DeanFelsherMD

PubMed

• A big step for MYC-targeted therapies.
  Anja Deutzmann, Danielle F Atibalentja, Dean W Felsher> ;Trends in Cancer. 2024 Apr 4
• Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma.
  Deutzmann, A., Sullivan, D., Li, W., Chen, X., Tong, L., Mahauad-Fernandez, W., Bell, J., Mosley, A., Koehler, A., Li, Y., Dhanasekaran, R., Felsher, D.> ;Nature Communications. 2024 Feb 1
• 3 citations
  Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity.
  Eleanor Valenzi, Harinath Bahudhanapati, Jiangning Tan, Tracy Tabib, Daniel I Sullivan, Mehdi Nouraie, John Sembrat, Li Fan, Kong Chen, Silvia Liu, Mauricio Rojas, Aud...> ;The European Respiratory Journal. 2023 Jul 1
• 10 citations
  MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.
  Benjamin A H Smith, Anja Deutzmann, Kristina M Correa, Corleone S Delaveris, Renumathy Dhanasekaran, Christopher G Dove, Delaney K Sullivan, Simon Wisnovsky, Jessica C...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Mar 14
• 2 citations
  MYC Overexpression Drives Immune Evasion in Hepatocellular Carcinoma That Is Reversible through Restoration of Proinflammatory Macrophages.
  Renumathy Dhanasekaran, Aida S Hansen, Jangho Park, Lea Lemaitre, Ian Lai, Nia Adeniji, Sibu Kuruvilla, Akanksha Suresh, Josephine Zhang, Varsha Swamy, Dean W Felsher> ;Cancer Research. 2023 Feb 15
• 8 citations
  MYC oncogene elicits tumorigenesis associated with embryonic, ribosomal biogenesis, and tissue-lineage dedifferentiation gene expression changes.
  Delaney K Sullivan, Anja Deutzmann, Josiah Yarbrough, Maya S Krishnan, Arvin M Gouw, David I Bellovin, Stacey J Adam, Daniel F Liefwalker, Renumathy Dhanasekaran, Dean...> ;Oncogene. 2022 Nov 1
• Na/H-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells.
  Yao-Yu Gong, Hongguang Shao, Yu Li, Patricia Brafford, Zachary E Stine, Jing Sun, Dean W Felsher, Jordan S Orange, Steven M Albelda, Chi V Dang> ;Cancer Research Communications. 2022 Aug 1
• Azapodophyllotoxin Causes Lymphoma and Kidney Cancer Regression by Disrupting Tubulin and Monoglycerols.
  Arvin M Gouw, Vineet Kumar, Angel Resendez, Fidelia B Alvina, Natalie S Liu, Katherine Margulis, Ling Tong, Richard N Zare, Sanjay V Malhotra, Dean W Felsher> ;ACS Medicinal Chemistry Letters. 2022 Apr 14
• Tackling heterogeneity in treatment-resistant breast cancer using a broad-spectrum therapeutic approach.
  Leroy Lowe, J William LaValley, Dean W Felsher> ;Cancer Drug Resistance. 2022 Jan 1
• 11 citations
  Anti-PD-L1 F(ab) Conjugated PEG-PLGA Nanoparticle Enhances Immune Checkpoint Therapy.
  Christina K Lee, Danielle F Atibalentja, Lilian E Yao, Jangho Park, Sibu Kuruvilla, Dean W Felsher> ;Nanotheranostics. 2022 Jan 1
• 2 citations
  Cyclic adenosine monophosphate/phosphodiesterase 4 pathway associated with immune infiltration and PD-L1 expression in lung adenocarcinoma cells.
  Ling Tong, Minjie Shan, Wen Zou, XianLing Liu, Dean W Felsher, Jingjing Wang> ;Frontiers in Oncology. 2022 Jan 1
• 215 citations
  The MYC oncogene - the grand orchestrator of cancer growth and immune evasion.
  Renumathy Dhanasekaran, Anja Deutzmann, Wadie D. Mahauad-Fernandez, Aida S. Hansen, Arvin M. Gouw, Dean W. Felsher> ;Nature Reviews. Clinical Oncology. 2021 Sep 10
• 6 citations
  Twist1 is required for the development of UVB‐induced squamous cell carcinoma
  Fernando Eguiarte-Solomon, Nicholas Blazanin, Okkyung Rho, Steve Carbajal, Dean W. Felsher, Phuoc T. Tran, John DiGiovanni> ;Molecular Carcinogenesis. 2021 Mar 13
• 40 citations
  Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging
  Hao Chen, Kangquan Shou, Si Chen, Chunrong Qu, Zhiming Wang, Lei Jiang, Mark Zhu, Bingbing Ding, Kun Qian, Aiyan Ji, Hongyue Lou, Ling Tong, Alexander Hsu, Yuebing Wan...> ;Advanced Materials. 2021 Apr 1
• 6 citations
  A mathematical model of tumor regression and recurrence after therapeutic oncogene inactivation.
  Sharon S. Hori, Ling Tong, Srividya Swaminathan, Mariola Liebersbach, Jingjing Wang, Sanjiv S. Gambhir, Dean W. Felsher> ;Scientific Reports. 2021 Jan 14
• 1 citations
  Generation of a Tetracycline Regulated Mouse Model of MYC-Induced T-Cell Acute Lymphoblastic Leukemia.
  Wadie D Mahauad-Fernandez, Kavya Rakhra, Dean W Felsher> ;Methods in Molecular Biology. 2021 Jan 1
• 50 citations
  Genomic Analysis of Vascular Invasion in HCC Reveals Molecular Drivers and Predictive Biomarkers
  Maya Krishnan, Anand Rajan Kd, Jangho Park, Vinodhini Arjunan, Fernando Jose Garcia Marques, Abel Bermudez, Olivia A. Girvan, Nam S. Hoang, Jun Yin, Mindie H. Nguyen, ...> ;Hepatology. 2021 Jun 1
• 121 citations
  Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
  Liyang Cui, Arvin M. Gouw, Edward L. LaGory, Shenghao Guo, Nabeel Attarwala, Yao Tang, Ji Qi, Yun Sheng Chen, Zhou Gao, Kerriann M. Casey, Arkadiy A. Bazhin, Min Chen,...> ;Nature Biotechnology. 2021 Mar 1
• 11 citations
  The Myc and Ras Partnership in Cancer: Indistinguishable Alliance or Contextual Relationship?
  Wadie D. Mahauad-Fernandez, Dean W. Felsher> ;Cancer Research. 2020 Sep 15
• 13 citations
  MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC.
  Renumathy Dhanasekaran, Jangho Park, Alekesey Yevtodiyenko, David I. Bellovin, Stacey J. Adam, Anand Rajan Kd, Meital Gabay, Hanan Fernando, Julia Arzeno, Vinodhini Ar...> ;Molecular Therapy. Nucleic Acids. 2020 Sep 4
• 32 citations
  MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
  Srividya Swaminathan, Aida S. Hansen, Line Dam Heftdal, Renumathy Dhanasekaran, Anja Deutzmann, Wadie D. M. Fernandez, Daniel F. Liefwalker, Crista Horton, Adriane Mos...> ;Nature Communications. 2020 Jun 5
• 29 citations
  MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity.
  Renumathy Dhanasekaran, Virginie Baylot, Minsoon Kim, Sibu P. Kuruvilla, David I. Bellovin, Nia Adeniji, Anand Rajan Kd, Ian Lai, Meital Gabay, Ling Tong, Maya Krishna...> ;Elife. 2020 Jan 14
• 38 citations
  The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them
  Martyn T. Smith, Kathryn Z. Guyton, Nicole Kleinstreuer, Alexandre Borrel, Andres Cardenas, Weihsueh A. Chiu, Dean W. Felsher, Catherine F. Gibbons, William H. Goodson...> ;Cancer Epidemiology, Biomarkers & Prevention. 2020 Jan 1
• 13 citations
  Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
  Yulin Li, Daniel Thomas, Anja Deutzmann, Ravindra Majeti, Dean W. Felsher, David L. Dill> ;Scientific Reports. 2019 Nov 14
• 102 citations
  The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth
  Arvin M. Gouw, Katherine Margulis, Natalie S. Liu, Sudha Janaki Raman, Anthony A. Mancuso, Georgia G. Toal, Ling Tong, Adriane Mosley, Annie L. Hsieh, Delaney K. Sulli...> ;Cell Metabolism. 2019 Sep 3
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Abstracts/Posters

• The Glutathione Redox System Is Essential to Prevent Ferroptosis Caused by Impaired Lipid Metabolism in Clear Cell Renal Cell Carcinoma
  Dean Felsher, MD, Nature, Orlando, FL, 12/9/2019