DavidAWilliamsMD

PubMed

• 3 citations
  Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease.
  Michael Spencer Chapman, Alyssa H Cull, Marioara F Ciuculescu, Erica B Esrick, Emily Mitchell, Hyunchul Jung, Laura O'Neill, Kirsty Roberts, Margarete A Fabre, Nichola...> ;Nature Medicine. 2023 Dec 1
• 4 citations
  Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome.
  Roxane Labrosse, Julia I Chu, Myriam A Armant, John K Everett, Danilo Pellin, Niharika Kareddy, Andrew L Frelinger, Lauren A Henderson, Amy E O'Connell, Amlan Biswas, ...> ;Blood. 2023 Oct 12
• 2 citations
  Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
  Daniel C De Souza, Nicolas Hebert, Erica B Esrick, M Felicia Ciuculescu, Natasha M Archer, Myriam Armant, Étienne Audureau, Christian Brendel, Giuseppe Di Caprio, Fréd...> ;Nature Communications. 2023 Sep 20
• 4 citations
  Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease.
  Mary Eapen, Ruta Brazauskas, David A Williams, Mark C Walters, Andrew St Martin, Benjamin L Jacobs, Joseph H Antin, Kira Bona, Sonali Chaudhury, Victoria H Coleman-Cow...> ;Journal of Clinical Oncology. 2023 Apr 20
• 2 citations
  Consensus Recommendations for Managing Childhood Cancer Survivors at Risk for Stroke After Cranial Irradiation: A Delphi Study.
  Lisa B Kenney, Bethany L Ames, Mary S Huang, Torunn Yock, Daniel C Bowers, Larissa Nekhlyudov, David Williams, Melissa M Hudson, Nicole J Ullrich> ;Neurology. 2022 Oct 18
• Transient neonatal hemolytic anemia due to the novel gamma globin gene mutation HBG2:C.290T>C, p.Leu97Pro (hemoglobin Wareham).
  Lev Gorfinkel, Franziska Wachter, Hong-Yuan Luo, Eileen Hansbury, David A Williams, Archana Agarwal, David H K Chui, Alan B Cantor> ;Pediatric Blood & Cancer. 2023 Jan 1
• 9 citations
  Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies.
  Boya Liu, Christian Brendel, Divya S Vinjamur, Yu Zhou, Chad Harris, Meaghan McGuinness, John P Manis, Daniel E Bauer, Haiming Xu, David A Williams> ;Molecular Therapy. 2022 Aug 3
• 2 citations
  Advocacy for research starting early in the life course.
  Tina L Cheng, Carolyn Russo, Conrad Cole, David A Williams> ;Pediatric Research. 2022 May 1
• 1 citations
  Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects.
  Sara Canovas Nunes, Serena De Vita, Andrew Anighoro, François Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad Harris, Lu Yang,...> ;Blood Cancer Journal. 2022 Apr 14
• 24 citations
  Clonal hematopoiesis in sickle cell disease.
  L Alexander Liggett, Liam D Cato, Joshua S Weinstock, Yingze Zhang, S Mehdi Nouraie, Mark T Gladwin, Melanie E Garrett, Allison Ashley-Koch, Marilyn J Telen, Brian Cus...> ;The Journal of Clinical Investigation. 2022 Feb 15
• 2 citations
  Deletion of murineleads to de-repression ofvia decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
  Hiroto Horiguchi, Haiming Xu, Beatrice Duvert, Felicia Ciuculescu, Qiuming Yao, Amit Sinha, Meaghan McGuinness, Chad Harris, Christian Brendel, Anja Troeger, Roberto C...> ;Small Gtpases. 2022 Jan 1
• 1 citations
  Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6
  Raffaele Renella, Katelyn Gagne, Ellen M. Beauchamp, Jonathan Fogel, Aleksej Perlov, Mireia Sola, Thorsten M. Schlaeger, Inga Hofmann, Akiko Shimamura, Benjamin L. Ebe...> ;American Journal of Hematology. 2021 Oct 22
• 8 citations
  Restored Macrophage Function Ameliorates Disease Pathophysiology in a Mouse Model for IL10 Receptor-deficient Very Early Onset Inflammatory Bowel Disease.
  Mania Ackermann, Adele Mucci, Amanda McCabe, Sandy Frei, Kayla Wright, Scott B. Snapper, Nico Lachmann, David R. Williams, Christian Brendel> ;Journal of Crohn's & Colitis. 2021 Sep 25
• 70 citations
  Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C).
  Janet Chou, Craig D. Platt, Saddiq Habiballah, Alan A. Nguyen, Megan Elkins, Sabrina Weeks, Zachary Peters, Megan Day-Lewis, Tanya Novak, Myriam Armant, Lucinda Willia...> ;The Journal of Allergy and Clinical Immunology. 2021 Sep 1
• 168 citations
  Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
  Erica B. Esrick, Leslie Lehmann, Alessandra Biffi, Maureen Achebe, Christian Brendel, Marioara F. Ciuculescu, Heather Daley, Brenda L. MacKinnon, Emily Morris, Amy Fed...> ;The New England Journal of Medicine. 2021 Jan 21
• 2 citations
  Peripheral blood smears of children with multisystem inflammatory syndrome demonstrate prominence of early myeloid forms with morphologic evidence of toxic change.
  Jonathan Paolino, David A. Williams> ;Pediatric Blood & Cancer. 2021 Jan 1
• Two Decades of Molecular Therapy and a 35-Year Personal View of Changes in Gene Therapy.
  Williams, D. A.> ;Mol. Ther.. 2019 Feb 19
• 51 citations
  Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients.
  Erica B. Esrick, John P. Manis, Heather Daley, Cristina Baricordi, Helene Trebeden-Negre, Francis J. Pierciey, Myriam Armant, Sarah Nikiforow, Matthew M. Heeney, Wendy...> ;Blood Advances. 2018 Oct 9
• Stereotyping across intersections of race and age: Racial stereotyping among White adults working with children.
  Priest, N.,Slopen, N.,Woolford, S.,Philip, J. T.,Singer, D.,Kauffman, A. D.,Mosely, K.,Davis, M.,Ransome, Y.,Williams, D.> ;PLoS ONE. 2018 Sep 13
• T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency.
  Clarke, E. L.,Connell, A. J.,Six, E.,Kadry, N. A.,Abbas, A. A.,Hwang, Y.,Everett, J. K.,Hofstaedter, C. E.,Marsh, R.,Armant, M.,Kelsen, J.,Notarangelo, L. D.,Collman, ...> ;Genome Med. 2018 Sep 29
• 55 citations
  The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
  Akshay A. D’Cruz, Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Shu Wang, Alyce A. Chen, Mathilde Gavillet, Arshed Al-Obeidi, Kate E. Lawlor, James E Vince, Michel...> ;Science Signaling. 2018 Sep 4
• DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs.
  Park, H. H.,Triboulet, R.,Bentler, M.,Guda, S.,Du, P.,Xu, H.,Gregory, R. I.,Brendel, C.,Williams, D. A.> ;Mol Ther Nucleic Acids. 2018 Sep 10
• A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target.
  Gavillet, M.,Martinod, K.,Renella, R.,Wagner, D. D.,Williams, D. A.> ;Am. J. Hematol.. 2017 Nov 11
• Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors.
  Alonso-Ferrero, M. E.,van Til, N. P.,Bartolovic, K.,Mata, M. F.,Wagemaker, G.,Moulding, D.,Williams, D. A.,Kinnon, C.,Waddington, S. N.,Milsom, M. D.,Howe, S. J.> ;Exp. Hematol.. 2017 Sep 16
• The gp130 Cytokine IL-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients.
  De Vita, S.,Li, Y.,Harris, C. E.,McGuinness, M. K.,Ma, C.,Williams, D. A.> ;Stem Cells. 2017 Dec 14
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Abstracts/Posters

• Investigation of Cell-Contact Dependent Alterations in Immune Synapse Formation between T Cells and BCP-ALL Cells
  David A Williams, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Outcome of Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome
  David A Williams, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Advancing the Treatment of Hemoglobinopathies: Gene Therapy for Beta Thalassemia and Sickle Cell Disease 
  60th American Society of Hematology Annual Meeting - 11/30/2018