EverettEVokesMD

Oncology • Chicago, IL

Head & Neck Cancer, Hematologic Oncology, Thoracic Cancer

John E. Ultmann Professor of Medicine and Radiation Oncology, University of Chicago Medicine

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Office
5841 S. MARYLAND
M/C 6092
Chicago, IL 60637
Phone+1 773-702-9306

Fax+1 773-702-4427
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Education & Training

University of ChicagoFellowship, Hematology and Medical Oncology, 1983 - 1986
University of Southern California/LAC+USC Medical CenterResidency, Internal Medicine, 1982 - 1983
Advocate Health Care/Advocate Illinois Masonic Medical CenterResidency, Internal Medicine, 1980 - 1982
University of Bonn Faculty of MedicineClass of 1980

Certifications & Licensure

IL State Medical License 1981 - 2026
IN State Medical License 2023 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2009, 2012-2014
Chicago Magazine: Top Doctors Castle Connolly, 2004, 2006, 2008, 2012, 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2005-2008, 2013
Elected Member The American Society for Clinical Investigation, 1998
Super Doctor SuperDoctors.com
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Clinical Trials

Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer Start of enrollment: 1996 Jun 01
Completed
Phase 2
Carboplatin, Paclitaxel, and Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed During Surgery Start of enrollment: 1998 Jul 01
Completed
Phase 3
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer Start of enrollment: 1999 Oct 01
Completed
Phase 1, Phase 2
ZD 1839 in Treating Patients With Metastatic or Recurrent Cancer of the Head and Neck Start of enrollment: 2001 Mar 01
Completed
Phase 2
Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer Start of enrollment: 2001 Jul 01
Completed
Phase 1
Docetaxel Based Chemotherapy Plus or Minus Induction Chemotherapy to Decrease Events in Head and Neck Cancer (DeCIDE) Start of enrollment: 2004 Nov 01
Completed
Phase 3
A Study of Chemoradiotherapy for Intermediate Stage/Selected Stage IV Cancers of the Head and Neck Start of enrollment: 2004 Jan 01
Completed
Phase 2
Bevacizumab, Paclitaxel, Carboplatin, and Radiation Therapy to the Chest in Treating Patients With Locally Advanced Non-Small Cell Lung Cancer Start of enrollment: 2006 Jun 01
Terminated
Phase 1
Cetuximab (ERBITUX®) Added to Two Concurrent Chemoradiotherapy Platforms in Locally Advanced Head and Neck Cancer Start of enrollment: 2006 Jul 01
Completed
Phase 2
Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer
Completed
Phase 1, Phase 2
The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere) [SMART] Trial for Non-Small Cell Lung Cancer (NSCLC) Start of enrollment: 2009 Apr 01
Terminated
Phase 2
Dose Escalation of Bevacizumab With Ambulatory Blood Pressure Monitoring in Patients With Advanced Non-squamous NSCLC Start of enrollment: 2010 Mar 01
Completed
Not Applicable
Dose Escalation Study of RAD001 in Combination w/Chemotherapy & Radiation in Patients With NSCLC Start of enrollment: 2010 Feb 01
Terminated
Phase 1
Cetuximab and Lenalidomide in Head and Neck Start of enrollment: 2010 Feb 01
Completed
Phase 2
Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer Start of enrollment: 2003 Jan 27
Completed
Phase 2
Organ Preservation in the Multispeciality Therapy of Stage II-IV Locally Advanced Head and Neck Cancer Start of enrollment: 2003 Mar 01
Completed
Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141) Start of enrollment: 2014 May 29
Completed
Phase 3
Study of Rovalpituzumab Tesirine (SC16LD6.5) for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Delta-Like Protein 3-Expressing Small Cell Lung Cancer Start of enrollment: 2016 Jan 25
Completed
Phase 2
Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches Start of enrollment: 2014 Nov 01
Completed
Phase 2
Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Sep 01
Completed
Phase 2, Phase 3
Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Start of enrollment: 2015 Dec 29
Active, not recruiting
Phase 3
De-Escalation Therapy for Human Papillomavirus Negative Disease Start of enrollment: 2019 Aug 26
Recruiting
Phase 2
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Publications & Presentations

PubMed

Evaluation of Major Pathologic Response and Pathologic Complete Response as Surrogate End Points for Survival in Randomized Controlled Trials of Neoadjuvant Immune Che...
Jacobi B Hines, Robert B Cameron, Alessandra Esposito, Leeseul Kim, Luca Porcu, Antonio Nuccio, Giuseppe Viscardi, Roberto Ferrara, Giulia Veronesi, Patrick M Forde, J...> ;Journal of Thoracic Oncology. 2024 Mar 8
Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites.
Hou, Y., Yang, K., Wang, L., Wang, J., Huang, X., Piffko, A., Luo, S., Yu, X., Rao, E., Martinez, C., Bugno, J., Mack, M., Vokes, E., Pitroda, S., Chmura, S., Weichsel...> ;Clinical Cancer Research. 2024 Mar 1
1 citations
Bintrafusp Alfa With CCRT Followed by Bintrafusp Alfa Versus Placebo With CCRT Followed by Durvalumab in Patients With Unresectable Stage III NSCLC: A Phase 2 Randomiz...
Everett E Vokes, Francoise Mornex, Ahmet Sezer, Ying Cheng, Jian Fang, David Vicente Baz, Timucin Cil, Alex A Adjei, Myung-Ju Ahn, Fabrice Barlesi, Enriqueta Felip, Ed...> ;Journal of Thoracic Oncology. 2024 Feb 1
3 citations
Bintrafusp Alfa Versus Pembrolizumab in Patients With Treatment-Naive, Programmed Death-Ligand 1-High Advanced NSCLC: A Randomized, Open-Label, Phase 3 Trial.
Byoung Chul Cho, Jong Seok Lee, Yi-Long Wu, Irfan Cicin, Manuel Cobo Dols, Myung-Ju Ahn, Kristof Cuppens, Rémi Veillon, Ernest Nadal, Josiane Mourão Dias, Claudio Mart...> ;Journal of Thoracic Oncology. 2023 Dec 1
Epstein-Barr Virus DNA Screening in Asymptomatic People without Known Nasopharyngeal Cancer.
Izumchenko, E., Vokes, E.> ;NEJM Evidence. 2023 Jul 1
4 citations
Early-Stage Lung Cancer: Using Circulating Tumor DNA to Get Personal.
Christine M Bestvina, Marina C Garassino, Joel W Neal, Heather A Wakelee, Maximilian Diehn, Everett E Vokes> ;Journal of Clinical Oncology. 2023 Sep 1
Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies.
Xiaofei Wang, Zachary R McCaw, Lu Tian, Thomas E Stinchcombe, Everett Vokes, Ethan B Ludmir, Lee-Jen Wei> ;JAMA Network Open. 2023 Jun 1
1 citations
A multicenter, open-label, randomized, phase II study of cediranib with or without lenalidomide in iodine 131-refractory differentiated thyroid cancer.
A J Rosenberg, C-Y Liao, T Karrison, J A de Souza, F P Worden, B Libao, M K Krzyzanowska, D N Hayes, E Winquist, V Saloura, K Prescott, V M Villaflor, T Y Seiwert, R B...> ;Annals of Oncology. 2023 Aug 1
1 citations
"Timing is Everything": the evolving role of immune checkpoint inhibition in nasopharyngeal carcinoma.
A J Rosenberg, E E Vokes> ;Annals of Oncology. 2023 Mar 1
1 citations
Plain language summary of the CheckMate 816 study results: nivolumab plus chemotherapy given before surgery for non-small-cell lung cancer.
Patrick M Forde, Jonathan Spicer, Shun Lu, Mariano Provencio, Tetsuya Mitsudomi, Mark M Awad, Enriqueta Felip, Stephen R Broderick, Julie R Brahmer, Scott J Swanson, K...> ;Future Oncology. 2023 Mar 1
3 citations
Brief Report: Discordance Between Liquid and Tissue Biopsy-Based Next-Generation Sequencing in Lung Adenocarcinoma at Disease Progression.
Misha C Tran, Garth W Strohbehn, Theodore G Karrison, Sherin J Rouhani, Jeremy P Segal, Ardaman Shergill, Philip C Hoffman, Jyoti D Patel, Marina C Garassino, Everett ...> ;Clinical Lung Cancer. 2023 May 1
2 citations
New reporting items and recommendations for randomized trials impacted by COVID-19 and force majeure events: a targeted approach.
Tiffany H Leung, James C Ho, Aya El Helali, Everett E Vokes, Xiaofei Wang, Herbert Pang> ;Annals of Translational Medicine. 2023 Jan 15
12 citations
High-Dose Once-Daily Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: CALGB 30610 (Alliance)/RTOG 0538.
Jeffrey Bogart, Xiaofei Wang, Gregory Masters, Junheng Gao, Ritsuko Komaki, Laurie E Gaspar, John Heymach, James Bonner, Charles Kuzma, Saiama Waqar, William Petty, Th...> ;Journal of Clinical Oncology. 2023 May 1
Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non-Small-Cell Lung Cancer.
Rohan R Katipally, Liam F Spurr, Stanley I Gutiontov, William Tyler Turchan, Philip Connell, Aditya Juloori, Renuka Malik, Michael S Binkley, Alice L Jiang, Sherin J R...> ;JCO Precision Oncology. 2023 Jan 1
What is the ideal endpoint in early-stage immunotherapy neoadjuvant trials in lung cancer?
Robert B Cameron, Jacobi B Hines, Valter Torri, Luca Porcu, Jessica Donington, Christine M Bestvina, Everett Vokes, James M Dolezal, Alessandra Esposito, Marina C Gara...> ;Therapeutic Advances in Medical Oncology. 2023 Jan 1
22 citations
Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade.
Liam F Spurr, Carlos A Martinez, Wenjun Kang, Mengjie Chen, Yuanyuan Zha, Robyn Hseu, Stanley I Gutiontov, William T Turchan, Connor M Lynch, Kelli B Pointer, Paul Cha...> ;Nature Cancer. 2022 Dec 1
17 citations
Uncertainty-informed deep learning models enable high-confidence predictions for digital histopathology.
James M Dolezal, Andrew Srisuwananukorn, Dmitry Karpeyev, Siddhi Ramesh, Sara Kochanny, Brittany Cody, Aaron S Mansfield, Sagar Rakshit, Radhika Bansal, Melanie C Bois...> ;Nature Communications. 2022 Nov 2
4 citations
A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck.
Cherie-Ann O Nathan, D Neil Hayes, Theodore Karrison, Olivier Harismendy, José M Flores, Tara Moore-Medlin, Everett E Vokes, J Silvio Gutkind, Prakash Neupane, Glenn M...> ;Clinical Cancer Research. 2022 Dec 1
14 citations
Phase Ib Study of Telisotuzumab Vedotin in Combination With Erlotinib in Patients With c-Met Protein-Expressing Non-Small-Cell Lung Cancer.
D Ross Camidge, Fabrice Barlesi, Jonathan W Goldman, Daniel Morgensztern, Rebecca Heist, Everett Vokes, Alex Spira, Eric Angevin, Wu-Chou Su, David S Hong, John H Stri...> ;Journal of Clinical Oncology. 2023 Feb 10
1 citations
2022 Presidential Address: Advancing Equitable Cancer Care Through Innovation.
Everett E Vokes> ;Journal of Clinical Oncology. 2022 Sep 1
2 citations
Phase I study of nab-paclitaxel-based induction followed by nab-paclitaxel-based concurrent chemotherapy and re-irradiation in previously treated head and neck squamou...
Ari J Rosenberg, Nishant Agrawal, Alexander T Pearson, Zhen Gooi, Elizabeth Blair, Louis Portugal, John F Cursio, Aditya Juloori, Jeffrey Chin, Kathryn Rouse, Victoria...> ;British Journal of Cancer. 2022 Nov 1
Characterizing Lymph Node Burden With Elective Unilateral Neck Irradiation in Human Papillomavirus-Positive Tonsil Squamous Cell Carcinoma: Defining the Upper Limits.
Jared H Hara, Stanley I Gutiontov, Sophia Uddin, Ari J Rosenberg, Alexander T Pearson, Zhen Gooi, Elizabeth A Blair, Nishant Agrawal, Everett E Vokes, Daniel T Ginat, ...> ;Cureus. 2022 Jul 1
600 citations
Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer.
Patrick M Forde, Jonathan Spicer, Shun Lu, Mariano Provencio, Tetsuya Mitsudomi, Mark M Awad, Enriqueta Felip, Stephen R Broderick, Julie R Brahmer, Scott J Swanson, K...> ;The New England Journal of Medicine. 2022 May 26
A Global Approach to Cancer Equity in the Hispanic/Latinx Population.
Sybil R Green, Gladys Rodriguez, Enrique Soto-Perez-de-Celis, Everett E Vokes> ;JCO Oncology Practice. 2022 May 1
2 citations
Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma.
Vivek Nair, Samuel Auger, Sara Kochanny, Frederick M Howard, Daniel Ginat, Olga Pasternak-Wise, Aditya Juloori, Evgeny Izumchenko, Nishant Agrawal, Ari Rosenberg, Ever...> ;JAMA Network Open. 2022 Apr 1
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Journal Articles

OPTIMA: A Phase II Dose and Volume De-Escalation Trial for Human Papillomavirus-Positive Oropharyngeal Cancer
L Portugal, E A Blair, J M Melotek, M W Lingen, N Agrawal, A Dekker, Z Gooi, D T Ginat, C C Foster, E E Vokes, D J Haraf, Annals of Oncology

Other

Methods to overcome radiation resistance in head and neck cancer
Vokes EE, Brockstein BE, Yoo DS
http://www.uptodate.com/contents/methods-to-overcome-radiation-resistance-in-head-and-neck-cancer
UpToDate, Wolters Kluwer Health - 2012-04-20
Treatment of metastatic and recurrent head and neck cancer
Vokes EE, Brockstein BE
http://www.uptodate.com/contents/treatment-of-metastatic-and-recurrent-head-and-neck-cancer
UpToDate, Wolters Kluwer Health - 2013-03-05
Locally advanced squamous cell carcinoma of the head and neck: Approaches combining chemotherapy and radiation therapy
Vokes EE, Brockstein BE
http://www.uptodate.com/contents/locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck-appro
UpToDate, Wolters Kluwer Health - 2013-04-12

Press Mentions

New Study Supports Saving More Lung Tissue in Lung Cancer SurgeriesMarch 24th, 2023
Thomas Spiegel Appointed Vice President and Health System Chief Quality Officer at UChicago MedicineNovember 2nd, 2022
ASCO Annual Meeting Returns to Chicago, Celebrates New Progress in CancerJune 15th, 2022
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Grant Support

Program 4 (Clinical And Experimental Therapeutics)National Cancer Institute2008–2012
Tas:: 75 0850 ::Tas Recovery ACT - Actnow Clinical Trial 8418 UnderDivision Of Cancer Treatment2009
Early Therapeutics Development With Phase II EmphasisDivision Of Cancer Treatment2009
Early Therapeutics Development With Phase II EmphasisNational Cancer Institute2007
Carcinogenesis And Novel Therapeutics In Oral CancerNational Institute Of Dental &Craniofacial Research1996–2001
Planning And EvaluationNational Cancer Institute1996–2001
Core--Protocol And Data Management OfficeNational Cancer Institute1996–2001
Cooperative StudyNational Cancer Institute1994–2000
Intravenous Administration Of 14C Losoxantrone (DUP941) For Solid TumorsNational Center For Research Resources1997
Core--Biostatistical And Data Management FacilityNational Cancer Institute1992–1995
Clinical InvestigationsNational Cancer Institute1992–1995