EricJLenzeMD

Psychiatry • Saint Louis, MO

Geriatric Psychiatry

Professor and Head of Psychiatry, Washington University School of Medicine

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Office
1 Barnes Jewish Hospital Plz
Ste 15340
Saint Louis, MO 63110
Phone+1 314-286-1700

Fax+1 314-286-1777
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Summary

Department head, clinical trialist, geriatric psychiatrist.

Education & Training

UPMC Medical EducationFellowship, Geriatric Psychiatry, 1998 - 1999
Washington University/B-JH/SLCH ConsortiumResidency, Psychiatry, 1994 - 1998
Washington University in St. Louis School of MedicineClass of 1994

Certifications & Licensure

IL State Medical License 2020 - 2026
MO State Medical License 2007 - 2025
PA State Medical License 1998 - 2008
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Geriatric Psychiatry

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012

Clinical Trials

Drug Therapy for Generalized Anxiety Disorder Among the Elderly Start of enrollment: 2004 Dec 01
Completed
Phase 4
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults Start of enrollment: 2005 Aug 01
Completed
Phase 4
Acetylcholinesterase Inhibitors to Improve Cognitive Function and Overall Rehabilitation After a Stroke Start of enrollment: 2003 Apr 01
Completed
Phase 4
Incomplete Response in Late Life Depression: Getting to Remission (IRL GREY) Start of enrollment: 2009 Aug 01
Completed
Phase 4
Enhanced Medical Rehabilitation for Disablement Start of enrollment: 2009 Aug 01
Completed
Phase 2
Treatment Resistant Depression (Pilot) Start of enrollment: 2012 Apr 01
Completed
Not Applicable
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders Start of enrollment: 2012 Sep 01
Completed
Phase 1, Phase 2
Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging Start of enrollment: 2011 Oct 01
Completed
Phase 1, Phase 2
Medication Enhanced Rapid Therapy Start of enrollment: 2014 Jan 13
Terminated
Phase 1
Enhanced Medical Rehabilitation in Older Adults Start of enrollment: 2014 Jul 29
Completed
Not Applicable
Buprenorphine Used With Treatment Resistant Depression in Older Adults Start of enrollment: 2016 Jun 01
Completed
Phase 1, Phase 2
Clinical Study of Generic and Brand Bupropion in Depression Start of enrollment: 2014 Jun 25
Completed
Phase 4
Electroencephalography Guidance of Anesthesia Start of enrollment: 2015 Jan 01
Active, not recruiting
Not Applicable
Mindfulness-Based Stress Reduction, Health Education and Exercise Start of enrollment: 2015 Apr 01
Completed
Not Applicable
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults Start of enrollment: 2017 Feb 24
Completed
Phase 4
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training Start of enrollment: 2016 Aug 31
Completed
Phase 4
Modified Application of Cardiac Rehabilitation for Older Adults Start of enrollment: 2019 Nov 04
Active, not recruiting
Not Applicable
A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 Infection Start of enrollment: 2020 Apr 10
Completed
Phase 2
Behavioral Activation and Medication Optimization for Perioperative Mental Health Feasibility Study Start of enrollment: 2021 Nov 17
Completed
Not Applicable
Roles: Contact, Sub-Investigator
Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan Start of enrollment: 2023 Oct 01
Enrolling by invitation
Phase 4
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Perioperative mental health intervention for depression and anxiety symptoms in older adults study protocol: design and methods for three linked randomised controlled ...
Katherine J Holzer, Kimberly A Bartosiak, Ryan P Calfee, Chet W Hammill, Simon Haroutounian, Benjamin D Kozower, Theresa A Cordner, Emily M Lenard, Kenneth E Freedland...> ;BMJ Open. 2024 Apr 3
A multi- and mixed-method adaptation study of a patient-centered perioperative mental health intervention bundle.
Joanna Abraham, Alicia Meng, Ana Baumann, Katherine J Holzer, Emily Lenard, Kenneth E Freedland, Eric J Lenze, Michael S Avidan, Mary C Politi> ;BMC Health Services Research. 2023 Oct 27
An investigation of the potential clinical utility of critical slowing down as an early warning sign for recurrence of depression.
Natasha A Tonge, J Philip Miller, Evan D Kharasch, Eric J Lenze, Thomas L Rodebaugh> ;Journal of Behavior Therapy and Experimental Psychiatry. 2024 Mar 1
Correction: Digital and precision clinical trials: innovations for testing mental health medications, devices, and psychosocial treatments.
Eric Lenze, Patricia Arean, Torous, J.> ;Neuropsychopharmacology. 2024 Jan 1
1 citations
Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.
Breno S Diniz, Johanna Seitz-Holland, Raghav Sehgal, Jessica Kasamoto, Albert T Higgins-Chen, Eric Lenze> ;The American Journal of Geriatric Psychiatry. 2024 Jan 1
Innovative Technologies in CNS Trials: Promises and Pitfalls for Recruitment, Retention, and Representativeness.
Jacqueline Lutz, Abhishek Pratap, Eric J Lenze, Durga Bestha, Jessica M Lipschitz, Stella Karantzoulis, Uma Vaidyanathan, Jessica Robin, William Horan, Stephen Brannan...> ;Innovations in Clinical Neuroscience. 2023 Sep 1
Digital and precision clinical trials: innovations for testing mental health medications, devices, and psychosocial treatments.
Eric Lenze, Patricia Arean, Torous, J.> ;Neuropsychopharmacology. 2024 Jan 1
Depression, anxiety, and suicidal ideation in adults with COVID-induced parosmia.
Emily Stoller, Dorina Kallogjeri, Jay F Piccirillo, Eric J Lenze, Nyssa Fox Farrell, Hentati, F.> ;International Forum of Allergy & Rhinology. 2023 Dec 1
4 citations
Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer's disease, and Depression.
Maria Ly, Gary Z Yu, Ali Mian, Austin Cramer, Somayeh Meysami, David A Merrill, Amjad Samara, Sarah A Eisenstein, Tamara Hershey, Ganesh M Babulal, Eric J Lenze, John ...> ;The American Journal of Geriatric Psychiatry. 2023 Oct 1
3 citations
Treatment-Resistant Late-Life Depression: A Review of Clinical Features, Neuropsychology, Neurobiology, and Treatment.
Subha Subramanian, Hanadi A Oughli, Marie Anne Gebara, Ben Julian A Palanca, Eric J Lenze> ;The Psychiatric Clinics of North America. 2023 Jun 1
Beginning to Address an Implementation Gap in Asthma: Clinicians' Views of Prescribing Reliever Budesonide-Formoterol Inhalers and SMART in the United States.
James G Krings, Tejas C Sekhar, Vanessa Chen, Kathryn V Blake, Kaharu Sumino, Aimee S James, Amber K Clover, Eric J Lenze, Ross C Brownson, Mario Castro> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Sep 1
1 citations
Targeting Slow Wave Sleep Deficiency in Late-Life Depression: A Case Series With Propofol.
Rachel L Rios, MohammadMehdi Kafashan, Orlandrea Hyche, Emily Lenard, Brendan P Lucey, Eric J Lenze, Ben Julian A Palanca> ;The American Journal of Geriatric Psychiatry. 2023 Aug 1
13 citations
Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.
Eric J Lenze, Benoit H Mulsant, Steven P Roose, Helen Lavretsky, Charles F Reynolds 3rd, Daniel M Blumberger, Patrick J Brown, Pilar Cristancho, Alastair J Flint, Mari...> ;The New England Journal of Medicine. 2023 Mar 23
2 citations
Is Anxiety in Late Life an Uncharted Territory?-Questioning the USPSTF Draft Recommendation Statement for Anxiety Screening in Older Adults.
Carmen Andreescu, Eric Lenze, Helen Lavretsky> ;JAMA Psychiatry. 2023 Mar 1
17 citations
Corrigendum to Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participant...
Pilar Cristancho, Emily Lenard, Eric J Lenze, J Philip Miller, Patrick J Brown, Steven P Roose, Carolina Montes-Garcia, Daniel M Blumberger, Benoit H Mulsant, Helen La...> ;The American Journal of Geriatric Psychiatry. 2023 Jun 1
2 citations
SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids.
Yukitoshi Izumi, Angela M Reiersen, Eric J Lenze, Steven J Mennerick, Charles F Zorumski> ;Translational Psychiatry. 2023 Feb 3
1 citations
Recruiting for a Randomized Clinical Trial for Late-Life Depression During COVID-19: Outcomes of Provider Referrals Versus Facebook Self-Referrals.
Nicholas J Ainsworth, Hailey Wright, Ksenya Tereshchenko, Daniel M Blumberger, Alastair J Flint, Eric J Lenze, Athina Perivolaris, Benoit H Mulsant> ;The American Journal of Geriatric Psychiatry. 2023 May 1
2 citations
Prospective Study of the Impact of Outpatient Intensive Cardiac Rehabilitation on Diet Quality, Health-related Quality of Life, and Cardiovascular Health Indices.
Fatima Lakhani, Susan B Racette, Lauren K Park, Elena Deych, Dominique Williams, Kristin M McKenzie, Natalie A Stranczek, Erin J McKenzie, Eric J Lenze, Dotti Durbin, ...> ;The American Journal of Cardiology. 2023 Apr 1
2 citations
Combined Cognitive Training and Vortioxetine Mitigates Age-Related Declines in Functional Brain Network Integrity.
Jill D Waring, Samantha E Williams, Angela Stevens, Anja Pogarčić, Joshua S Shimony, Abraham Z Snyder, Christopher R Bowie, Eric J Lenze> ;The American Journal of Geriatric Psychiatry. 2023 Jun 1
1 citations
Association between lean muscle mass and treatment-resistant late-life depression in the IRL-GRey randomized controlled trial.
Nicholas J Ainsworth, Ram Brender, Neta Gotlieb, Haoyu Zhao, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Ginger E Nicol, Charles F Reynolds, Wei Wang, Benoit H M...> ;International Psychogeriatrics. 2023 Dec 1
5 citations
Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine.
Emma Mastrobattista, Eric J Lenze, Charles F Reynolds, Benoit H Mulsant, Julie Wetherell, Gregory F Wu, Daniel M Blumberger, Jordan F Karp, Meryl A Butters, Ana Paula ...> ;The American Journal of Geriatric Psychiatry. 2023 Jan 1
A pilot randomized sham controlled trial of bilateral iTBS for depression and executive function in older adults.
Pilar Cristancho, Jyoti Arora, Tomoyuki Nishino, Jacinda Berger, Alexandre Carter, Daniel Blumberger, Philip Miller, Abraham Snyder, Deanna Barch, Eric J Lenze> ;International Journal of Geriatric Psychiatry. 2023 Jan 1
2 citations
Central-positive complexes in ECT-induced seizures: Possible evidence for thalamocortical mechanisms.
Emma R Huels, MohammadMehdi Kafashan, L Brian Hickman, ShiNung Ching, Nan Lin, Eric J Lenze, Nuri B Farber, Michael S Avidan, R Edward Hogan, Ben Julian A Palanca> ;Clinical Neurophysiology. 2023 Feb 1
1 citations
Symptom-driven inhaled corticosteroid/long-acting beta-agonist therapy for adult patients with asthma who are non-adherent to daily maintenance inhalers: a study proto...
James G Krings, Kaitlyn M Wojcik, Vanessa Chen, Tejas C Sekhar, Kelly Harris, Abigail Zulich, Kaharu Sumino, Ross Brownson, Eric Lenze, Mario Castro> ;Trials. 2022 Dec 5
5 citations
Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition.
Hanadi Ajam Oughli, Marie Anne Gebara, Adam Ciarleglio, Helen Lavretsky, Patrick J Brown, Alastair J Flint, Nuri B Farber, Jordan F Karp, Benoit H Mulsant, Charles F R...> ;The American Journal of Geriatric Psychiatry. 2023 Mar 1
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Journal Articles

Bioequivalance and Therapeutic Equivalence of Generic and Brand Bupropion in Adults with Major Depression: A Randomized Clinical Trial
J Philip Miller, Eric J Lenze, Clinical Pharmacology & Therapeutics
Cognitive Improvement in Older Adults in the Year After Hip Fracture: Implications for Brain Resilience in Advanced Aging
Ginger Nicol, Eric J Lenze, The American Journal of Geriatric Psychiatry
Reduced GABAergic Cortical Inhibition in Aging and Depression
Jordan F Karp, Eric J Lenze, Nature

Authored Content

Cognitive Improvement in Older Adults in the Year After Hip Fracture: Implications for Brain Resilience in Advanced AgingJuly 2018

Press Mentions

Seniors with Anxiety Frequently Don’t Get Help. Here’s WhyMarch 12th, 2023
A Scientific Grand Slam – Washington University School of Medicine in St. LouisMarch 10th, 2023
Older People with Anxiety Often Don't Get Help. Here's WhyMarch 6th, 2023
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Grant Support

Mindfulness- Based Stress Reduction And Cognitive Function In Stress And AgingNational Center For Complementary &Alternative Medicine2011
2/3-Incomplete Response In Late-Life Depression: Getting To RemissionNational Institute Of Mental Health2009–2011
Risk Genes For Late-Life Depression After HIP FractureNational Institute Of Mental Health2008–2011
Enhanced Medical Rehabilitation For Late-Life Depression After DisablementNational Institute Of Mental Health2010
Enhanced Acute Medical Rehabilitation For Late-Life Depression After HIP FractureNational Institute Of Mental Health2009
Pharmacotherapy Of Latelife Generalized Anxiety DisorderNational Institute Of Mental Health2008–2009
Risk Genes For Late-Life Depression After HIP FractureNational Institute Of Mental Health2007
Pharmacotherapy Of Latelife Generalized Anxiety DisorderNational Institute Of Mental Health2005–2006
Depression Treatment In Medically Rehabilitating ElderlyNational Institute Of Mental Health2001–2005