EvaCatharinaGuinanMD

Pediatric Hematology & Oncology • Boston, MA

Professor of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School

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Office
450 Brookline Avenue
Dana-Farber Cancer Institute
Boston, MA 02215
Phone+1 617-632-4932

Fax+1 617-632-3770
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Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1984 - 1986
Dana-Farber Cancer InstituteResidency, Pediatrics, 1982 - 1984
Children's Hospital/Boston Medical CenterResidency, Pediatrics, 1980 - 1982
Harvard Medical SchoolClass of 1980

Certifications & Licensure

MA State Medical License 1984 - 2025
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors for Cancer Castle Connolly, 2011-2024
Boston Magazine Castle Connolly, 2010-2024
America's Top Doctors Castle Connolly, 2009-2024

Clinical Trials

Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy Start of enrollment: 2000 Feb 01
Completed
Phase 1
Laboratory-Treated Lymphocyte Infusion After Haploidentical Donor Stem Cell Transplant Start of enrollment: 2005 Jun 01
Completed
Phase 1
Study of Opebacan in Patients Undergoing Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Start of enrollment: 2007 Feb 01
Terminated
Phase 1, Phase 2
Delayed Infusion of Ex Vivo Anergized Peripheral Blood Mononuclear Cells Following CD34 Selected Peripheral Blood Stem Cell Transplant From A Haploidentical Donor For Patients With Acute Leukemia and Myelodysplasia Start of enrollment: 2006 Jun 01
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Publications & Presentations

PubMed

4 citations
Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial.
Eva C Guinan, Laura Contreras-Ruiz, Kerry Crisalli, Charles Rickert, Ivy Rosales, Robert Makar, Robert Colvin, Edward K Geissler, Birgit Sawitzki, Paul Harden, Qizhi T...> ;American Journal of Transplantation. 2023 Dec 1
2 citations
Expanded HCT-CI Definitions Capture Comorbidity Better for Younger Patients of Allogeneic HCT for Nonmalignant Diseases.
Larisa Broglie, Brian D Friend, Saurabh Chhabra, Brent R Logan, Caitrin Bupp, Gary Schiller, Bipin N Savani, Edward Stadtmauer, Allistair A Abraham, Mahmoud Aljurf, Sh...> ;Transplantation and Cellular Therapy. 2023 Feb 1
4 citations
Ex vivo generation of regulatory T cells from liver transplant recipients using costimulation blockade
Katsuyoshi Shimozawa, Laura Contreras-Ruiz, Sofia Sousa, Ruan Zhang, Urvashi Bhatia, Kerry C Crisalli, Lisa L. Brennan, Laurence A. Turka, James F. Markmann, Eva C. Gu...> ;American Journal of Transplantation. 2021 Sep 15
3 citations
Engineering serendipity: When does knowledge sharing lead to knowledge production?
Jacqueline N. Lane, Ina Ganguli, Patrick Gaule, Eva C. Guinan, Karim R. Lakhani> ;Strategic Management Journal. 2021 Jun 1
220 citations
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
Birgit Sawitzki, Paul N. Harden, Petra Reinke, Aurélie Moreau, James A. Hutchinson, David Game, Qizhi Tang, Eva C. Guinan, Manuela Battaglia, William J. Burlingham, Ia...> ;Lancet. 2020 May 23
22 citations
Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Tr...
Matt S. Zinter, Brent R. Logan, Caitrin Fretham, Anil Sapru, Allistair Abraham, Mahmoud Aljurf, Staci D. Arnold, Andrew S. Artz, Jeffery J. Auletta, Saurabh Chhabra, E...> ;Biology of Blood and Marrow Transplantation. 2020 Feb 1
19 citations
Comparison of High Doses of Total Body Irradiation in Myeloablative Conditioning before Hematopoietic Cell Transplantation.
Mitchell Sabloff, Saurabh Chhabra, Tao Wang, Caitrin Fretham, Natasha Kekre, Allistair Abraham, Kehinde Adekola, Jeffery J. Auletta, Christopher A. Barker, Amer Beitin...> ;Biology of Blood and Marrow Transplantation. 2019 Aug 29
36 citations
Use of Crowd Innovation to Develop an Artificial Intelligence–Based Solution for Radiation Therapy Targeting
Raymond H. Mak, Matthias Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo J.W.L. Aerts, Christopher L. Williams, Karim R. Lakhani, Eva C. Guinan> ;JAMA Oncology. 2019 May 1
2 citations
Alloanergization Method for Inducing Allospecific Hyporesponsiveness in PBMC Exposed to Allostimulation In Vitro in the Context of Costimulatory Molecule Blockade.
Christine M. Barbon, Kenneth J. Janec, R. H. Kelner, James E. Norton, Eva C. Guinan> ;Methods in Molecular Biology. 2019 Jan 1
5 citations
Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model
Qing Shuo Zhang, Matthew Deater, Ngoc Phan, Andrea N. Marcogliese, Angela Major, Eva C. Guinan, Markus Grompe> ;Pediatric Blood & Cancer. 2019 Jan 1
13 citations
Toward a more scientific science
Pierre Azoulay, Joshua Graff-Zivin, Brian Uzzi, Dashun Wang, Heidi Williams, James A. Evans, Ginger Zhe Jin, Susan F. Lu, Benjamin F. Jones, Katy Börner, Karim R. Lakh...> ;Science. 2018 Sep 21
1 citations
The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
Marsha A. Wilcox, Adam Savitz, Anjené M. Addington, Gary S. Gray, Eva C. Guinan, John W. Jackson, Thomas Lehner, Sharon-Lise T. Normand, Hardeep Ranu, Geetha Senthil, ...> ;NPJ Schizophrenia. 2018 Jun 27
9 citations
Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation.
Jeff K. Davies, Lisa L. Brennan, John R. Wingard, Christopher R. Cogle, Neena Kapoor, Ami J. Shah, Bimalangshu R. Dey, Thomas R. Spitzer, Marcos de Lima, Laurence J.N....> ;Clinical Cancer Research. 2018 Sep 1
2 citations
rBPI21 (Opebacan) Promotes Rapid Trilineage Hematopoietic Recovery in a Murine Model of High-Dose Total Body Irradiation.
Kenneth J. Janec, Huaiping Yuan, James E. Norton, R. H. Kelner, Christian K. Hirt, Rebecca A. Betensky, Eva C. Guinan> ;American Journal of Hematology. 2018 May 11
16 citations
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca–/– and Fancg–/– Mice by Intraoral Administration of GS-Nitroxide (JP4...
John Willis, Michael W. Epperly, Renee Fisher, Xichen Zhang, Donna Shields, Wen Hou, Hong Wang, Song Li, Peter Wipf, Kalindi Parmar, Eva C. Guinan, Justin Steinman, Jo...> ;Radiation Research. 2018 Mar 27
8 citations
A Field Experiment on Search Costs and the Formation of Scientific Collaborations
Kevin Boudreau, Thomas J. Brady, Ina Ganguli, Patrick Gaule, Eva C. Guinan, Anthony N. Hollenberg, Karim R. Lakhani> ;The Review of Economics and Statistics. 2017 Oct 1
14 citations
Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis.
Andrew A. Hill, Po-Ru Loh, Ragu B. Bharadwaj, Pascal Pons, Jingbo Shang, Eva C. Guinan, Karim R. Lakhani, Iain Kilty, Scott A. Jelinsky> ;Gigascience. 2017 May 1
61 citations
Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study
Parinda A. Mehta, Stella M. Davies, Thomas Leemhuis, Kasiani C. Myers, N A Kernan, Susan E. Prockop, Andromachi Scaradavou, Richard J. O’Reilly, David A. Williams, Les...> ;Blood. 2017 Apr 20
17 citations
Three sides to a story: Child, parent, and nurse perspectives on the child's experience during hematopoietic stem cell transplantation
Christina Ullrich, Angie Mae Rodday, Kristin Bingen, Mary Jo Kupst, Sunita K. Patel, Karen L. Syrjala, Lynnette L. Harris, Christopher J. Recklitis, Grace Chang, Eva C...> ;Cancer. 2017 Aug 15
28 citations
Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study
Richard T. Maziarz, Ruta Brazauskas, Min Chen, A. A. McLeod, Rodrigo Martino, John R. Wingard, M Aljurf, Minoo Battiwalla, Christopher C. Dvorak, B. Geroge, Eva C. Gui...> ;Bone Marrow Transplantation. 2017 Feb 1
42 citations
Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance, Novelty, and Resource Allocation in Science
Kevin Boudreau, Eva C. Guinan, Karim R. Lakhani, Christoph Riedl> ;Management Science. 2016 Oct 1
196 citations
Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure
Paul G. Richardson, Marcie L. Riches, Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Amanda M. Termuhlen, Sally Arai, Stephan A. Grupp, Eva C. Guinan, Paul L. Mar...> ;Blood. 2016 Mar 31
31 citations
Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation.
Eva C. Guinan, G. A. Cole, W. H. Wylie, R. H. Kelner, Kenneth J. Janec, H. Yuan, J. Oppatt, Lisa L. Brennan, Laurence A. Turka, James F. Markmann> ;American Journal of Transplantation. 2016 Jul 1
27 citations
Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2–/– (C57BL/6) Mice
, , , , , , , , , , , , , , , , , , , > ;Radiation Research. 2016 Jan 20
6 citations
Parent Outlook: How Parents View the Road Ahead as They Embark on Hematopoietic Stem Cell Transplantation for Their Child
Christina Ullrich, Angie Mae Rodday, Kristin Bingen, Mary Jo Kupst, Sunita K. Patel, Karen L. Syrjala, Lynnette L. Harris, Christopher J. Recklitis, Lisa A. Schwartz, ...> ;Biology of Blood and Marrow Transplantation. 2016 Jan 1
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Journal Articles

The Open Translational Science in Schizophrenia (OPTICS) Project: An Open-Science Project Bringing Together Janssen Clinical Trial and NIMH Data
Eva C Guinan, Joseph S Ross, Adam J Savitz, Nature

Press Mentions

Can AI Tools Segment A Cancer Tumor as Well as an Oncologist?May 21st, 2019
Harvard, Dana-Farber AI Challenge Uses Crowdsourcing to Improve Cancer CareApril 18th, 2019
Scientists Are Training the Body to Accept New OrgansJanuary 22nd, 2019
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Grant Support

rBPI21: Development of a novel radiation mitigatorDARPA2012–Present
In Vivo Irradiations With Patients Undergoing Radiation Therapy: DANA Farber CancNational Institute Of Allergy And Infectious Diseases2010–2011
Potential Role of rBPI21 in Ameliorating Radiation Toxicity: A Murine ModelDARPA2008–2011
Ex Vivo Alloanergization To Improve Immunity After Haploidentical TransplantNational Cancer Institute2009–2010
Rbpi21 &Endotoxin-Directed Innate Immunity In Stem Cell TransplantationNational Heart, Lung, And Blood Institute2008–2009
Endotoxin-directed Innate Immunity in Patients Undergoing Hematopoietic Stem Cell TransplantationDana Foundation2007–2009
Clinical CoreNational Cancer Institute2008
Cellular Correction Of Congenital Hematopoietic DisordersNational Heart, Lung, And Blood Institute2000–2002
Centers For Clinical Research On TransplantationDivision Of Blood Diseases And Resources1998–2000
Phase I/II Study Of Pixy 321 For Patients With Marrow Failure SyndromesNational Center For Research Resources1996–1997
Phase I/II Trial Of Pixy-321 For Patients With Amegakarypcytic ThrombocytopeniaNational Center For Research Resources1996
Phase I Study Of Recombinant Human Interleukin 11National Center For Research Resources1996