Falk W.LohoffMD

PubMed

• Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder.
  Zillich, L., Cetin, M., Hummel, E., Poisel, E., Fries, G., Frank, J., Streit, F., Foo, J., Sirignano, L., Friske, M., Lenz, B., Hoffmann, S., Adorjan, K., Kiefer, F., ...> ;Alcohol, Clinical & Experimental Research. 2024 Feb 1
• Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization St...
  Rosoff, D., Bell, A., Mavromatis, L., Hamandi, A., Park, L., Jung, J., Pacher, P., Ray, D., Davey Smith, G., Wagner, J., Lohoff, F.> ;Circulation. Genomic and Precision Medicine. 2024 Feb 1
• 2 citations
  Multi-omics analysis of alcohol effects on the liver in young and aged mice.
  Lea Zillich, Josephin Wagner, Rachel H McMahan, Lauren M Park, Colin Hodgkinson, Elizabeth J Kovacs, Falk W Lohoff> ;Addiction Biology. 2023 Dec 1
• 3 citations
  PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction.
  Matyas, C., Trojnar, E., Zhao, S., Arif, M., Mukhopadhyay, P., Kovacs, A., Fabian, A., Tokodi, M., Bagyura, Z., Merkely, B., Kohidai, L., Lajko, E., Takacs, A., He, Y....> ;JACC. Basic to Translational Science. 2023 Oct 1
• 1 citations
  Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging.
  Muhammad Arif, Csaba Matyas, Partha Mukhopadhyay, Burhan Yokus, Eszter Trojnar, Janos Paloczi, Bruno Paes-Leme, Suxian Zhao, Falk W Lohoff, György Haskó, Pal Pacher> ;Geroscience. 2023 Oct 1
• 2 citations
  Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.
  Daniel B Rosoff, Andrew S Bell, Josephin Wagner, Lucas A Mavromatis, Ali Hamandi, Lauren Park, Jeesun Jung, Falk W Lohoff> ;Cellular and Molecular Gastroenterology and Hepatology. 2024 Jan 1
• 1 citations
  Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.
  Daniel B Rosoff, Lucas A Mavromatis, Andrew S Bell, Josephin Wagner, Jeesun Jung, Riccardo E Marioni, George Davey Smith, Steve Horvath, Falk W Lohoff> ;Nature Aging. 2023 Aug 1
• 4 citations
  Multi-omic underpinnings of epigenetic aging and human longevity.
  Lucas A Mavromatis, Daniel B Rosoff, Andrew S Bell, Jeesun Jung, Josephin Wagner, Falk W Lohoff> ;Nature Communications. 2023 Apr 19
• 7 citations
  Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system.
  Andrew S Bell, Josephin Wagner, Daniel B Rosoff, Falk W Lohoff> ;Neuroscience and Biobehavioral Reviews. 2023 Jun 1
• 8 citations
  Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis.
  Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M Nievergelt, Adam X Maihofer, Maria C Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Y...> ;Molecular Psychiatry. 2023 Mar 29
• 2 citations
  Base Editing Therapeutics and Ischemic Stroke.
  Josephin Wagner, Andrew S Bell, Falk W Lohoff> ;ACS Chemical Neuroscience. 2022 Dec 7
• 4 citations
  Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomi...
  Andrew S Bell, Daniel B Rosoff, Lucas A Mavromatis, Jeesun Jung, Josephin Wagner, Falk W Lohoff> ;Journal of the American Heart Association. 2022 Nov 1
• 27 citations
  Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function.
  Daniel B Rosoff, Andrew S Bell, Jeesun Jung, Josephin Wagner, Lucas A Mavromatis, Falk W Lohoff> ;Journal of the American College of Cardiology. 2022 Aug 16
• 13 citations
  Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study.
  Lucas A Mavromatis, Daniel B Rosoff, Renata B Cupertino, Hugh Garavan, Scott Mackey, Falk W Lohoff> ;JAMA Psychiatry. 2022 Sep 1
• 9 citations
  Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder.
  Jeesun Jung, Daniel L McCartney, Josephin Wagner, Joyce Yoo, Andrew S Bell, Lucas A Mavromatis, Daniel B Rosoff, Colin A Hodgkinson, Hui Sun, Melanie Schwandt, Nancy D...> ;Biological Psychiatry. 2023 Feb 15
• 7 citations
  Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging.
  Jeesun Jung, Daniel L McCartney, Josephin Wagner, Daniel B Rosoff, Melanie Schwandt, Hui Sun, Corinde E Wiers, Luana Martins de Carvalho, Nora D Volkow, Rosie M Walker...> ;Molecular Psychiatry. 2022 Sep 1
• Genetic and Neurophysiological Biomarkers of Neuroplasticity Inform Post-Stroke Language Recovery.
  Haley C Dresang, Denise Y Harvey, Sharon X Xie, Priyanka P Shah-Basak, Laura DeLoretta, Rachel Wurzman, Shreya Y Parchure, Daniela Sacchetti, Olufunsho Faseyitan, Falk...> ;Neurorehabilitation and Neural Repair. 2022 Jun 1
• 3 citations
  Brain-Derived Neurotrophic Factor Gene Polymorphism Predicts Response to Continuous Theta Burst Stimulation in Chronic Stroke Patients.
  Shreya Parchure, Denise Y Harvey, Priyanka P Shah-Basak, Laura DeLoretta, Rachel Wurzman, Daniela Sacchetti, Olufunsho Faseyitan, Falk W Lohoff, Roy H Hamilton> ;Neuromodulation. 2022 Jun 1
• 4 citations
  Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder.
  Falk W Lohoff> ;Frontiers in Psychiatry. 2022 Jan 1
• 14 citations
  Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/gl...
  Falk W. Lohoff, Toni-Kim Clarke, Zachary Kaminsky, Rosie M. Walker, Mairead L. Bermingham, Jeesun Jung, Stewart W. Morris, Daniel B. Rosoff, Archie Campbell, Miruna C....> ;Molecular Psychiatry. 2021 Dec 2
• 11 citations
  Correction of depression-associated circadian rhythm abnormalities is associated with lithium-response in bipolar disorder.
  Monica Federoff, Michael McCarthy, Amit Anand, Wade H. Berrettini, Holli Bertram, Abesh Kumar Bhattacharjee, Cynthia V. Calkin, Carla Conroy, William Coryell, Nicole D...> ;Bipolar Disorders. 2021 Nov 26
• 17 citations
  Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections.
  Daniel B Rosoff, Joyce Yoo, Falk W. Lohoff> ;Communications Biology. 2021 Oct 28
• 5 citations
  Genetic Variation in PADI6-PADI4 on 1p36.13 Is Associated with Common Forms of Human Generalized Epilepsy.
  Russell J. Buono, Jonathan P. Bradfield, Zhi Wei, Michael R. Sperling, Dennis J. Dlugos, Michael Privitera, Jacqueline A. French, Warren D. Lo, Patrick Cossette, Steve...> ;Genes. 2021 Sep 18
• 2 citations
  Brain-Derived Neurotrophic Factor Gene Polymorphism Predicts Response to Continuous Theta Burst Stimulation in Chronic Stroke Patients
  Shreya Parchure, Denise Y. Harvey, Priyanka P. Shah-Basak, Laura DeLoretta, Rachel Wurzman, Daniela Sacchetti, Olufunsho Faseyitan, Falk W. Lohoff, Roy H. Hamilton> ;Neuromodulation. 2021 Jul 12
• 77 citations
  Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
  Daniel L. McCartney, Josine L. Min, Rebecca C Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Se...> ;Genome Biology. 2021 Jun 29
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