EduardoDavidLeonardoMD

PubMed

• 1 citations
  Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood.
  Qingyuan Meng, Alvaro L Garcia-Garcia, Alex Dranovsky, E David Leonardo> ;Scientific Reports. 2023 Feb 22
• 5 citations
  Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior.
  Muhammad O Chohan, Jared M Kopelman, Hannah Yueh, Zeinab Fazlali, Natasha Greene, Alexander Z Harris, Peter D Balsam, E David Leonardo, Edgar R Kramer, Jeremy Veenstra...> ;Molecular Psychiatry. 2022 Mar 1
• 39 citations
  Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT 1A receptor-dependent manner
  Alvaro L. Garcia-Garcia, Sarah E. Canetta, J M Stujenske, Nesha S. Burghardt, Mark S. Ansorge, Alex Dranovsky, E D Leonardo> ;Molecular Psychiatry. 2018 Oct 1
• 55 citations
  Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice.
  Mary Youssef, Piray Atsak, Jovani Cardenas, Stylianos Kosmidis, E. David Leonardo, Alex Dranovsky> ;Scientific Reports. 2019 Mar 11
• 15 citations
  Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis.
  Mary Youssef, Varsha Krish, Greer S. Kirshenbaum, Piray Atsak, Tamara J. Lass, Sophie R. Lieberman, E. David Leonardo, Alex Dranovsky> ;Hippocampus. 2018 Aug 1
• 20 citations
  Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses
  Antoine Besnard, Tomer Langberg, Sally Levinson, Duong Chu, Cinzia Vicidomini, Kimberly N. Scobie, Andrew J. Dwork, Victoria Arango, Gorazd Rosoklija, J. John Mann, Re...> ;Cell Reports. 2018 Jun 12
• 132 citations
  A Novel Method for Chronic Social Defeat Stress in Female Mice
  Alexander Z. Harris, Piray Atsak, Zachary H. Bretton, Emma S Holt, Raisa Alam, Mitchell P. Morton, Atheir I. Abbas, E. David Leonardo, Scott S. Bolkan, René Hen, Joshu...> ;Neuropsychopharmacology. 2018 May 1
• 1 citations
  An opening for humor in melancholy
  E. David Leonardo, Alex Dranovsky> ;Nature Neuroscience. 2017 Dec 1
• 41 citations
  Serotonin Signaling through Prefrontal Cortex 5-HT1A Receptors during Adolescence Can Determine Baseline Mood-Related Behaviors.
  Alvaro L. Garcia-Garcia, Qingyuan Meng, Sarah E. Canetta, Alain M. Gardier, Bruno P. Guiard, Christoph Kellendonk, Alex Dranovsky, E. David Leonardo> ;Cell Reports. 2017 Jan 31
• 3 citations
  5-HT1A Agonist Properties Contribute to a Robust Response to Vilazodone in the Novelty Suppressed Feeding Paradigm.
  Alvaro L. Garcia-Garcia, Miriam Navarro-Sobrino, Gila Pilosof, Pradeep Banerjee, Alex Dranovsky, E. David Leonardo> ;The International Journal of Neuropsychopharmacology. 2016 Jun 28
• 20 citations
  Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety.
  Alvaro L. Garcia-Garcia, Qingyuan Meng, Jesse W. Richardson-Jones, Alex Dranovsky, E. D. Leonardo> ;Neuroscience. 2016 May 3
• 32 citations
  5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking
  In-Jee You, Sherie R. Wright, Alvaro L. Garcia-Garcia, Andrew R. Tapper, Paul D. Gardner, George F. Koob, E. David Leonardo, Laura M. Bohn, Sunmee Wee> ;Neuropsychopharmacology. 2016 Apr 1
• 2 citations
  Neuroscience: The power of positivity.
  Alex Dranovsky, E. David Leonardo> ;Nature. 2015 Jun 18
• 29 citations
  Hippocampal subfields and major depressive disorder.
  Benjamin Adam Samuels, E. David Leonardo, René Hen> ;Biological Psychiatry. 2015 Feb 1
• Erratum to: 5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
  Garcia-Garcia, A. L.,Newman-Tancredi, A.,Leonardo, E. D.> ;Psychopharmacology (Berl.). 2014 Jan 15
• 19 citations
  Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors.
  Benjamin Adam Samuels, E. David Leonardo, Alex Dranovsky, Amanda J. Williams, Erik H. F. Wong, Addie May I. Nesbitt, Richard D. McCurdy, René Hen, Mark D. Alter> ;Plos One. 2014 Jan 17
• 142 citations
  5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
  Alvaro L. Garcia-Garcia, Adrian Newman-Tancredi, E. David Leonardo> ;Psychopharmacology. 2014 Jan 11
• 63 citations
  Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior
  Zoe R. Donaldson, David A. Piel, Tabia L Santos, Jesse W. Richardson-Jones, E. David Leonardo, Sheryl G. Beck, Frances A. Champagne, René Hen> ;Neuropsychopharmacology. 2014 Jan 1
• 63 citations
  Rethinking 5-HT1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior
  Stefanie C. Altieri, Alvaro L. Garcia-Garcia, E. David Leonardo, Anne M. Andrews> ;ACS Chemical Neuroscience. 2013 Jan 16
• 61 citations
  Modeling treatment-resistant depression
  Benjamin Adam Samuels, Eduardo David Leonardo, Reto Gadient, Amanda J. Williams, Jin Zhou, Denis J. David, Alain M. Gardier, Erik H. F. Wong, René Hen> ;Neuropharmacology. 2011 Sep 1
• 144 citations
  Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety
  Jesse W. Richardson-Jones, Caryne Craige, T. H. Nguyen, H. F. Kung, Alain M. Gardier, Alex Dranovsky, Denis J. David, Bruno P. Guiard, Sheryl G. Beck, Rene Hen, E. D. ...> ;The Journal of Neuroscience. 2011 Apr 20
• 309 citations
  5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
  Jesse W. Richardson-Jones, Caryne Craige, Bruno P. Guiard, Alisson Stephen, Kayla L. Metzger, Hank F. Kung, Alain M. Gardier, Alex Dranovsky, Denis J. David, Sheryl G....> ;Neuron. 2010 Jan 14
• 64 citations
  Molecular heterogeneity along the dorsal-ventral axis of the murine hippocampal CA1 field: a microarray analysis of gene expression.
  E. D. Leonardo, Jesse W. Richardson-Jones, Etienne Sibille, A. Kottman, René Hen> ;Neuroscience. 2006 Jan 1
• 104 citations
  Genetics of Affective and Anxiety Disorders
  E. D. Leonardo, René Hen> ;Annual Review of Psychology. 2006 Jan 1
• Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons.
  Ebens A, Brose K, Leonardo ED, Hanson MG, Bladt F, Birchmeier C, Barres BA, Tessier-Lavigne M> ;Neuron. 1996-12-01
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Journal Articles

• Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-induced Impairments in Dendritic Spines and Fear Responses  
  Besnard, A., Langberg, T., Levinson, S., Chu, D., Vicidomini, C., Scobie, K.N., Dwork, A.J., Arango, V., Rosoklija, G.B., Mann, J.J., Hen, R., Leonardo, E.D., Boldrini..., Cell Reports, 1/12/2018
• Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis  
  Youssef, M., Krish, V.S., Kirshenbaum, G.S. Atsak, P., Lass, T.J., Lieberman, S.R., Leonardo, E.D., Dranovsky, A., Hippocampus, 1/1/2018
• Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor dependent manner  
  Garcia-Garcia, A.L., Canetta, S., Stujenske, J.M., Burghardt, N.S., Ansorge, M.S., Dranovsky, A., Leonardo, E.D., Molecular Psychiatry, 1/1/2017
• Serotonin signaling through Prefrontal Cortex 5-HT1A receptors during adolescence can determine baseline mood-related behaviors  
  Garcia-Garcia, A.L., Meng, Q., Canetta, S., Gardier, A.M., Guiard, B.P., Kellendonk, C., Dranovsky, A., Leonardo, E.D., Cell Reports, 1/1/2017
• An opening for humor in Melancholy  
  Leonardo, E.D., Dranovsky, A., Nature Neuroscience, 1/1/2017
• 5-HT1A agonist properties contribute to a robust response to Vilazodone in the novelty suppressed feeding paradigm  
  Garcia-Garcia, A.L., Navarro-Sobrino, M., Pilosof, G., Banerjee, P., Dranovsky, A., Leonardo E.D., Int. J Neuropsychopharmacol, 1/1/2016
• 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking  
  You, I.J., Wright, S.R., Garcia-Garcia, A.L., Tapper, A.R., Gardner, P.D., Koob, G.F., Leonardo, E.D., Bohn, L.M., Wee, S., Neuropsychopharmacology, 1/1/2016
• Hippocampal Subfields and Major Depressive Disorder  
  Samuels, B.A., Leonardo, E.D., Hen, R., Biological Psychiatry, 1/1/2015
• Developmental effects of serotonin 1A autoreceptor on anxiety and social behavior  
  Donaldson, Z.R., Calizo, L.H., Piel, D.A., Santos, T.L., Richardson-Jones, J., Leonardo, E.D., Beck, S.G., Champagne, F.A., Hen, R, Neuropsychopharmacology, 1/1/2014
• 5-HT1A receptors in mood and Anxiety: Recent insights into autoreceptor vs heteroreceptor function  
  Garcia-Garcia, A., Newman-Tancredi, A., and Leonardo, E.D., Psychopharmacology, 1/1/2014
• Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior  
  Altieri, S.C., Garcia-Garcia, A.L., Leonardo, E.D., Andrews A.M., ACS Chemical Neuroscience, 1/1/2013
• Is there a role for adult hippocampal stem cells and their progeny in response to chronic stress?  
  Dranovsky A., Leonardo E.D., Behavioral Brain Research, 1/1/2012
• Antidepressants recruit new neurons to improve stress response regulation  
  Surget, A., Tanti, A., Leonardo, E.D., Langueray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., Belzung, C., Molecular Psychiatry, 1/1/2011
• Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety  
  Richardson-Jones, J.W., Craige, C.P., Nguyen, T.H., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Guiard, B.P., Beck, S.G., Hen, R., and Leonardo, E.D., Journal of Neuroscience, 1/1/2011
• 5-HT1A autoreceptors determine vulnerability to stress and response to antidepressants  
  Richardson-Jones, J.W., Craige, C.P., Guiard, B.P., Stephen, A.K., Metzger, K.L., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Beck, S.G., Hen, R., and Leona..., Neuron, 1/1/2010
• Flexible Accelerated STOP TetO-knockin (FAST): A versatile and efficient new gene modulating system  
  Tanaka, K.J., Ahmari, S.E., Leonardo, E.D., Richardson-Jones, J.W., Budreck, E.C., Scheiffele, P., Sugio, S., Inamura, N., Ikenaka, K., and Hen, R., Biological Psychiatry, 1/1/2010
• Vertebrate homologues of UNC-5 are candidate Netrin receptors  
  Leonardo, E.D., Hinck, L., Masu, M., Keino-Masu, K., Ackerman, S. and Tessier-Lavigne, M., Nature, 1/1/1997
• Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system  
  Serafini, T., Colamarino, S.A., Leonardo, E.D., Wang, H., Beddington, R., Skarnes, W.C. and Tessier-Lavigne, M., Cell, 1/1/1996
• Deleted in colorectal carcinoma encodes a netrin receptor  
  Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E.D., Chan, S., Culotti, J. and Tessier-Lavigne, M., Cell, 1/1/1996
• A new vector for cloning large eukaryotic DNA segments in Escherichia coli  
  Leonardo E.D., and Sedivy, J.M., Bio/Technology, 1/1/1990
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Books/Book Chapters

• Psychiatry 
  Chapter: Neurobiology of Anxiety Disorders 
  Page 320 - 340Meaney, M.J., Liebowitz, M.L., Leonardo, E.D.Editors: Allan Tasman, Jerald Kay, Jeffrey A. Lieberman, Michael First, and Michelle Riba.Wiley-BlackwellEdition 4th,2015
• Anxiety Disorders: Theory, Research and Clinical Practice 
  Chapter: Animal Models of Anxiety Disorders: Behavioral and Genetic Approaches 
  Page 156 - 168Richardson-Jones, J.W., Leonardo, E.D., Hen, R., and Ahmari, S.E.Editors: Helen Blair Simpson.Cambridge University Press2010
• Clinical Manual of Anxiety Disorders 
  Chapter: Social Phobia 
  Page 63 - 86Schneier, F.R., Luterek, J.A., Heimberg, R.G., and Leonardo, E.Editors: Dan J. Stein.American Psychiatric Publishing, Inc.2004
• Guidebook to the Extracellular Matrix, Anchor and Adhesion Proteins 
  Chapter: DCC Family 
  Page 179 - 182Leonardo E.D., Tessier-Lavigne, M., Culotti, J.G.Editors: Thomas Kreis and Ron Vale.Oxford University Press1999
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Lectures

• Serotonin signaling through Prefrontal Cortex 5-HT1A receptors during adolescence can bi-directionally determine baseline Mood-related behaviours 
  Cork, Ireland - 1/1/2018
• Lifelong Mood and Anxiety Setpoints 
  1/1/2017
• Setting Lifelong Mood and Anxiety Setpoints: Insights from Studies in Mice 
  1/1/2014
• Contribution of Serotonin 1A Auto and Heteroreceptors to Anxiety, Depression, and the Antidepressant Response 
  Montpellier, France - 1/1/2012
• Vilazodone: Serotonin 1A Receptor Partial Agonist and Reuptake Inhibitor 
  Chicago, IL - 1/28/2010
• The Nature of the Nurture: Gene-Environment Interactions in Psychiatry 
  Colegio Medico del Peru, Lima, Peru - 1/1/2010
• The role of 5-HT1A Auto and Heteroreceptors in Anxiety and Depression 
  1/1/2010
• Antidepressant Mechanisms and Neurogenesis 
  Jackson Laboratories, Bar Harbor, ME - 1/1/2007
• Gene-Environment Interactions in Psychiatry 
  1/1/2004
• Molecular studies of Axonal Chemorepulsion 
  Instituto Santiago Ramon y Cajal, Madrid, Spain - 1/1/1995
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Other

• Genetics of Affective and Anxiety Disorders 
  Leonardo, E. D., and Hen, R., Annual Review of Psychology
  1/1/2006
• Molecular Studies of Axonal Chemorepulsion 
  Leonardo ED, University of California
  1/1/1997
• Guidance of Developing Axons by Netrin-1 and its Receptors 
  Leonardo, E.D., Hinck, L., Masu, M., Keino-Masu, K., Fazeli, A., Stoeckli, E.T., Ackerman, S.A., Weinberg, R.A., and Tessier-Lavigne, M., Cold Spring Harbor Symposia on Quantitative Biology
  1/1/1997