ElizabethJoanShaneMD

Endocrinology • New York, NY

Osteoporosis & Bone Metabolism Medicine, Parathyroid

Professor of Medicine at Columbia University Medical Center

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Office
180 Fort Washington Avenue
New York, NY 10032
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Education & Training

New York Presbyterian Hospital (Columbia Campus)Fellowship, Endocrinology, Diabetes, and Metabolism, 1978 - 1981
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 1976 - 1978
University of Toronto Faculty of MedicineClass of 1975

Certifications & Licensure

NY State Medical License 1979 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Top Doctors: New York Metro Area Castle Connolly, 2002-2014
Super Doctor SuperDoctors.com

Clinical Trials

Osteoporosis Prevention After Heart Transplant Start of enrollment: 1997 Sep 01
Completed
Phase 3
Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation Start of enrollment: 2005 Nov 01
Completed
Phase 2, Phase 3
Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women Start of enrollment: 2008 Aug 20
Completed
Phase 2, Phase 3
Vitamin D Repletion in Primary Hyperparathyroidism Start of enrollment: 2011 Oct 01
Completed
Phase 4
Primary Hyperparathyroidism (PHPT): Early Effect of Vitamin D Start of enrollment: 2010 May 01
Withdrawn
Phase 2, Phase 3
Vitamin D HIV Study on Postmenopausal Women Start of enrollment: 2011 Jan 01
Completed
Phase 1, Phase 2
Forteo Trial on Idiopathic Osteoporosis in Premenopausal Women Start of enrollment: 2012 Aug 02
Completed
Phase 2
Denosumab for Prevention of Post-Teriparatide Bone Loss in Premenopausal Women With IOP Start of enrollment: 2014 Nov 19
Completed
Phase 2
Bisphosphonates for Prevention of Post-Denosumab Bone Loss Start of enrollment: 2018 Jan 29
Completed
Phase 2
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Publications & Presentations

PubMed

Individual trabecula segmentation validation in first- and second-generation high-resolution peripheral computed tomography compared to micro-computed tomography in th...
Andreea Teodora Dinescu, Bin Zhou, Yizhong Jenny Hu, Sanchita Agarwal, Xiang-Dong Edward Guo, Elizabeth Shane> ;JBMR Plus. 2024 Feb 1
3 citations
Clinical characteristics of pregnancy and lactation associated osteoporosis: An online survey study.
Ananya V Kondapalli, Mafo Kamanda-Kosseh, John M Williams, Stephanie Shiau, Mariana Bucovsky, Ivelisse Colon, Elizabeth Shane, Adi Cohen> ;Osteoporosis International. 2023 Aug 1
3 citations
Osteocyte lacunae in transiliac bone biopsy samples across life span.
Stéphane Blouin, Barbara M Misof, Matthias Mähr, Nadja Fratzl-Zelman, Paul Roschger, Sonja Lueger, Phaedra Messmer, Petra Keplinger, Frank Rauch, Francis H Glorieux, A...> ;Acta Biomaterialia. 2023 Feb 1
23 citations
Hypercalcemia: A Review.
Marcella Donovan Walker, Elizabeth Shane> ;JAMA. 2022 Oct 25
4 citations
Treatment of postmenopausal osteoporosis patients with teriparatide for 24 months reverts forming bone quality indices to premenopausal healthy control values.
Eleftherios P Paschalis, Sonja Gamsjaeger, Klaus Klaushofer, Elizabeth Shane, Adi Cohen, Jan Stepan, Imre Pavo, Erik F Eriksen, Kathleen A Taylor, David W Dempster> ;Bone. 2022 Sep 1
4 citations
Spine Volumetric BMD and Strength in Premenopausal Idiopathic Osteoporosis: Effect of Teriparatide Followed by Denosumab.
Sanchita Agarwal, Elizabeth Shane, Thomas Lang, Stephanie Shiau, Mafo Kamanda-Kosseh, Mariana Bucovsky, Joan M Lappe, Julie Stubby, Robert R Recker, Yizhong Hu, Zexi W...> ;The Journal of Clinical Endocrinology and Metabolism. 2022 Jun 16
Bone and fat hormonal crosstalk with antiretroviral initiation
Arnold Z. Olali, Qiuhu Shi, Donald R. Hoover, Mariana Bucovsky, Elizabeth Shane, Michael T. Yin, Ryan D. Ross> ;Bone. 2022 Jan 1
9 citations
Whole exome sequencing reveals potentially pathogenic variants in a small subset of premenopausal women with idiopathic osteoporosis.
Adi Cohen, Joseph A. Hostyk, Evan H. Baugh, Christie M. Buchovecky, Vimla Aggarwal, Robert R. Recker, Joan M. Lappe, David W. Dempster, Hua Zhou, Mafo Kamanda-Kosseh, ...> ;Bone. 2022 Jan 1
8 citations
Denosumab After Teriparatide in Premenopausal Women with Idiopathic Osteoporosis.
Elizabeth Shane, Stephanie Shiau, Robert R. Recker, Joan M. Lappe, Sanchita Agarwal, Mafo Kamanda-Kosseh, Mariana Bucovsky, Julie Stubby, Adi Cohen> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Nov 24
6 citations
In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.
T.G. Goetz, Nandini Nair, Stephanie Shiau, Robert R. Recker, Joan M. Lappe, David W. Dempster, Hua Zhou, Binsheng Zhao, X. E. Guo, Wei Shen, Thomas L. Nickolas, Mafo K...> ;Osteoporosis International. 2021 Oct 19
9 citations
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography
Elliott Goff, Federica Buccino, Chiara Bregoli, Jonathan P. McKinley, Basil Aeppli, Robert R. Recker, Elizabeth Shane, Adi Cohen, Gisela Kuhn, Ralph Müller> ;Bone. 2021 Jun 27
14 citations
The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin.
Jingzhu Zhang, Adi Cohen, Bo Shen, Liming Du, Alpaslan Tasdogan, Zhiyu Zhao, Elizabeth Shane, Sean J. Morrison> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Jun 22
1 citations
Effect of vitamin D3 and calcium carbonate supplementation on muscle strength in postmenopausal women living with HIV.
Michael T. Yin, Mariana Bucovsky, John C. Williams, Danielle Brunjes, Arindam RoyChoudhury, Ivelisse Colon, David C. Ferris, Susan Olender, P. Christian Schulze, Anjal...> ;Antiviral Therapy. 2021 Mar 11
13 citations
Effect of teriparatide on bone remodeling and density in premenopausal idiopathic osteoporosis: A phase II trial
Adi Cohen, Stephanie Shiau, Nandini Nair, Robert R. Recker, Joan M. Lappe, David W. Dempster, Thomas L. Nickolas, Hua Zhou, Sanchita Agarwal, Mafo Kamanda-Kosseh, Mari...> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Oct 1
14 citations
Bone tissue material composition is compromised in premenopausal women with Type 2 diabetes.
Stamatia Rokidi, Vicente F C Andrade, Victoria Zeghbi Cochenski Borba, Elizabeth Shane, Adi Cohen, Jochen Zwerina, Eleftherios P. Paschalis, Carolina Aguiar Moreira> ;Bone. 2020 Sep 11
20 citations
Alterations of bone material properties in adult patients with X-linked hypophosphatemia (XLH).
Nadja Fratzl-Zelman, Sonja Gamsjaeger, Stéphane Blouin, Roland Kocijan, Pia Plasenzotti, Stamatia Rokidi, Kamilla Nawrot-Wawrzyniak, Katharina M. Roetzer, Gökhan Uyani...> ;Journal of Structural Biology. 2020 Sep 1
11 citations
Current anti-depressant use is associated with cortical bone deficits and reduced physical function in elderly women
Sanchita Agarwal, Carmen Germosen, Nayoung Kil, Mariana Bucovsky, Ivelisse Colon, John C. Williams, Elizabeth Shane, Marcella D. Walker> ;Bone. 2020 Jul 27
5 citations
Prospective study evaluating changes in bone quality in premenopausal women with breast cancer undergoing adjuvant chemotherapy
Madeleine B Hopson, Maika Onishi, Danielle Awad, Donna Buono, Matthew Maurer, Katherine D. Crew, Elizabeth Shane, Dawn L. Hershman, Kevin Kalinsky> ;Clinical Breast Cancer. 2020 Jun 1
7 citations
Serum extracellular vesicles expressing bone activity markers associate with bone loss after HIV antiretroviral therapy.
Erika G Marques de Menezes, Janaina Ramallho, Mariana Bucovsky, Elizabeth Shane, Michael T. Yin, Philip J. Norris> ;AIDS. 2020 Mar 1
5 citations
Abnormal microarchitecture and stiffness in postmenopausal women with isolated osteoporosis at the 1/3 radius
Alexander S. Dash, Sanchita Agarwal, Donald J. McMahon, Felicia Cosman, Jeri Nieves, Mariana Bucovsky, X. Edward Guo, Elizabeth Shane, Emily M. Stein> ;Bone. 2020 Mar 1
4 citations
Regional Variations of HR-pQCT Morphological and Biomechanical Measurements of the Distal Radius and Tibia and Their Associations with Whole Bone Mechanical Properties
Bin Zhou, Zhendong Zhang, Yizhong Hu, Ji Wang, Y. Eric Yu, Shashank Nawathe, Kyle K. Nishiyama, Tony M. Keaveny, Elizabeth Shane, X. Edward Guo> ;Journal of Biomechanical Engineering. 2019 Sep 1
28 citations
Women With Pregnancy and Lactation-Associated Osteoporosis (PLO) Have Low Bone Remodeling Rates at the Tissue Level.
Adi Cohen, Mafo Kamanda-Kosseh, David W. Dempster, Hua Zhou, Ralph Müller, Elliott Goff, Ivelisse Colon, Mariana Bucovsky, Julie Stubby, Thomas L. Nickolas, Emily M. S...> ;Journal of Bone and Mineral Research. 2019 Sep 1
4 citations
A Lot of Progress, With More to Be Done: A Response to NIH Pathways to Prevention Report "Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Preventi...
Benjamin Z. Leder, Bart L. Clarke, Elizabeth Shane, Sundeep Khosla, Douglas P. Kiel> ;Journal of Bone and Mineral Research. 2019 Sep 1
7 citations
Disrupted radial and tibial microarchitecture in patients with monoclonal gammopathy of undetermined significance.
Emily M. Stein, Alexander S. Dash, Mariana Bucovsky, Sanchita Agarwal, J Fu, S Lentzsch, Elizabeth Shane> ;Osteoporosis International. 2019 Mar 1
9 citations
A Randomized Placebo-Controlled Trial of Low- Versus Moderate-Dose Vitamin D3 Supplementation on Bone Mineral Density in Postmenopausal Women With HIV
Michael T. Yin, Arindam RoyChoudhury, Mariana Bucovsky, Ivelisse Colon, David C. Ferris, Susan Olender, Sanchita Agarwal, Anjali Sharma, Cosmina Zeana, Barry S. Zingma...> ;Journal of Acquired Immune Deficiency Syndromes. 2019 Mar 1
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Journal Articles

Disrupted Radial and Tibial Microarchitecture in Patients with Monoclonal Gammopathy of Undetermined Significance
E Shane, E M Stein, S Lentzsch, J Fu, Osteoporosis international
Abnormal Microarchitecture and Stiffness in Postmenopausal Women Using Chronic Inhaled Glucocorticoids
E Dimango, E Shane, E M Stein, Osteoporosis international

Press Mentions

Rarity Complicates Research, Treatment for Unexplained Premenopausal OsteoporosisMarch 10th, 2021
Crisis in the Treatment of OsteoporosisJune 23rd, 2016
Inactivity in Men Is Linked to Broken Bones, Study SaysJuly 3rd, 2007
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