EmmanuelC.BesaMD

PubMed

• 9 citations
  Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to po...
  Onima Chowdhury, Jennifer O'Sullivan, Nikolaos Barkas, Guanlin Wang, Gemma Buck, Angela Hamblin, Ayalew Tefferi, Haifa K. Al-Ali, Giovanni Barosi, Timothy Devos, Heinz...> ;Leukemia. 2021 Apr 1
• 19 citations
  Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide.
  Mahmoud R. Gaballa, Emmanuel C. Besa> ;Annals of Hematology. 2014 Mar 14
• 141 citations
  Deferasirox Reduces Serum Ferritin and Labile Plasma Iron in RBC Transfusion–Dependent Patients With Myelodysplastic Syndrome
  Alan F. List, Maria R. Baer, David P. Steensma, Azra Raza, Jason Esposito, Noelia Martinez-Lopez, Carole Paley, John Feigert, Emmanuel C. Besa> ;Journal of Clinical Oncology. 2012 Apr 30
• 9 citations
  HHV-8-associated multicentric Castleman's disease in HIV-negative patient: a novel therapy for an orphan disease.
  Maria Magdalena Sbenghe, Emmanuel C. Besa, Amit Mahipal, Alina Dulau Florea, Paul F. Bray, Jaime Caro> ;The Oncologist. 2012 Jan 1
• 7 citations
  Interactive computer‐based programs for a cancer learning center
  Emmanuel C. Besa, Linda Z. Nieman, Rosaline Joseph> ;Journal of Cancer Education. 2009 Oct 1
• Phase I trial of bortezomib, mitoxantrone and etoposide in relapsed/refractory acute leukemia.
  Filicko-O'Hara J, Mookerjee B, Carabasi MH, Besa E, Wagner JL, Flomenberg N> ;J. Clin. Oncol.. 2008-05-20
• 7 citations
  Rituximab in autoimmune pancytopenia: a case report and review of literature
  Lisa D. Reale, Emmanuel C. Besa> ;Annals of Hematology. 2007 May 31
• A second case of myelodysplastic syndrome with t(9;12)(q22;p12).
  Mandana Mahmoodi, Vanlila K. Swami, Emmanuel C. Besa, Hope H. Punnett> ;Cancer Genetics and Cytogenetics. 2005 Mar 1
• 95 citations
  Cryoprecipitate poor plasma does not improve early response in primary adult thrombotic thrombocytopenic purpura (TTP).
  Z. R. Zeigler, Richard K. Shadduck, Jeffrey F. Gryn, Peter B. Rintels, James N. George, Emmanuel C. Besa, David C. Bodensteiner, Bernard J. Silver, Robert E Kramer> ;Journal of Clinical Apheresis. 2001 Jan 1
• 20 citations
  Plasminogen activator inhibitor (PAI‐1) antigen levels in primary TTP and secondary TTP post‐bone marrow transplantation
  Maya T. Anthony, Z. R. Zeigler, John Lister, Jane M. Raymond, Richard K. Shadduck, Robert E. Kramer, Jeffrey Gryn, Peter B. Rintels, Emmanuel C. Besa, James N. George,...> ;American Journal of Hematology. 1998 Sep 1
• 7 citations
  A pilot trial of 13-cis-retinoic acid and alpha-tocopherol with recombinant human erythropoietin in myelodysplastic syndrome patients with progressive or transfusion-d...
  Emmanuel C. Besa, Susan J. Kunselman, Peter C. Nowell> ;Leukemia Research. 1998 Aug 1
• 53 citations
  Plasma von Willebrand factor antigen (vWF:AG) and thrombomodulin (TM) levels in adult thrombotic thrombocytopenic purpura/hemolytic uremic syndromes (TTP/HUS) and bone...
  Z. R. Zeigler, C. S. Rosenfeld, D. F. Andrews, J. Nemunaitis, Jane M. Raymond, Richard K. Shadduck, R. E. Kramer, Jeffrey Gryn, Peter B. Rintels, Emmanuel C. Besa, Jam...> ;American Journal of Hematology. 1996 Dec 1
• 12 citations
  Clinical heterogeneity reflects biologic diversity in chronic lymphocytic leukemia
  Jonni S. Moore, David F. Friedman, Leslie E. Silberstein, Emmanuel C. Besa, Peter C. Nowell> ;Critical Reviews in Oncology/hematology. 1995 Aug 1
• 4 citations
  Richter's syndrome associated with loss of response to transforming growth factor-beta
  Peter C. Nowell, Jonni S. Moore, Floyd E. Fox, Renold J. Capocasale, Jeffrey A. Kant, Emmanuel C. Besa> ;Leukemia Research. 1994 Feb 1
• 71 citations
  Thrombospondin levels in patients with malignancy.
  George P. Tuszynski, Monica Smith, Vicki L. Rothman, David M. Capuzzi, Rosaline Joseph, Julian Katz, Emmanuel C. Besa, Joseph Treat, Hanna I. Switalska> ;Thrombosis and Haemostasis. 1992 Jun 1
• 8 citations
  Myelodysplastic syndromes (refractory anemia). A perspective of the biologic, clinical, and therapeutic issues.
  Emmanuel C. Besa> ;The Medical Clinics of North America. 1992 May 1
• 59 citations
  Treatment with 13-cis-retinoic acid in transfusion-dependent patients with myelodysplastic syndrome and decreased toxicity with addition of alpha-tocopherol.
  Emmanuel C. Besa, Janet L. Abrahm, Mary Bartholomew, Martin Hyzinski, Peter C. Nowell> ;The American Journal of Medicine. 1990 Dec 1
• 30 citations
  Survey of Exposure to Genotoxic Agents in Primary Myelodysplastic Syndrome: Correlation with Chromosome Patterns and Data on Patients without Hematological Disease
  Helen Goldberg, Ed Lusk, Jonni S. Moore, Peter C. Nowell, Emmanuel C. Besa> ;Cancer Research. 1990 Nov 1
• Intravenous immunoglobulin. A promising new therapy for idiopathic thrombocytopenic purpura.
  Besa, E. C.> ;Postgraduate medicine. 1989 Nov 1
• 29 citations
  Prognostic significance of single chromosome abnormalities in preleukemic states
  Peter C. Nowell, Emmanuel C. Besa> ;Cancer Genetics and Cytogenetics. 1989 Oct 1
• 49 citations
  Karyotypic stability in chronic B-cell leukemia.
  Peter C. Nowell, Lisa Moreau, Patrick Growney, Emmanuel C. Besa> ;Cancer Genetics and Cytogenetics. 1988 Jul 15
• 13 citations
  Defective T cell-mediated, isotype-specific immunoglobulin regulation in B cell chronic lymphocytic leukemia
  Jonni S. Moore, Michael B. Prystowsky, Richard G. Hoover, Emmanuel C. Besa, Peter C. Nowell> ;Blood. 1988 Apr 1
• 46 citations
  Rapid transient reversal of anemia and long-term effects of maintenance intravenous immunoglobulin for autoimmune hemolytic anemia in patients with lymphoproliferative...
  Emmanuel C. Besa> ;The American Journal of Medicine. 1988 Apr 1
• 9 citations
  Approach to mild anemia in the elderly.
  Emmanuel C. Besa> ;Clinics in Geriatric Medicine. 1988 Feb 1
• 48 citations
  Chromosome Studies in Preleukemic States V. Prognostic Significance of Single versus Multiple Abnormalities
  Peter C. Nowell, Emmanuel C. Besa, Theresa Stelmach, Janet Finan> ;Cancer. 1986 Dec 15
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Journal Articles

• Hematologic problems in pregnancy. II Aplastic Anemia in pregnancy: Analysis of 5 cases and review of pertinent literature.  
  Borromeo V, Besa E, Caviles AP, Philippine Journal of Internal Medicine
• Primary adenocarcinoma of the jejunum.  
  Besa EC, Acta Medica Philippina
• Immunoadsorption of IgG molecules from the plasma of multiple myeloma and autoimmune hemolytic anemia patients. Proceedings of the Haemonetics Research Institute for A...  
  Ray PK, Idiculla A, Rhoades JE, Jr., Besa EC, Bassett JG, Cooper DR, Journal of Plasma Therapy
• Myelodysplastic syndromes: Recent advances in the biology and therapy of this complex disease.  
  Besa EC, Cancer Therapeutics
• Metastasis of an esophageal carcinoma to the soft tissue in the elbow.  
  Kumar A, Kulkarni R, Besa EC, Oncology Spectrums; Lung Cancer
• Unusually prolonged complete remission with fludarabine and cyclophosphamide followed by Rituximab in refractory, previously treated, CLL—a case report.  
  Kulkarni R, Kumar A, Besa EC, Oncology Spectrums
• Aberrant Blood Grouping Results in a Patient with Splenomegaly and Thrombocytopenia.  
  Sapanara NL, Swami V, Besa EC, Laboratory Medicine
• A Chronic Myelomonocytic Leukemia (CMML) with t(9;12)(q22;p12).  
  Mahmoodi M, Punett HH, Besa EC, Swami VK, Current Opinion in Hematology
• Deferasirox Reduces Serum Ferritin and Labile Plasma Iron in Red Blood Cell Transfusion Dependent Patients with Myelodysplastic Syndrome.  
  List AF, Baer MR, Steensma DP, Raza A, Esposito J, Martinez-Lopez N, Paley C, Feigert J, and Besa E, J Clin Oncology
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Books/Book Chapters

• Taurine in Nutrition and Neurology. 
  Chapter: The Sulphur-containing Amino Acid Pathway in Normal and Malignant Cell Growth 
  Page 127 - 141Baskin SJ, Wakayama K, Knight T, Jepson JH, Besa ECEditors: RJ Huxtable and H. Pasantes-Morales.Plenum Publishing Co, New York
• Current Topics in Hematology. 
  Chapter: Physiologic Mechanisms and the Hematopoietic Effects of the Androstanes and their Derivatives 
  Page 124 - 195Gardner FH, Besa ECEditors: S Piomelli and S Yachnin.Alan R Liss Inc, New York
• Aplastic Anemia. 
  Chapter: Treatment of Refractory Anemia with Etiocholanolone and Prednisolone (Etio-Pred). Initial clinical experience 
  Page 415 - 424Gardner FH, Besa EC, Dale DC, Wolff SMEditors: S. Hibino, F, Tanaka, and N.T. Shahidi.University Park Press, Baltimore
• Hematologic Problems in Renal Disease. 
  Chapter: Sickle Cell Anemia and the Kidney 
  Page 69 - 101Besa EC, Jepson JHEditors: JH Jepson.Addison-Wiley Publishing Co, MA
• Medullary Aplasia. 
  Chapter: The Effects of Steroids and Metabolites on Bone Marrow Function 
  Page 197 - 203Gardner FH, Besa ECEditors: Y Najean.Masson Publishing USA, Inc, New York, NY
• Fundamentals of Internal Medicine. 
  Chapter: Chapter 60. Introduction to Anemia and Approach to Patients with Anemia. Chapter 61. Megaloblastic Anemia., Chapter 62. Bone Marrow Failure, Sideroblastic Anemia, and Myelophthisic Anemia 
  Page 297 - 310Besa ECEditors: D Kaye and LF Rose.C. V. Mosby Co, St Louis
• Internal Medicine for Dentistry. 
  Chapter: Chapter 60. Introduction to Anemia and Approach to Patients with Anemia. Chapter 61. Megaloblastic Anemia., Chapter 62. Bone Marrow Failure, Sideroblastic Anemia, and Myelophthisic Anemia 
  Page 311 - 323Besa ECEditors: LF Rose and D Kaye.C.V. Mosby Co, St. Louis
• Vitamins and Cancer- Human Cancer Prevention by Vitamins and Micronutrients. 
  Chapter: Clinical trials and In Vitro Studies of 13 Cis Retinoic Acid in the Myelodysplastic Syndrome 
  Page 453 - 469Besa EC, Hyzinski M, Nowell PC, Abrahm JLEditors: FL Meyskens and KN Prasad.Humana Press Inc, New Jersey
• Hematology, The National Medical Series for Independent Study. 
  Besa EC, Catalano PM, Kant JA, Jeffries LCHarwall Publishing Company, Malvern, Pennsylvania, Williams & Wilkens, Baltimore, MD
• Hematology and Coagulation, ASCP CaseSet. 
  Chapter: Myelodysplastic Syndrome, Unclassifiable, Case Studies 
  Page 370 - 375Besa EC, Kandra AEditors: G Gulati, J Filicko-O’Hara, JR Krause.
• Hematology and Coagulation, ASCP CaseSet. 
  Chapter: Paroxysmal Nocturnal Hemoglobinuria, Case Studies 
  Page 187 - 188Besa EC, Kandra AEditors: G Gulati, J Filicko-O’Hara, JR Krause.
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Abstracts/Posters

• The use of 3beta etiocholanolone in the treatment of aplastic anemia and myelofibrosis.
  Gardner FH, Besa EC, Blood
• Taurine levels and cellular membrane changes in human leukemic cells.
  Besa EC, Wakayama K, Finney C, Baskin SI, Blood
• Response to adriamycin (A) containing regimens in metastatic breast cancer and possible role of maintenance therapy.
  Lane SD, Besa EC, Joseph RR, 18th Annual Meeting of the American Society of Clinical Oncology
• Reticulocytopenic crisis in autoimmune hemolytic anemia: Presence of a serum IgG erythroid stem cell inhibitor and it's removal by extracorporeal immunoadsorption.
  Mangan KF, Besa EC, Blood
• Increased 3H thymidine uptake of bone marrow cells with lithium in aplastic anemia patients who responded clinically to lithium carbonate.
  Besa EC, Blum SF, Travis SF, Clinical Research
• Lymphocytopenic effects of high-dose intravenous glogulin (IGIV) in chronic lymphocytic leukeia (CLL).
  Besa EC, Holroyd C, American Society of Clinical Oncology
• High-dose cytosine arabinoside (ARA-C) in recurrent myeloid blast crisis of CML.
  Hyzinski M, Besa EC, Joseph RR, The American Society of Clinical Oncology
• An update in the prospective study of treatment of aplastic anemia (AA) with Etiocholanolone-Prednisolone (Etio-Pred).
  Besa EC, Gardner FH, The International Congress of Hematology- Asian Division, Manila, Philippines
• Sequential chromosomal and clinical studies in agnogenic myeloid metaplasia.
  Besa EC, Nowell PC, Murphy SM, Gardner FH, Blood
• Complete hematologic and cytogenetic remission in a patient with dysmyelopoietic syndrome treated with 13 cis-retinoic acid.
  Besa EC, Granick J, Itri L, Nowell PC, Blood
• High-dose intravenous immunoglobulin in the management of pregnancy in women with immune thrombocytopenic purpura.
  Besa EC, Solan AJ, Marfatia U, MacNab MW, Blood
• Clinical evolution of karyotype and phenotype is rare in chronic lymphocytic leukemia.
  Hannam-Harris A, Finan J, Besa EC, Nowell PC, The American Association for Cancer Research
• Clinical trials of 13 cis-retinoic acid in myelodysplastic syndrome.
  Besa EC, Nowell PC, Itri LM, 2nd International Conference on the Modulation and Mediation of Cancer by Vitamins and Micronutrient, Tucson, Arizona
• In vitro evaluation of 13 cis-retinoic acid (CRA) in myelodysplastic syndrome (MDS).
  Hyzinski M, Besa EC, Abrahm JL, 2nd International Conference on the Modulation and Mediation of Cancer by Vitamins and Micronutrient, Tucson, Arizona
• Clinical trials and in vitro evaluation of 13 cis-retinoic acid in myelodysplastic syndrome.
  Besa EC, Hyzinski M, Nowell PC, Itri LM, Abrahm JL, The American Society of Clinical Oncology
• High dose prolonged 13 cis-retinoic acid RA is required for clinical response in myelodysplastic syndrome (MDS).
  Besa EC, Hyzinski M, Nowell PC, Abrahm JL, Blood
• High-dose intravenous immunoglobulin in treatment of life-threatening delayed hemolytic transfusion reaction.
  Oyer R, Swami V, Besa EC, Blood
• Effect of IgA-binding factor on immunoglobulin secretion by neoplastic human B cells.
  Moore JS, Hoover RG, Besa EC, Nowell PC, 6th International Congress of Immunology, Toronto, Canada
• Increased survival in myelodysplastic syndrome (MDS) patients on high dose long term 13 cis-retinoic acid (RA); Decrease of RA toxicity with alpha-tocopherol (AT).
  Besa EC, Abrahm JL, Nowell PC, ASCO
• Comparison of efficacy and toxicity of 13-cis Retinoic acid (RA) with or without alpha-tocopherol in myelodysplasia.
  Besa EC, Abrahm JL, Nowell PC, Blood
• A relatively non-toxic combination for untreated patients with advanced intermediate and high grade non-Hodgkins lymphoma (NHL) (COP-BLAN-MEL).
  Barnes SG, Hamilton R, Besa EC, Bartholomew M, and Central Pennsylvania Oncology Group, ASCO
• Breast self examination: A computer assisted instruction program for the Macintosh.
  Hornig-Rohan J, Besa EC, Gabrielson I, Hornig-Rohan M, Joseph R, Parker JA, Popky GL, Journal of Cancer Education
• Reversal of platelet dysfunction and thrombocytopenia by intravenous immunoglobulin G in immune thrombocytopenic purpura.
  Besa EC, Kowalska MA, Zeigler ZR, Karczewski J, Murphy A, Tuszynski GP, Blood
• Elevated platelet associated IgG (PAIGG) in patients with myelodysplastic syndromes (MDS).
  Burton SI, Besa EC, Zeigler ZR, Blood
• The effects of intravenous immunoglobulin (IVIG) in the leukemic activity of chronic lymphocytic leukemia (CLL).
  Besa EC, Moore J, Nowell PC, Blood
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Lectures

• The Medical College of Pennsylvania Breast Cancer Teaching Module. 
  Philadelphia, Pennsylvania
• Designing an Integrated Self-Learning Computer Program for Effective Cancer Teaching. 
  University of Virginia School of Medicine, Charlottesville, Virginia
• Tracking Student Use of Required Computer Aided Instruction Software in Curriculum. 
  Thomas Jefferson Univarsity, Philadelphia, Pennsylvania
• Tracking Systems for Student Computer Use. 
  Burnaby, British Columbia, Canada
• You Can Lead the Horse to Water–Tracking Students’ Use of CAI. 
  Burnaby, British Columbia, Canada
• Evaluation of a computer-based learning program by a built-in tracking software using scores in quizzes and management of case-simulated patients. 
  Copenhagen, Denmark
• Bone marrow and plasma levels of all-trans-retinoic acid in normal and myelodysplastic syndrome patients. 
  American Society of Hematology 38th Annual Meeting, Orlando, Florida
• Current Status in the Treatment of Chronic Myelogenous Leukemia. 
  Plaza Hotel, MetroManila, Philippines
• Biology, Current and Investigative Therapy of Multiple Myeloma. 
  Plaza Hotel, MetroManila, Philippines
• Diagnosis and Current Management of Chronic Lymphocytic Leukemia. 
  Plaza Hotel, MetroManila, Philippines
• Early Data on a New Combination Chemotherapy Using Topotecan, Fludarabine, Ara-C, and G-CSF for Aggressive Myelodysplastic Syndromes in the Elderly. 
  5Th International Symposium on Myelodysplastic Syndromes, Prague, Czech Republic
• Prolonged survival in chronic phase chronic myelogenous leukemia (CP-CML) using maximally tolerated doses of interferon-alpha (IFN-A). 
  American Society of Clinical Oncology, 35th Annual Meeting, Atlanta, Georgia
• Therapeutic strategies based on new molecular concepts in myelodysplastic syndromes. 
  Central Pennsylvania Oncology Group, Harrisburg, Pennsylvania
• Towards a Peer-Reviewed and Updated Image and Case Bank by the American Society of Hematology. 
  Slice of Life Workshop and Computers in Healthcare Education Symposium, Salt Lake City, Utah
• An Update on Treatment of Myelodysplastic Syndrome and Transformed Leukemias. 
  Hershey Hotel, Hershey, Pennsylvania
• Topotecan, Adriamycin and Decadron (TAD) –A new combination for relapsed multiple myeloma. 
  VIIIth International Myeloma Workshop, Banff, Alberta, Canada
• Is Free and Accurate Medical Information on the Internet Possible in the New Economy? New Ways to Survive the Dot Com Age. 
  Slice of Life For Medial Multimedia Developers and Educators, University of Toronto, Toronto, Canada
• A Library of Teaching Cases for Hematology Course Directors in Case Bank of the American Society of Hematology (ASH). 
  Slice of Life For Medial Multimedia Developers and Educators, University of Toronto, Toronto, Canada
• Management of Thrombocytopenia and Update in the Treatment of Myelodysplastic Syndrome. 
  University of the Philippines – Philippine General Hospital
• Delayed Response to Lenalidomide in International Prognostic Scoring System (IPSS) Low Risk Myelodysplastic Syndrome (MDS). 
  American Society of Hematology 49th Annual Meeting & Exposition, Atlanta, GA
• Update on Treatment of Acute Myelogenous Leukemia. 
  Philippine General Hospital, University of the Philippines, College of Medicine, Manila, Philippines
• Current Perspective in the Biology and Treatment of MDS. 
  Hacettepe University, Institute of Oncology, Department of Basic Oncology, Ankara- Turkey
• Treating Serious Hematologic Malignancies in the Philippines. 
  Mandaluyong, Metro Manila, Philippines
• Recent Advances in the Treatment of Chronic Myelogenous Leukemia (CML). 
  Philippine Society of Hematology & Blood Transfusion, Mandaluyong, Metro Manila, Philippines
• Demethylating Agents in the Treatment of Myelodysplastic Syndromes. 
  Philippine Society of Hematology & Blood Transfusion, Subic Bay, Zambales, Philippines
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Other

• Chronic Myelogenous Leukemia. 
  Besa EC
  http://emedicine.medscape.com/article/199425-overview
• Paroxysmal Nocturnal Hemoglobinuria. 
  Besa EC
  http://emedicine.medscape.com/article/207468-overview
• Secondary Polycythemia. 
  Besa EC
  http://emedicine.medscape.com/article/205039-overview
• Polycythemia, Secondary. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/205039-overview
• Myelodysplastic Syndrome. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/207347-overview
• Paroxysmal Nocturnal Hemoglobinuria. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/207347-overview
• Bone Marrow Failure. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/199003-overview
• Polycythemia Vera. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/205114-overview
• Chronic Myeloid Leukemia. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/204647-overview
• Myelophthisic Anemia. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/204647-overview
• Hairy Cell Leukemia. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/200580-overview
• Acute Promyelocytic Leukemia. 
  Besa, EC and Woermann U, EMedicine from Web MD
  http://emedicine.medscape.com/article/1495306-overview
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