DavidJeffreySimonMD

Emergency Medicine • Ellwood City, PA

Physician

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Office
724 Pershing Street
Ellwood City Hospital
Ellwood City, PA 16117
Phone+1 724-752-6744

Fax+1 610-617-6280
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Summary

Dr. David Simon, MD is an emergency medicine physician in Ellwood City, Pennsylvania. He is currently licensed to practice medicine in Pennsylvania, Florida, and California. He is affiliated with Ellwood City Medical Center, LLC.

Education & Training

UPMC Medical EducationInternship, Internal Medicine, 1975 - 1976
University of Pittsburgh School of MedicineClass of 1975

Certifications & Licensure

CA State Medical License 1981 - Present
PA State Medical License 1976 - 2024
FL State Medical License 1989 - 1998

Publications & Presentations

PubMed

24 citations
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
Roi Ankawa, Nitzan Goldberger, Yahav Yosefzon, Elle Koren, Marianna Yusupova, Daniel Rosner, Alona Feldman, Shulamit Baror-Sebban, Yosef Buganim, David J. Simon, Marc ...> ;Developmental Cell. 2021 Jul 12
A good gut feeling on Sarm1-mediated axon degeneration
Victoria E. von Saucken, David J. Simon> ;Protein & Cell. 2021 Apr 26
5 citations
An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53.
David J. Simon, Deanna M Belsky, Margot E. Bowen, Christine Y.J. Ohn, Melanie K. O’Rourke, Rebecca J. Shen, Garam Kim, Jason Pitts, Laura D. Attardi, Marc Tessier-Lavigne> ;Developmental Cell. 2021 Apr 5
80 citations
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).
Maya Maor-Nof, Zohar Shipony, Rodrigo Lopez-Gonzalez, Lisa Nakayama, Yong Jie Zhang, Julien Couthouis, Jacob A. Blum, Patricia A. Castruita, Gabriel R. Linares, Kai Ru...> ;Cell. 2021 Feb 4
5 citations
Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway.
Zirong Gu, Natasha Koppel, John Kalamboglas, Gabriella Alexandrou, Jie Li, Corey Craig, David J. Simon, Marc Tessier-Lavigne, Mark L. Baccei, John H. Martin, Yutaka Yo...> ;The Journal of Neuroscience. 2020 May 29
12 citations
Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration
Nicholas T. Hertz, Eliza L. Adams, Ross A. Weber, Rebecca J. Shen, Melanie K. O’Rourke, David J. Simon, Henry Zebroski, Olav Olsen, Charles W. Morgan, Trevor R. Mileur...> ;Neuron. 2019 Aug 7
35 citations
Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration.
Guiping Wang, David J. Simon, Zhuhao Wu, Deanna M Belsky, Evan Heller, Melanie K. O’Rourke, Nicholas T. Hertz, Henrik Molina, Guisheng Zhong, Marc Tessier-Lavigne, Xia...> ;Elife. 2019 May 1
83 citations
Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.
Lu O. Sun, Sara B. Mulinyawe, Hannah Y. Collins, Adiljan Ibrahim, Qingyun Li, David J. Simon, Marc Tessier-Lavigne, Ben A. Barres> ;Cell. 2018 Dec 13
18 citations
Therapeutic opportunities and pitfalls in the treatment of axon degeneration
David J. Simon, Trent A. Watkins> ;Current Opinion in Neurology. 2018 Dec 1
10 citations
Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression
Edward C.G. Pym, Nikhil Sasidharan, Katherine L. Thompson-Peer, David J. Simon, Anthony Anselmo, Ruslan I. Sadreyev, Qi Hall, Stephen Nurrish, Joshua M. Kaplan> ;Elife. 2017 May 6
101 citations
Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species
Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Fre...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 May 24
96 citations
Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling.
David J. Simon, Jason Pitts, Nicholas T. Hertz, Jing Yang, Yuya Yamagishi, Olav Olsen, Milica Tesic Mark, Henrik Molina, Marc Tessier-Lavigne> ;Cell. 2016 Feb 25
216 citations
Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit
Jing Yang, Zhuhao Wu, Nicolas Renier, David J. Simon, Kunihiro Uryu, David S. Park, Peter A. Greer, Cathy Tournier, Roger J. Davis, Marc Tessier-Lavigne> ;Cell. 2015 Jan 15
944 citations
iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging
Nicolas Renier, Zhuhao Wu, David J. Simon, Jing Yang, Pablo Ariel, Marc Tessier-Lavigne> ;Cell. 2014 Nov 6
44 citations
Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.
Olav Olsen, Dara Y. Kallop, Todd McLaughlin, Sarah Huntwork-Rodriguez, Zhuhao Wu, Cynthia Duggan, David J. Simon, Yanmei Lu, Courtney Easley-Neal, Kentaro Takeda, Phil...> ;The Journal of Neuroscience. 2014 May 7
159 citations
A Caspase Cascade Regulating Developmental Axon Degeneration
David J. Simon, Robby M. Weimer, Todd McLaughlin, Dara Y. Kallop, Karen Stanger, Jing Yang, Dennis D.M. O'Leary, Rami N. Hannoush, Marc Tessier-Lavigne> ;The Journal of Neuroscience. 2012 Dec 5
152 citations
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
David J. Simon, Jon M. Madison, Annie L. Conery, Katherine L. Thompson-Peer, Michael J. Soskis, Gary Ruvkun, Joshua M. Kaplan, John Kim> ;Cell. 2008 May 30
14 citations
Constant amplitude of postsynaptic responses for single presynaptic action potentials but not bursting input during growth of an identified neuromuscular junction in t...
Stefan R. Pulver, Dirk Bucher, David J. Simon, Eve Marder> ;Journal of Neurobiology. 2005 Jan 1
Associations of renal function with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead work...
Weaver, V.M., Schwartz, B.S., Ahn, K., Stewart, W.F., Kelsey, K.T., Todd, A.C., Wen, J., Simon, D.J., Lustberg, M.E., Parsons, P.J., Silbergeld, E.K., Lee, B.> ;Environ Health Perspect. 2003 Oct
32 citations
Serotonin in the developing stomatogastric system of the lobster, Homarus americanus.
Kathryn S. Richards, David J. Simon, Stefan R. Pulver, Barbara S. Beltz, Eve Marder> ;Journal of Neurobiology. 2003 Feb 5
Migraine and reduced work performance: a population-based diary study.
Von Korff, M., Stewart, W. F., Simon, D. J., Lipton, R. B.> ;Neurology. 1998 Jun
16 citations
GABA Enhances Transmission at an Excitatory Glutamatergic Synapse
Scott Gutovitz, John T. Birmingham, Jason A. Luther, David J. Simon, Eve Marder> ;The Journal of Neuroscience. 2001 Aug 15
Associations of lead biomarkers with renal function in Korean lead workers.
Weaver, V. M., Lee, B. K., Ahn, K. D., Lee, G. S., Todd, A. C., Stewart, W. F., Wen, J., Simon, D. J., Parsons, P. J., Schwartz, B. S.> ;Occup Environ Med. 2003 Aug
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Press Mentions

Crackdown on Unproven Stem Cell Therapies Long Overdue, Ottawa Scientist SaysJuly 10th, 2019
Deepak Chopra Explains the Deeper Meaning of YogaMay 20th, 2018
Post #54 – How to Optimize Your Immune System? – Part IV – by DestressingJune 28th, 2016

Hospital Affiliations

Ellwood City Medical Center, LLCEllwood City, Pennsylvania