EricMullinsMD

PubMed

• Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.
  Axel Montagne, Angeliki M Nikolakopoulou, Zhen Zhao, Abhay P Sagare, Gabriel Si, Divna Lazic, Samuel R Barnes, Madelaine Daianu, Anita Ramanathan, Ariel Go, Erica J La...> ;Nature Medicine. 2024 Apr 5
• Multicenter assessment and longitudinal study of the prevalence of antibodies and related adaptive immune responses to AAV in adult males with hemophilia.
  Pabinger, I., Ayash-Rashkovsky, M., Escobar, M., Konkle, B., Mingot-Castellano, M., Negrier, C., Pan, L., Rajavel, K., Yan, B., Chapin, J., Mullins, E.> ;Gene Therapy. 2024 Feb 14
• 1 citations
  Illustrated State-of-the-Art Capsules of the ISTH 2023 Congress.
  Susan R Kahn, Donald M Arnold, Caterina Casari, Karl C Desch, Katrien M J Devreese, Emmanuel J Favaloro, Florian Gaertner, Samantha C Gouw, Paolo Gresele, Arjan W Grif...> ;Research and Practice in Thrombosis and Haemostasis. 2023 May 1
• 3 citations
  Whole-exome analysis of adolescents with low VWF and heavy menstrual bleeding identifies novel genetic associations.
  Brooke Sadler, Charles G. Minard, Gabe Haller, Christina A. Gurnett, Sarah H. O'Brien, Allison P. Wheeler, Shilpa Jain, Mukta Sharma, Ayesha Zia, Roshni Kulkarni, Eric...> ;Blood Advances. 2021 Nov 22
• 17 citations
  Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy.
  Eric S. Mullins, Rebecca Geer, Megan Metcalf, Jeanne Piccola, Adam Lane, Lee Ann E. Conard, Tanya L. Kowalczyk Mullins> ;Pediatrics. 2021 Apr 1
• 11 citations
  Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation
  Joni M. Prasad, Oscar Negrón, Xinli Du, Eric S. Mullins, Joseph S. Palumbo, Jessica M. Gilbertie, Magnus Höök, Steven P. Grover, Rafal Pawlinski, Nigel Mackman, Jay L....> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Jan 5
• 20 citations
  The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development.
  Birgit M. Reipert, B. Gangadharan, C. J. Hofbauer, Verena Berg, Helmut Schweiger, J. Bowen, Jan Blatny, Karin Fijnvandraat, Eric S. Mullins, Jenny Klintman, Christoph ...> ;Blood Advances. 2020 Nov 24
• 13 citations
  The spectrum and severity of bleeding in adolescents with low von Willebrand factor-associated heavy menstrual bleeding.
  Lakshmi Srivaths, Charles G. Minard, Sarah H. O'Brien, Allison P. Wheeler, Eric S. Mullins, Mukta Sharma, Robert F. Sidonio, Shilpa Jain, Ayesha Zia, Margaret V. Ragni...> ;Blood Advances. 2020 Jul 14
• 14 citations
  Long-term safety and efficacy results from the phase 3b, open-label, multicentre Continuation study of rurioctocog alfa pegol for prophylaxis in previously treated pat...
  Pratima Chowdary, Eric S. Mullins, Barbara A. Konkle, Catherine E. McGuinn, Young Shil Park, Oleksandra Stasyshyn, Bulent Zulfikar, Werner Engl, Srilatha Tangada> ;Haemophilia. 2020 Jun 28
• 11 citations
  Heparin Mimic Material Derived from Cellulose Nanocrystals
  Zahra J. Gallagher, Sara Fleetwood, Terence L. Kirley, Maureen A. Shaw, Eric S. Mullins, Neil Ayres, E. Johan Foster> ;Biomacromolecules. 2020 Feb 14
• 12 citations
  Neuron‐generated thrombin induces a protective astrocyte response via protease activated receptors
  Padmesh S. Rajput, Jessica Lamb, Shweta Kothari, Benedict Pereira, Daniel Soetkamp, Yizhou Wang, Jie Tang, Jennifer E. Van Eyk, Eric S. Mullins, Patrick D. Lyden> ;Glia. 2020 Feb 1
• 27 citations
  Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation
  Lakmali Munasinghage Silva, Andrew Gary Lum, Collin Tran, Molly W. Shaw, Zhen Gao, Matthew J. Flick, Niki M. Moutsopoulos, Thomas H. Bugge, Eric S. Mullins> ;Blood. 2019 Jul 18
• 50 citations
  Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion.
  Yi Yang, Amanda Stang, Patrick G. Schweickert, Nadia A. Lanman, Erin N. Paul, Brett P. Monia, Alexey S. Revenko, Joseph S. Palumbo, Eric S. Mullins, Bennett D. Elzey, ...> ;Cancer Research. 2019 Jul 1
• 10 citations
  Elimination of the fibrinogen integrin αMβ2-binding motif improves renal pathology in mice with sickle cell anemia
  Nasimuzzaman, Paritha Arumugam, Eric S. Mullins, Jeanne M. James, Katherine VandenHeuvel, Marilou G. Narciso, Maureen A. Shaw, Sarah McGraw, Bruce J. Aronow, Punam Malik> ;Blood Advances. 2019 May 14
• 17 citations
  Real‐world experience with use of Antihemophilic Factor (Recombinant), PEGylated for prophylaxis in severe haemophilia A
  Amy L. Dunn, Sanjay P Ahuja, Eric S. Mullins> ;Haemophilia. 2018 May 1
• 253 citations
  Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.
  Axel Montagne, Angeliki M. Nikolakopoulou, Zhen Zhao, Abhay P. Sagare, Gabriel Si, Divna Lazic, Samuel Barnes, Madelaine Daianu, Anita Ramanathan, Ariel Go, Erica J. L...> ;Nature Medicine. 2018 Feb 5
• 2 citations
  Successful management of concurrent acquired hemophilia A and a lupus anticoagulant in a pediatric hematopoietic stem cell transplant patient
  LaQuita M Jones, Christopher E. Dandoy, Sonata Jodele, Kasiani C. Myers, Lori Luchtman-Jones, Charles T. Quinn, Eric S. Mullins, Javier El-Bietar> ;Bone Marrow Transplantation. 2018 Jan 12
• 2 citations
  Subcutaneous diphtheria and tetanus vaccines in children with haemophilia: A pilot study and review of the literature.
  Beverly A. Schaefer, Ralph A. Gruppo, Eric S. Mullins, Cristina Tarango> ;Haemophilia. 2017 Nov 1
• 77 citations
  Thrombin promotes diet-induced obesity through fibrin-driven inflammation
  Anna K. Kopec, Sara R. Abrahams, Sherry Thornton, Joseph S. Palumbo, Eric S. Mullins, Senad Divanovic, Hartmut Weiler, A. Phillip Owens, Nigel Mackman, Ashley Goss, Jo...> ;The Journal of Clinical Investigation. 2017 Jul 24
• 28 citations
  Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.
  Maureen A. Shaw, Zhen Gao, Kathryn E. McElhinney, Sherry Thornton, Matthew J. Flick, Adam Lane, Jay L. Degen, Jae K. Ryu, Katerina Akassoglou, Eric S. Mullins> ;The Journal of Neuroscience. 2017 Apr 5
• 20 citations
  Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells.
  Sherry Thornton, Harini Raghu, Carolina Cruz, Malinda Frederick, Joseph S. Palumbo, Eric S. Mullins, Kasper Almholt, Pernille A Usher, Matthew J. Flick> ;Blood Advances. 2017 Mar 28
• 56 citations
  Extended half-life pegylated, full-length recombinant factor VIII for prophylaxis in children with severe haemophilia A.
  Eric S. Mullins, Oleksandra Stasyshyn, M. T. Álvarez-Román, D. Osman, R. Liesner, Werner Engl, Marlies Sharkhawy, Brigitt E. Abbuehl> ;Haemophilia. 2017 Mar 1
• 8 citations
  Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice
  Maureen A. Shaw, Keith W. Kombrinck, Kathryn E. McElhinney, David R Sweet, Matthew J. Flick, Joseph S. Palumbo, Mei Cheng, Naomi L. Esmon, Charles T. Esmon, Alexander ...> ;Blood. 2016 Aug 4
• 18 citations
  Evaluation and Management of Adolescents with Abnormal Uterine Bleeding.
  Tanya L. Kowalczyk Mullins, Rachel J. Miller, Eric S. Mullins> ;Pediatric Annals. 2015 Sep 1
• 41 citations
  Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice
  Paritha Arumugam, Eric S. Mullins, Shiva Kumar Shanmukhappa, Brett P. Monia, Anastacia Loberg, Maureen A. Shaw, Tilat A. Rizvi, Janaka Wansapura, Jay L. Degen, Punam M...> ;Blood. 2015 Oct 8
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Journal Articles

• Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells  
  Thornton S, Raghu H, Cruz C, Frederick MD, Palumbo JS, Mullins ES, Almholt K, Usher PA, and Matthew J. Flick, Blood Advances, 1/1/2017
• Blood compatibility of heparin-inspired, lactose containing, polyureas depends on the chemistry of the polymer backbone  
  Huang Y, Shaw MA, Warmin MR, Mullins ES, and Ayres N, Polym. Chem., 1/1/2016

Books/Book Chapters

• Pathobiology of Human Disease 
  Chapter: Congenital Coagulopathies 
  Page 1562 - 1574Mullins ESEditors: Mitchell LMMN.Academic Press, San Diego2014
• Cancer-associated Thrombosis: New Findings in Translational Science, Prevention and Treatment 
  Chapter: Genetic analysis of hemostatic factors in cancer. 
  Palumbo JS, Mullins ES and Degen JLEditors: AA Khorana and CW Francis.Taylor & Francis Ltd., London2007

Abstracts/Posters

• Plasminogen is protective from development of neuroinflammatory paralysis via preservation of fibrin matrices.
  ES Mullins, GRC, Plasminogen Activation & Extracellular Proteolysis, 1/1/2016
• Thrombin and thrombin targets drives mortality and organ dysfunction in sickle cell disease.
  ES Mullins, FASEB SRC, Proteases in Hemostasis and Vascular Biology, 1/1/2011
• Fibrin(ogen) deficiency ameliorates the severity of transfusion related acute lung injury in mice.
  ES Mullins, American Society of Hematology, 1/1/2009
• Genetic elimination of prothrombin in adult mice compromises both vascular integrity and host defense.
  ES Mullins, FASEB SRC, Proteases in Hemostasis and Vascular Biology, 1/1/2007
• Conditional Disruption of the Murine Prothrombin Gene
  ES Mullins, American Society of Hematology, 1/1/2006
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Lectures

• Plasmin-Mediated Fibrinolysis Enables Macrophage Migration Via Liberation from Fibrin Interactions 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Menorrhagia and Hemostasis 
  1/1/2017
• Platelet Disorders 
  1/1/2017
• Emergency Management of Hemophilia 
  1/1/2016
• Myeloproliferative Disorders 
  1/1/2016
• Plasmin(ogen) Exacerbates Inflammation, Demyelination, and Paralysis in a Murine Model of Multiple Sclerosis 
  1/1/2016
• Plasmin(ogen) mediates macrophage migration in a fibrin(ogen) dependent mechanism. 
  1/1/2016
• A Multidisciplinary Discussion of Evaluation and Management of Adolescents with Abnormal Uterine Bleeding 
  1/1/2015
• Approach to the Bleeding Patient 
  1/1/2015
• Hematology SITE Exam Review 
  1/1/2015
• Thrombin-mediated proteolysis in sickle cell pathology. 
  1/1/2015
• To DUB or Not DUB: A Multidisciplinary Case Discussion of Evaluation and Management of Adolescents with Abnormal Uterine Bleeding 
  1/1/2015
• Thrombosis in a Patient with Pelvic Inflammatory Disease 
  1/1/2014
• Plasminogen deficiency is protective from paralysis in a murine model of multiple sclerosis. 
  1/1/2014
• Mice with genetic modifications in prothrombin limiting activation cleavage events to meizothrombin. 
  1/1/2013
• Evaluation of Menorrhagia and Hemostasis 
  1/1/2012
• Bleeding Disorders for Hematology Fellows 
  1/1/2012
• Primary Hemostasis 
  1/1/2012
• Secondary Hemostasis 
  1/1/2012
• Bleeding Disorders: Work Up and Management 
  1/1/2012
• Mice with genetic alterations of prothrombin limiting activation cleavage events to meizothrombin survive to adulthood, but exhibit altered hemostasis. 
  1/1/2012
• Hemophilia 
  1/1/2011
• Factor XIII deficiency improves motor function in mice challenged with experimental autoimmune encephalomyelitis. 
  1/1/2011
• Von Willebrand's Disease and Approach to Bleeding Disorders 
  1/1/2010
• The Primary Care Pediatrician's Approach to the Bleeding Patient 
  1/1/2010
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Other

• The SIPPET Trial: A Tale of Two Factors. 
  ES Mullins, Bloodline, A Newsletter for Members of the Bleeding Disorders Community, Volume 1
  1/1/2017
• A New Model for Treating Hemophilia A. 
  ES Mullins, Bloodline, A Newsletter for Members of the Bleeding Disorders Community, Volume 2
  1/1/2016
• Women and Bleeding Disorders. 
  Mullins TK and Mullins ES, Bloodline, A Newsletter for Members of the Bleeding Disorders Community, Volume 1
  1/1/2015