FrankSLeeMD

Pathology • Philadelphia, PA

Anatomic Pathology, Clinical Pathology

Associate Professor, Pathology & Laboratory Medicine, Perelman School of Medicine

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Office
3400 Spruce St
Philadelphia, PA 19104
Phone+1 215-662-6503
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Summary

Dr. Frank Lee, MD is a board certified pathologist in Philadelphia, Pennsylvania. He is currently licensed to practice medicine in Pennsylvania and New Jersey. He is affiliated with Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, and Pennsylvania Hospital.

Education & Training

Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1991 - 1994
Harvard Medical SchoolClass of 1991

Certifications & Licensure

NJ State Medical License 2018 - 2025
PA State Medical License 1998 - 2024
American Board of Pathology Anatomic Pathology

Publications & Presentations

PubMed

Hypoxia Inducible Factor pathway proteins in high-altitude mammals.
Frank S Lee> ;Trends in Biochemical Sciences. 2024 Jan 1
2 citations
High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele.
Kelsey Jorgensen, Daisheng Song, Julien Weinstein, Obed A Garcia, Laurel N Pearson, María Inclán, Maria Rivera-Chira, Fabiola León-Velarde, Melisa Kiyamu, Tom D Brutsa...> ;Molecular Biology and Evolution. 2023 Jul 5
3 citations
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.
Daisheng Song, Kai Peng, Bradleigh E Palmer, Frank S Lee> ;The EMBO Journal. 2022 Nov 17
13 citations
HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics
Xin Yi Chan, Eugenia Volkova, Joon Eoh, Rebecca Black, Lilly Fang, Rayyan Gorashi, Jihyun Song, Jing Wang, Morgan B. Elliott, Sebastian F. Barreto-Ortiz, James K. Chen...> ;Iscience. 2021 Mar 2
8 citations
High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein.
Daisheng Song, Abigail W. Bigham, Frank S. Lee> ;The Journal of Biological Chemistry. 2021 Jan 1
Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle.
Tom D. Brutsaert, Melissa Kiyamu, Gianpietro Elias Revollendo, Jenna L Isherwood, Frank S. Lee, Maria Rivera-Ch, Fabiola León-Velarde, Sudipta Ghosh, Abigail W. Bigham> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Oct 27
18 citations
Tibetan PHD2, an allele with loss-of-function properties.
Daisheng Song, Bradleigh E. Navalsky, Wei Guan, Cassandra Ingersoll, Tao Wang, Emanuele Loro, Lydia Eeles, Kyle B. Matchett, Melanie J. Percy, John Walsby-Tickle, Jame...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 May 15
Erratum: Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude (Proceedings of the National Academy of Sciences of the United State...
Tom D. Brutsaert, Melisa Kiyamu, Gianpietro Elias Revollendo, Jenna L Isherwood, Frank S. Lee, Maria Rivera-Ch, Fabiola León-Velarde, Sudipta Ghosh, Abigail W. Bigham> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Feb 11
1 citations
An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23.
Daisheng Song, Wei Guan, Lea M. Coon, Aref Al-Kali, Jennifer L. Oliveira, Frank S. Lee> ;Hypoxia. 2019 Dec 13
28 citations
Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.
Tom D. Brutsaert, Melisa Kiyamu, Gianpietro Elias Revollendo, Jenna L Isherwood, Frank S. Lee, Maria Rivera-Ch, Fabiola León-Velarde, Sudipta Ghosh, Abigail W. Bigham> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Nov 26
7 citations
Substrates of PHD
Frank S. Lee> ;Cell Metabolism. 2019 Oct 1
44 citations
Update on mutations in the HIF: EPO pathway and their role in erythrocytosis
Terence R.J. Lappin, Frank S. Lee> ;Blood Reviews. 2019 Jul 16
Author Correction: Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis.
Shujing Liu, Gao Zhang, Jianping Guo, Xiang Chen, Jingce Lei, Kan Ze, Liyun Dong, Xiangpeng Dai, Yang Gao, Daisheng Song, Brett L. Ecker, Ruifeng Yang, Caitlin Feltche...> ;Nature Communications. 2019 Mar 11
11 citations
Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
Shujing Liu, Gao Zhang, Jianping Guo, Xiang Chen, Jingce Lei, Kan Ze, Liyun Dong, Xiangpeng Dai, Yang Gao, Daisheng Song, Brett L. Ecker, Ruifeng Yang, Caitlin Feltche...> ;Nature Communications. 2018 Dec 21
16 citations
Loss-of-function zinc finger mutation in the EGLN1 gene associated with erythrocytosis.
Margje Sinnema, Daisheng Song, Wei Guan, Johanna W. H. Janssen, Richard van Wijk, Bradleigh E. Navalsky, Kai Peng, Albertine E. Donker, Alexander P.A. Stegmann, Frank ...> ;Blood. 2018 Sep 27
15 citations
Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.
Kiran Musunuru, Daniel Bernstein, F. Sessions Cole, Mustafa K. Khokha, Frank S. Lee, Shin Lin, Thomas V. McDonald, Ivan P. Moskowitz, Thomas Quertermous, Vijay G. Sank...> ;Circulation. Genomic and Precision Medicine. 2018 Apr 1
5 citations
Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.
Patrick R. Arsenault, Daisheng Song, Marian Bergkamp, Andrew M. Ravaschiere, Bradleigh E. Navalsky, Paul M. Lieberman, Frank S. Lee> ;Chembiochem. 2016 Dec 14
13 citations
The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.
Patrick R. Arsenault, Daisheng Song, Yu Jin Chung, Tejvir S. Khurana, Frank S. Lee> ;Molecular and Cellular Biology. 2016 Sep 15
7 citations
Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis: Indications for Distinct Functional R...
Marije Bartels, Marieke M. van der Zalm, Brigitte A. van Oirschot, Frank S. Lee, Rachel H. Giles, Marieke J. H. A. Kruip, Jerney J. Gitz-Francois, Wouter W. van Soling...> ;Human Mutation. 2015 Nov 1
16 citations
Identification of prolyl hydroxylation modifications in mammalian cell proteins.
Patrick R. Arsenault, Katherine J. Heaton-Johnson, Lin-Sheng Li, Daisheng Song, Vinicius S. Ferreira, Nish Patel, Stephen R. Master, Frank S. Lee> ;Proteomics. 2015 Apr 1
196 citations
Human high-altitude adaptation: forward genetics meets the HIF pathway
Abigail W. Bigham, Frank S. Lee> ;Genes & Development. 2014 Oct 15
35 citations
The role of PHD2 mutations in the pathogenesis of erythrocytosis.
Betty Gardie, Melanie J. Percy, David Hoogewijs, Rasheduzzaman Chowdhury, Celeste Bento, Patrick R. Arsenault, Stéphane Richard, Helena Almeida, Joanne Ewing, Frédéric...> ;Hypoxia. 2014 Jul 1
60 citations
Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing
Daisheng Song, Lin Sheng Li, Patrick R. Arsenault, Qiulin Tan, Abigail W. Bigham, Katherine J. Heaton-Johnson, Stephen R. Master, Frank S. Lee> ;The Journal of Biological Chemistry. 2014 May 23
41 citations
A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism
Patrick R. Arsenault, Fei Pei, Rebecca Lee, Heddy Kerestes, Melanie J. Percy, Brian Keith, M. Celeste Simon, Terence R.J. Lappin, Tejvir S. Khurana, Frank S. Lee> ;The Journal of Biological Chemistry. 2013 Nov 22
157 citations
Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor.
Jeanne Mendell, Hamim Zahir, Nobuko Matsushima, Robert J. Noveck, Frank S. Lee, Shuquan Chen, George Zhang, Minggao Shi> ;American Journal of Cardiovascular Drugs. 2013 Jun 20
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Press Mentions

FORMA Therapeutics’ Olutasidenib Shows Promising Activity Against IDH1-Mutated AMLOctober 26th, 2020
Loss of Phd2 Cooperates with BRAFV600E to Drive MelanomagenesisDecember 21st, 2019

Hospital Affiliations

Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania
Pennsylvania HospitalPhiladelphia, Pennsylvania