FadyMalikMDPhD

PubMed

• Efficacy and Safety of aficamten in Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy: Results From the REDWOOD-HCM Trial, Cohort 4.
  Ahmad Masri, Mark V Sherrid, Theodore P Abraham, Lubna Choudhury, Pablo Garcia-Pavia, Christopher M Kramer, Roberto Barriales-Villa, Anjali T Owens, Florian Rader, She...> ;Journal of Cardiac Failure. 2024 Mar 15
• Tricuspid Regurgitation and Clinical Outcomes in Heart Failure With Reduced Ejection Fraction.
  Adamo, M., Metra, M., Claggett, B., Miao, Z., Diaz, R., Felker, G., McMurray, J., Biering-Sørensen, T., Heitner, S., Kupfer, S., , Solomon, S., Divanji, P., Malik, F.,...> ;JACC. Heart Failure. 2024 Mar 1
• Cardiac Troponin and Treatment Effects of Omecamtiv Mecarbil: Results From the GALACTIC-HF Study.
  Felker, G., Solomon, S., Metra, M., Mcmurray, J., Diaz, R., Claggett, B., Lanfear, D., Vandekerckhove, H., Biering-Sørensen, T., Lopes, R., Arias-Mendoza, A., Momomura...> ;Journal of Cardiac Failure. 2024 Jan 11
• Rewarding Site-Based Research: A Step Toward Improving the Ecosystem of Heart Failure Clinical Trials.
  Matthew G Dimond, Mona Fiuzat, Anu Lala-Trindade, Patrice Desvigne-Nickens, Christopher M O'Connor, Mentz, R., Whellan, D., Walsh, M., Costanzo, M., Yehya, A., Malik, ...> ;JACC. Heart Failure. 2024 Jan 1
• 3 citations
  Sex Differences in Heart Failure With Reduced Ejection Fraction in the GALACTIC-HF Trial.
  Maria Pabon, Jon Cunningham, Brian Claggett, G Michael Felker, John J V McMurray, Marco Metra, Rafael Diaz, Xiaowen Wang, Alexandra Arias-Mendoza, Diana Bonderman, Mar...> ;JACC. Heart Failure. 2023 Dec 1
• 1 citations
  Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy: SEQUOIA-HCM Baseline Characteristics and Study Design.
  Caroline J Coats, Martin S Maron, Theodore P Abraham, Iacopo Olivotto, Matthew M Y Lee, Michael Arad, Nuno Cardim, Chang-Sheng Ma, Lubna Choudhury, Hans-Dirk Düngen, P...> ;JACC. Heart Failure. 2024 Jan 1
• 1 citations
  The Effect of Omecamtiv Mecarbil in Hospitalized Patients as Compared With Outpatients With HFrEF: An Analysis of GALACTIC-HF.
  Kieran F Docherty, John J V McMurray, Rafael Diaz, G Michael Felker, Marco Metra, Scott D Solomon, Kirkwood F Adams, Michael Böhm, Douglas Marshall Brinkley, Luis E Ec...> ;Journal of Cardiac Failure. 2024 Jan 1
• 6 citations
  Aficamten for Drug-Refractory Severe Obstructive Hypertrophic Cardiomyopathy in Patients Receiving Disopyramide: REDWOOD-HCM Cohort 3.
  Anjali T Owens, Ahmad Masri, Theodore P Abraham, Lubna Choudhury, Florian Rader, John D Symanski, Aslan T Turer, Timothy C Wong, Albree Tower-Rader, Caroline J Coats, ...> ;Journal of Cardiac Failure. 2023 Nov 1
• 5 citations
  Efficacy of omecamtiv mecarbil in heart failure with reduced ejection fraction according to N-terminal pro-B-type natriuretic peptide level: insights from the GALACTIC...
  Kieran F Docherty, John J V McMurray, Brian L Claggett, Zi Michael Miao, Kirkwood F Adams, Alexandra Arias-Mendoza, John G F Cleland, Rafael Diaz, Luis E Echeverria Co...> ;European Journal of Heart Failure. 2023 Feb 1
• 1 citations
  Omecamtiv Mecarbil in Black Patients With Heart Failure and Reduced Ejection Fraction: Insights From GALACTIC-HF.
  David E Lanfear, Joyce N Njoroge, Kirkwood F Adams, Inder Anand, James C Fang, Felix Ramires, Karen Sliwa-Hahnle, Aysha Badat, Lesley Burgess, Eiran Z Gorodeski, Celes...> ;JACC. Heart Failure. 2023 May 1
• 11 citations
  Effects of omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: the GALACTIC-HF trial.
  Marco Metra, Matteo Pagnesi, Brian L Claggett, Rafael Díaz, G Michael Felker, John J V McMurray, Scott D Solomon, Diana Bonderman, James C Fang, Cândida Fonseca, Eva G...> ;European Heart Journal. 2022 Dec 21
• 18 citations
  A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants.
  Fady I Malik, Laura A Robertson, Danielle R Armas, Edward P Robbie, Anna Osmukhina, Donghong Xu, Hanbin Li, Scott D Solomon> ;JACC. Basic to Translational Science. 2022 Aug 1
• 4 citations
  Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial.
  Scott D Solomon, Brian L Claggett, Zi Michael Miao, Rafael Diaz, G Michael Felker, John J V McMurray, Marco Metra, Ramon Corbalan, Gerasimos Filippatos, Assen R Goudev...> ;European Heart Journal. 2022 Jun 14
• 7 citations
  Developments in Exercise Capacity Assessment in Heart Failure Clinical Trials and the Rationale for the Design of METEORIC-HF.
  Gregory D Lewis, Kieran F Docherty, Adriaan A Voors, Alain Cohen-Solal, Marco Metra, David J Whellan, Justin A Ezekowitz, Piotr Ponikowski, Michael Böhm, John R Teerli...> ;Circulation. Heart Failure. 2022 May 1
• 3 citations
  Correction to: Reldesemtiv in Patients with Spinal Muscular Atrophy: a Phase 2 Hypothesis-Generating Study.
  Stacy A. Rudnicki, Jinsy A. Andrews, Tina Duong, Bettina M. Cockroft, Fady I. Malik, Lisa Meng, Jenny Wei, Andrew A. Wolff, Angela Genge, Nicholas E. Johnson, Carolina...> ;Neurotherapeutics. 2021 Jul 1
• 12 citations
  A Novel Small Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics.
  Huamei He, Tomas Baka, James A. Balschi, Alykhan Motani, Kathy Nguyen, Qingxiang Liu, Rebecca Slater, Brooke M. Rock, Chen Wang, Christopher M. Hale, Georgios Karamanl...> ;Circulation. Heart Failure. 2021 Oct 28
• 44 citations
  Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial.
  G. Michael Felker, Scott D. Solomon, Brian Claggett, Rafael Diaz, John J.V. McMurray, Marco Metra, Inder S. Anand, Marisa G. Crespo-Leiro, Ulf Dahlström, Eva Goncalves...> ;JAMA Cardiology. 2021 Oct 13
• 8 citations
  Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.
  Scott Collibee, Gustave Bergnes, Chihyuan Chuang, Luke W. Ashcraft, Jeffrey Gardina, Marc Garard, Chris R. Jamison, Kevin Lu, Pu-Ping Lu, Alexander Muci, Antonio A. Ro...> ;Journal of Medicinal Chemistry. 2021 Oct 12
• 57 citations
  Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.
  Chihyuan Chuang, Scott Collibee, Luke W. Ashcraft, Wenyue Wang, Mark Vander Wal, Xiaolin Wang, Darren T. Hwee, Yangsong Wu, Jingying Wang, Eva R. Chin, Peadar Cremin, ...> ;Journal of Medicinal Chemistry. 2021 Oct 4
• Pharmacokinetics, Tolerability, and Safety of Single and Multiple Omecamtiv Mecarbil Doses in Healthy Japanese and Caucasian Subjects
  Ashit Trivedi, Fady I. Malik, Mia Mackowski, Shauna Hutton, Makoto Aoki, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;European Journal of Drug Metabolism and Pharmacokinetics. 2021 Aug 20
• 2 citations
  Prescription and acceptance of durable medical equipment in FORTITUDE-ALS, a study of reldesemtiv in ALS: post hoc analyses of a randomized, double-blind, placebo-cont...
  Stacy A. Rudnicki, Jinsy A. Andrews, Angela Genge, Carlayne E. Jackson, Noah Lechtzin, Timothy M. Miller, Bettina M. Cockroft, Fady I. Malik, Lisa Meng, Jenny Wei, And...> ;Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2021 Jul 5
• 4 citations
  Pharmacokinetic Evaluation of the CYP3A4 and CYP2D6 Drug-Drug Interaction and CYP3A4 Induction Potential of Omecamtiv Mecarbil: Two Open-Label Studies in Healthy Subje...
  Ashit Trivedi, Fady I. Malik, Pegah Jafarinasabian, Hanze Zhang, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Pharmacology in Drug Development. 2021 Jun 19
• 53 citations
  Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF
  John R. Teerlink, Rafael Diaz, G. Michael Felker, John J.V. McMurray, Marco Metra, Scott D. Solomon, Tor Biering-Sørensen, Michael Böhm, Diana Bonderman, James C. Fang...> ;Journal of the American College of Cardiology. 2021 Jul 13
• 8 citations
  Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.
  Josine M. de Winter, Charlotte Gineste, Elisa Minardi, Lorenza Brocca, Maira Rossi, Tamara C. Borsboom, Alan H. Beggs, Monique Bernard, David Bendahan, Darren T. Hwee,...> ;Human Molecular Genetics. 2021 Jun 26
• 9 citations
  The effect of the cardiac myosin activator, omecamtiv mecarbil, on right ventricular structure and function in chronic systolic heart failure (COSMIC-HF).
  Tor Biering-Sørensen, Masatoshi Minamisawa, Jiankang Liu, Brian Claggett, Alexander Papolos, G. Michael Felker, John J.V. McMurray, Jason C. Legg, Fady I. Malik, Narim...> ;European Journal of Heart Failure. 2021 Apr 7
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Journal Articles

• Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure  
  John R Teerlink, David E Lanfear, Thomas M Suter, Narimon Honarpour, Siddique A Abbasi, Fady I Malik, Christopher E Kurtz, The New England Journal of Medicine