DouglasBryanYoungMD

PubMed

• 75 citations
  The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia
  Martin Vordermeier, Gobena Ameni, Stefan Berg, Richard P. Bishop, Brian D. Robertson, Abraham Aseffa, R. Glyn Hewinson, Douglas B. Young> ;Comparative Immunology, Microbiology and Infectious Diseases. 2012 May 1
• 12 citations
  OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection.
  Robert J. Snelgrove, Megan M. Cornere, Lorna Edwards, Belinda Dagg, James Keeble, Angela Rodgers, Daphne Lyonga, Graham R. Stewart, Douglas B. Young, Barry Walker, Tra...> ;The Journal of Infectious Diseases. 2012 Mar 15
• 178 citations
  Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.
  Kristine B. Arnvig, Iñaki Comas, Nicholas R. Thomson, Joanna Houghton, Helena I. Boshoff, Nicholas J. Croucher, Graham Rose, Tim Perkins, Julian Parkhill, Gordon Douga...> ;Plos Pathogens. 2011 Nov 3
• 91 citations
  Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.
  Nitya Krishnan, Wladimir Malaga, Patricia Constant, Maxine Caws, Tran Thi Hoang Chau, Jenifer Salmons, Nguyen Thi Ngoc Lan, Nguyen Duc Bang, Mamadou Daffé, Douglas B. ...> ;Plos One. 2011 Sep 8
• Field evaluation of the efficacy of Mycobacterium bovis bacillus Calmette-Guerin against bovine tuberculosis in neonatal calves in Ethiopia.
  Ameni, G., Vordermeier, M., Aseffa, A., Young, D.B., Hewinson, R.G.> ;Clin Vaccine Immunol. 2010 Oct
• Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines.
  Gideon, H.P., Wilkinson, K.A., Rustad, T.R., Oni, T., Guio, H., Kozak, R.A., Sherman, D.R., Meintjes, G., Behr, M.A., Vordermeier, H.M., Young, D.B., Wilkinson, R.J.> ;PLoS Pathog. 2010
• 134 citations
  Identification of small RNAs in Mycobacterium tuberculosis
  Kristine B. Arnvig, Douglas B. Young> ;Molecular Microbiology. 2009 Aug 1
• 17 citations
  Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis.
  Katalin A. Wilkinson, Sandra M. Newton, Graham R. Stewart, Adrian R. Martineau, Janisha Patel, Susan M. Sullivan, Jean-Louis Herrmann, Olivier Neyrolles, Douglas B. Yo...> ;BMC Microbiology. 2009 May 14
• 155 citations
  Eliminating latent tuberculosis
  Douglas B. Young, Hannah P. Gideon, Robert J. Wilkinson> ;Trends in Microbiology. 2009 May 1
• 13 citations
  Molecular Analysis of Mycobacterium tuberculosis Strains with an Intact pks15/1 Gene in a Rural Community of Mexico
  Areli Martínez-Gamboa, Alfredo Ponce-de-León, Arturo Galindo-Fraga, Miriam Bobadilla-del-Valle, Midori Kato-Maeda, Brian D. Robertson, Douglas B. Young, Peter M. Small...> ;Archives of Medical Research. 2008 Nov 1
• 23 citations
  Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India.
  Saroj K. Young, Jorg M. Ponnighaus, Suman Jain, Sebastian Lucas, Sujai Suneetha, Diana N. J. Lockwood, Douglas B. Young, Paul E. M. Fine> ;Plos Neglected Tropical Diseases. 2008 Apr 9
• 222 citations
  Confronting the scientific obstacles to global control of tuberculosis
  Douglas B. Young, Mark D. Perkins, Kenneth Duncan, Clifton E. Barry> ;The Journal of Clinical Investigation. 2008 Apr 1
• 18 citations
  A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties.
  Marcela Henao-Tamayo, Ana Paula Junqueira-Kipnis, Diane J. Ordway, Mercedes Gonzales-Juarrero, Graham R. Stewart, Douglas B. Young, Robert J. Wilkinson, Randall J. Bas...> ;Vaccine. 2007 Oct 10
• 99 citations
  Unusual features of the cell cycle in mycobacteria: polar-restricted growth and the snapping-model of cell division.
  Niren R. Thanky, Douglas B. Young, Brian D. Robertson> ;Tuberculosis. 2007 May 1
• 3 citations
  Systems biology and its impact on anti-infective drug development
  Michael P. H. Stumpf, Brian D. Robertson, Ken Duncan, Douglas B. Young> ;Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progres Des Recherches Pharmaceutiques. 2007 Jan 1
• 19 citations
  Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives
  Gustavo Stadthagen, Mary Jackson, Patricia Charles, Frédéric Boudou, Nathalie Barilone, Michel Huerre, Patricia Constant, Avraham Liav, Iveta Bottova, Jérôme Nigou, Th...> ;Microbes and Infection. 2006 Jul 1
• 91 citations
  A role for dendritic cells in the dissemination of mycobacterial infection
  Ian R. Humphreys, Graham R. Stewart, David J. Turner, Janisha Patel, Danai Karamanou, Robert J. Snelgrove, Douglas B. Young> ;Microbes and Infection. 2006 Apr 1
• 87 citations
  Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity
  Sylvain Pitarque, Jean-Louis Herrmann, Jean-Luc Duteyrat, Mary Jackson, Graham R. Stewart, François Lecointe, Bruno Payré, Olivier Schwartz, Douglas B. Young, Gilles M...> ;The Biochemical Journal. 2005 Dec 15
• 149 citations
  Mycobacterial mutants with defective control of phagosomal acidification
  Graham R. Stewart, Janisha Patel, Brian D. Robertson, Aaron Rae, Douglas B. Young> ;Plos Pathogens. 2005 Nov 25
• 29 citations
  Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis.
  Graham R. Stewart, Katalin A. Wilkinson, Sandra M. Newton, Susan M. Sullivan, Olivier Neyrolles, John Wain, Janisha Patel, Kara-Lee Pool, Douglas B. Young, Robert J. W...> ;Infection and Immunity. 2005 Oct 1
• 42 citations
  Alternative Luciferase for Monitoring Bacterial Cells under Adverse Conditions
  Siouxsie Wiles, Kathryn Ferguson, Martha Stefanidou, Douglas B. Young, Brian D. Robertson> ;Applied and Environmental Microbiology. 2005 Jul 1
• 27 citations
  Genotypic Analysis of the Earliest Known Prehistoric Case of Tuberculosis in Britain
  G. Michael Taylor, Douglas B. Young, Simon Mays> ;Journal of Clinical Microbiology. 2005 May 1
• 98 citations
  The OtsAB Pathway Is Essential for Trehalose Biosynthesis in Mycobacterium tuberculosis
  Helen N. Murphy, Graham R. Stewart, Vladimir V. Mischenko, Alexander S. Apt, Richard Harris, Mark S. B. McAlister, Paul C. Driscoll, Douglas B. Young, Brian D. Robertson> ;The Journal of Biological Chemistry. 2005 Apr 15
• 39 citations
  Mycobacterium bovis bacille Calmette Guerin infection of human neutrophils induces CXCL8 secretion by MyD88-dependent TLR2 and TLR4 activation.
  Gabriela Godaly, Douglas B. Young> ;Cellular Microbiology. 2005 Apr 1
• 53 citations
  Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2.
  Katalin A. Wilkinson, Graham R. Stewart, Sandra M. Newton, H. Martin Vordermeier, John Wain, Helen N. Murphy, Katherine Horner, Douglas B. Young, Robert J. Wilkinson> ;Journal of Immunology. 2005 Apr 1
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