DeborahJHartMD

PubMed

• 64 citations
  Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
  Martha C. Castaño-Betancourt, Daniel S. Evans, Yolande F. M. Ramos, Cindy G. Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, Jeroen van Rooij, Virginia B. Kr...> ;Plos Genetics. 2016 Oct 4
• 9 citations
  A comparison of radiographic anatomic axis knee alignment measurements and cross-sectional associations with knee osteoarthritis
  L Goulston, Sanchez-Santos, Stefania D'Angelo, K M Leyland, Deborah J. Hart, Tim D. Spector, Cyrus Cooper, Elaine M. Dennison, David J. Hunter, Nigel K Arden> ;Osteoarthritis and Cartilage. 2016 Apr 1
• 4 citations
  Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS).
  Alireza Moayyeri, Deborah J. Hart, Harold Snieder, Christopher J Hammond, Tim D. Spector, Claire J. Steves> ;Twin Research and Human Genetics. 2016 Feb 1
• 29 citations
  Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women
  Stefan Kluzek, Anne-Christine Bay-Jensen, Andrew Judge, Morten A. Karsdal, Matthew Shorthose, Tim D. Spector, Deborah J. Hart, J Newton, Nigel K Arden> ;Biomarkers. 2015 Nov 17
• 29 citations
  Individuals with high bone mass have an increased prevalence of radiographic knee osteoarthritis
  Sarah A Hardcastle, Paul Dieppe, Celia L Gregson, Nigel K Arden, Tim D. Spector, Deborah J. Hart, Mark H. Edwards, Elaine M. Dennison, C Cooper, Adrian Sayers, Martin ...> ;Bone. 2015 Feb 1
• 99 citations
  Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors
  Hanneke J. M. Kerkhof, S.M.A. Bierma-Zeinstra, Nigel K Arden, Sarah Metrustry, Martha C. Castaño-Betancourt, Deborah J. Hart, A. Hofman, Fernando Rivadeneira, Edwin H....> ;Annals of the Rheumatic Diseases. 2014 Dec 1
• The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.
  Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini FM, Jones G, Arden NK, Doher...> ;Ann. Rheum. Dis.. 2014-12-01
• Subclinical deformities of the hip are significant predictors of radiographic osteoarthritis and joint replacement in women. A 20 year longitudinal cohort study.
  Thomas GER, Palmer AJR, Batra RN, Kiran A, Hart D, Spector T, Javaid MK, Judge A, Murray DW, Carr AJ, Arden NK, Glyn-Jones S> ;Osteoarthr. Cartil.. 2014-10-01
• 19 citations
  Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis
  Orit Blumenfeld, Frances M K Williams, Ana M. Valdes, Deborah J. Hart, Ida Malkin, Tim D. Spector, Gregory Livshits> ;Cytokine. 2014 Sep 1
• Osteophytes, enthesophytes, and high bone mass: a bone-forming triad with potential relevance in osteoarthritis.
  Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ, Edwards MH, Dennison EM, Cooper C, Williams M, Davey Smith G, Tobias JH> ;Arthritis Rheumatol. 2014-09-01
• 35 citations
  Prevalence of radiographic hip osteoarthritis is increased in high bone mass.
  Sarah A Hardcastle, Paul Dieppe, Celia L Gregson, David J. Hunter, Geraint Thomas, Nigel K Arden, Tim D. Spector, Deborah J. Hart, M J Laugharne, G A Clague, Mark H. E...> ;Osteoarthritis and Cartilage. 2014 Aug 1
• 16 citations
  Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance
  Ramos Yfm., Sarah Metrustry, Nigel K Arden, Anne-Christine Bay-Jensen, Marian Beekman, de Craen Ajm., L. A. Cupples, Tõnu Esko, Evangelos Evangelou, David T. Felson, D...> ;Journal of Medical Genetics. 2014 Sep 1
• 18 citations
  SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.
  Erfan Aref-Eshghi, Yuhua Zhang, Deborah J. Hart, Ana M. Valdes, Andrew Furey, Glynn Martin, Guang Sun, Proton Rahman, Nigel K Arden, Tim D. Spector, Guangju Zhai> ;Plos One. 2014 May 22
• 103 citations
  Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
  Unnur Styrkarsdottir, Gudmar Thorleifsson, Hafdis T. Helgadottir, Nils Bomer, Sarah Metrustry, S.M.A. Bierma-Zeinstra, Annelieke M Strijbosch, Evangelos Evangelou, Deb...> ;Nature Genetics. 2014 May 1
• Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in ...
  Valdes AM, Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra S, Hart D, Hofman A, Karsdal M, Kloppenburg M, Kroon HM, Slagboom EP, Spector TD, Uitterlinden AG, van ...> ;Osteoarthr. Cartil.. 2014-05-01
• 11 citations
  Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis
  Tuhina Neogi, Anushka Soni, Sally A Doherty, Laura L Laslett, Rose A. Maciewicz, Deborah J. Hart, Weiya Zhang, Kenneth Muir, Margaret Wheeler, Cyrus Cooper, Tim D. Spe...> ;Annals of the Rheumatic Diseases. 2014 Jan 1
• 21 citations
  Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study
  Orit Blumenfeld, Frances M K Williams, Deborah J. Hart, Tim D. Spector, Nigel K Arden, Gregory Livshits> ;Osteoarthritis and Cartilage. 2013 Jul 1
• 50 citations
  Neuropathic features of joint pain: a community-based study.
  Anushka Soni, R N Batra, Stephen Gwilym, Tim D. Spector, Deborah J. Hart, Nigel K Arden, Cyrus Cooper, Irene Tracey, Muhammad Javaid> ;Arthritis and Rheumatism. 2013 Jul 1
• Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
  Peters MJ, Broer L, Willemen HLDM, Eiriksdottir G, Hocking LJ, Holliday KL, Horan MA, Meulenbelt I, Neogi T, Popham M, Schmidt CO, Soni A, Valdes AM, Amin N, Dennison ...> ;Ann. Rheum. Dis.. 2013-03-01
• 200 citations
  The UK adult twin registry (TwinsUK resource)
  Alireza Moayyeri, Christopher J Hammond, Deborah J. Hart, Tim D. Spector> ;Twin Research and Human Genetics. 2013 Feb 1
• 8 citations
  Lower limbs composition and radiographic knee osteoarthritis (RKOA) in Chingford sample--a longitudinal study.
  Orit Blumenfeld, Frances M K Williams, Deborah J. Hart, Nigel K Arden, Tim D. Spector, Gregory Livshits> ;Archives of Gerontology and Geriatrics. 2013 Jan 1
• 29 citations
  Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS)
  Alireza Moayyeri, Christopher J Hammond, Deborah J. Hart, Tim D. Spector> ;Journal of Bone and Mineral Research. 2012 Oct 1
• 15 citations
  Longitudinal study of variation in body mass index in middle-aged UK females
  Gregory Livshits, Ida Malkin, Frances M K Williams, Deborah J. Hart, Alan Hakim, Tim D. Spector> ;Age. 2012 Oct 1
• 24 citations
  Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: a 19-year prospective study of 1003 women.
  A. S. Nicholls, Amit Kiran, Muhammad Javaid, Deborah J. Hart, Tim D. Spector, Andrew Carr, Nigel K Arden> ;The Knee. 2012 Aug 1
• 89 citations
  The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study.
  K M Leyland, Deborah J. Hart, Muhammad Javaid, Andrew Judge, Amit Kiran, Anushka Soni, L Goulston, Cyrus Cooper, Tim D. Spector, Nigel K Arden> ;Arthritis and Rheumatism. 2012 Jul 1
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