EdwardGusShawMDFASTRO

Radiation Oncology • Winston Salem, NC

Professor of Radiation Oncology, Wake Forest University

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Office
Medical Center Blvd
Winston Salem, NC 27157
Phone+1 336-716-2255

Fax+1 336-713-6565
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Residency, Radiation Oncology, 1983 - 1987
Rush Medical College of Rush University Medical CenterClass of 1983

Certifications & Licensure

AZ State Medical License 1988 - Present
NC State Medical License 1995 - 2022
FL State Medical License 1987 - 1998
MN State Medical License 1984 - 1995
IA State Medical License 1986 - 1988
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Top MD Consumers Checkbook

Clinical Trials

Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Start of enrollment: 1998 Oct 01
Completed
Phase 2, Phase 3
Radiation Therapy With or Without RSR13 in Treating Patients With Brain Metastases Start of enrollment: 2000 Feb 01
Completed
Phase 3
Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer Start of enrollment: 2000 Sep 01
Completed
Phase 3
Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Start of enrollment: 2002 Apr 01
Terminated
Phase 3
Sertraline Compared With Hypericum Perforatum (St.John's Wort) in Treating Depression Start of enrollment: 2004 Mar 01
Completed
Phase 3
Survival TRaining for ENhancing Total Health (STRENGTH) Start of enrollment: 2003 Sep 01
Completed
Phase 2
Oxandrolone Compared With Megestrol in Preventing Weight Loss in Patients Receiving Chemotherapy for Cancer Start of enrollment: 2004 Mar 01
Completed
Phase 3
Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Start of enrollment: 2001 Jul 01
Completed
Phase 2
Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma Start of enrollment: 2004 Jan 01
Completed
Phase 2
Radiation Therapy in Treating Young Patients With Gliomas Start of enrollment: 2006 Nov 01
Completed
Phase 2
Yoga or Educational Wellness Class for Women With Stage I, Stage II, or Stage III Breast Cancer Undergoing Chemotherapy Start of enrollment: 2010 Jan 01
Completed
Not Applicable
Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Start of enrollment: 2010 Aug 01
Completed
Phase 2
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Publications & Presentations

PubMed

Smoking and Radiation-induced Skin Injury: Analysis of a Multiracial, Multiethnic Prospective Clinical Trial.
Ryan T Hughes, Edward H Ip, James J Urbanic, Jennifer J Hu, Kathryn E Weaver, Mark O Lively, Karen M Winkfield, Edward G Shaw, Luis Baez Diaz, Doris R Brown, Jon Stras...> ;Clinical Breast Cancer. 2022 Dec 1
85 citations
Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-...
Erica Hlavin Bell, Peixin Zhang, Edward G. Shaw, Jan C. Buckner, Geoffrey R. Barger, Dennis E. Bullard, Minesh P. Mehta, Mark R. Gilbert, Paul D. Brown, Keith J. Stelz...> ;Journal of Clinical Oncology. 2020 Jul 24
18 citations
Final report from Intergroup NCCTG 86-72-51 (Alliance): a phase III randomized clinical trial of high-dose versus low-dose radiation for adult low-grade glioma.
William G. Breen, S. Keith Anderson, Xiomara W. Carrero, Paul D. Brown, Karla V. Ballman, Brian P. O'Neill, Walter J. Curran, Ross A. Abrams, Nadia N. Laack, Ralph Lev...> ;Neuro-Oncology. 2020 Jun 9
17 citations
Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study.
Eunkyung Lee, Cristiane Takita, Jean L. Wright, Susan Slifer, Eden R. Martin, James J. Urbanic, Carl D. Langefeld, Glenn J. Lesser, Edward G. Shaw, Jennifer J. Hu> ;Human Genomics. 2019 Jun 13
23 citations
Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients
Christina K. Cramer, Tiffany L. Cummings, Rachel N. Andrews, Roy E. Strowd, Stephen R. Rapp, Edward G. Shaw, Michael D. Chan, Glenn J. Lesser> ;Current Treatment Options in Oncology. 2019 Apr 8
11 citations
Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial.
Christina K. Cramer, Natalie K. Alphonse-Sullivan, Scott Isom, Linda J. Metheny-Barlow, Tiffany L. Cummings, Brandi R. Page, Doris R. Brown, Arthur W. Blackstock, Ann ...> ;Journal of Cancer Research and Clinical Oncology. 2019 Feb 1
19 citations
Mild cognitive impairment in long-term brain tumor survivors following brain irradiation
Christina K. Cramer, Neil McKee, L. Doug Case, Michael D. Chan, Tiffany L. Cummings, Glenn J. Lesser, Edward G. Shaw, Stephen R. Rapp> ;Journal of Neuro-Oncology. 2019 Jan 1
26 citations
Association Between Inflammatory Biomarker C-Reactive Protein and Radiotherapy-Induced Early Adverse Skin Reactions in a Multiracial/Ethnic Breast Cancer Population
Jennifer J. Hu, James J. Urbanic, L. Doug Case, Cristiane Takita, Jean L. Wright, Doris R. Brown, Carl D. Langefeld, Mark O. Lively, Sandra E. Mitchell, Anu Thakrar, D...> ;Journal of Clinical Oncology. 2018 Jul 10
6 citations
Quality of life of irradiated brain tumor survivors treated with donepezil or placebo: Results of the WFU CCOP research base protocol 91105.
Michelle J. Naughton, L. Douglas Case, Ann M. Peiffer, Michael D. Chan, Volker W. Stieber, Dennis F. Moore, Steven Charles Falchuk, James Piephoff, William Jeffery Ede...> ;Neuro-Oncology Practice. 2018 May 10
Self-reported adherence and biomarker levels of CoQ10 and alpha-tocopherol
Mara Z. Vitolins, L. Douglas Case, Stephen R. Rapp, Mark O. Lively, Edward G. Shaw, Michelle J. Naughton, Jeffrey K. Giguere, Glenn J. Lesser> ;Patient Preference and Adherence. 2018 Apr 24
4 citations
A Randomized Double-Blind Placebo-Controlled Trial of Fruit and Vegetable Concentrates on Intermediate Biomarkers in Head and Neck Cancer.
Mridul Datta, Edward G. Shaw, Glenn J. Lesser, L. Douglas Case, Mara Z. Vitolins, Charles J. Schneider, Bart Frizzell, Christopher A. Sullivan, Mark O. Lively, Elizabe...> ;Integrative Cancer Therapies. 2018 Mar 1
21 citations
Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation
Catherine Okoukoni, Emory R. McTyre, Diandra N. Ayala Peacock, Ann M. Peiffer, Roy E. Strowd, Christina K. Cramer, William H. Hinson, Steve Rapp, Linda J. Metheny-Barl...> ;Advances in Radiation Oncology. 2017 Aug 30
3 citations
National Institute on Aging /Alzheimer's Association criteria for Mild Cognitive Impairment applied to chemotherapy treated breast cancer survivors.
Abigail R Gifford, Julia Lawrence, Laura D. Baker, Ernie P. Balcueva, Doug Case, Suzanne Craft, Amy E Curtis, Leah Griffin, David L. Groteluschen, Heidi D. Klepin, Gle...> ;Journal of Oncology Research. 2017 Jan 1
600 citations
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner, Edward G. Shaw, Stephanie L. Pugh, Arnab Chakravarti, Mark R. Gilbert, Geoffrey R. Barger, Stephen W. Coons, Peter Ricci, Dennis E. Bullard, Paul D. Br...> ;The New England Journal of Medicine. 2016 Apr 6
59 citations
A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy
Julia Lawrence, Leah Griffin, Ernie P. Balcueva, David L. Groteluschen, Thomas A. Samuel, Glenn J. Lesser, Michelle J. Naughton, L. D. Case, Edward G. Shaw, Stephen R....> ;Journal of Cancer Survivorship. 2016 Feb 1
21 citations
Adult patients with supratentorial pilocytic astrocytoma: long-term follow-up of prospective multicenter clinical trial NCCTG-867251 (Alliance)
Paul D. Brown, S. Keith Anderson, Xiomara W. Carrero, Brian P. O'Neill, Caterina Giannini, Eva Galanis, Sunjay Shah, Ross A. Abrams, Walter J. Curran, Jan C. Buckner, ...> ;Neuro-Oncology Practice. 2015 Dec 1
48 citations
Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue
Brandi R. Page, Edward G. Shaw, Lingyi Lu, David Bryant, David Grisell, Glenn J. Lesser, Drew C. Monitto, Michelle J. Naughton, Stephen R. Rapp, Steven R. Savona, Sunj...> ;Neuro-Oncology. 2015 Oct 1
144 citations
Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial
Stephen R. Rapp, L. Doug Case, Ann M. Peiffer, Michelle M. Naughton, Michael D. Chan, Volker W. Stieber, Dennis F. Moore, Steven Charles Falchuk, James Piephoff, Willi...> ;Journal of Clinical Oncology. 2015 May 20
10 citations
Feasibility of implementing a community-based randomized trial of yoga for women undergoing chemotherapy for breast cancer.
Suzanne C. Danhauer, Leah Griffin, Nancy E. Avis, Stephanie J. Sohl, Michelle T. Jesse, Elizabeth L. Addington, Julia Lawrence, Michael J. Messino, Jeffrey K. Giguere,...> ;The Journal of Community and Supportive Oncology. 2015 Apr 1
4 citations
Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106.
Kathryn M. Greven, L.D. Case, Lawrence Nycum, Patricia Zekan, David D. Hurd, Ernie P. Balcueva, Glenn Mills, Robin Zon, Patrick J. Flynn, David D. Biggs, Edward G. Sha...> ;The Journal of Community and Supportive Oncology. 2015 Mar 1
73 citations
Induction of Robust Type-I CD8+ T-cell Responses in WHO Grade 2 Low-Grade Glioma Patients Receiving Peptide-Based Vaccines in Combination with Poly-ICLC
Hideho Okada, Lisa H. Butterfield, Ronald L. Hamilton, Aki Hoji, Masashi Sakaki, Brian Ahn, Gary Kohanbash, Jan Drappatz, Johnathan A. Engh, Nduka Amankulor, Mark O. L...> ;Clinical Cancer Research. 2015 Jan 15
39 citations
Predictors of survival, neurologic death, local failure, and distant failure after gamma knife radiosurgery for melanoma brain metastases.
Matthew T. Neal, Michael D. Chan, John T. Lucas, Amritraj Loganathan, Christine Dillingham, Edward Pan, John H. Stewart, J. Daniel Bourland, Edward G. Shaw, Stephen B....> ;World Neurosurgery. 2014 Dec 1
Erratum to: Local control and toxicity outcomes in brainstem metastases treated with single fraction radiosurgery: is there a volume threshold for toxicity?
Kilburn, J. M.,Ellis, T. L.,Lovato, J. F.,Urbanic, J. J.,Bourland, J. D.,Munley, M. T.,deGuzman, A. F.,McMullen, K. P.,Shaw, E. G.,Tatter, S. B.,Chan, M. D.> ;J. Neurooncol.. 2014 Sep 23
72 citations
A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy
D.N. Ayala-Peacock, Ann M. Peiffer, John T. Lucas, Scott Isom, J. Griff Kuremsky, James J. Urbanic, J. Daniel Bourland, Adrian W. Laxton, Stephen B. Tatter, Edward G. ...> ;Neuro-Oncology. 2014 Sep 1
54 citations
Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma.
Anna K. Paulsson, Kevin P. McMullen, Ann M. Peiffer, William H. Hinson, W.T. Kearns, Annette J. Johnson, Glenn J. Lesser, Thomas L. Ellis, Stephen B. Tatter, Waldemar ...> ;American Journal of Clinical Oncology. 2014 Apr 1
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Press Mentions

AAPM 2022 Presidential Symposium: Impact of Medical Physics to Transform Health Care ApproachesJuly 14th, 2022
Love Languages Author: How to Be There for a Spouse with Alzheimer’sDecember 11th, 2017
Adding Chemotherapy Following Radiation Treatment Improves Survival for Adults with a Slow-Growing Type of Brain Tumor, Study ShowsFebruary 5th, 2014
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Grant Support

Comprehensive Cancer Center Of Wake Forest University CCOP Research BaseNational Cancer Institute2007–2011
A Bi-Institutional Pilot Study Of Vaccinations For Patients With Low Grade GliomaNational Cancer Institute2009–2010
Clinical ResearchNational Cancer Institute2007
Cccwfu Research Base GrantNational Cancer Institute1999–2006
Pilot--Clinical ResearchNational Cancer Institute2001–2002