FrankW.SmartMDFACC FACP FHFSA

Adult Congenital Heart Disease, Heart Failure & Transplantation, Cardiovascular Disease Genetics

Gerald S Berenson Professor of Medicine, and Pharmacology Chief Section of Cardiology Department of Medicine Kenneth Ardoin/Pfizer Endowed Chair in Cardiovascular Research Louisiana State University Health Science Center New Orleans, Louisiana Director Heart and Vascular Service Line University Medical Center, New Orleans

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Office
3700 St. Charles Av
New Orleans, LA 70115
Phone+1 504-412-1390

Fax+1 504-568-2147
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Education & Training

Baylor College of MedicineFellowship, Cardiovascular Disease, 1988 - 1991
Ochsner Clinic FoundationResidency, Internal Medicine, 1985 - 1988
Louisiana State University School of Medicine in New OrleansClass of 1985

Certifications & Licensure

LA State Medical License 1985 - 2024
NJ State Medical License 2006 - 2013
TX State Medical License 1991 - 2007
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2004-2014
Inside Jersey Magazine Top Doctors Castle Connolly, 2009-2011
Top Doctors: New York Metro Area Castle Connolly, 2007-2011
NJ.com Top Doctors Castle Connolly, 2009
New Jersey Life - Top Heart Doctors and OB-GYN Castle Connolly, 2009
Fellow (FACC) American College of Cardiology
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

PREVENT-HF: Prevention of Heart Failure Events With Impedance Cardiography Testing Start of enrollment: 2007 Jan 01
Unknown status
Phase 4
Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy Start of enrollment: 2010 Apr 01
Completed
Not Applicable
A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters Start of enrollment: 2010 Aug 01
Completed
Not Applicable
A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System Start of enrollment: 2012 Dec 01
Terminated
Phase 3
Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF Start of enrollment: 2013 Oct 02
Completed
Phase 3
Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED) Start of enrollment: 2013 Nov 29
Completed
Phase 2
Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure and Preserved Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-PRESERVED) Start of enrollment: 2013 Nov 06
Completed
Phase 2
Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events Start of enrollment: 2013 Oct 01
Completed
Phase 3
Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects Who Are Intolerant to Statins Start of enrollment: 2014 Jun 01
Completed
Phase 3
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Publications & Presentations

PubMed

2 citations
Implantable Hemodynamic Monitors Improve Survival in Patients With Heart Failure and Reduced Ejection Fraction.
Zile, M., Ducharme, A., Troughton, R., Paul, S., Sears, S., Johnson, N., Henderson, J., Adamson, P., , Lindenfeld, J., Costanzo, M., Maisel, A., Mehra, M., Smart, F., ...> ;Journal of the American College of Cardiology. 2024 Feb 13
2 citations
Hemodynamic-Guided Heart Failure Management in Patients With Either Prior HF Hospitalization or Elevated Natriuretic Peptides.
Akshay S Desai, Alan Maisel, Mandeep R Mehra, Michael R Zile, Anique Ducharme, Sara Paul, Samuel F Sears, Frank Smart, Kunjan Bhatt, Selim Krim, John Henderson, Nessa ...> ;JACC. Heart Failure. 2023 Jun 1
4 citations
Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.
Hanyu Ni, Elizabeth Jordan, Daniel D Kinnamon, Jinwen Cao, Garrie J Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens, Brian Lowes, D...> ;Journal of the American College of Cardiology. 2023 May 30
11 citations
Hemodynamically-Guided Management of Heart Failure Across the Ejection Fraction Spectrum: The GUIDE-HF Trial.
Michael R Zile, Mandeep R Mehra, Anique Ducharme, Samuel F Sears, Akshay S Desai, Alan Maisel, Sara Paul, Frank Smart, Gillian Grafton, Sachin Kumar, Tareck O Nossuli,...> ;JACC. Heart Failure. 2022 Dec 1
5 citations
The GUIDE-HF trial of pulmonary artery pressure monitoring in heart failure: impact of the COVID-19 pandemic.
Michael R Zile, Akshay S Desai, Maria Rosa Costanzo, Anique Ducharme, Alan Maisel, Mandeep R Mehra, Sara Paul, Samuel F Sears, Frank Smart, Christopher Chien, Ashrith ...> ;European Heart Journal. 2022 Jul 14
6 citations
The Relationship Between Body Mass Index and In-Hospital Mortality in the Contemporary Era of an Acute Myocardial Infarction Management.
Gabby Elbaz-Greener, Guy Rozen, Shemy Carasso, Fabio Kusniec, Ibrahim Marai, Maneesh Sud, Bradley H. Strauss, Frank W. Smart, David Planer, Offer Amir> ;Vascular Health and Risk Management. 2021 Sep 10
169 citations
Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial.
JoAnn Lindenfeld, Michael R. Zile, Akshay S. Desai, Kunjan Bhatt, Anique Ducharme, Douglas A. Horstmanshof, S.R. Krim, Alan S. Maisel, Mandeep R. Mehra, Sara C. Paul, ...> ;Lancet. 2021 Sep 11
4 citations
The Relationship Between Body Mass Index and In-Hospital Mortality in Patients Following Coronary Artery Bypass Grafting Surgery.
Gabby Elbaz-Greener, Guy Rozen, Shemy Carasso, Fabio Kusniec, Merav Yarkoni, Ibrahim Marai, Bradley H. Strauss, Harindra C. Wijeysundera, Frank W. Smart, Eldad Erez, R...> ;Frontiers in Cardiovascular Medicine. 2021 Jan 1
39 citations
Hemodynamic-GUIDEd management of Heart Failure (GUIDE-HF).
JoAnn Lindenfeld, William T. Abraham, Alan S. Maisel, Michael R. Zile, Frank W. Smart, Maria Rosa Costanzo, Mandeep R. Mehra, Anique Ducharme, Samuel F. Sears, Akshay ...> ;American Heart Journal. 2019 Aug 1
2 citations
Sudden cardiac arrest as the initial presentation for left ventricular noncompaction cardiomyopathy.
Avaneesh Jakkoju, Rakesh Jakkoju, Vishnupriya Kuchana, Pedro Cox-Alomar, Frank W. Smart, D. Luke Glancy> ;Proceedings. 2019 Jul 31
Gerald Sanders Berenson, 1922–2018
Frank W. Smart> ;European Heart Journal. 2019 Feb 7
2 citations
Mechanisms of Discrepancy Between Pulmonary Artery Wedge Pressure and Left Ventricular End-Diastolic Pressure in Heart Failure With Preserved Ejection Fraction.
Elias B. Hanna, Frank W. Smart, Eliana Hanna Deschamps> ;JACC. Heart Failure. 2018 Mar 1
58 citations
Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney.
David J. Polhemus, Rishi K. Trivedi, Juan Gao, Zhen Li, Amy Scarborough, Traci T. Goodchild, Kurt J. Varner, Huijing Xia, Frank W. Smart, Daniel R. Kapusta, David J. L...> ;Journal of the American College of Cardiology. 2017 Oct 24
14 citations
Sympathoinhibitory Effect of Radiofrequency Renal Denervation in Spontaneously Hypertensive Rats With Established Hypertension.
Juan Gao, Edmund K. Kerut, Frank W. Smart, Akemi Katsurada, Dale M. Seth, L. Gabriel Navar, Daniel R. Kapusta> ;American Journal of Hypertension. 2016 Dec 1
36 citations
Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling
David J. Polhemus, Juan Gao, Amy Scarborough, Rishi K. Trivedi, Kathleen H. McDonough, Traci T. Goodchild, Frank W. Smart, Daniel R. Kapusta, David J. Lefer> ;Circulation Research. 2016 Jul 22
Letter by Hanna and Smart Regarding Article, "Clinical Diagnosis of Pulmonary Hypertension".
Elias B. Hanna, Frank W. Smart> ;Circulation. 2015 Sep 1
8 citations
Proteoglycans from Lungs of Rabbits Treated with Pronase and Cadmium Chloride1–3
Bhandaru Radhakrishnamurthy, Neil Jeansonne, Frank W. Smart, Gerald S. Berenson> ;The American Review of Respiratory Disease. 2015 May 14
23 citations
Photoplethysmography as a single source for analysis of sleep-disordered breathing in patients with severe cardiovascular disease.
Offer Amir, Deganit Barak-Shinar, Antonietta Henry, Frank W. Smart> ;Journal of Sleep Research. 2012 Feb 1
4 citations
Long-term assessment of nocturnal Cheyne-Stokes respiration in patients with heart failure
Offer Amir, Deganit Barak-Shinar, Rafael Wolff, Hagar Paz, Guy Dori, Frank W. Smart, Basil S. Lewis> ;Sleep & Breathing = Schlaf & Atmung. 2011 Dec 1
2 citations
The value of cardiac magnetic resonance imaging in the diagnosis of isolated non-compaction of the left ventricle.
Offer Amir, Reynolds M. Delgado, Biswajit Kar, Frank W. Smart> ;The Israel Medical Association Journal. 2009 May 1
33 citations
Application of Implantable Hemodynamic Monitoring in the Management of Patients With Diastolic Heart Failure: A Subgroup Analysis of the COMPASS-HF Trial
Michael R. Zile, Robert C. Bourge, Tom D. Bennett, Lynne W. Stevenson, Yong K. Cho, Philip B. Adamson, Mark F. Aaron, Juan M. Aranda, William T. Abraham, Frank W. Smar...> ;Journal of Cardiac Failure. 2008 Dec 1
389 citations
Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures.
Michael R. Zile, Tom D. Bennett, Martin St. John Sutton, Yong K. Cho, Philip B. Adamson, Mark F. Aaron, Juan M. Aranda, William T. Abraham, Frank W. Smart, Lynne W. St...> ;Circulation. 2008 Sep 30
387 citations
Randomized Controlled Trial of an Implantable Continuous Hemodynamic Monitor in Patients With Advanced Heart Failure: The COMPASS-HF Study
Robert C. Bourge, William T. Abraham, Philip B. Adamson, Mark F. Aaron, Juan M. Aranda, Anthony Magalski, Michael R. Zile, Andrew Smith, Frank W. Smart, Mark O’Shaughn...> ;Journal of the American College of Cardiology. 2008 Mar 18
882 citations
Right Ventricular Function and Failure Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure
Norbert F. Voelkel, Robert A. Quaife, Leslie A. Leinwand, Robyn J. Barst, Michael D. McGoon, Daniel R. Meldrum, Jocelyn Dupuis, Carlin S. Long, Lewis J. Rubin, Frank W...> ;Circulation. 2006 Oct 24
143 citations
Utility of Impedance Cardiography for the Identification of Short-Term Risk of Clinical Decompensation in Stable Patients With Chronic Heart Failure
Milton Packer, William T. Abraham, Mandeep R. Mehra, Clyde W. Yancy, Christine E. Lawless, Judith E. Mitchell, Frank W. Smart, Rachel Bijou, Christopher M. O'Connor, B...> ;Journal of the American College of Cardiology. 2006 Jun 6
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Press Mentions

February Is Heart Awareness Month, Know Your Risk FactorsFebruary 11th, 2023
CDC Investigating Heart Inflammation in Some Young People After COVID VaccineJune 11th, 2021
The LSU Health Network Partners with Ninety One Inc. To Bring Artificial Intelligence and Precision Medicine to Cardiology in the Fight Against Covid-19April 9th, 2020
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Grant Support

Renal Denervation Effects on Diastolic Heart FailureJohnson and Johnson2011–2014

Committees

Member, Accademic Cardiology Leadership Council of The American College of Cardiology 2020 - Present
member, Stronger Hearts Committee of American Heart Association 2013 - Present
Board of Governors Representative, Quality and Outcomes Committee of The America College of Cardiology 2015 - 2018
member, Board of Governors of The American College of Cardiology 2014 - 2018
member, Educational Committee of American College of Cardiology 2013 - 2017