Chen, Masayuki Fukata, Ryan Ichikawa, David Q. Shih, Xiaolan Zhang> ;Immunobiology. 2017 Jul 1
• 23 citations
  Insights on the use of biosimilars in the treatment of inflammatory bowel disease.
  Michael K Zheng, David Q. Shih, Gary C Chen> ;World Journal of Gastroenterology. 2017 Mar 21
• 124 citations
  Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis
  Markus Tschurtschenthaler, Timon E. Adolph, Jonathan W. Ashcroft, Lukas Niederreiter, Richa Bharti, Svetlana Saveljeva, Joya Bhattacharyya, Magdalena B. Flak, David Q....> ;The Journal of Experimental Medicine. 2017 Feb 1
• 45 citations
  Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.
  Hong Zhang, Libo Zheng, Dermot P.B. McGovern, Ariel M. Hamill, Ryan Ichikawa, Yoshitake Kanazawa, Justin Luu, Kotaro Kumagai, Marianne Cilluffo, Masayuki Fukata, Steph...> ;Journal of Immunology. 2017 Jan 27
• 15 citations
  Outcomes with Anti-Tumour Necrosis Factor-Alpha Therapy and Serology in Patients with Denovo Crohn’s Disease After Ileal Pouch Anal Anastomosis
  Lori Robbins, Karen Zaghiyan, Gil Y. Melmed, Eric A. Vasiliauskas, Shahzad Ahmed, Dermot P.B. McGovern, Shervin Rabizadeh, Namita Singh, Carol J. Landers, Andrew Ippol...> ;Journal of Crohn's & Colitis. 2017 Jan 1
• Join now to see all

Journal Articles

• Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study  
  A. V. Weizman, B. Huang, S. Targan, M. Dubinsky, P. Fleshner, M. Kaur, A. Ippoliti, D. Panikkath, E. Vasiliauskas, D. Shih, D. P. McGovern, G. Y. Melmed., J Cutan Med Surg, 1/1/2014
• Inflammatory Bowel Disease Associated Colorectal Neoplasia  
  M. Vu, J. Chang, J. Chen, D. Q. Shih., Journal of Gastrointestinal & Digestive System, 1/1/2012

Books/Book Chapters

• Antimicrobial peptides: Properties, Functions and Role in Immune Response 
  Chapter: Antimicrobial Peptides in Intestinal Inflammation and Infection 
  T. C. Hing, D. Q. Shih, et. al.Nova Science Publishers, Inc.2012
• Ulcerative Colitis - Epidemiology, Pathogenesis and Complications 
  Chapter: Exraintestinal Manifestations of Ulcerative Colitis 
  Page 131.0 - 172.0B. Huang, L. Y. Kwan, D. Q. Shih.Tech Publishing2011

Abstracts/Posters

• IBD-Associated Effects of Fat-Derived Mediators in the Regulation of Adiponectin Receptor 1 (AdipoR1) in Human Colonocytes
  A. Sideri, D. Q. Shih, P. Fleshner, R. Arsenescu, J. R. Turner, C. Pothoulakis, I. Karagiannidis., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Genetic Variation Associated Medically Refractory Ulcerative Colitis Requiring Colectomy
  T. Haritunians, D. Li, X. Yan, E. Mengesha, S. S. Rich, S. Onengut-Gumuscu, W. Chen, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Intestinal Cathelicidin Level Indicates Inflammatory Bowel Disease Activity and Mediates Anti-Inflammatory Effects in Colitis
  S. Ho, M. Cheng, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Microarray Analysis of Ulcerative Colitis and Correlation With Conventional Clinical and Histologic Features
  B. P. Halloran, J. J. Chang, D. P. McGovern, S. Targan, A. Thiesen, D. Q. Shih, R. N. Fedorak, P. F. Halloran, Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• TL1A Modulates the Differential Effect of IL-17 Blockade on Mucosal Inflammation
  K. L. Wallace, L. Zheng, Y. Kanazawa, H. Zhang, R. Ichikawa, J. Chen, M. Sidhu, X. Zhang, D. Q. Shih., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Medical Prophylaxis After Ileocolic Resection for Crohn's Disease - No Need to Rush
  K. N. Zaghiyan, G. Y. Melmed, M. Dubinsky, E. A. Vasiliauskas, D. P. McGovern, A. Ippoliti, D. Q. Shih, et. al, Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Modulation of Thiopurine Metabolism by Anti-TNF Therapy
  J. Yoon, B. L. Huang, G. Y. Melmed, J. Amin, A. Ippoliti, D. P. B. McGovern, S. R. Targan, E. A. Vasiliauskas, D. Q. Shih, Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Genetic and Serological Predictors of H. Pylori Infection in Patients with Inflammatory Bowel Disease
  B. L. Huang, J. Amin, M. Stewart, J. Yoon, G. Y. Melmed, A. Ippoliti, E. A. Vasiliauskas, S. R. Targan, D. P. B. McGovern, D. Q. Shih, Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2014
• Human Monoclonal Antibodies against Clostridium Difficile Toxin a and B Inhibit Inflammatory Responses and Epithelial Cell Damage to Toxins a and B in Human Peripheral...
  T. Hing, H. W. Koon, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Effects of Substance P on Pro and Anti-inflammatory Responses of Human Mesenteric Preadipocytes Isolated from IBD Patients
  A. Sideri, K. Bakirtzi, R. Arsenescu, P. Fleshner, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Perianal Crohn's Disease Is Associated with Distal Colonic Disease, IBD-related Serologies and Immune-related Genetic Variation
  M. Kaur, D. Panikkath, D. Li, D. Berel, E. A. Vasiliauskas, A. Ippoliti, M. Dubinsky, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Preoperative Serum Biologic Levels Do Not Impact Postoperative Outcomes in Ulcerative Colitis
  C. C. Lau, M. Dubinsky, G. Y. Melmed, E. A. Vasiliauskas, D. P. McGovern, D. Berel, A. Ippoliti, Z. A. Murrell, A. Ippoliti, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Higher Preoperative Serum Biologic Levels Are Associated with Postoperative Complications in Crohn's Diseae Patients
  C. C. Lau, M. Dubinsky, G. Y. Melmed, E. A. Vasiliauskas, D. P. McGovern, D. Berel, Z. A. Murrell, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Influence of Biologic Agents on Short-term Postoperative Complications in Patients with Crohn's Disease: A Prospective, Single-surgeon Cohort Study
  C. C. Lau, M. Dubinsky, G. Y. Melmed, E. A. Vasiliauskas, D. P. McGovern, D. Berel, A. Ippoliti, Z. A. Murrell, A. Ippoliti, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Intestinal Cathelicidin Levels Predict Prognosis of Ulcerative Colitis Patients
  H. W. Koon, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Complications and Length of Stay after Cholecystectomy Are Increased among Men with IBD
  H. Al-Jiboury, A. V. Weizman, D. Berel, M. Berns, M. Dubinsky, S. R. Targan, E. A. Vasiliauskas, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Thromboembolic Risk in Hospitalized IBD Patients Is Compounded by Traditional Risk Factors and Hypercoagulable States
  A. N. Levy, J. M. Anderson, H. Horton, E. Sun, E. A. Vasiliauskas, M. Dubinsky, P. Fleshner, D. Q. Shih, et. al, Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Clinical, Serologic, and Genetic Associations in Patients with Ocular Manifestations in Inflammatory Bowel Disease
  S. Taleban, D. Li, S. R. Targan, A. Ippoliti, E. A. Vasiliauskas, J. I. Rotter, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Potential Synergism between Anti-TNF and Thiopurine Therapy: Increased Thiopurine Metabolites by Anti-TNF
  J. L. Yoon, B. L. Huang, S. S. Karsan, G. Y. Melmed, A. Ippoliti, M. Dubinsky, M. Kaur, M. Nguyen, P. Vora, P. Fleshner, D. P. McGovern, S. R. Targan, E. A. Vasiliausk..., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Genetic and Serologic Associations with 6-MMP Preferential Metabolizers Reveal Novel Pathways That May Be Involved in Thiopurine Metabolism
  S. S. Karsan, B. L. Huang, j. L. Yoon, M. Dubinsky, D. Berel, X. Yan, G. Y. Melmed, A. Ippoliti, X. Guo, K. D. Taylor, M. Kaur, J. I. Rotter, S. R. Targan, E. A. Vasil..., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Constitutive TL1A Expression Modulates Colonic Fibrosis on TNBS-induced Colitis in Mice
  X. Zhang, H. Li, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting, Gastroenterology, 1/1/2013
• Anti-fibrogenic Roles of Cathelicidin in Chronic Colitis Associated Colonic Fibrosis
  J. H. Yoo, S. Ho, M. Cheng, D. H. Tran, Y. Kubota, T. Hing, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Preadipocyte-specific Effects on Human Colonocyte Proinflammatory Responses Are Obesity and IBD-dependent
  A. Sideri, K. Bakirtzi, R. Arsenescu, P. Fleshner, D. Q. Shih, et. al., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• L. Zheng, X. Zhang, R. Ichikawa, J. Chen, K. Wallace, C. Pothoulakis, H. W. Koon, S. R. Targan, D. Q. Shih., Digestive Disease Weekly National Scientific Meeting. Gastroenterology, 1/1/2013
• Reversal of Murine Colitis and Fibrosis by Neutralizing TL1A Antibody: Potential Novel Therapy to Alter Natural History of Crohn's Disease
  D. Q. Shih, L. Zheng, X. Zhang, et. al., The 16th International Congress of Mucosal Immunology, 1/1/2013
• Join now to see all

Lectures

• Differentiation Of ES Cells Into Insulin Expressing Cells In Vitro 
  Keble College, Oxford, England - 1/12/2000
• Hepatocyte Nuclear Factor-1alpha Is an Essential Regulator of Bile Acid and Plasma Cholesterol Metabolism 
  Philadelphia, PA - 1/22/2001
• Using Embryonic Stem Cells to Generate Insulin Secreting Pancreatic Endocrine Cells 
  San Francisco, CA - 1/14/2005
• Induction of an IBD Gene, TL1A, in Antigen Presenting Cells 
  San Diego, CA - 1/18/2008
• Microbial Induction of an IBD Associated Gene, TL1A 
  Villa Graziadio, Pepperdine University, CA - 1/15/2009
• Characterization of an Inflammatory Bowel Disease Gene TL1A 
  UCLA, CA - 1/19/2009
• Role of Autophagy in the Induction of an Inflammatory Bowel Disease Gene TL1A 
  Cedars Sinai Medical Center, CA - 1/23/2009
• Microbial Induction of an IBD Gene, TL1A 
  Judith D. Tamkin Auditorium, UCLA, CA - 1/15/2009
• Moderator for Inflammatory Bowel Disease Case Discussion 
  Santa Monica, CA - 1/9./2009
• Constitutive in vivo Expression of TNFSF15 in Myeloid or Lymphoid Cells Induce Mild Small Bowel Inflammation in Mice 
  New Orleans, LA - 1/2./2010
• Severity of Cytomegalovirus Infection on Pathology Specimens is Associated with Colectomy Rates and Response to Antiviral Therapy in Inflammatory Bowel Disease Patients 
  New Orleans, LA - 1/5./2010
• New Frontiers in Treatment and Research in IBD 
  Irvine, CA - 1/23/2010
• New Frontiers in New Frontiers in IBD Research 
  Los Angeles, CA - 1/16/2011
• Role of TL1A in Murine Models of Gut Inflammation and Fibrosis 
  1/11/2011
• Clinical, Serologic, and Genetic Associations With Low Bone Density in Patients With Inflammatory Bowel Disease 
  Chicago, IL - 1/7./2011
• Predicting Crohn's Disease Post-Operative Recurrence Using Clinical, Endoscopic, Serologic and Genetic Factors 
  Chicago, IL - 1/10/2011
• In Vivo Constitutive Expression of an IBD Associated Gene TNFSF15 Causes Severe Inflammation and Induces Fibrostenotic Disease in 2 Murine Models of Chronic Colitis 
  Chicago, IL - 1/10/2011
• Moderator for Animal Models of Intestinal Inflammation Oral Session 
  Chicago, IL - 1/10/2011
• Therapies for Inflammatory Bowel Disease 
  West Hills Medical Center, West Hills, CA - 1/20/2011
• Inflammatory Bowel Disease Therapies 
  Northridge Hospital Medical Center, Northridge, CA - 1/18/2011
• Optimizing Thiopurine Therapy in IBD Management 
  Los Angeles, CA - 1/17/2012
• Moderator for Inflammatory Bowel Disease 
  Los Angeles, CA - 1/9./2012
• USC IBD Grand Round 
  Los Angeles, CA - 1/17/2012
• Moderator for Innate Immune Function in IBD Pathogenesis 
  San Diego, CA - 1/22/2012
• Reversal of Murine Colitis and Fibrosis by Neutralizing TL1A Antibody: Potential Novel Therapy to Alter Natural History of Crohn's Disease 
  San Diego, CA - 1/22/2012
• Join now to see all